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®

043700

G-7059

9. Procaterol HCl

17)

Meptin -Mini Tablets

Procaterol Hydrochloride.......................25 µg 1. g 18) 6 100 g 50

®

substance P

1. 2. OG22 Procaterol hydrochloride JAN 8-Hydroxy-5-[(1RS,2SR)-1-hydroxy-2-isopropylaminobutyl]-2(1H)-quinolinone monohydrochloride hemihydrate C16H22N2O3HCl1/2H2O 335.83 195 Procaterol hydrochloride ~ formic acid methanol ethanol ether 1 100 pH 4.0-5.0 1 20

procaterol HCl

(pg/mL)

50 µg 100 µg

18) 2. Procaterol HCl 24 11.65%

(

1.1 hr 1.5 hr 97 pg/mL 226 pg/mL

)

Not determined 3.6 hr

50

g

100 g 9.93%

·

1.

1-5)

salbutamol 2.

isoproterenol orciprenaline

1-3)

·

1 6 1

procaterol HCl 50 µg 2 1 2 2 procaterol HCl 25 µg 1 1 1 2

Procaterol HCl isoproterenol, trimetoquinol, orciprenaline 3.

2

salbutamol

-

1-4)

procaterol HCl isoproterenol, trimetoquinol, orciprenaline salbutamol 4.

6-11)

1.

isoproterenol salbutamol Procaterol HCl 5. 6. Treadmill loading test 7. Procaterol HCl 8. isoproterenol procaterol HCl Procaterol HCl salbutamol Procaterol HCl

12)

PCA

(1) (2) (3) (4) (5)

[ [ ] [ ]

[ ]

]

procaterol HCl trimetoquinol, orciprenaline, 2.

] [ 6.

(1) (2)

13)

procaterol HCl 3.

14)

Epinephrine, isoproterenol catecholamine adrenoreceptor

influenza C virus

15-16)

Catecholamines (eg.epinephrine , isoproterenol)

Xanthine (eg. theophylline, aminophylline, diprophylline) )

(

Xanthine adrenoreceptor

8.

12

9. ( 10. (1) rats procaterol HCl 30 mg/kg/day mg/kg/day 19,20) rats SD rats procaterol HCl 210 PTP PTP PTP )

steroids steroids Steroids (betamethasone , prednisolone, hydrocortisone sodium succinate) (furosemide) 4. 22,757 644 2.83% ( 1980 12 1999 12 ) (1) 1) 2) steroids (2) / 0.1% ~ 5% 0.1% xanthine

(2)

104 rat

21)

79/84 4 ~ 1000

1) Yabuuchi, Y. et al.: J. Pharmacol. Exp. Ther. 202 (2), 326, 1977 2) Himori, N. et al.: Br. J. Pharmacol. 61 (1), 9, 1977 3) Yamashita, S. et al.: J. Pharmacol. Pharmac. 30 (5), 273, 1978 4) Yabuuchi, Y.: Br. J. Pharmacol. 61 (4), 513, 1977 5) Kawamura, K. et al.: In-house report 6) Koda, A. et al.: Arerugi (Allergy) 28 (5), 417, 1979 7) Ito, K. et al.: Shinyaku to Rinsho (J. New Remed. Clinics) 27 (12), 2127, 1978 8) Nakazawa, T. et al.: Gendai no Shinryo (Clin. Med.) 21 (1), 35, 1979 9) Ito, K.: Kiso to Rinsho (Clin. Rep.) 14 (11), 3549, 1980 10) Yui, Y. et al.: In-house data 11) Tomita, Y.: Gendai Iryo (Modern Med. Treat.) 12 (12), 1771, 1980 12) Kase, Y. et al.: Oyoyakuri (Pharmacometrics) 15 (4), 705, 1978 13) Akasaka, T. et al.: Shonika Shinryo (J. Pediat. Pract.) 44 (2), 239, 1981 14) Miura, M. et al.: Am. Rev. Respir. Dis., 141, A387, 1990 15) Ouchi, K., et al.: Immunopharmacology, 20, 81, 1990 16) Kawamura, K. et al.: Kiso to Rinsho (Clin. Rep.), 24 (4), 1981, 1990 17) Katsumata, U. et al.: Tohoku J. Exp. Med., 158, 105, 1989 18) Tashiro, S. et al.: Yakuri to Chiryo (Basic Pharmacol. Ther.) 26 (2), 185, 1998 19) Kurosumi, M. et al.:Oyoyakuri (Pharmacometrics) 17 (5), 691, 1979 20) Kawano, K. et al.: Oyoyakuri (Pharmacometrics) 17 (5), 713, 1979 21) Jack, D. et al.: Toxicology 27, 315, 1983 22) Sasaki, K. et al.:Yakuri to Chiryo Basic Pharmacol. Ther. 8 (12), 4735, 1980 23) Arai, Y. et al.: Shonika Shinryo (J. Pediat. Pract.) 43 (11), 2367, 1980 24) Wagatsuma, Y. et al.: Yakuri to Chiryo (Basic Pharmacol. Ther.) 8 (10), 3857, 1980 25) Nakayama, Y. et al.: Shonika Shinryo (J. Pediat. Pract.) 44 (1), 103, 1981 26) Baba, M. et al.: Shonika Rinhso (Jpn. J. Pediat.) 34 (4), 913, 1981 27) Nishima, S. et al.: Shindan to Chiryo (Diag. Treat.) 69 (1), 166, 1981 28) Matsuyama, H. et al.: Shonika Rinhso (Jpn. J. Pediat.) 43 (2), 373, 1990

59.4% 199/335

48.0% 145/302 94.0%

22~28)

( )

GOT GPT LDH

1)

5. 6. (1) (2) procaterol HCl 7. rat

15

ET0302

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