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MAHARASHTRA UNIVERSITY OF HEALTH SCIENCES, NASHIK

(From Academic Year 2010-11 & onwards)

Syllabus for MD/MS (Ayu) Preliminary Examination

PAPER-I RESEARCH METHODOLOGY AND MEDICAL STATISTICS Theory teaching periods Practicals 3 x 1 hour (Weekly) 3 x 2 hour (Weekly)

Marks 50

A

Methods Of Research

1) Aims and Objectives for Research in Ayurved, Principles of Ancient (Ayurvedic) methods of research, Modern methods of research, Definitions of research, classification of research, serendipity research, motivation of research, Terminology of research. 2) Principles, Methods and Guidelines for a) Literary research b) Fundamental research c) Drug research d) Clinical research a) Literary research :Manuscriptology, Concordance studies, Critical, Comprehensive, Standard and Annotated Editions, Evidence levels of Literary references, importance of prerreview Journals, Anecdotal references, citation index medical databases pubmed. b) Fundamental and Qualitative research, Principles, Methods and Guidelines, Research Designs. c) Drugs Research :Screening of drugs, Ethno medical methods, in vitro screening, in vivo screening, in silico screening, Collection, authentication, and standardization of raw drugs, in process quality control (IPQC), finished goods Identity, purity, and strength. Biological screening of drugs Bioethics Safety: acute, sub - acute, and chronic oral and parenteral toxicity, aerosol toxicity, teratogenicity, mutagenicity, carcinogenicity, local irritancy Pharmacokinetics: absorption, metabolism, distribution and excretion Pharmacodynamics: models for different studies. d) Clinical research:Ethical aspects, IEC, definitions Phases of clinical trials, criteria for selection of patients, assessment criteria, randomization, placebo, case studies, case series, cohort studies, case control studies, meta - analysis, epidemiological surveys, blinding, response variable, trial design, safety criteria, adverse drug reactions (ADR), pharmacovigilance, clinical data management (CDM) 3) Methods of survey of medicinal plants, field survey, botanical identification of medicinal plants, traditional methods, taxonomical methods, histological methods, preservation of medicinal plants.

4) Radioisotopes and their application in Medical Research, basis of selection of radioisotopes for their use in vivo. Types of radiations, units of radiation measurement. Radio immune assay (RIA), Biological effects of radiation, 5) Principles, application and instrumentation of following instruments in modern and Ayurvedic research: Chromatography: paper, thin layer, HPTLC, HPLC, GC-MS Colorimetry, spectrophotometry, UV - Visible, AAS and IRS Electrophoresis, paper and PAGE, Calorimeter for BMR.

Marks 50

B Medical Statistics

1) 2) Introduction: Application of Statistics methods to Ayurvedic research (i) Sources and Presentation of Data - Qualitative (or discrete) data, Quantitative (or continuous data) (ii) Methods of presentation - Tabulation, Graphical, Diagram. (i) Measures of Location - Average and Percentiles. (ii) Measures of central tendency - Mean, Median, Mode, (iii) Measures of location - percentiles, Graphic method, Arithmetical methods, Application and uses of percentiles. Variability and Its Measures Types, Biological, Real, Experimental, Measures of variability - Range, Semi - interquartile range (Q), Mean deviation, Standard deviation (SD) Coefficient of variation (CV). Normal Distribution and Normal Curve Demonstration of a normal distribution, Normal curve, Standard normal deviate (Z), Asymmetrical distributions. Sampling Representative sample, Precision, Sample size, Sample bias, sampling techniques, Simple random sampling. Systematic stratified, Multistage, cluster, Multiphase. Probability (Chance) Addition law of probability, Multiplication law, Binomial probability distribution, Probability chance from shape of normal distribution or normal curve etc. Sampling Variability and Significance Sampling distribution, Significance, Estimation of Population parameters etc. Testing statistical hypothesis Types of hypothesis, Tests of significance, their indications, applicability, advantages and limitations, calculation and interpretation - Z - test, student's t ' test - unpaired, paired, variance ratio test (F test), Analysis of variance test (ANOVA), chi - square test, Wilcoxon Sign Rank Test and Wilcoxon Rank Sum test etc. Concept of regression and correlation and their interpretation. Demography and Vital statistics. Designing and Methodology of an Experiment of a Study steps and methodology format for presentation of any research work. 13) Role of Computer Any 10 Experiments must be done by the students I) Experiments for drug standardization and study. 1) Herbal testing profiles. 2) Botanical standardization a) Morphological & Organoleptic tests b) Herbarium preparation c) Microscopic study d) Micrometry (Quantitative Microscopy) e) Powdered drug testing (* study of Microscopes, Micrometers, camera Lucida, Stains, reagents used for microscopy etc.) 3) Experiments for chemical analysis a) Determination of Foreign matter b) Determination of Moisture % c) Determination of Ash value, ash analysis d) Determination of Extractive value. e) Qualitative tests for extracts f) Tests for UV analysis g) Chromatography (* Study of Oven, Soxhlet apparatus, distillation apparatus, Mono pan balance, Muffle furnace, spectrophotometer, Centrifuge, etc.)

3)

4)

5)

6)

7)

8) 9)

10) 11) 12)

4) Proximal analysis of food. a) Estimation of carbohydrates b) Estimation of proteins c) Estimation of crude fibers 5) Oils & Fats testing a) Specific gravity b) Refractive index c) Estimation of Iodine value d) Estimation of Saponification value e) Estimation of peroxide value f) Acid value 6) Tests for preparations like asavas, aristas, tablets etc a) Determination of pH value b) Determination of Alcohol content of Asavas andArista c) Determination of Sugar content of Asavas and Arista d) Determination of Viscocisty (Oswald's viscometer) e) Determination of specific gravity f) Determination of Disintigration time for tablets g) Hardness test for tablets h) Friability test for tablets (* study of polarimeter, Abe's refractometer, Viscometer, etc) Reference Book 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 Ayurvedic Anusandhan Paddhati Research Methodology Drug Survey Methods in Biostatistics Introduction to Biostatistics Practical Problem in statistics Health Statistics A Short text book of Medical Statistics Introduction to clinical Research Medical Statistics Statistics and Truth Research: How to Plan, Speak & Write About it Practical Pharmaceutical Chemistry I & II Fundamental of Clinical Trials Remington's Pharmaceutical Sciences Text Book Clinical Practical Biochemistry Text Book of Inorganic Chemical Analysis Text Book of Pharmacognocy The Ayurvedic Pharmacopoeia of India P.V.Sharma Prof. V.J.Thakar Mayaram Uniyal B.K.Mahajan Nuldali Bancroft D.N.Elhance N.S.H.Rao A.B.Hill William C. Scheffer Vd. Shriram Savrikar C.Radhakrishna Rao Cifford Howkins Beckett A.H. Lawrence M.Friedman Harold Varley A. Vogel Trease and Evans Department of AYUSH, G.O.I.

Theory No. of Papers Duration Section A (Research Methods) Section B (Medical Statistics) Max. Marks Min Marks for Passing

One 3 hours 50 Marks 50 Marks 100 Marks 50 Marks

(At least 20 marks in each section must be obtained by the student, but the total of both sections should be at least 50 marks for passing)

Research Methodology and Medical Statistics Time Maximum Marks 3hrs 100

Notes: 1) Solve any 2 questions out of Q. No. 1,2 & 3 in each section. Q. No. 4 is compulsory in each section. 2) Simple calculator is allowed in the examination hall. 3) Biometric Statistical charts are allowed for reference in the examination hall. 4) ---Section A Research Methodology Q.No. 1) -------------------------15 Q.No.2) -------------------------15 Q.No.3)-------------------------15 Q.No.4) Solve any four from the following (4x5)=20 a) ----b) ---c) -------d) ------e) --------Section B Medical Statistics Q.No. 1) -------------------------15 Q.No.2) -------------------------15 Q.No.3)-------------------------15 Q.No.4) Solve any four from the following (4x5)=20 a) ----b) ---c) -------d) ------e) --------Practical A) Research Methodology 1) 2) 3) B) Experiment Viva ­ voce Practical Record book Max. Max. 50 Marks 20 Marks 20 Marks 10 Marks 50 Marks 20 Marks 20 Marks 10 Marks (50 Marks) (50 Marks)

Medical Statistics 1) 2) 3)

Spotting (5 spots of 5 minutes and 4 marks each) Viva ­ voce Practical Record book

PAPER- II MAULIK SIDDHANT

(Any one of the following groups should be taken as per Naidanikiya or Anaidanikiya group)

Group-A Anaidanikiya (Non-Clinical)

2. (a) 2. (b) 2. (c) 2. (d)

Basic Principles of Ayurveda. Basic principles of Sharir Basic Principles of Dravya guna and Rasa-Shastra. Basic underline practical principles of Medicine.

Group-B Naidanikiya (Clinical)

2.(a) 2.(b) 2.(c) 2.(d)

Basic Priciples of Rog Nidan and Vikriti Vigyanam Fundamentals of Shalya and Shalakya Tantra Basic Principles of Prasuti Tantra, Stri-Rog and Kaumarbhritya Underline practical principles of Medicine.

Paper ll MAULIK SIDDHANT Group-A ANAIDANIKIYA (NON-CLINICAL) 2. (a) Basic Principles of Ayurveda

(Basic Principale of Ayurvedic Medicine)

NUMBER OF LECTURES THEORY MARKS PRACTICAL MARKS NUMBER OF PAPER DETAIL SYLLABUS POINT PATTARN OF THEORY PAPER

: : : : : :

ONECE IN WEEK (Minimum 25 Lectures) 25 25 ONE - SECTION 1 ATTACHED SEPARATE SHEET Question paper pattern

Note : There will be three questions, out of which Q No. (1) will be compulsory & Any one question is to be solved between 2 & 3 of K-Varga

Maulik Sidhanta Q. No.1) Compulsory Q.No.2) Or Q.No.3) 12 Marks 13 Marks 12 Marks

Title of practical examination & Marks: Viva =20marks, One compilation = 5 Marks compilation Should have at least 25 pages but not more than 30 pages. Relevant commentaries and updated references should be included in compilation. Reference books : 1. Selected /useful quotation from Charak samhita, Susrut Samhita, Ashtang hridhayam,Ashtang sangraha etc along with commentries 2. Sarvadarshon Sangraha - Umashankar Sing 3. Tarkasangraha 4. Sankhyakarika 5. Ayurvedika maulik siddhant- Prof V. J.Thakar

Detail Syllabus points 1) Specific Knowledge of principles of Sankhya & Vaisheshik alongwith other darshanas incorporated in Ayurvedic Literature i.e. with applied aspect

A) B)

2)

Srushti Uttapattikrama (l="Vh

Karyakaran Siddhanta Importance of Ayurvedic Philosophical Concept A) Purusha Vivechan (iqjQ"k foospu)

mRirhdze) (dk;Zdkj.k fl/nkar) foKkuh;e)

B) C) D)

3) 4) 5)

Vedana Vidnyaniyam (osnuk Dukha hetavaha (nq%[k Mokshasya

gsro) Swarupam (eks{kL; LojQi)

Determination of Padartha and its applied aspects. Determination of Praman and its applied and Research aspects. Basic Principles of Ayurved and its applied aspectsA) Tridosha Siddhant (f_knks"k fl/nkar) B) Pancha Mahabhuta Siddhant C) D) E)

(iapegkHkwr fl/nkar) Samanya Vishesha Siddhant (lkekU; fo'ks"k fl/nkar) Swabhavoparamvada (LoHkkoksijeokn) Lokpurusha samya Siddhant (yksd iqjQ"k lkE; fl/nkar)

6) 7)

Vadamargas Description of Tantrayukti, its utility, number and knowledge of technical terms of Ayurved.

2. (b) Basic principles of Sharir

(Rachana Sharir and Kriya Sharir)

Theory teaching periods Practicals

3 x 1 hour (Weekly) 3 x 2 hour (Weekly)

Study of the main principles of practical rachana sharir & Kriya sharer (anatomy and physiology). Specific study of the following matters in the preview of prakriti & vikriti: 1) 2) 3) Study of Sira & Dhamani along with the study of Snayu, Nadi, and Kandara. Analysis of srotas according to Charak & Sushrut. Detailed study of marma, with definition, variety, description, site anatomical distribution, specific action & establishment of its importance. 4) 5) Knowledge of Agni, its importance, specific variety and characteristics. Narration of Mahasrotas, description of kostha, anatomical & physiological study of Hridya (Heart), Kloma, Phuphus (Lungs) Yakrit, Pliha, Unduk, Vrikka (Kidney), Nabhi, Dimba, Basti etc. Functional study of Dhatu, Oja, Gyanedriya, Mana, Buddhi etc. & other related structures.

Reference Books 1. Related matters of Charak Samhita 2. Sharir sthan of Sushrut 3. Related matters of Ashtang Samgraha and Hridaya 4. Pratyaksha Shariram 5. Abhinava Shariram 6. Parishadya Shabdartha Shariram

Format of Practical / Oral Examination Sr. No. 01 02 Heading of Practical Oral/Viva Short Compilation on basic principles of Rachana Sharir & Kriya Sharir Total Marks 20 05 25

2. (c). Basic Principles of Dravyaguna and Rasa-shastra

Dravyaguna and Rasa-shastra & Bhaishajyakalpana

Lectures - 30

(Dravyaguana 15 + Rasa & B.Kalpana-15)

Total Theory Marks- 25 Total Practical/Oral Marks-25 Practical & specific knowledge of the principles described in Dravyaguna Shastra. Determination of specific Ganas (Charak & Sushrut) & Vargas (Bhavprakash).

Determination of practical importance of Rasa, guna, veerya, vipaka, prabhava & karma principles. Knowledge of the technical terms i.e. karmas (e.g.Dipan, Pachan, etc as per Sharangadhar Samhita) described in Dravyaguna. Classification of Rasa-dravya & their practical utility. Introduction of Rasa, Maharasa, Uprasa,Sadharanrasa, Dhatu, Updhatu, Ratna, Uparatna, Visha, & Upavishas. Introduction of Panchavidha kashaya kalpana, formulation of Asava, Arishta, Bhasma, Loha, Mandur, formulations of rasa-adusadhi, formulation of Ghrita ,Tail, Avaleha and Paka kalpana and their practical knowledge & utility.

Format of Question Paper Section C : Basic Principles of Dravyaguna and Rasa-shastra Q.No. 1 Nature of Questions One LAQ on Dravyaguna OR Two SAQ on Dravyaguna One LAQ on Rasashastra & B.Kalpana OR Two SAQ on Rasashastra & B. Kalpana Division of Marks 13X1 b 7X1& 6x1 12X1 OR 6X2 Total Total Marks 13

2

12 25

Format of Practical / Oral Examination Sr. No. 1 2 Hediang of Practical Oral/Viva Short Compilation on basic principles of Dravyguna or Rasashatra & Bhaishajyakalpana Total Markas 20 05 25

Reference Books

1 2 3 4 5 6 7 8 9 10 Charaksamhita Sushrut samhita Ashtang hridaya Dravyaguna Vigyan Bhavprakash Nighantu Dravyaguna Vigyan Dravyaguna Hastamalak Aushadhigunadharma Shastra Kriyatmakaushadhiparichay vidnyan Dravyaguna Vidnyan -

11 12 13 14 15 16 17 18 19

Dravyaguna Vidnyan Rasaratnasamucchaya Rasendrasarasamgraha Kriyatmaka Aushadha Parichaya Vigyan Rasatarangini Rasendrachintamani Yogratnakar Sharangdhar Samhita` Aushadhi-Gundharma Shastra

-

Yadavji Trikamji Dr.Krishnachandra Chunekar Priyavrata Sharma Banawarilal Mishra Pt. Vishvanath Dvivedi Pt. Vishvanath Dvivedi Vd. A.P.Deshpande, Vd. Javalgekar, Vd. Ranade Vd.V.M.Gogate

Vishvanath Dvivedi Sadananda Sharma

Gangadhar Shastri Gune

2. (d) Basic Underlines Practical Principles of Medicine General knowledge of the basic principles of modern medicine, Homeopathy, Unani, Siddha, Chainic, Tibbati and other prevailing systems of medicine in the purview of the basic principles of Ayurvedic Medicine. Description of general and specific principles of kayacikitsa Determination of dosha & dushya, Knowledge of avarana (overriding) of doshas, specific knowledge of samsarga and sannipata of Dosha, Description of srotodusti, sequence of treatment of the different variety of diseases and group of diseases. Practical knowledge of the principles of treatment, increase of Kshina Dosha and depletion of vriddha dosha, shadvidha upakram, dvividha upakrama (Santarpana & Apatarpana) and Shadvidhakriyakalopakrama etc . Proper knowledge of methods of Rasayana & Vajikarana and the medicinal formulations to be used in those processes. Practical importance of purvakarma, pashchatkarma & methods of Panchakarma, knowledge of diseases related to difference systems like Pranavaha, Raktavaha etc. 1 2 3 4 5 6 Charaka Samhita with chakrapanidutta Sushrut Samhita related to medicine Ashtang Samgraha and Ashtang Hridaya related to medicine Cikitsadarsha Kayachikitsa Rog Pariksha Vidhi -

Pandit Rajesvardutta Shastri Ramaraksha Pathaka Priyavrat Sharma

Group-B NAIDANIKIYA (CLINICAL) 2. (a).Basic Principles of Rog -Nidan & Vikriti Vigyanam

Lectures-25 Total Theory Marks- 25 Total Practical/Oral Marks-25 Introduction of Nindanpanchaka, Shatkriyakal,Agni,Aam,Strotas & Vyadhikshamatva. Introduction to various methods of the examination of diseases and patients specially Dvividha, Trividha, chaturvidha, Panchavidha, Shadvidha, Astavidha & Dasavidha pariksha and their specific utility in medical science. Knowledge of different new methods and instruments related to examination of patients. Examination of vitiated dosha, dhatu & mala. Assessment of importance of examination in different diseases, proper knowledge of avarana of dosha, dhatu & mala. Importance of features due to avarana as specific causative factors in the production of the diseases. Proper acquaintance of Ashayapakarsha, Trividha rogmarga, sanchayadi-kriyakala as per etiopathological view. Specific knowledge of pathogenesis (Samprapti) of diseases and its importance in the manifestation of disease. Format of Question Paper Section A : Basic Principles of Rog -Nidan & Vikriti Vigyanam Q.No. 1 2 Nature of Questions One LAQ on Rognidan & V.Vigyan OR One LAQ on Rognidan & V.Vigyan Two SAQ on Rognidan & V.Vigyan Format of Practical / Oral Examination Sr. No. 1 2 Hediang of Practical Oral/Viva Related Short Compilation Not more than 50 pages Total Reference Books 1 2 3 4 5 6 7 8 9 10 Sutra-Nidan-Vimana-Indriya Sthan of Charak Samhita Related matters from Brihat trayee and Laghu trayee Madhava Nidan Ayurvediya Vyadhi Vigyan Rog Pariksha Vidhi Abhinava Vikriti Vigyan Nidan Chikitsa Hastamalak Vikruti Vigyanam Rogvigyan Vikruti Vigyan Rogvigyan Vikruti Vigyan Markas 20 05 25 Division of Marks 13X1 Or 13x1 6X2 Total Total Marks 13 12 25

Madhukosha Commentary Yadavji Trikamji Acharya Priyavrat Sharma Raghuvir Prasada Divedi Vidyadhar Shukla Vd. Y.G. Joshi Vd. Ranade, Vd. Paranjape

2. (b) Basic Principles of Shalya & Shalakya Tantra Characteristics of rakta and establishment of its 4th doshatwa in the perview of the knowledge of dosha, dhatu & mala. Proper knowledge of diseases described in Shalyatantra and their etiology, pathogenesis, clinical features and treatment. Knowledge of Yantra, Shastra & Anustrastra. Merits and demerits of shastra. Practical knowledge of astavidha shastra karma in different diseases. Surgical diseases and their methods. Kinds of Vrana, methods of vrana bandhan, sixty procedures of vranas, importance of application of Kshar, method of prepartion of Kshar. A brief knowledge of required medicines for kshar preparation. Method of application of Kshar in different diseases, knowledge of application of Kshar, knowledge of agnikarma and its applicability, practical knowledge and description of different variety of rakta mokshana like siravedha, Shrings, Jalouka and Alabu. Proper knowledge of diseases above the clavicle, their etiology and clinical features. Knowledge of practical application and method of preparation of different procedures applicable in diseases above the clavicle like ashchyotan, vidalaka, putapaka, tarpana, Anjan, Dhumpana, Kavala, Gandusha, Raktamokshan, nasya, Sirovasti etc. Description along with practical application of newer instruments applied in different diseases depicted in Shalakya Tantra.

Reference Books 1. Related matters of Sushrut Samhita, Ashtang Samgraha and Ashtang Hridaya 2. Saushruti--Ramanth Dvivedi 3. Shalya samanvaya

2. (c) Basic Principles of Prasuti tantra, Stri Rog and Kaumarbhritya Description of importance of female anatomy, anatomy of uterus, associated hormones of menstrual cycle, ovum, fertilization & implantation, formation of twin pregnancy, underlying causes of the formation of foetus, Sada-dhatvatmka form of fetus, Maternal factors, and development of foetus, foetal implantation, Endometrial membrane, Nutrition of the foetus, Sex formation in foetus and ante-natal and pre-natal care, formation of Jarayu (amniotic membrane) and Placenta. Different stages of labour management, haemorrhage and its control, types of foetal expulsion, Therapeutic measures of normal labour, Abnormal labour, knowledge of cephalo-pelvic disproportion, Mudhagarbha (Obstructed labour), complications and treatment of abortion and miscarriage, Post-labour measures, cutting of umbilical cord, abnormalities of lactation. Yoni-Vyapada, Stanya Rog, general disease in female, Rakta gulma (hydatidiform mole), Breast and Uterine cancer, Uterine prolapse, exogenous vaginal diseases. Etiology,

pathogenesis and symptomatic treatment of diseases occurring in females, knowledge of methods uttrar Basti, pichu, Varti, lepa, dhupan (fumigation), dhavan (douching), agnikarma (Cauterisation) etc. Different types and uses of various surgical methods in different female disorders. Neonatal examination, Neo-natal care and nutrition of New born (neonate). Balashosa (Marasmus), Pari-Garbhika, phakka (Rickets), jalashirsha (Hydrocephalus) and other diseases like kasa, swasa, Grahani, Diarrhoea, paksaghata (Paralysis), Heart diseases, Kukunaka (Conjunctivitis), obstructed anus, Phimosis and horn, Trachoma, Charmadala, Kshiralaska, Ulvaka Rog, Vomiting, Child epilepsy, Worm infestations,

Talukantaka, Treatment of diseases due to (grahavadha) external demons according to their etiology and symptoms.

Reference Books 1. Related portion of Charak Samhita 2. Kashyapa Samhita 3. Harita Samhita 4. Abhinav Prasuti Tantra 5. Abhinav Stri rog Vigyan 6. Kumat Tantra Samccaya -- Ayodhya Prasad Achal -- Ayodhya Prasad Achal -- Ramanath dvivedi

2. (d) Underlying Practical Principles of Treatment General knowledge of the basic principles of modern medicine, Homeopathy, Unani, Siddha, Chainic, Tibbati and other prevailing systems of medicine in the purview of the basic principles of Ayurvedic Medicine. Description of general and specific principles of kayacikitsa Determination of dosha & dushya, knowledge of avarana (over riding) of doshas, specific knowledge of samsarga and sannipata of Dosha, Description of srotodusti, sequence of treatment of the different variety of diseases and group of diseases. Practical knowledge of the principles of treatment, increase of Kshina Dosha and depletion of vrddha dosha, shadvidha upakram, dvividha upakrama (Santarpana & Apatarpana) and

Shadvidhakriyakalopakrama etc . Proper knowledge of methods of Rasayana & Vajikarana and the medicinal formulations to be used in those processes. Practical importance of purvakarma, pashchatkarma & methods of Panchakarma, knowledge of diseases related to difference systems like Pranavaha, Raktavaha etc.

Reference Books 1. Charak Samhita with cakrapanidutta 2. Sushrut Samhita related to medicine 3. Ashtang Samgraha and Ashtang Hridaya related to medicine 4. Cikitsadarsha 5. Kayachikitsa 6. Rog Pariksha Vidhi 7. Panchakarma Vigyan - Pandit Rajesvardutta Shastri - Ramaraksha Pathak - Priyavrat Sharma - Haridas Sridhar Kasture

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