Read AiBSTNewsletterNovember2005A4 text version

November, 2005

Newsletter

Volume 8

MOU with Obafemi Awolowo University (OAU)

In accordance with the mutual desire to promote further cooperation

between the Obafemi Awolowo University, Ile-Ife, Nigeria (OAU) and the African Institute for Biomedical Science & Technology, Harare, Zimbabwe (AiBST) entered into a Memorandum of Understanding for the purpose of academic and research collaboration. The two institutions will establish a partnership that will result in collaborative academic efforts focusing on teaching research and community development. The partnership will have at least four areas of emphasis ­ research collaboration and joint publication among teaching/research staff, exchange of educational materials and scientific equipment, student/staff exchanges and the promotion of social activities and cultural understanding. Using both actual and virtual exchange activities, the proposed collaboration will enhance and facilitate the role of OAU and AiBST in capacity building at both local and international levels.

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Recent Events

1. Visit by Dr Oluseye O. Bolaji 2. Inaugural HPLC Course 3. Visit by Chinhoyi University 4. Seminar on Malaria

Upcoming Events

1. Dr Collen Masimirembwa will be giving 2 plenary lectures, two workshop lectures and conduct 3 workshop exercises at the `First North-South Conference and Workshops in Pharmacogenetics' in Kuala Lumpur, Malaysia. 12-17th of December, 2005.

Inaugural HPLC Course

Chemical analysis is a key activity in many industries including the pharmaceutical industry, quality control laboratories and production industries (e.g. beverage and dairy industries), environmental pollution analysts, toxicology laboratories, and biomedical research institutes. Accurate identification and quantification of chemical components ensures that

(Continued on page 2)

Chinhoyi University

Chinhoyi University was formed in 2003. It is one of the many provisional universities being formed in Zimbabwe in order to meet the increaisng demands for graduate education. Like most such universities, it offers both science and arts degrees. The challenge in the sciences is the availability of good laboratories, equipment and reagents. So, though the University is offering a BSc degree in Biotechnology, it does not have a basic laboratory to carry out practical work. This brings with it severe limitations in the training of students as they

Contact details

Visiting Address:

1st Floor LAPF Center Jason Moyo Av/Chinhoyi St Harare Zimbabwe

Optimising anti-Malaria Therapy in Africans.

Dr Bolaji of Obafemi Awolowo University (OAU), Nigeria conducted this months seminar while on a business visit to AiBST. He shared his research results and extensive experience with anti-malaria therapy in Africans. Name: BOLAJI, Oluseye Oladotun Date of Birth: July 28, 1954 Professional Title: Associate Professor Nationality: Nigerian Education: 1983 Ph.D. (Pharmacy) University of Strathclyde, Glasgow, UK 1980 1976 M. Phil. (Pharmaceutical Chemistry) University of Ife, (now Obafemi Awolowo University), Ile-Ife, Nigeria B. Pharmacy University of Ife, Ile-Ife, Nigeria

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Postal: P.O. Box 2294

Harare, Zimbabwe

Fax: 263 4 710562 Phone: 263 4 710563/4 Website: www.aibst.com

Email: [email protected]

"Where there is no vision the people will perish....." Proverbs 29 v 18

Page 2

Newsletter

Inaugural HPLC Course

(Continued from page 1)

quality products are made available to various clients. Of all bio-analytical methods for the identification and quantification of different chemicals, HPLC with UV and fluorescence detection is an extremely important technique. It is, therefore, a cause of concern that there are few highly qualified personnel in the use of HPLC in Africa. An even more disturbing fact is that during such training, the students have very limited access to the equipment to have a real practical appreciation of the scope of HPLC applications. This has resulted in Dr. Collen Masimirembwa (PhD, DPhil) Mr C Nyakutira (BSc) many theoretical bio-analytical chemists who have to AiBST Varichem Pharmaceuticals (Pvt) Ltd 215 Willowvale Rd be trained on the job on the real machine, a costly ex- P.O.Box 2294 Harare Willowvale ercise for the employer. Zimbabwe P.O.Box ST 611 By organising this HPLC course AiBST is aiming to achieve a number of goals:

Update professionals on the theory and practices of HPLC

Tel: 263 4 710563/4 Fax: 263 4 710462 [email protected] Southerton Harare Tel: 263 4 667763-5 Mr T Matema (MSc) Horizon Chemicals 8b Lorraine Drive Bluffhill Harare Tel: 263 4 305826 Mobile: 263 11 705333

Mr H Masiyachengu (MSc) Medicines Control Authority of Zimbabwe 106 Baines Ave Harare Introduce postgraduate students to HPLC technology Tel: 263 4 736981-5 Fax: 263 4 736980 Initiate dialogue between the Medicines Control [email protected]

ity of Zimbabwe (MCAZ) and pharmaceutical companies on the best and acceptable practise in HPLC-based drug analysis. This was achieved by co-organising the course with the MCAZ and by having one of the tutors coming from that organisation. Two course participants where also from MCAZ. One of the tutors was from one of the leading pharmaceutical industries and a number of the participants where from some of the top pharmaceutical companies in Zimbabwe. Encourage dialogue between HPLC users from industry, academia and regulatory industries. Introduce participants to international trends and guidelines in the use of HPLC technology from regulatory aspects to equipment maintenance and calibration requirements.

Mr and Mrs Kawenda Consoltech Harare Zimbabwe [email protected]

The tutors: from left to right: 1. Mr Masiyachengu, 2. Mr Matema 3. Dr. Masimirembwa 4. Mr Nyakutira.

Optimization of anti-Malaria Therapy

Major Awards: 1980-1983 University of Ife Staff Training Fellowship 1993 CIDA/NSERC Research Fellowship 1993/94 Smithkline Beecham Travel Fellowship 1996 Chartered Chemist References of seven (7) selected publications: 1. Bolaji O. O., Sadare I. O., Babalola C. P. and Ogunbona F. A. (2002) Polymorphic oxidative metabolism of proguanil (CYP2C19) in a Nigerian population. Eur J Clin Pharmacol 2002; 58:543-545. 2. Bolaji OO, Onyeji CO, Ogundaini AO, Olugbade TA, Ogunbona FA. Bioavailability of drotaverine hydrochloride in humans. Eur J Drug Metab Pharmacokinet 1996; 21:217-221. 3. Bolaji OO, Coutts RT, Baker GB. Metabolism of trimipramine in vitro by human CYP2D6 isozyme. Res Comm Chem Path Pharmacol 1993; 82:111-120. 4. Bolaji OO, Onyeji CO, Ogungbamila FO, Ogunbona FA, Ogunlana EO. High-performance liquid method for the determination of drotaverine in human plasma and urine. J Chromatogr 1993; 622:93-97. 5. 6. 7. Bolaji OO, Babalola CP, Dixon PAF. Characterization of the principal metabolite in man by 1H nmr spectroscopy. Xenobiotica 1991; 21:447-450. Bolaji OO. Studies of some factors affecting the binding of drugs to serum albumin. Ph.D. Thesis, University of Strathclyde, Glasgow, 1983. (Supervisor: Prof. G. C. Wood). Bolaji OO. Metabolic studies of pyrimethamine in man. M.Phil. Thesis, University of Ife, Ile-Ife, 1980. (Supervisor: Prof. F. A. Ogunbona)

Issue 8

Page 3

Obafemi Awolowo University (OAU) and AiBST

(Continued from page 1)

Outcomes of this collaboration will include: 1. The establishment of common goals between OAU and AiBST. 2. The creation and strengthening of linkages between OAU and AiBST for specific programmes and projects of mutual benefit. 3. Research collaboration in Basic and Applied Sciences, Pharmacy, Medicine and Technology. 4. The exchange of Lecturers, Staff, Scholars and Students for teaching, advanced studies, research, curriculum development, capacity building and institutional development. 5. The establishment of other exchanges that will allow for the sharing of experiences, ideas, teaching and research materials, equipment and scientific literature. 6. The encouragement of faculty, staff and students to work with communities in their own regions as well as in international arena. This will result in faculty, staff and research students in the two institutions sharing lessons about community processes and participation in different societies thus gaining insight into the development process in countries of the partner institution. 7. Promotion of research collaborations between Nigeria and Zimbabwe through our respective institutions. 8. Encouraging the discovery of synergies for biomedical science and technology development within the African continent. 9. It is understood that the details of joint activities, conditions for utilization of the results achieved, and arrangements of specific visits, exchanges, and other forms of cooperation will be negotiated for each specific case. 10. It is also understood that any financial arrangements will be negotiated in each specific case and will depend upon the availability of funds. Both parties shall endeavour to secure local and foreign resources for supporting such exchanges and collaboration that may develop as a result of this Memorandum.

Chinhoyi University

will only know the theoretical aspects of a subject that critically requires an experimental component. The Head of the Biotechnology Department, Mr Jonathan Mufandaedza approached AiBST for assistance with designing and setting up of a laboratory for his department. Towards fostering a relationship with AiBST he organised a visit by his department to AIBST laboratories. He brought with him the eighteen first year students, four members of staff and two technicians. They arrived at AiBST laboratories in the morning and were welcomed by the Director, Dr. Collen Masimirembwa. After that they where led through a number of demonstrations in the laboratory. Mr Lazarus Chirombe, the General Manager and Chief Technician demonstrated to them safety issues in a biomedical laboratory. Dr. Collen masimirembwa then demonstrated to them the applications of high pressure liquid chromatography (HPLC). Mr Justen Manasa demonstrated Flow Cytometry as applied in the T-cell profiling. In the afternoon, they had demonstrations on molecular biology aspects as applied in our laboratory in diagnostic work (HIV-1 detection and detemrination of viral load) and in our research work towards the establishment of a DNA bank and a Pharmacogenetics Database of African populations. These demonstrations where done by Dr. Michael Chirara and Alice Matimba respectively. By 17.00hrs, the demonstrations where complete and the delegation was given an oppotunity to discuss their experience during the visit. After very interesting discussions the student's representative gave a vote of thanks so did the head of department. AiBST staff also appreciated the visti by the delegation as it further endorses AiBST status as a centre of biomedical excellence which is providing a valuable service in assisting other institutes in setting-up good laboatories and promtoing biomedical science in Zimbabwe. Mr Jonathan Mufandaedza had this to say about the visit, "This is an eye opener to both the students and the staff from my department and I hope that this is the begining of a long term relationship between my department of Biotechnology and AiBST."

Issue 8

Page 4

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