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When recommending an OTC cold sore treatment, consider that...

Only Abreva Can Speed Healing Like a Prescription, But Without One Clinically Proven &

OTC Cold Sore Treatment Active Ingredient(s) and Primary Effect FDA Approved To: Shorten Shorten Healing Symptom Time Duration


Docosanol 10% Allantoin Camphor Menthol Phenol Camphor Phenol Menthol Camphor Phenol Salicylic acid Petrolatum Camphor Menthol Phenol Meradimate Octisalate Octinoxate Oxybenzone Dimethicone Zinc Oxide Allantoin Pramoxine

Cell Entry Blocker1-5 * Skin protectant

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Median 4.1 days 1

Median 2.2 days 1

Blistex® Medicated CamphoPhenique® Medicated

} }



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} Analgesic

Analgesic Antiseptic / Drying agent Moisture barrier Analgesic







Chapstick® Medicated







Sunscreen Skin protectant Sunscreen / Skin protectant Skin protectant Analgesic

­ ­ ­ ­ ­ ­ ­

­ ­ ­ ­ ­ ­ ­

­ ­ ­ ­ ­ ­ ­

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Lysine +® Neosporin LTTM NovitraTM Pure® Lip Remedy ReleevTM Zilactin®

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Sunscreen / Zincum Oxydatum Skin protectant White Petrolatum Allantoin Zinc Oxide Benzalkonium chloride Benzyl Alcohol Moisture barrier Skin protectant Sunscreen / Skin protectant Disinfectant Anesthetic

* Helps block the cold sore infection from entering healthy cells, based on laboratory studies

Blistex is a trademark of Blistex Bracken Limited Partnership, Campho-Phenique is a trademark of Bayer Healthcare LLC, Carmex is a trademark of Carma Labor atories Inc., Chapstick is a trademark of Wyeth, Herpecin-L is a trademark of Signal Investment & Management Company, Neosporin is a trademark of Warner-Lambert Company LLC, Novitra is a trademark of B oericke & Tafel Incorporated, Pure Lip is a trademark of Pure Lip Inc., Releev is a trademark of Bio-Cal Company LLC,Superlysine Plus+ is a trademark of Quantum Inc.,Zilactin is a trademark of Zila Pharmaceuticals Inc .

Recommend The Abreva Healing Difference

The only product with a unique mode of action* available for treating cold sores

Cold sore starting!

Virus breaks through cell membrane to reproduce

Only Abreva speeds healing like a prescription, but without one

Clinically proven to... Shorten Healing Time... · Median healing time in clinical trials when applied at prodromal or erythema stage (p=0.008) was just 4.1 days1 · The only non-prescription treatment that has FDA approval to claim "Shortens Healing Time" Shorten Symptom Duration · Median time to relief of pain, burning, itching, and tingling was (p=0.002) just 2.2 days1 For more information about Abreva, please visit

Abreva helps strengthen the cell membrane

Abreva's unique mode of action helps protect healthy cells*2

* Based on laboratory studies Initiating Abreva at the Prodromal or Erythema stages helps improve its effectiveness1

1 Sacks SL et al. Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: a multicenter, randomized, placebo-controlled trial. J Am Acad Dermatol 2001;45:222-230 2 Pope LE et al. Anti-herpes simplex virus activity of n-docosanol correlates with intracellular metabolic conversion of the drug. Jnl Lipid Research V37, Issue 10, 1996: 2167-2178 3 Habbema L et al. n-Docosanol 10% cream in the treatment of recurrent herpes labialis: a randomized, double-blind placebo-controlled study. Acta Derm Venereol 1996 Nov; 76(6):479-481 4 Katz DH et al. Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex. Proceedings Natl Acad. Science V88, Issue 23; 1991:10825-10829 5 GSK data on file: Center for Drug Evaluation and Research: NDA Review

© 2005 GlaxoSmithKline Consumer Healthcare ABREVA logo and design are owned by GlaxoSmithKline

Heals fast ­ without a prescription


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