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August 2005

CURRICULUM VITAE

MARY E. EDGERTON, M.D., PH.D.

CONTACT INFORMATION

H. Lee Moffitt Cancer Center & Research Institute 12902 Magnolia Drive Mail Stop: SRB-3 Tampa, Florida 33612 Telephone: 813-745-8725 Email: [email protected]

PERSONAL DATA

Date of Birth: Jan 05, 1956 Place of Birth: Austin, Texas USA

EDUCATION

University of Texas, Austin; B.S. (Phi Beta Kappa); 1976; Physics, Special Honors University of East Anglia (U.K.); Ph.D. (Marshall Scholar); 1979; Biophysics Thesis: "Some Physical and Chemical Properties of Purple Membrane from Halobacterium halobium;" Ph.D. Supervisor: C. Greenwood, Ph.D. University of California, San Francisco, Fellow, 1979-1980, Post-doctoral Research; Mentor: W. Stoeckenius, Ph.D. State University of New York, Stony Brook, Research Associate, 1980-1981, Post-doctoral Research; Mentor: C-W. Wu, M.D. Medical College of Pennsylvania, M.D. (Alpha Omega Alpha), 1994, Medicine Medical College of Pennsylvania, Intern, 1994-1995, Internal Medicine University of Pennsylvania, Resident, 1995-1999, Pathology University of Pennsylvania, Fellow, 1999-2000, Surgical Pathology

LICENSES HELD

Commonwealth of Pennsylvania, M.D., 1998-2000, MD-067223-L State of Tennessee, M.D., 2000-present, MD-33909

CERTIFICATION

American Board of Pathology, Anatomic & Clinical Pathology, June 1999

Mary E. Edgerton, M.D., Ph.D. Page 2

ACADEMIC APPOINTMENTS

Visiting Professor, Department of Biochemistry, Medical College of Pennsylvania, 1991-1994 Assistant Professor, Department of Pathology, Vanderbilt University School of Medicine, 2000-2005 2nd Appointment, Biomedical Informatics, Vanderbilt University School of Medicine, 2000-present Associate Professor, Department of Interdisciplinary Oncology, University of South Florida School of Medicine, 2005-present

EMPLOYMENT

Analyst, 1981-1985, Exxon Research & Engineering Company Senior Analyst, 1985, Exxon Research & Engineering Company Senior Research Physicist, 1985-1990, Mobil Research & Development Corporation Architect for Multi-Disciplinary Informatics, H. Lee Moffitt Cancer Center & Research Institute, 2005present

PROFESSIONAL ORGANIZATIONS

College of American Pathologists United States and Canadian Academy of Pathology Association for Pathology Informatics American Medical Informatics Association

PROFESSIONAL ACTIVITIES

Intramural Committees Chair, Vanderbilt Ingram Cancer Center Clinical Pathology & Molecular Informatics Core Advisory Board, 2002 Member, Vanderbilt Ingram Cancer Center Tissue Core Advisory Board, 2002 Member, Dept of Biomedical Informatics Emphasis Course Committee, 2003 Member, Vanderbilt-Ingram Cancer Center Informatics Cluster Advisory Board, 2003 Intramural Resources Director, Vanderbilt Ingram Cancer Center Tissue Clinical Informatics Core, 2001-present Extramural Committees Junior Member, College of American Pathologists Informatics Committee, 1999-2001 Member, Association for Pathology Informatics Executive Planning Committee, 2000-present Chairman, Association for Pathology Informatics Research Committee, 2000-2003 Member, Association for Pathology Informatics Technical Standards Committee, 2001-2003 Member, National Cancer Institute Lung Progress Review Board, 2001 Chair, Bioinformatics Subcommittee, American Association of Cancer Institutes, 2001 Co-chair, Tissue Informatics Working Group, National Dialogue on Cancer, 2002-2003 Member, National Cancer Institute Lung Adenocarcinoma Group, 2002 Member, Cancer Biomedical Informatics Grid Integrative Cancer Research Workspace, 2004 Member, National Functional Genomics Consortium Advisory Board, 2004 Member, Multiple Myeloma Research Consortium/Multiple Myeloma Research Foundation Scientific Advisory Board 2005 Ad Hoc Journal Reviews Cancer Epidemiology Biomarkers and Prevention

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Journal of the National Cancer Institute Biomed Central Expert Reviews in Molecular Medicine Editorial Board Member Cancer Informatics 2005 Scientific Review Panels NCI Scientific Review Special Emphasis Panel, ZRG1 SSH (01), 2002 NCI Scientific Review IMAT (innovative Technologies) Panel, ZCA SRRB-C M1 P, 2002 NCI Program Project Site Visit, NCI-E RPRB (K2) 2003 NCI Special Emphasis Panel ZRG1 BST-D 51, 2004 NCI Epidemiology of Cancer (EPIC) Panel, 2004 Professional Awards Innovative Research Award, Mobil Research & Engineering Company, 1988

TEACHING ACTIVITIES

Medical School Path 501 Friday Group co-Leader, 10 hours, Fa 2000, Fa 2001, Fa 2004 Slide Laboratory, 9 hours, Fa 2000 Endocrine Week, 2 hours, Fa 2001 Breast Week, 2 hours, Fa 2003 Graduate School Biomedical Informatics Training Program · Developed Required Bioinformatics Course and Laboratory for 1st Offering Bioinformatics 310, 36 hours, Sp 2002 Bioinformatics Lab 310, 12 hours, Sp 2002 Interdisciplinary Graduate Program · Developed Curriculum for Bioinformatics Week Bioinformatics Week, Introductory Lectures, 2 hours, Sp 2002 Continuing Medical Education Advancing Pathology Informatics Imaging and the Internet Tissue Microarray Data Exchange Standards Workshop, Fa 2001, Organizer Oklahoma State Association of Pathologists, Fa 2002, Lecturer Automated Information Management in the Clinical Laboratory Tissue Microarray Data Exchange Workshop, Sp 2002, Lecturer Emerging Cancer Treatment Modalities: From Research to Practice, Sp 2004, Lecturer Resident Supervision Surgical Pathology, 6 hours/week Breast Consult Service, 3 hours/week

CIVIC ACTIVITIES

People to People Delegation of Biophysicists to People's Republic of China, 1988

Mary E. Edgerton, M.D., Ph.D. Page 4

RESEARCH PROGRAMS

COMPLETED Pagetoid Spread In Ductal Carcinoma in situ (Edgerton ME), ACS IRG, $20 000, 15% (no salary), 01/01/2000-12/31/2001 Vanderbilt NIDDK Biotechnology Center (George AL Jr), NIH U24, $483 816, 10%, 09/30/200008/31/2003 Tissue Microarray Informatics Standards Workshop (Edgerton ME), NIH R13, $5 000, 10% (no salary), 09/01/2001-08/31/2002 Tools for Electronic Collaboration (Edgerton ME), VUMC Discovery, $50,000, 10% (no salary), 01/01/2004 -07/31/2004 SPORE in GI Cancer (Coffey RJ Jr), NIH P50, $1,685,494, 10%, 06/01/2002-05/31/2007 SPORE in Breast Cancer (Arteaga CL), NIH P50, $1,698,500, 10%, 8/7/2003-5/31/2008 Cancer Center Support Grant (Moses HL), NIH P30, 10%, $4,747,451, 9/1/2004-08/31/2009 ONGOING Tennessee Valley Cooperative Human Tissue Network (Washington MK), NIH U01, $718,468, 25%, 04/01/2001-03/31/2006 Clinical & Microarray Data Predict Outcomes in Lung Cancer (Edgerton ME), NIH R01, $150,000, 20%, -03-31-2007

PUBLICATIONS AND PRESENTATIONS

Refereed Journal Articles TA Moore, ME Edgerton, G Parr, C Greenwood, RN Perham, Studies of an acid-induced species of purple membrane from Halobacterium halobium, Biochem. J 171: 469-476, 1978. ME Edgerton, TA Moore, C Greenwood, "Salt reversal of the acid-induced changes in purple membrane from Halobacterium halobium, FEBS Letters 95: 35-39, 1978. ME Edgerton, C Greenwood, Evidence for a model of regeneration of a protonated species, bR, from a phototransient, M, in the photochemical cycle of bacteriorhodopsin from Halobacterium halobium, Biochem Soc Trans 7: 1075-1077, 1979. ME Edgerton, TA Moore, C Greenwood, Investigations into the properties of an acid-induced species of purple membrane from Halobacterium halobium, Biochem J 189: 413-429, 1980. ME Edgerton, PG Brimblecombe, Thermodynamics of halobacterial environments, Can J Mic 27: 899-909, 1981. ME Edgerton, FA Handler, CW Wu, Methods for the analysis of the kinetics of cooperative binding of ligands to a two-site lattice, Biopolymers 22: 787-805, 1983. AJ DeGregoria, ME Edgerton, "Thermal modeling of Bridgman solidification using DISPL," in Advances in Computer Methods for Partial Differential Equations-V, Proceedings of the Fifth IMACS International Symposium on Computer Methods for Partial Differential Equations (R. Vichnevetesky and R. S. Stepleman, eds.), IMACS, New Brunswick, June 19-21, 1984 ME Edgerton, GD Byrne, WS Ho, Numerical calculation of the simultaneous absorption of two gases with reversible reactions, Computers and Chem Eng 10: 551-556, 1986. DW Morel, ME Edgerton, GE Warner, WJ Johnson, MC Phillips, GH Rothblat, Comparison of the intracellular metabolism and trafficking of 25-hydroxycholesterol and cholesterol in macrophages, J Lipid Res 37: 2041-2051, 1996.

Mary E. Edgerton, M.D., Ph.D. Page 5

ME Edgerton, RS Hoda, PK Gupta, Cytologic diagnosis of metastatic ovarian carcinoma in the urinary bladder: A case report and review of the literature, Diagn Cytopathol 20:156-159, 1999. ME Edgerton, SA Roberts, KT Montone, Immunohistochemical performance of antibodies on previously frozen tissue, Appl Immunohistochem Mol Morphol 8:244-8, 2000. ME Edgerton, R Taylor, JI Powell, R Simon, ET Liu, A bioinformatics tool to mine sequences for microarray studies of mouse models of oncogenesis, Bioinformatics 18: 774-775, 2002. JJ Berman, ME Edgerton, B Friedman, The tissue microarray data exchange specification: A community-based, open source tool for sharing tissue microarray data, BMC Medical Informatics and Decision Making 3:5, 2003. L Xie, BK Law, ME Aakre, M Edgerton, Y Shyr, NA Bhowmick, HL Moses, Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line, Breast Cancer Res 5: R187-R198, 2003. K Yanagisawa, Y Shyr, BJ Xu, PP Massion, PH Larsen, BC White, JR Roberts, M Edgerton, A Gonzalez, S Nadaf, JH Moore, RM Caprioli, DP Carbone, Proteomic patterns of tumour subsets and behavior in non-small cell lung cancer, Lancet 362: 433-439, 2003. N Yamagata, Y Shyr, K Yanagisawa, M Edgerton, TP Dang, A Gonzalez, S Nadaf, P Larsen, JR Roberts, JC Nesbitt, R Jensen, S Levy, JH Moore, JD Minna, DP Carbone, A training-testing approach to the molecular classification of resected non-small cell lung cancer, Clin Cancer Res 9:4695-704, 2003. PP Massion, PM Taflan, SM Jamshedur Rahman, P Yildiz, Y Shyr, ME Edgerton, MD Westfall, JR Roberts, JA Pietenpol, DP Carbone, AL Gonzalez, Significance of p63 amplification and overexpression in lung cancer development and prognosis, Cancer Res. 63:7113-7121, 2003. PP Massion, PM Taflan, Y Shyr, SM Rahman, P Yildiz, B Shakthour, ME Edgerton, M Ninan, JJ Andersen, AL Gonzalez, Early Involvement of the Phosphatidylinositol 3-kinase/Akt Pathway in Lung Cancer Progression. Am J Respir Crit Care Med. 170(10):1088-94. 2004 D Fisher, M Edgerton, L Tang, L Frey, Z Chen Searching for Meaningful Feature Interactions with Backward-Chaining Rule Induction. Proceedings IDA-05, 6th International Symposium on Intelligent Data Analysis Madrid, Spain, September 2005 [in press]. LJ Frey, ME Edgerton, DH Fisher, L Tang, L., Z Chen, Z. Using Prior Knowledge and Rule Induction Methods to Discover Molecular Markers of Prognosis in Lung Cancer. Proceeding of the American Medical Informatics Association Symposium. Washington, DC. 2005 [in press]

Book Chapters ME Edgerton, JE Johnson, PL Dutt, DL Page, Chapter 13 Extent and Multicentricity of In Situ and Invasive Carcinoma, in Bland KI, Copeland EM III (eds). The Breast: Comprehensive Management of Benign and Malignant Diseases. Third Edition. Elsevier Science, Philadelphia, 2003. Letters to the Editor JF Simpson, DL Page, ME Edgerton, "p53 in Mammary ductal carcinoma in situ, mutations in highgrade lesions only?" J Natl Cancer Inst. 93 :666-7, 2001 Abstracts ME Edgerton, "Development of Data Analysis Strategies for Gene Pathway Discovery using Supervised and Unsupervised Techniques," Abstract, The Third International Meeting on

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MICROARRAY DATA, STANDARDS ANNOTATIONS, ONTOLOGIES, AND DATABASES March 28-31, 2001, Stanford University, Palo Alto,CA. KD Mannes, ME Edgerton, JF Simpson, RA Jensen, DL Page, "Pagetoid Spread in Ductal Carcinoma In Situ: Characterization and Computer Simulation," Abstract, United States and Canadian Academy of Pathology (USCAP) Annual Meeting 2002. R Debski, K Ely, ME Sanders, ME Edgerton, "COX-2, EGF-R, ER, PR, and HER2/NEU Expression in Papillary Thyroid Carcinoma," Abstract, United States and Canadian Academy of Pathology (USCAP) Annual Meeting 2003. T Caldwell and M Edgerton, "The Metaclinic Database System," Intelligent Systems in Molecular Biology (ISMB) Annual Conference 2004. Jacob DS, Edgerton ME, Wiles KR, Washington MK, "Secure, Web-based Tissue Inventory and tracking System for Non-Consented Collections, "International Society for Biological and Environmental Repositories (ISBER) Annual Meeting 2004 MS Ross and ME Edgerton, "Bar Coding," International Society for Biological and Environmental Repositories (ISBER) Annual Meeting 2004 ME Edgerton and MK Washington, "Infrastructure Requirements for a Tissue-Clinical Informatics Resource," International Society for Biological and Environmental Repositories (ISBER) Annual Meeting 2004 ME Edgerton, LJ Frey and DH Fisher, "Molecular and Morphological Correlates in Lung Cancer," United States and Canadian Academy of Pathology (USCAP) Annual Meeting 2005 (accepted).

Presentations at Scientific Meetings Bioinformatics Tools for the Molecular Classification of Disease: A Guide to Internet Tools to Access Current Knowledge and Support Genomic, 10/26/2000, CAP Today/CAP Focus Session in Advancing Pathology Informatics Imaging and the Internet, Pittsburgh PA (Invited Speaker) Comparison of Supervised and Unsupervised Methods for Data Analysis, 11/13/2001, Statistical Analysis of Microarray Data: Navigating the Microarray Minefield, Washington DC (Invited Speaker) Pagetoid Spread in Ductal Carcinoma in Situ: Characterization and Computer Simulation, 05/05/2002, VUMC Workshop on Mathematics Models in Cancer, Nashville TN (Invited Speaker) Standards for Tissue Microarray Data Exchange, 09/09/2003, MGED6, Aix-en-Provence, France (Invited Speaker) Bioinformatics Tutorial: Data Exchange Standards for Microarray Technology, 12/08/2002, The European Heath Record Exchange (TEHRE), London UK (Invited Speaker) Discoveries with Combined Clinical and Gene Expression Array Data in Lung Cancer, 03/22/2004, Emerging Cancer Treatment Modalities: From Research to Practice, Copper Mountain CO (Invited Speaker) Secure, Web-based Tissue Inventory and tracking System for Non-Consented Collections, 10/18/2004, International Society for Biological and Environmental Repositories (ISBER) Annual Meeting, Perugia IT Using rule induction to discover molecular targets in lung cancer Microarray data, 04/18/2005, American Association for Cancer Research Annual Meeting, Annaheim CA Vanderbilt SPORES, 05/04/2005, International Society of Biospecimen and Environmental Repositories (ISBER) Meeting, Seattle WA

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