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CTR Cancerogenesi Ambientale e Valutazioni del Rischio Anni dal 2010 a oggi 1. Mascolo MG, Perdichizzi S, Rotondo F, Morandi E, Guerrini A, Silingardi P, Vaccari M, Grilli S, Colacci A. BALB/c 3T3 cell transformation assay for the prediction of carcinogenic potential of chemicals and environmental mixtures. Toxicol In Vitro. 24(4):1292-300. 2010

2. Colacci A., Mascolo M.G., Perdichizzi S., Gazzilli S., Quercioli D., Rotondo F., Morandi E., Guerrini A., Silingardi P., Grilli S. and Vaccari M. Different sensitivity of BALB/c 3T3 cell clones in the response to carcinogens Elsevier Editorial System for Toxicology in vitro (accettato maggio 2011).

Anni 2000 ­ 2009 3. Vaccari, M., Argnani, A., Horn, W., Silingardi, P., Grilli, S., Giungi, M., Mascolo, M.G. and Colacci, A. In vitro effects of fenretinide on cell-matrix interactions Anticancer Research, 20, 3059-3066, 2000

4. Manara MC, Baldini N, Serra M, Lollini PL, De Giovanni C, Vaccari M, Argnani A, Maurici D, Picci P and Scotlandi K, Bone. Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene 26:215-220, 2000

5. R. Serra, M. Villani, A. Colacci, A cellular automata model for the simulation of in vitro carcinogenesis tests, in: T. Worsch, S. Bandini (Eds.), Proceedings of ACRI 2000, Springer, London, 2000

6. Serra R., Villani M., Castelli L. and Colacci A. Modelling the birth of transformation foci in cell cultures. IJCAS - International Journal of Computing Anticipation System, Vol. 8, pp. 1-7, 2001

7. Serra R., Villani M. and Colacci A. Differential equations and cellular automata models of the growth of cell cultures and transformation foci. Complex Systems, 13, pp. 347-380, 2001.

8. Bolognesi C., Nucci MC, Colacci AM, Grilli S, Ippoliti F, Mucci N, Spica VR, Barbieri A., Canitano N., Chiozzotto D., Di Renzo L., Giordano E., Horn W., Roggieri P., Risi A., Silingardi P., Vaccari M., Violante FS Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project. Epidemiol. Prev. 29, 91-95, 2005

9. Barbieri A., Nucci MC, Sabatini L., Risi A., Bolognesi C., Colacci AM, Violante FS. Occupational exposure to antineoplastic drugs in a hospital setting: biological and environmental monitoring. Epidemiol Prev.29, 8789, 2005 .

10. Morandi E., Zingaretti C., Chiozzotto D., Severini C., Seteria A., Horn W., Vaccari M., Serra R., Silingardi P. and Colacci A. A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines. Cancer Lett., 231, 74-86, 2006

11. Colacci A. La nutrigenomica nella scienza dell'alimentazione ADI Magazine, Rivista Scientifica dell'Associazione Italiana di Dietetica e di Nutrizione Clinica, 4, pp. 335-338, Dicembre 2006

12. Maffei R., Marasca R., Martinelli S., Castelli I., Santachiara R., Morandi E., Zucchini P., Fontana M., Giacobbi F., Silingardi P., Bonacorsi G., Temperani P., Masini L., Colacci A., Serra R. and Torelli G Angiopoietin-2 expression in B-cell chronic lymphocytic leukemia: association with clinical outcome and immunoglobulin heavy-chain mutational status., Leukemia, 21: 1312-1315, 2007

13. R. Serra, M. Villani C. Damiani, A. Graudenzi, A. Colacci, S. A. Kauffman. Interacting Random Boolean Networks (long paper) European Conference on Complex Systems Dresda, October 1-5, 2007 paper #165 (long paper)

14. Morandi E, Severini C, Quercioli D, D'Ario G, Perdichizzi S, Capri M, Farruggia G, Mascolo MG, Horn W, Vaccari M, Serra R, Colacci A, Silingardi P Gene expression time-series analysis of camptothecin effects in U87-MG and DBTRG-05 glioblastoma cell lines (2008) Mol Cancer. 7: 66

15. Serra R., Villani M., Graudenzi A, Colacci A., Kauffmann S.A. The influence of the topology of regulatory networks on the distribution of avalanches in gene expression data Networks and Heterogeneous Media, 2008

16. Serra R., Villani M., Graudenzi A, Colacci A., Kauffmann S.A. The simulation of gene knock-out in scalefree random Boolean models of genetic networks Networks and Heterogeneous Media, 3: 333-343, 2008

17. Morandi E, Severini C, Quercioli D, Perdichizzi S, Mascolo MG, Horn W, Vaccari M, Nucci MC, Lodi V, Violante FS, Bolognesi C, Grilli S, Silingardi P, Colacci A. Gene expression changes in medical workers exposed to radiation Radiat Res. 72(4):500-509 2009

Anni 1988 -1999 18. Lattanzi, G., Colacci, A., Grilli, S., Mazzullo, M., Prodi, G., Taningher, M. and Turina, M.P. Binding of hexachloroethane to biological macro-molecules from rat and mouse organs. J. Toxicol. Environ. Health, 24: 403-411, 1988.

19. Prodi, G., Colacci, A., Grilli, S., Lattanzi, G., Mazzullo, M. and Turina, M.P. Comparison of the covalent binding of various chloroethanes with nucleic acids. In: F. Feo, P. Pani, A. Columbano, R. Garcea (eds.), Chemical Carcinogenesis, pp. 93-102. Plenum Publishing Corporation, 1988.

20. Cantelli-Forti, G., Hrelia, P., Paolini, M., Colacci, A. Attività mutagena e fitofarmaci. La difesa delle piante, 11: 167-184, 1988

21. Parodi, S., Lutz, W.K., Colacci, A., Mazzullo, M., Taningher, M. and Grilli, S. Results of animal studies suggest a nonlinear dose-response relationship for benzene effects. Environ. Health Perspect., 82: 171-176, 1989.

22. Mazzullo, M., Bartoli, S., Bonora, B., Colacci, A., Grilli, S., Lattanzi, G., Niero, A., Turina, M.P. and Parodi, S. Benzene adducts with rat nucleic acids and proteins: dose-response relationship after treatment in vivo. Environ. Health Perspect., 82: 259-266, 1989.

23. Turina, M.P., Colacci, A., Grilli, S., Mazzullo, M., Prodi, G., Lattanzi, G., Bonora, B., Bartoli, S., Guidotti, L. Metabolic activation and covalent binding to nucleic acids of pentachloroethane as short-term test of genotoxicity. Res. Comm. Chem. Pathol. Pharmacol., 63: 81-91, 1989.

24. Colacci, A., Bartoli, S., Bonora, B., Buttazzi, C., Lattanzi, G., Mazzullo, M., Niero, A., Turina, M.P. and Grilli, S. Covalent binding of 1,1,1,2- tetrachloroethane to nucleic acids as evidence of genotoxic activity. J. Toxicol. Environ. Health, 26: 485-495, 1989.

25. Lattanzi, G., Bartoli, S., Bonora, B., Colacci, A., Grilli, S., Niero, A. and Mazzullo, M. The different genotoxicity of p-dichlorobenzene in mouse and rat: measurement of the in vivo and in vitro covalent interaction with nucleic acids. Tumori, 75: 305-310, 1989.

26. Perocco, P., Ancora, G., Rani, P., Valenti, A.M., Mazzullo, M., Colacci, A. and Grilli, S. Evaluation of genotoxic effects of the herbicide dicamba using in vivo and in vitro test systems. Environ. Mol. Mutagen., 15: 131-135, 1990.

27. Colacci, A., Bartoli, S., Bonora, B., Niero, A., Silingardi, P. and Grilli, S. In vivo and in vitro interaction of 1,2-dichlorobenzene with nucleic acids and proteins of mice and rats. Tumori, 76: 339-344, 1990.

28. Colacci, A., Bartoli, S., Bonora, B., Mazzullo, M., Niero, A., Perocco, P., Silingardi, P. and Grilli, S. The covalent interaction of 1,4-dibromobenzene with rat and mouse nucleic acids: in vivo and in vitro studies. Toxicol. Lett., 54: 121-127, 1990.

29. Colacci, A., Perocco, P., Vaccari, M., Mazzullo, M., Albini, A., Parodi, S., Taningher, M. and Grilli, S. In vitro transformation of BALB/c 3T3 cells by 1,1,2,2- tetrachloroethane. Jpn. J. Cancer Res., 81: 786-792, 1990.

30. Grilli, S., Bartoli, S., Bonora, B., Colacci, A., Lattanzi, G., Mazzullo, M., Niero, A., Perocco, P. and Turina, M.P. Genotoxicity of chloroethanes and structure-activity relationships. In: F. Feo, P. Pani, A. Columbano, (eds.), Modulating Factors In Multistage Chemical Carcinogenesis, pp. 381-391. Plenum Publishing Corporation, 1991. 31. Taningher, M., Parodi, S., Grilli, S., Colacci, A., Mazzullo, M., Bordone. R. and Santi, L. Lack of correlation between alkaline DNA fragmentation and DNA covalent binding induced by polychloroethanes after in vivo administration. problems related to the assessment of a carcinogenic hazard. Cancer Detect. Prevent., 15: 35-39, 1991.

32. Bartoli, S., Bonora, B., Colacci, A., Niero, A. and Grilli, S. DNA damaging activity of methyl parathion. Res. Comm. Chem. Pathol. Pharmacol., 71: 209-218, 1991.

33. Colacci, A., Bartoli, S., Bonora, B., Guidotti, L., Lattanzi, G., Mazzullo, M., Niero, A., Perocco, P., Silingardi, P. and Grilli, S. Chloroform bioactivation leading to nucleic acids binding. Tumori, 77: 285-290, 1991.

34. Grilli, S., Ancora, G., Rani, P., Valenti, A.M., Mazzullo, M. and Colacci, A. In vivo unwinding fluorimetric assay as evidence of the damage induced by fenarimol and dnoc in rat liver DNA. J. Toxicol. Environ. Health, 34: 485-494, 1991.

35. Perocco, P., Colacci, A., Santucci, M.A., Vaccari, M. and Grilli, S. Transforming activity of ethylene dibromide in BALB/c 3T3. Res. Comm. Chem. Pathol. Pharmacol., 73: 159-172, 1991.

36. Colacci, A., Perocco, P., Da Vià, C., Silingardi, P., Vaccari, M., Nanni, P., De Giovanni, C., Lollini, P-L, Nicoletti, G., Albini, A., Parodi, S., Dolcetti, R., Boiocchi, M. and Grilli, S. In vitro cell transformation by

halogenated compounds: an in vtro model to study multistep carcinogenesis. In: La cancerogenesi come processo, pp. 53-58. Edi-Ermes ­ Milano, 1991

37. Virgili M, Saverino O, Vaccari M, Barnabei O and Contestabile A, Temporal, regional and cellular selectivity of neonatal alteration of the thyroid state on neurochemical maturation in the rat Exp. Brain Res., 83: 555-561, 1991

38. Colacci, A., Perocco, P., Bartoli, S., Da Vià, C., Silingardi, P., Vaccari, M. and Grilli, S. Initiating activity of 1,1,2,2-tetrachloroethane in two-stage BALB/c 3T3 cell transformation. Cancer Letters, 64: 145-153, 1992.

39. Paolini M, Mersica R., Pozzetti L., Silingardi P., Grilli S. and Cantelli-Forti G.. (1992). Strategies for advancement of short-term mutagenicity tests: on the optimal ionic strenght for the liver microsomal assay. Carcinogenesis, 13: 1403-1408.

40. Melchiori, A., Colacci, A., Lollini, P-L., De Giovanni, C., Carlone, S., Grilli, S., Parodi, S. and Albini, A. Induction of invasive and experimental metastasis potential in BALB/c 3T3 cells by benzo(a)pyrene transformation. Invasion and Metastasis, 12: 1-11, 1992.

41. Colacci, A., Perocco, P., Vaccari, M., Silingardi, P., Da Vià, C., De Giovanni, C., Lollini, PL., Nanni, P., Nicoletti, G., Albini, A., Parodi, S. and Grilli, S. In vitro assay of halogenated compounds transforming activity as suitable model for studying multistep carcinogenesis. In: D. Kanduc, P. Pani (eds.), Carcinogenesis as Process, pp. 71-76. University of Bari, 1992.

42. Mazzullo, M., Bartoli, S., Bonora, B., Colacci, A., Lattanzi, G., Niero, A., Silingardi, P. and Grilli, S. In vivo and in vitro interaction of trichloroethylene with macromolecules from various organs of rat and mouse. Res. Comm. Chem. Pathol. Pharmacol., 76: 192-208, 1992.

43. Grilli, S., Parodi, S., Taningher, M. and Colacci, A. Comparative metabolism and genotoxicity data on benzene: their role in cancer risk assessment. In: C. Zervos (ed.), Oncogene and Transgenics Correlates of Cancer Risk Assessment, pp. 263-291. New York: Plenum Press, 1992.

44. Parodi, S., Malacarne, D., Grilli, S., Colacci, A. and Taningher, M. Dose-response relationship for benzene: human and experimental carcinogenicity data. In: C. Zervos (ed.), Oncogene and Transgenics Correlates of Cancer Risk Assessment, pp. 293-303. New York: Plenum Press, 1992.

45. Colacci, A., Albini, A., Melchiori, A., Nanni, P., Nicoletti, G., Noonan, D., Parodi, S. and Grilli, S. Induction of a malignant phenotype in BALB/c 3T3 cells by 1,1,2,2-tetrachloroethane. Int. J. Oncol., 2: 937-945, 1993.

46. Perocco, P., Colacci, A. and Grilli, S. In vitro cytotoxic and cell transforming activities exerted by the pesticides cyanazine, dithianon, diflubenzuron, procymidone, and vinclozolin on BALB/c 3T3 cells. Env. Mol. Mutagen., 21: 81-86, 1993.

47. Perocco, P., Colacci, A., and Grilli, S. In vitro cell transformation induced by the pesticide fenarimol. Res. Comm. Chem. Pathol. Pharmacol., 80: 345-356, 1993.

48. Albini, A. and Colacci, A. Inhibition of malignant tumor cell invasion: an approach to antiprogression. In: G. Bronzetti et al. (eds.), Antimutagenesis and Anticarcinogenesis Mechanism III, pp. 335-350. New York: Plenum Press, 1993.

49. Adatia, R., Albini, A., Colacci, A., De Giovanni, C., Nanni, P., Giunciuglio, D., Parodi, S., Grilli, S. and Perocco, P. Induction of chemotactic and invasive phenotype in BALB/c 3T3 cells by 1,2-dibromoethane transformation. Invasion & Metastasis, 13: 234-243, 1993.

50. Hrelia, P., Vivagni, F., Maffei, F., Morotti, M., Colacci, A., Perocco, P., Grilli, S., Cantelli-Forti, G. Genetic safety evaluation of pesticides in different short-term tests. Mutation Res. 321: 219-228, 1994

51. Grilli, S., Bartoli, S., Perocco, P. and Colacci, A. Experimental carcinogenesis and anticarcinogenesis: a summary of the current status. WORKSHOP "Postgraduate Course: Chemoprevention in Oncology. Santa Margherita Ligure, Genova, Italy, 11-13 November 1993." Eur. J. Cancer Prevention, 3: 382-385, 1994.

52. Grilli, S. e Colacci, A. Stima del rischio cancerogeno: un contributo alla definizione dei livelli di accettabilità. In: A. Zavatti et al. (eds.), Quaderni Di Tecniche Di Protezione Ambientale (38): L'Uomo e l'Ambiente, pp. 145-154. Bologna: Pitagora Editrice, 1994.

53. Grilli, S. Le basi scientifiche per la valutazione della cancerogenicità della chemioprevenzione dei tumori da sostanze chimiche. In: G. Biasco (ed.), Cancerogenesi ed Anticancerogenesi. Valutazione di strategie integrate sperimentali e cliniche nella prevenzione oncologica, pp. 11-25. Università degli Studi di Bologna, 1994.

54. Silingardi P., Klein J.-L., Mesnil M. and Yamasaki H. (1994). Growth suppression of transformed balb/c 3t3 cells by transforming growth factor 1 occurs only inthe presence of their normal counterparts. Carcinogenesis, 15: 1181-1185.

55. Colacci, A. Modelli in vitro a medio termine: la trasformazione cellulare In: G. Biasco (ed.), Cancerogenesi ed Anticancerogenesi. Valutazione di strategie integrate sperimentali e cliniche nella prevenzione oncologica, pp. 71-80. Università degli Studi di Bologna, 1994.

56. Colacci, A., Perocco, P., Vaccari, M., Da Vià, C., Silingardi, P., Manzini, E., Horn, W., Bartoli, S. and Grilli, S. 1,2-dibromoethane as initiating agent for cell transformation. Jpn. J. Cancer Res., 86: 168-173, 1995.

57. Perocco, P., Colacci, A., Del Ciello, C. and Grilli, S. Transformation of BALB/c 3T3 cells in vitro by the fungicides captan, captafol and folpet. Jpn. J. Cancer Res., 86: 941-947, 1995.

58. Perocco, P., Colacci, A., Bonora, B. and Grilli, S. In vitro transforming effect of the fungicides metalaxyl and zineb. Teratog. Carcinog. Mutagen., 15: 73-80, 1995.

59. Perocco, P., Colacci, A., Del Ciello, C. and Grilli, S. Cytotoxic and cell transforming effects of the insecticide, lindane (-hexachlorocyclohexane) on BALB/c 3T3 cells. Res. Comm. Chem. Pathol. Pharmacol., 89: 329-339, 1995.

60. Taningher, M., Perrotta, A., Malacarne, D., Parodi, S., Zedda, A.I., Colacci, A., Grilli, S. Lack of significant promoting activity by benzene in the rat liver model of carcinogenesis. J. Toxicol. Environ. Health, 45: 481488, 1995

61. Colacci, A., Vaccari, M., Perocco, P., Da Vià, C., Silingardi, P., Manzini, E., Horn, W., and Grilli, S. Enhancement of BALB/c 3T3 cells transformation by 1,2-dibromoethane promoting effect. Carcinogenesis 17: 225-231, 1996.

62. Perocco P, Del Ciello C, Colacci A, Pozzetti L, Paolini M, Cantelli-Forti G, Grilli S. Cytotoxic activity and transformation of BALB/c 3T3 cells in vitro by the insecticide acephate. Cancer Lett. 106: 147-153, 1996.

63. Scotlandi, K., Serra, m., Nicoletti, G., Vaccari, M., Manara, M.C., Nini, G., Landuzzi, L., Colacci, A., Bacci, G., Bretoni, F., Picci, P., Campanacci, M., Baldini N. Multidrug resistance and malignancy in human osteosarcoma. Cancer Res., 56: 2434-2439, 1996.

64. Vaccari M., Argnani A., Horn W., Silingardi P., Giungi M., Mascolo M.G., Bartoli S., Grilli S. and Colacci A. Effects of the protease inhibitor antipain on cell malignant transformation. Anticancer Res. 19: 589-596, 1999.

65. Colacci A., Vaccari, M., Cabri, W., Bernasconi, E. Use of alpha-lipoic acid as an antimetastatic agent (Uso dell'acido alfa lipoico nel trattamento antimetastatico) Patent Number MI99A 000728, 9.4.1999.

Monografie 1. Inquinamento atmosferico urbano e rischio cancerogeno di: G. Assennato, A. Colacci, P. Comba, A. Di Iorio, S. Grilli, S. Lagorio e R. Romizi Lega Italiana per la Lotta contro i Tumori, Roma, 1995

2. Rischio cancerogeno da pesticidi di: G. Assennato, I. Camoni, D. Cavone, A. Colacci, P. Comba, A. Di Iorio, S. Grilli, S. Lagorio, R. Molli, M. Musti, R. Romizi, L. Settimi Lega Italiana per la Lotta contro i Tumori, Roma, 1996

Capitoli Libri 1. Aspetti tossicologici dell'analisi di rischio A. Colacci In: Siti Contaminati: Indagini, analisi di rischio e tecniche di bonifica, a cura di Luca Bonomo, pp. 427-446. Politecnico di Milano e Centro per la Formazione Permanente POLIEDRA, 2000. 2. Cancerogenesi A. Colacci In: Oncologia Genetica, a cura di Dino Amadori e Sandro Grilli, pp. 21-39. Poletto Editore. Milano. 2001 3. Introduzione alla chemio prevenzione A. Colacci In: Oncologia Genetica, a cura di Dino Amadori e Sandro Grilli, pp. 123-129. Poletto Editore. Milano. 2001 4. Chemioprevenzione nei gruppi a rischio A. Colacci In: Oncologia Genetica, a cura di Dino Amadori e Sandro Grilli, pp. 191-205. Poletto Editore. Milano. 2001 5. Analisi di rischio: aspetti tossicologici A. Colacci In: Bonifica dei siti contaminati: Caratterizzazione e tecnologie di risanamento a cura di Luca Bonomo, pp 676-693 McGraw-Hill Publishing Group Italia, Milano 2005

6. Is the extrapolation of carcinogenicity results from animals to humans always feasible? S. Grilli e A. Colacci In: Cancer medicine at the dawn of the 21st century Eds G.Biasco and S. Tanneberger, pp 65-68 Bononia University Press 2006

Brevetti 1. Colacci A., Vaccari, M., Cabri, W., Bernasconi, E. Use of alpha-lipoic acid as an antimetastatic agent (Uso dell'acido alfa lipoico nel trattamento antimetastatico) Patent Number MI99A 000728, 9.4.1999 (Italia) e PCT/EP00/03100 15.01.2001 (USA, EU), IPC A61k31/385

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