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BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE

Benigno Rodriguez, MD

eRA COMMONS USER NAME (credential, e.g., agency login) BENIGNOR

Senior Instructor of Medicine Director, CWRU Center for AIDS Research Clinical Core

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY

Javeriana University, Bogota, Colombia Gorgas Memorial Institute, University of Alabama and Peruvian University "Cayetano Heredia" University of Valencia, Spain Javeriana University School of Med, Bogota, Colombia

MSc Diploma Master's MD

Current 1997 1996 1990

Clinical Epidemiology and Biostatistics Clinical Tropical Med & Hygiene Tropical & Parasitic Diseases Medicine

A. Positions and Honors.

1990­1992 1992­1995 1995 1995­1997 1997­2000 2000-2002 2002-2003 1997­2003 2003-2004 2005-Present Director, El Pando Healthcare Center and staff physician, Intensive Care Unit, San Juan de Dios Hospital, Santa Marta, Colombia. Resident, Internal Medicine. San Ignacio University Hospital, Bogota, Colombia. Instuctor of Internal Medicine, Emergency Dept. San Ignacio University Hospital, Bogota, Colombia. Instructor, Internal Medicine and Infectious Diseases. Javeriana University School of Medicine, Bogota, Colombia. Chairman, Committee for the Prevention and Control of Nosocomial Infections. San Ignacio University Hospital, Bogota, Colombia. Fellow, Infectious Diseases. Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH. Chief Fellow, Division of Infectious Diseases. Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH. Assistant Professor, Internal Medicine and Infectious Diseases. Javeriana University School of Medicine, Bogota, Colombia. Fellow, HIV Medicine. Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH. Senior Instructor of Medicine, Case Western Reserve University Division of Infectious Diseases, Cleveland, OH

COMMITTEES, STUDY SECTIONS, ADVISORIES 1999-Present Scientific Advisor, Shoreland 1999-Present Editorial Board, Travel Medicine Monthly 2003-2004 Experimental Therapeutics Research Agenda Committee, AIDS Clinical Trials Group. 2005 Reviewer, NIH AIDS Discovery and Development of Therapeutics Study Section 2005 Reviewer, Universitywide AIDS Research Program for the Basic Clinical/HIV Treatment, Opportunistic Infections and HIV-Related Malignancies Study Section, University of California 2006 Reviewer, Universitywide AIDS Research Program for the Basic Clinical/HIV Treatment, Opportunistic Infections and HIV-Related Malignancies Study Section, University of California 2007 Reviewer, Universitywide AIDS Research Program for the Basic Clinical/HIV Treatment, Opportunistic Infections and HIV-Related Malignancies Study Section, University of California 2008 Reviewer, "Mechanisms and Management of Cardiovascular and Metabolic Complications of HIV/AIDS" special interest study section. National Heart, Blood and Lung Institute, National Institutes of Health

B. Peer-reviewed publications

1. Rodríguez B, Morillo LE, Sanín LC. Espectro clínico de la apnea obstructiva del sueño. Univ Med 1994; 35: 67-77.

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Rodríguez B. Farmacoterapia en el anciano. Trib Med Col 1995; 92: 204-9. Rodríguez B. Osteoporosis en el anciano. Trib Med Col 1995; 92: 275-81. Rodríguez B. Estado actual de los aminoglucósidos en neumonía por Gram-negativos. Univ Med 1994; 35: 44-7. Rodríguez B. Diagnóstico diferencial de la diarrea en pacientes con SIDA. Actual Biomed Col 1994; 2: 22-8. Rodríguez B, Vásquez E, Sussmann O, Mattar S, Jaramillo CA. Antimicrobial susceptibility and serotyping of Pseudomonas aeruginosa strains isolated in Bogotá, Colombia. Eur J Clin Microbiol Infect Dis 2000; 19: 152-4. Rodríguez B, Woolley I, Lederman MM, Zdunek D, Hess G, Valdez H. Effect of GB Virus C (GBV-C) Coinfection on Response to Antiretroviral Treatment in HIV-Infected Patients. J Infect Dis 2003; 187: 504-507. Hunt PW, Deeks SG, Rodríguez B, Valdez H, Shade SB, Abrams DI, Kitahata MM, Krone M, Neilands TB, Brand RJ, Lederman MM, Martin JN. Continued CD4+ T-cell Count Increases in HIV-infected Adults Experiencing Four Years of Viral Suppression on Highly Active Antiretroviral Therapy. AIDS 2003; 17: 1907-1915. Rodríguez B, Valdez H, Freimuth W, Butler T, Asaad R, Lederman MM. Plasma Levels of B-Lymphocyte Stimulator (BLyS) Increase with HIV Disease Progression. AIDS 2003; 17: 1983-1985. Roy S, Kaplan EL, Rodríguez B, Schreiber JR, Salata RA, Palavecino E, John CC. A Family Cluster of Five Cases of Group A Streptococcal Pneumonia. Pediatrics 2003; 112: e61-e65. Perez A, Dennis RJ, Rodríguez B, Castro AY, Delgado VA, Lozano JM, Castro MC. An Interrupted Time Series Analysis of Parenteral Antibiotic Use in Colombia. J Clin Epidemiol 2003; 56: 1013-1020. Chakraborty B, Kiser P, Rangel HR, Weber J, Mirza M, Marotta ML, Asaad R, Rodríguez B, Valdez H, Lederman MM, Quiñones-Mateu M. Can HIV-1 Superinfection Compromise Antiretroviral Therapy? AIDS 2004; 18: 132-134. Lederman MM, Veazey RS, Mosier DE, Hartley O, Dufour J, Mefford M, Piatak M, Lifson JD, Rodríguez B, Blauvelt A, Offord RE. Targeted Inhibition of CCR5 with PSC-RANTES Is Sufficient to Block Intravaginal Transmission of SHIV in Rhesus Macaques. Science 2004; 306: 485-487. Jiang W, Lederman MM, Salkowitz JR, Rodríguez B, Harding CV, Sieg SF. Impaired Monocyte Maturation in Response to CpG Oligodeoxynucleotide is Related to Viral RNA Levels in HIV Disease and Is At Least Partially Mediated by Deficiencies in Type I Interferon Responsiveness and Production. J Virol 2005; 79: 4109-19. Sieg SF, Rodríguez B, Asaad R, Jiang W, Bazdar DA, Lederman MM. Peripheral S Phase T Cells in HIV Disease Have a Central Memory Phenotype and Largely Lack Evidence for Recent T Cell Receptor Engagement. J Infect Dis 2005; 192: 62-70. Rodríguez B, Bobak DA. Management of Hepatitis C in HIV-infected Patients. Curr Infect Dis Rep 2005;7: 91-102. Loupa,CV, Lederman MM, Valdez H, Salata RA, McComsey GA, Gripshover B, Fulton S, Lisgaris MV, Kucia M, Asaad R, Cline J, Rodríguez B. New Entrants to HIV Care Are Presenting Only at Marginally Earlier Stages of Disease but May Increasingly Represent Groups Perceived at Lower Risk. J Int Assoc Physicians AIDS Care 2005; 4: 47-51. Mayanja-Kizza H, Rodríguez B, Quinones-Mateu M, Mirza M, Aung H, Yen-Lieberman B, Starkey C, Horton L, Peters P, Baseke J, Johnson JL, Toossi Z. Persistent replication of human Immunodeficiency virus-1 (HIV-1) despite treatment of pulmonary tuberculosis (TB) in dually infected subjects, Clin Diagn Lab Immunol 2005; 12:1298-304. Loupa CV, Rodríguez B, McComsey G, Gripshover B, Salata RA, Valdez H, Lisgaris MV, Fulton S, Lederman MM. Gender differences in HIV RNA and CD4 counts, but not in AIDS-defining illnesses or treatment initiation and CD4based HAART initiation threshold, in new entrants to HIV care. Clin Microbiol Infect 2006; 12:389-91. Rodríguez B, Lederman MM, Jiang W, Bazdar DA, Gàrate K, Harding CV, Sieg SF. Interferon-alpha differentially rescues CD4+ and CD8+ T cells from apoptosis in HIV infection. AIDS 2006 26; 20: 1379-89. Yonkers NL, Rodríguez B, Post AB, Asaad R, Jones L, Lederman MM, Lehmann PV, Anthony DD. HIV coinfection impairs CD28 mediated costimulation of HCV-specific CD8 Cells. J Infect Dis 2006; 194: 391-400. Gandhi RT, Spritzler J, Chan E, Asmuth DM, Rodríguez B, Merigan TC, Hirsch MS, Shafer RW, Robbins GK, Pollard RB for the ACTG 384 Team. Effect of Baseline- and Treatment-Related Factors on Immunologic Recovery After Initiation of Antiretroviral Therapy in HIV-1-Positive Subjects: Results From ACTG 384. J Acquir Immune Defic Syndr 2006; 42: 426-34. Rodríguez B, Sethi AK, Cheruvu V, Mackay W, Bosch RJ Kitahata M, Boswell SL, Matthews C, Bangsberg D, Martin,J, Whalen CC, Yadavalli S, Sieg S, Deeks S, Lederman MM. Presenting Plasma Viremia Is a Minor Determinant of CD4 T Cell Losses in Untreated HIV Infection. JAMA 2006; 296: 1498-1506. Lederman MM, Penn-Nicholson A, Stone SF, Sieg SF, Rodríguez B. Monitoring clinical trials of therapeutic vaccines in HIV infection: role of treatment interruption. Curr Op HIV AIDS 2007; 2: 56­61. Lederman MM, Penn-Nicholson A, Stone SF, Sieg SF, Rodríguez B. Monitoring clinical trials of therapeutic vaccines in HIV infection: role of treatment interruption. Curr Op HIV AIDS 2007; 2: 56­61. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodríguez B, Teixeira-Johnson L, Landay A, Martin JN, Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2007; 12: 1365-1371.

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27. Gange SJ, Kitahata MM, Saag MS, Bangsberg DR, Bosch RJ, Brooks JT, Calzavara L, Deeks SG, Eron JJ, Gebo KA, Gill MJ, Haas DW, Hogg RS, Horberg MA, Jacobson LP, Justice AC, Kirk GD, Klein MB, Martin JN, McKaig RG, Rodríguez B, Rourke SB, Sterling TR, Freeman AM, Moore RD. Cohort Profile: The North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Int J Epidemiol 2007; 0: p. dyl286v1-8 28. Lederman MM, Smeaton L, Smith KY, Rodríguez B, Pu M, Wang H, Sevin A, Tebas P, Sieg SF, Medvik K, Margolis DM, Pollard R, Ertl HCJ, Valdez H. In Chronic HIV-1 Infection, Cyclosporine A Provides No Sustained Immunologic Benefit to Persons Starting Suppressive Antiretroviral Therapies ­ Results of A Randomized Controlled Trial of the AIDS Clinical Trials Group: A5138. J Infect Dis 2006; 194: 1677-1685. 29. Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg S, Debernardo R, Garate K, Rodríguez B, Margolis LB, Lederman MM. Abnormal activation and cytokine spectra in lymph nodes of persons chronically infected with HIV1. Blood 2007; 109: 4272-4279. 30. Rodríguez B, Sethi AK, Cheruvu V, Bosch RJ, Martin J, Deeks S, Lederman MM. Presenting Plasma Viremia Is a Minor Determinant of CD4 T Cell Losses in Untreated HIV Infection. Reply. JAMA 2007; 297: 806-807. 31. Wilkin TJ, Su Z, Kuritzkes DR, Hughes M, Flexner C, Gross R, Coakley E, Greaves W, Godfrey C, Skolnik PR, Rodríguez B, Gulick RM. Chemokine Coreceptor Tropism among Antiretroviral-Experienced Patients Screening for a Clinical Trial of a CCR5 Inhibitor: AIDS Clinical Trial Group 5211. Clin Infect Dis 2007; 44: 591-595. 32. Yonkers NL, Rodríguez B, Milkovich KA, Asaad R, Lederman MM, Heeger PS, Anthony DD. TLR Ligand Dependent Activation of Naïve CD4 T Cells by Plasmacytoid Dendritic Cells is Impaired in HCV Infection. J Immunol 2007; 178: 4436-4444. 33. Rodríguez B, Valdez H, Mijch A, Watson K, Lederman MM, Mccomsey GA, Loupa CV, Woolley I. Statins Transiently Blunt HAART-Induced CD4+ T Cell Gains, But Have No Long-Term Effect On Virologic Response To HAART. J Int Assoc Physicians AIDS Care 2007 2007 Jun 19; [Epub ahead of print]. 34. Jiang W, Lederman MM, Harding CV, Rodríguez B, Mohner RJ, Sieg SF. TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function. Eur J Immunol 2007; 37:2205-2213. 35. Marra CM, Sinha S, Clifford D, Evans S, Letendre S, Henry K, Para MF, Ellis R, Rodríguez B, Hall C, Schiffitto G, McArthur JC, Shriver S, Millar L, Aweeka F, Coombs R, Robertson K, for the Adult AIDS Clinical Trials Group 736 Study Team. Cerebrospinal Fluid HIV and Cognitive Function in Individuals Receiving Potent Antiretroviral Therapy. In Print. 36. Kitahata MM, Rodríguez B, Haubrich R, Boswell S, Mathews WC, Lederman MM, Kahn JO, Lober WB, Crane HM, Moore RD, Saag MS. Cohort Profile: The Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS). Int J Epidemiol 2008. In print. C. Current Research Support ONGOING AI69918-01 (Moore) 7/01/06 - 6/30/11 NIH/NIAID The North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) Establish a collaboration of North American HIV/AIDS cohorts and a data center for compilation of data to address HIV/AIDS research questions that cannot be accomplished through smaller cohorts; address scientific aims that focus on the failure of highly-active antiretroviral therapy (HAART);address additional scientific aims related to events that cannot be as well-studied in smaller cohorts; to develop and apply novel statistical and epidemiological methodology that is applicable to these scientific research initiatives. Role: Site Principal Investigator. AI067039-01 (Saag) 7/1/05 ­ 6/30/10 NIH/NIAID CFAR Network of Integrated Clinical Systems (CNICS) Build a infrastructure for exchange, storage and retrieval of real-time clinical care data on HV-infected patients receiving care at teaching institutions of excellence across the United States. To develop mechanisms for enrollment of further CFARs across the Nation. To conduct high-quality observational longitudinal research in the clinical course of HIV infection. Role: Site Principal Investigator; ViceChair, Research Coordination Core; Chair, Coinfections Sub-core. AI036219 (Yadavalli) 09/24/2007 - 03/31/2009 NIH/NIAID CFAR India supplement To establish a patient care and research database in Andra Pradesh, and to build research capacity using HIV observational data.

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Role: Co-investigator AI025879-17S2 (Rodríguez) 09/15/2005 - 12/31/2008 NIH/NIAID Targeted Evaluation to Support the President's Plan for Emergency AIDS Relief Assess the role of CD4+ T cell count monitoring and plasma HIV RNA measurements, as well as HIV genotypic resistance testing, in monitoring patients receiving antiretroviral therapy in Uganda. Role: Principal investigator. AI069501-01 (Lederman) 2/13/07 ­ 11/30/13 NIH/NIAID Adult AIDS Clinical Trials Unit Develop, implement, and analyze results of clinical treatment trials for HIV infection and its complications Role: Co-Investigator AI-36219 (Lederman) 4/1/93-3/31/09 NIH/NIAID Directs - $985,121; Indirect $514,879 Center for AIDS Research (CFAR) Promote increased collaboration between basic and clinical researchers through a central administrative structure, development of appropriate forums for sharing and exchange of ideas and pilot funding for interdisciplinary research. Also to enhance the depth and breadth of AIDS research by coordinated development of core activities and recruitment of new investigators. Role: Associate Director, Clinical Core; Coordinator of US-based studies, Clinical Epidemiology and Biostatistics Core R21 AI066957-01A2 (Anthony) 3/01/07-2/28/09 NIAID/NIH Immunity of neoantigen response in HCV, HIV, and HCV-HIV. Determine if baseline DC, B cell, or T cell frequency or function in HCV, HIV, and HCV-HIV infection predicts neoantigen or recall antigen responsiveness as determined by vaccine induced humoral immune response. Role: Co-investigator

R01-DK68361 (Anthony) 04/01/06 ­ 03/31/11 NIDDK/NIH r Role of immature DC in host defense against HCV. Assess the role of dendritic cell dysfunction in disease progression in HCV infection and HIV/HCV coinfection. Role: Co-investigator

Completed Research DE017335-01 (Sieg) 07/15/2005 - 05/31/2008 NIH Oral Defensins Bridge Innate and Adaptive Immunity(Sieg) To test the hypothesis that responses to beta defensins are impaired in HIV disease, we will evaluate antigen presenting cells from HIV-infected persons for their phenotypic and functional responses to beta defensins. Role: Co-investigator.

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