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2nd Annual Institute for Molecular Virology Symposium "Viral Host Exploitation and Escape" May 9th, 2006 Coffman Memorial Union Theater 8am-6pm Symposium Program 7:55 ­ 8:00 8:00-9:00 Welcome and Opening Remarks (Louis Mansky) Morning Keynote Lecture: John Coffin (Intro by Reuben Harris) "HIV-host interaction: New insights from new tools."

Morning Session Convenors: Karin Musier-Forsyth & Michael Murtaugh 9:00-9:20 Brandie Kovaleski and Karin Musier-Forsyth HIV Gag-LysRS interaction Yasuhiro Ikeda HIV infection block in mouse cells Patricja Lech and Nikunj Somia Isolation and characterization of cells resistant to HIV-1 Morning break; View posters Stefan Jonsson and Reuben Harris Retroviral restriction by Artiodactyl APOBEC3 Holly Sadler, Mark Stenglein, Reuben Harris and Louis Mansky APOBEC3G expression levels and HIV infectivity Jennifer Smith, Paul Bohjanen and Leslie Schiff Reovirus integrated cellular stress response Patricia Devaux ,Veronika von Messling, Warangkhana Songsungthong, Christoph Springfeld, and Roberto Cattaneo. "Redundant host response control: tyrosine 110 in the measles virus phosphoprotein mediates a block to interferon signaling"



10:00-10:30 10:30-10:50




11:50-1:00 Lunch Afternoon Session Convenors: Kay Faaberg & James Lokensgard 1:00-1:20 Chungling Hu Non-fusogenic measles virus rescue


Zhengguo Xiao and Matt Mescher Heterogeneity of antiviral CTL response Raj Aravalli and James Lokensgard HSV-infected microglial cells & apotosis & immune mediators Afternoon break Katy Fraser and Steve Rice RNA pol II and HSV-1 ICP22 Travis Taylor and Wade Bresnahan Host innate immune response to HCMV Afternoon Keynote Lecture: Lynn Enquist (Intro by Wade Bresnahan) Infection and spread of an alphaherpevirus in neurons Closing Remarks (Louis Mansky) Reception & Poster Session (Atrium and Theater Stage)


2:00-2:20 2:20-2:40



4:00 4:00-6:00

Poster Presentations Poster Authors/Title 1 Yue Wang, Jun Han, Hong Liu and Kay S. Faaberg "PRRSV Chimeric Infectious Clones Affect Virus Replication" 2 Jun Han Identification of a dispensable region and intracellular trafficking of PRRSV nonstructural protein 2 Christoph Springfeld, Veronika von Messling, Marie Frenzke, Guy Ungerechts, Christian J. Buchholz and Roberto Cattaneo Oncolytic efficacy and enhanced safety of measles virus activated by tumorsecreted matrix metalloprotease Peter Southern Direct epithelial damage by herpes simplex virus and increased susceptibility to human immunodeficiency virus Josh Noser The Ras/Raf-1/MEK/ERK signaling pathway dictates the oncolytic properties of VSV Kah-Whye Peng Role of Ligand Affinity and Receptor Density on Cytopathic Killing by Her-2 Retargeted Oncolytic Measles Viruses Vincent Leonard, Michael D. Muehlebach and Roberto Cattaneo Modulation of fusion efficiency by residues in the center of the transmembrane domain of the fusion and hemagglutinin proteins of measles virus Leah Randles, Jamie Nugent, and Patricia E. Tam Coxsackievirus Persistence in Spinal Cord is Linked to Pathogenesis of Chronic Muscle Weakness Cristina Marques Modulation of pro-inflammatory immune responses during herpes encephalitis Wade Schulz and Patricia E. Tam High-throughput, Nonradioactive Determination of RNA Secondary Structure and its Use in Analysis of the Coxsackievirus B1 5' UTR Stacy Cantrell and Wade Bresnahan HCMV Tegument Protein pp71 Relieves hDaxx Mediated Repression of HCMV Replication Lalitha Belur Adeno-associated Virus Vector-Mediated Widespread Distribution and Transgene Expression in Mouse Brain Alistair McGregor A novel gene (UL48.5) may play a role in HSV-1 reactivation from latency in vivo Janna Hill DNA Microarrays to Diagnose Prion Disease







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Anna Strain and Stephen Rice Enhanced transcription of the HSV-1 ICP27 gene by a novel mechanism Joe Palmquist Persistent GDNF expression following herpes encephalitis Maxim Cheeran A critical role for interleukin-10 during cytomegalovirus encephalitis Ratna Prasad Mulupuri, Jeffery Zimmerman, and Michael Murtaugh Persistent viral infection without polyclonal B cell activation Veronika von Messling, Nicholas Svitek and Roberto Cattaneo The determinants of morbillivirus tropism Terri Mattila In situ analysis of HIV-specific CD8+ T cells in human lymphoid tissue Rodrigo Giacaman and Mark C. Herzberg HIV-1 Co-Receptor Up-Regulation by Porphyromonas gingivalis in Oral Keratinocytes Besik Kankia and Karin Musier-Forsyth Effect of HIV-1 Nucleocapsid Protein on the Strand-exchange Reactions in Nucleic Acids Studied by Direct Measurements of Optical Density Renu Kumar, Peter Southern and Mark Herzberg Cell Surface Targets for Virion Binding to Human Palatine Tonsil Ioulia Rouzina and Karin Musier-Forsyth Mechanism of HIV-1 nucleocapsid protein-mediated mini-tar RNA/DNA annealing Anjalee Vacharaksa and Mark Herzberg HIV-1 Reduced the Resistance to Candida Invasion in TERT-2 Ryuta Sakuma Use of intrinsic restriction factors for HIV-1 gene therapy My-Nuong Vo, Ioulia Rouzina, Siddhartha A. Datta, George Barany, Alan Rein, Karin Musier-Forsyth Investigation of the chaperone activities of HIV-1 NC and Gag reveal the dominant role of nucleic acid aggregation in facilitating the TAR RNA/DNA annealing step of minus-strand transfer Mark Stenglein and Reuben Harris APOBEC3B and APOBEC3F inhibit L1 retrotranscription by a DNA deamination-independent mechanism Anil Asrani and Kristin Gebhard-Abts A novel way to titer HIV-1 using a TZM-bl reporter-cell line and quantitative realtime PCR Manuel Llano and Eric Poeschla A molecular model for LEDGF/p75-mediated chromatin tethering of HIV-1 integrase


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2006 IMV Symposium Planning Committee: Wade Bresnahan Kay Faaberg Paul Jardine Reuben Harris James Lokensgard Louis Mansky Michael Murtaugh Karin Musier-Forsyth Academic financial support for the 2006 IMV Symposium was provided by: Academic Health Center Medical School Office of the Vice President for Research School of Dentistry School of Veterinary Medicine. Corporate financial support was provided by: Bio-Rad Laboratories Qiagen, Inc.


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