Read MS_09_17658A_AACC_ScienceBook_booklet6_061709.pdf text version

It starts with an observation. It turns into an equation. And eventually it changes the way we look at the world. It's science. And it starts here, with you.

Put science on your side.

ARCHITECT; ARCHITECT: i 1000sr, i 2000, i 2000sr, c 4000, i 4000sr, ci 4100, c 8000, ci 8200, c 16000, ci 16200, CORE; CELL-DYN; CELL-DYN Ruby 2.0; AbbottLink; ACCELERATOR; AEROsET; ARCHITour; Abbott m2000; Ibis; i-sTAT; Abbott Plex-ID; Precision Xceed Pro; Xmatrx; sCIENCEBOOk; Labs Are Vital; and Put science on your side. are trademarks of Abbott Laboratories. Afinion is a trademark of Axis-shield POC As. 1-877-4ABBOTT

© 2009 Abbott Laboratories MS_09_17658/v1-22 Jun 2009 Printed in USA

Abbott 100 Abbott Park Road Dept 049B, Bldg AP6C-5 Abbott Park, IL 60064

Welcome to the AACC/ASCLS, Chicago 2009 ­ SCIENCEBOOK EDITION!

Welcome to the second issue of SCIENCEBOOK. This issue highlights all of the exciting events brought to you by Abbott and the 2009 AACC.

IN THIS SPECIAL ISSUE · IN-booTH PrESENTATIoN SCHEdULE · workSHoP SCHEdULE · ProdUCT HIgHLIgHTS · Green initiatives and more

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Volume 2



Put science on your side.


Welcome to the AACC. I could use this space to tell you about the exciting news and product offerings you'll see at the Abbott Diagnostics booth this year -- like the ARChITECT ci4100 (in A note from development) integrated Mike Warmuth immunoassay/chemistry analyzer, or the innovative research we're doing to find better diagnostic tools for deadly diseases like hIV, ovarian cancer, and kidney failure. Instead, I'd like to take this opportunity to thank you for your business and share some of the many ways Abbott Diagnostics employees are working to earn and keep your business every day. I hope you're seeing evidence of this commitment. · So far this year, we're maintaining the highest product availability rates and the lowest number of backorders we've had in the past 10 years.

· We're investing in the development of new products like novel biomarkers and new instrument platforms that will diagnose disease to enable optimal efficiency, I look forward to seeing you at the Abbott booth. economy, and outcomes. As one example, Ed Michael, the executive vice president of Abbott's diagnostics Regards, businesses including ADD, point of care and molecular, recently created the Abbott Diagnostics New Technology Group. Through this group, we are investing heavily today to explore and develop the diagnostic technologies Mike Warmuth you'll need 10-15 years from now. President, Abbott Diagnostics Division

In my first six months in this role, I traveled around the country and around the world meeting with dozens of customers like you to listen to what we're doing well and what you need us to do better. Let me reassure you that we hear you loud and clear and that we are taking action throughout our organization to take your satisfaction even higher. But don't take my word for it. I hope you'll spend some time at our AACC booth (#2031) to see this firsthand. Abbott was the first company to bring you a commercial test to screen blood for hIV; we advanced prostate cancer diagnostics with the leading automated PSA test; we're working on the first new diagnostic test for acute kidney injury to be developed in more than 50 years; and we're the first company to bring you a complete family of instruments for your small- to large-volume IA/CC testing needs. Abbott's ARChITECT family of products will allow you to standardize the results and operations across your laboratory network -- which is increasingly important, with focus on Electronic Medical Records (EMRs). We're making key investments in this business today to ensure that you will continue to see more "firsts" and innovations like these coming out of Abbott Diagnostics for years to come.

Put science on your side.

Diagnostics is our expertise. "Put science on your side" is our commitment. Science not only represents thought, knowledge, discipline, and complexity, but also solutions. Every day at Abbott Diagnostics, we are working to provide you the tools necessary to meet your goals. With Abbott solutions, it is easy for you to link sophisticated instruments and reliable results with education and services that help meet the needs of your clinicians and improve patient care. It all ties to a contribution that elevates your lab's impact throughout the entire health care system. By eliminating everyday frustrations, together we can advance everyday science. Visit our booth and learn about our growing portfolio of solutions.

Coming Soon ARCHITECT ci4100 ARCHITECT c4000

Science can transform a lab. Great science can transform a laboratorian.

The ARCHITECT family of analyzers magni es the impact of sophisticated technologies by delivering the rst truly integrated portfolio of immunoassay and chemistry instruments. Featuring unique technologies like the Robotic Sample Handler, FlexRate and CHEMIFLEX, ARCHITECT systems make it easier to get to the science that really matters. Ask your Abbott representative about our growing portfolio or visit for more information.


ci16200 c16000 ci8200 c8000 i4000 SR i2000 SR i1000 SR

Put science on your side.

© 2009 Abbott Laboratories AR_09_15207/v1


See our ads running now in major publications!


In-booth presentations on a variety of topics covering new marker development and more!



10am 11am 1pm 2pm 3pm 4pm

Evaluation of the c4000, Rob kerekes, Charge Technologist, Core Laboratory Chemistry, Huron Perth Healthcare Alliance Improved Cardiac Care: Embracing 99th %ile Troponin Values, Alan HB Wu, PhD, University of California, san Francisco, san Francisco General Hospital Achieving Efficiency through a Lean Design, Cindy Johnson, Director of Laboratory Operations, CentraCare Laboratory services Leveraging Technology Enablers to Manage Results and Throughput, Chris Otto, Chemistry supervisor, Christus santa Rosa Hospital ­ City Centre, san Antonio, TX Labs Are Vital Workflow Modeling to Optimize Hematology Efficiency, Linda stubbs, senior Workflow specialist, Abbott Diagnostics Evaluation of Two Immunoassays for Monitoring Low Blood Levels of Tacrolimus, Daniel Levine, PhD, The Rogosin Institute/Weill Cornell Medical College Consistently Report STAT Results Quickly with the Complete ARCHITECT Family of Instruments, susan Farber, Vice President, Enterprise Analysis Corporation Workflow Modeling to Optimize Hematology Efficiency, Linda stubbs, senior Workflow specialist, Abbott Diagnostics Optimizing Lab Processes Through the Use of Scalable Automation Solutions, sharon Cox, Core Lab supervisor, st. Francis Hospital Defining Reference Intervals for Serum Tumor Markers, Dr. ken sikaris, MD, Director of Chemical Pathology, sonic Health/Melbourne Pathology Abbott Diabetes Care: Patient Safety Best Practices in Blood Glucose Monitoring, Gary sneed, Point of Care Coordinator, Oklahoma Heart Hospital Earlier Detection of Acute HIV Infection with Combination Antigen-Antibody Assays ­ The Public Health Need, Peter A. Leone, MD, University of North Carolina school Evaluation of the c4000, Rob kerekes, Charge Technologist, Core Laboratory Chemistry, Huron Perth Healthcare Alliance




10am 11am 1pm 3pm 4pm



10am 11am 1pm

Stop back often... something's always happening on the stage; guest speakers, Abbott product overviews, educational sessions and more!



The science continues to evolve, allowing us to offer more innovative and sophisticated solutions. We are dedicated to laboratories and clinicians around the world. We advance everyday science and improve clinical outcomes ­ together.

DISCOVEr Innovative Abbott Solutions


ArChITECT ­ The first full family of stand-alone and integrated immunoassay and clinical chemistry systems offers a variety of solutions to meet your workflow needs. Come view a demonstration of the newest members of the ARChITECT family ­ the ci4100 integrated system and c4000 chemistry system for lower- to mid-volume testing. ci4100/c4000 is in



ARChITECT ci4100


ARChITECT ci8200

ARChITECT ci16200


Attend a demonstration of the Afinion analyzer, an immunoassay system designed for use in physicians' office laboratories. The simple, easy and fast way to a glycated hemoglobin or albumin creatinine ratio result for your laboratory.


Come hear about the latest Abbott solutions in disease state management. Cardiac and renal disease ­ Urine NGAL*, Cystatin C**, STAT Troponin-I, BNP Infectious disease ­ hepatitis: hCV Ag**, hBsAg (Quantitative)**, RealTime hBV*** Cancer disease section ­ hE4*/CA125, ProGRP*, RealTime high Risk hPV** Transplant assays and more! * In development ** Not available in the U.S. *** In development, not available in the U.S.



See how Abbott's CELL-DYN high Efficiency hematology solutions will advance the technology beyond the instrument to create a broader, more adaptable solution to enhancing laboratory efficiency.

CELL-DYN Ruby 2.0


Come learn more about the ACCELErATOr suite of integrated laboratory solutions. View the ACCELERATOR Automated Processing Systems, physical automation solutions that provide flexible preanalytic and postanalytical options, as well as direct connectivity to Abbott's ARChITECT platforms. Also see Instrument Manager, an expert software solution, offering configurable rules-based functionality such as auto-verification and integrated QC.


mOLECULAr ­ m2000, Xmatrx

Abbott Molecular is committed to making molecular diagnostics simple and efficient for today's laboratory professionals. Abbott Molecular's unique automation technologies include the Abbott m2000 realTime System and the Xmatrx Automated Slide Staining System. Through our development philosophy, automation strategy and clinical approach to design, the Abbott m2000 system will play a central role as you meet the demands of your evolving molecular lab. The Xmatrx provides you with breakthrough automation for front-end FISh processing while maximizing throughput and minimizing tech time. Stop by the Abbott booth for more details and a demonstration. m2000


Abbott PLEX-ID (in development) uses the Ibis technology, broad-range PCR followed by mass spectrometric analysis, for the detection of microbes. Come hear how you can bring your research to the next level with this exciting technology.



The i-STAT System from Abbott Point of Care can help optimize the partnership between critical care departments and the central lab. By providing a large menu of laboratory quality results at the patient's side within minutes in critical patient situations, the i-STAT System allows the central lab to focus resources on higher complexity tests and high-volume reference lab testing. The i-STAT System can provide blood gas, chemistry, electrolyte, coagulation and cardiac marker single-use cartridges in a simple, easy-to-use handheld platform that easily integrates with the LIS and Electronic Medical Records systems.



Join us to learn more about specific, practical steps you can take to minimize errors in hospital glucose testing and help ensure patient safety in your institution. Our Precision Xceed Pro blood glucose and ß-ketone monitoring system is designed to reduce the risk of errors that could threaten patient safety: from substance interference and patient identification errors to test strip contamination and blood sampling errors. Minimizing the chance of these errors is critical for protecting patients and your institution, and learning about new regulations and guidelines can secure your compliance. Point of care coordinators, lab personnel responsible for overseeing POC testing, and risk management professionals will all benefit from exploring potential sources of testing errors, as well as the solutions offered to reduce your risk. Precision Xceed Pro Blood Glucose and ß-Ketone Monitoring System is not a diagnostic product and is intended for blood glucose and ketone monitoring only.


Precision Xceed Pro


Meet our team of workflow consulting experts to hear how Abbott can optimize your lab using Lean and Six Sigma methods. Experience AbbottLink, a real-time advanced remote diagnostics monitoring system that can help maximize instrument uptime and streamline service processes through customer-facing access to Real-Time reports. This enables laboratories to view their Abbott Instruments' Diagnostics Status, and to assess Assay Utilization and Assay Efficiency reports anywhere there is internet access.


Abbott is pleased to sponsor the NACB Alvin Dubin Award

Professor Alvin Dubin Award for Outstanding Contributions to the Profession and the Academy As the Academy of AACC, the National Academy of Clinical Biochemistry's mission is to elevate the science and practice of clinical laboratory medicine by promoting research, education, and professional development in clinical biochemistry. Through its annual awards program, NACB celebrates the achievements of colleagues who have made significant contributions through scholarship and service to the profession. The award is named in honor of the late Academy member who contributed significantly to the development of NACB and served as President in 1983-84. The award recognizes a current or past member of the Academy who has made noteworthy advances enhancing the mission and stature of NACB.


helping the Environment Be a Greener Place

Expanded Polystyrene Shipping Container reuse Program

Abbott is playing its part in making a sustainable contribution to help the environment. Through our Expanded Polystyrene Shipping Container Reuse Program, customers are now able to recycle their containers! The program, which is free of charge, will allow customers to send certain refrigerated boxes back to Abbott. Abbott will check the condition of these containers and then reuse them for future shipments. This helps us: ·Save on natural resources · reduce waste to the landfill It's just one of the ways we can work together to improve the health of our environment.

Abbott Goes Green at the AACC

Abbott is committed to reducing its carbon footprint at this year's AACC. All electricity used in Abbott's booth will be offset by wind power generated from projects in the U.S. Even the conference bags that Abbott sponsored have been chosen for their earth-friendliness. The bags are made from 51% PET bottle recycled fabric, which diverts plastic bottles from landfills and gives them a renewed use! We encourage you to join us in exploring and promoting environmentally friendly practices and look forward to sharing other ways Abbott is striving to help the earth.





Six Sigma metrics to Define Quality for Integrated and Total Laboratory Automation Systems

· sten Westgard, Ms, Westgard QC, Inc. · Trish Roehrl, CentraCare · Christine C. Brown, Abbott Diagnostics Six Sigma metrics quantitatively express assay quality, combining analyzer and reagent performance. Sigma is calculated using Total Error Allowable (TEA), assay precision, and bias, or as Capability, based on TEA and precision. Sigma allows labs to select optimal QC rules. A new integrated clinical chemistry/immunoassay system, ARChITECT ci4100 (in development), was evaluated at customer lab familiarization sites. ARChITECT ci8200s and an ACCELERATOR Automated Processing System provides Total Laboratory Automation at a major medical complex. The impact of integrated systems and the combination of integrated systems and modular laboratory automation is described and the quality of these systems is assessed using Sigma metrics. Location: Fairmont Hotel, International Ballroom


recent Developments in Clinical Laboratory Oncology Testing

· Richard Moore, MD, Women and Infants Hospital · ken sikaris, MBBs, Melbourne Pathology · steve Marionneaux, Ms, MT (AsCP), st. Vincent's Comprehensive Cancer Center Program presents a novel ovarian cancer marker, describes how to set tumor marker reference intervals, and explains hematology testing for MDS. hE4 is a new marker for ovarian cancer with improved clinical sensitivity for this disease that typically is only detected in its late stages (5-year survival of only 20-30%). Appropriate definition of tumor marker reference intervals improves treatment decisions. Myelodysplastic syndromes are acquired clonal hematologic disorders characterized by ineffective and disorderly hematopoiesis, which results in peripheral cytopenias and morphologic abnormalities in the erythroid, myeloid, and/or megakaryocytic cell lines. These cellular abnormalities present monitoring challenges in the hematology lab. Location: Fairmont Hotel, International Ballroom


Due to capacity restrictions, participation may be limited without prior registration.


This area of our booth is dedicated to the exchange of scientific information. Please stop by to engage in discussions with Abbott scientists, learn about our workshops and obtain copies of scientific literature.





The role of Existing and Emerging Cardiac, metabolic and renal Biomarkers in the Diagnosis and management of Complex Patients with multiple Co-morbidities: Clinical and Laboratory Perspectives

· Alan s Maisel, MD, University of California, san Diego, school of Medicine/ Veterans Affairs Medical · Alan HB Wu, PhD, University of California , san Francisco, san Francisco General Hospital Clinicians face many challenges in the diagnosis and treatment of complex patients presenting with multiple co-morbid conditions. The rising prevalence of obesity, diabetes and the metabolic syndromes has led to increases in cardiovascular and renal diseases and their associated co-morbidities. Biomarkers for cardiovascular, metabolic and renal diseases are an important tool in the diagnosis and management of these patients. Case studies will demonstrate the clinical utility of biomarkers with clinical and laboratory perspectives. Biomarkers to be discussed include BNP, troponin, homocysteine, CRP and NGAL and their existing and emerging utility in initial risk assessment, acute coronary syndromes and heart failure. Location: Fairmont Hotel, International Ballroom


Best Practices for Patient Safety in Point of Care Blood Glucose monitoring

· James h. Nichols, PhD, DABCC, FACB, Tufts University, School of Medicine/Baystate health Minimizing the chance of errors in point of care glucose testing is critical for protecting patients and your institution. Dr. Nichols will explore potential sources of testing errors and outline specific best practices designed to reduce the risk of errors that could threaten patient safety ­ from substance interference and patient identification errors to test strip contamination and blood sampling errors. Location: Hyatt Regency, McCormick Place


Detection of Acute hIV Infection with Combination AntigenAntibody Assays: The Public health Need and User Experience

· Peter A. Leone, MD, University of North Carolina · C.Y. William Tong, MD, FRCP, Guy's and Thomas' NHs Foundation Trust · Mark Pandori, PhD, san Francisco Department of Public Health Acute hIV infection is associated with a high probability of secondary hIV transmission. however, acute hIV infections are rarely recognized. Because routine hIV antibody tests remain negative during the first four to five weeks of hIV infection, acute infections can only be diagnosed during this period by testing for viral antigen or nucleic acids. This workshop will provide data on the frequency of acute hIV infections that may go undiagnosed by assays that detect only antibody. Participants will gain an appreciation for the clinical ramifications of missed acute hIV infections including delays in treatment and increased risk of secondary transmission. Recent data will be reviewed on the increased number of hIV infections detected in diagnostic populations using combination antigen-antibody assays. Data will be presented comparing combination antigen-antibody assays with pooled nucleic acid testing in detection of acute hIV. Location: Fairmont Hotel, International Ballroom


Disease State or System


Title Improved performance of electrolyte analysis on ARCHITECT clinical chemistry systems: confirmed by Six Sigma metrics Impact of extended enzyme linearity on inaccuracy and imprecision of test results: A system level error budget approach Evaluation of urine/CSF assays on the Abbott ARCHITECT c4000 clinical chemistry system Evaluation of enzyme assays on the Abbott ARCHITECT c4000 clinical chemistry system Evaluation of general clinical chemistry assays on the Abbott ARCHITECT c4000 clinical chemistry system UVA Clinical Evaluation of Abbott Next Generation Calcium on the ARCHITECT ci8200 Creatinine assay with IDMS-traceable calibration for the Abbott ARCHITECT cSystems and AERoSET system Evaluation of a new Cystatin C assay on the Abbott ARCHITECT cSystems and AERoSET Clinical Chemistry Systems Clinical evaluation of a new Cystatin C Assay on the Abbott ARCHITECT cSystems and on AERoSET Clinical Chemistry Systems: Commutability and eGFR Streamlined workflow incorporating the ACCElERAToR Automated Processing System at Royal Perth Hospital Reagent Management System (RMS) to improve process quality and reagent documentation Serologic Screening of Pregnant Women in Korea for Primary Human Cytomegalovirus Infection Performance of STAT Troponin-I Immunoassay on the ARCHITECT i1000sr and i2000sr Instrument Platforms Assessment of the 99th Percentile and Functional Sensitivity of the ARCHITECT STAT Troponin-I Immunoassay with Serum, lithium Heparin and EDTA Plasma Specimens Analyses of Samples from a Normal Population for Troponin-I Concentrations Using Four Different Matrixes for the Zero-Concentration Calibrator Performance Characteristics of Troponin-I Assays Across 5 Instruments Assessment of Multiple Biomarkers for Diagnosis of Myocardial Infarction in Patients Presenting with Symptoms Suggestive of Acute Coronary Syndrome Architect HIV Ab/Ag Combo Performance on the ARCHITECT i1000SR System US Hepatitis Assay Migration from the ARCHITECT i2000/i2000SR System to the ARCHITECT i1000SR System Novel Batch Pretreatment Procedure for the ARCHITECT Tacrolimus Assay Evaluation of Cyclosporine on the Abbott ARCHITECT i2000 Immunoanalyzer Evaluation of the Abbott ARCHITECT Cyclosporine Assay Analytical performance of the ARCHITECT methotrexate immunoassay

First Author seago Gaffke Lucio shaw kasal Colberg Novamo Rota Rota Barnes Hemgesberg

Poster No. E-9 A-65 A-134 D-158 A-129 D-41 A-136 D-145 D-39 A-39 A-25

Presentation Date & Time Thursday, July 23 9:30am Tuesday, July 21 10:00am Tuesday, July 21 10:00am Wednesday, July 22 2:00pm Tuesday, July 21 10:00am Wednesday, July 22 2:00pm Tuesday, July 21 10:00am Wednesday, July 22 2:00pm Wednesday, July 22 2:00pm Tuesday, July 21 10:00am Tuesday, July 21 10:00am Wednesday, July 22 10:00am Tuesday, July 21 2:00pm Tuesday, July 21 2:00pm Tuesday, July 21 2:00pm Tuesday, July 21 2:00pm Tuesday, July 21 2:00pm Wednesday, July 22 10:00am Wednesday, July 22 10:00am Thursday, July 23 9:30am Thursday, July 23 9:30am Thursday, July 23 9:30am Thursday, July 23 9:30am Wednesday, July 22 2:00pm Wednesday, July 22 10:00am Wednesday, July 22 10:00am Wednesday, July 22 2:00pm Wednesday, July 22 2:00pm Wednesday, July 22 2:00pm


IACC Systems

Clinical Chemistry






Waterston Waterston

B-58 B-59



Hruska La'ulu Apple Vickstrom UetwillerGeiger Mukaida Chang Levine smith

B-11 B-43 B-42 C-133 C-118 E-131 E-142 E-149 E-101

Infectious Disease




Performance Characteristics of Six Intact Parathyroid Hormone Assays




A Chemiluminescent Microparticle HE4 Assay for the ARCHITECT Instrument System A Chemiluminescent Microparticle CYFRA 21-1 Assay for the ARCHITECT Instrument System Thyroid Autoimmunity and Trimester Specific Reference Intervals for Thyroid Function Tests in Pregnant Chinese Women Determination of Trimester-Specific Reference Intervals for Thyroid Function Tests in a Mixed South East Asian Population Urine neutrophil gelatinase-associated lipocalin (NGAl) as a biomarker for chronic cyclosporine nephrotoxicity after cardiac transplantation

Burkhart schmidt Lu Loh

C-55 C-41 D-97 D-107







Labs Are Vital, in collaboration with Channel One Network, launched an Awareness and Recruitment Campaign to inform students about the many career opportunities in the clinical lab sciences. To get them thinking about the possibilities of a career in the lab sciences, we conducted a video contest asking young people to tell us, "Why careers in the clinical lab sciences are vital." To assist with their research, we partnered with Diagnostics Detectives and the American Blood Centers to provide online information on web page where various videos and links to other resources were made available. From the many very creative videos submitted, one Grand Prize and two Runners Up were selected by the three award sponsoring associations, ASCP, APhL and ASCLS. In addition, the Grand Prize winning video aired on May 4th and was viewed by over 2.2 million students in 4,200 high school classrooms across the United States. Career Opportunities in



Laboratory Science is a critical healthcare field that impacts the health of every individual

WHO ARE "LABORATORY SCIENCE" PROFESSIONALS... detectives who conduct tests and analyze samples that help uncover information needed to make decisions related to patient diagnosis, treatment, prevention and monitoring ...critical to helping ensure healthcare safety


...there are tons of job opportunities available anywhere you want to be ...positions available at all levels, high school through Ph.D. graduates, offering good salaries and room for advancement

Our Grand Prize Winner is Kelly Peterson, a high school senior from Alamo, CA who received $2,500 from ASCP. Runners Up were Megan Dougherty from Inola, OK and Ms. Rice's Biology II Class from East Oktibbeha County h.S., MS. Each received $1,000 from APhL and ASCLS, respectively. Stop by the Labs Are Vital booth to get your 2009 Annual Report supplement.


...enjoy hands-on laboratory work ...are analytical problem solving

To learn more about careers in laboratory science,



© 2009 Abbott Laboratories MS_09_1624/v1

ArChITour Visiting Chicago-Area Students during AACC to Advance Education on Value of the Clinical Laboratory

As part of the Labs Are Vital Awareness and Recruitment Campaign, Abbott has been reaching out to high schools to educate students about lab sciences and careers in the lab sciences profession. During the week of AACC, the Abbott ARChITour will be visiting local Chicago-area students. The ARChITour is a custom-designed 18-wheeler featuring the Abbott ARChITECT ci8200, ci4100 (in development) and CELL-DYN Ruby 2.0 hematology analyzer. Students will learn about the value that clinical laboratories bring to the delivery of health care. Additionally, the students will benefit from a handson experience with sophisticated laboratory equipment ­ something they don't get exposure to in everyday biology courses! The goal of the program, of course, is to entice them toward a career in laboratory sciences. So if you're roving about town during the AACC and see what looks like a student field trip aboard the ARChITour, it probably is!



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