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Curriculum vitae PERSONAL Name: Date of birth: Place of birth: Citizenship: Marital Status: Work Address: Alejandra María Pacchioni. October 19, 1969. Buenos Aires, Argentina. Argentinean. Married. Department of Neurosciences. Medical University of South Carolina 173 Ashley Avenue BSB 403 Charleston, SC 29425 Tel.: (843) 792-1838. Fax: (843) 792-4423. Email: [email protected] 2235 Ashley Crossing Drive Apt # 5C Charleston, SC 29414. Tel.: (843) 766-3664.

Alejandra M. Pacchioni

Home Address:

ACTUAL POSITION Post Doctoral Researcher at Dr. Ron See Laboratory, Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA. April 2008-December 2009 PREVIOUS POSTDOCTORAL POSITION Post Doctoral Researcher at Dr. Peter W. Kalivas Laboratory, Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA. November 2004- April 2008. EDUCATION Graduate: (1999- 2004) PhD thesis title: "Neural mechanisms involved in the modulation of addictive properties of opiates and psychostimulants" Institution: School of Chemical Sciences, National University of Cordoba, Argentina. Advisor: Dr. Liliana M. Cancela. Undergraduate: Biochemist. School of Biochemical and Pharmaceutical Sciences, National University of Rosario, Argentina. (February 1996). FELLOWSHIP 1998-2002: Doctoral Fellowship, FOMEC, National University of Córdoba, Argentina.

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Curriculum vitae PRIZES AND TRAVEL AWARDS

Alejandra M. Pacchioni

2008: NHSN Travel Award, to participate at the 8th Annual International conference of National Hispanic Science Network on Drug of Abuse. Bethesda, MD. October 1st to 3rd, 2008. 2007: NHSN Young Investigator Panel Travel Grant, to participate at 7th Annual International conference of National Hispanic Science Network on Drug of Abuse. Miami Beach, Florida. September 26-28th, 2007. 2006: NIDA International Forum Travel Award to attend to 2006 NIDA International Forum and College of Problems of Drug Dependence 68th Annual Meeting, Scottsdale (Arizona), June 2006. 2003: SFN-IBRO Travel Award to attend to Society for Neuroscience 33rd Annual Meeting, New Orleans, November 2003. International Brain Research Organization (IBRO). 2002: S.A.F.E. Special Mention for the poster presentation, Argentinian Society of Experimental Pharmacology, Tandil, Buenos Aires, Argentine. 2001-2004: Encouragement Program to Teaching/Researcher Staff. University Higher Council Resolution N° 381/00.

PUBLICATIONS

(most recent first)

1. Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW. (2009) NAcetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci. 12(2):182-9. [Epub ahead of print Jan 11 2008] 2. Wiggins AT, Pacchioni AM, Kalivas PW. (2009) Integrin expression is altered after acute and chronic cocaine. Neurosci Lett. 450(3): 321-3. [Epub ahead of print Dec 7. 2008] 3. Alejandra M. Pacchioni, Joseph Vallone, Paul F. Worley, Peter W. Kalivas (2009). "Neuronal pentraxins modulate cocaine-induced neuroadaptations". J Pharmacol Exp Ther. 328(1):183-92. [Epub ahead of print Oct 7 2008] . 4. Blumer JB, Lord K, Saunders TL, Pacchioni A, Black C, Lazartigues E, Varner KJ, Gettys TW, Lanier SM.(2008). Activator of G-protein signaling 3 null mice: I.Unexpected alterations in metabolic and cardiovascular function. Endocrinology. 149(8): 3842-9. [Epub ahead of print May 1 2008]

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Curriculum vitae

Alejandra M. Pacchioni

5. Assis, MA, Pacchioni AM, Collino C, Paz MC,Sotomayor C, Basso AM, Cancela LM.(2008). A dopamine mechanism is implied in the acquisition and expression of amphetamine and stress-induced effects observed in the lymphocyte subpopulations. European Journal of Pharmacology. 584(2-3): 405-14. [Epub ahead of print Feb 12 2008] 6. Mackler S, Pacchioni A, Degnan R, Homan Y, Conti AC, Kalivas P, Blendy JA. (2008) "Requirement for the POZ/BTB protein NAC1 in acute but not chronic psychomotor stimulant response". Behavi Brain Res 187(1):48-55. [Epub ahead of print Nov 2 2007] 7. Boger HA, Middaugh LD, Patrick KS, Ramamoorthy S, Denehy ED, Zhu H, Pacchioni AM, Granholm AC, McGinty JF. (2007) "Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice". J Neurosci. 15;27(33):8816-25. 8. A.M. Pacchioni, J. Vallone, R.I. Melendez, A. Shih, T.H. Murphy, P.W. Kalivas.(2007) "Nrf2 Gene Deletion Fails to Alter Psychostimulant-induced Behavior or Neurotoxicity" Brain Res. 1127 (1): 26-35. [Epubahead of print Nov 17 2006] 9. Pacchioni, A.M., Bregonzio C., Cador M. and Cancela, LM. (2007) "A glutamate ­ dopamine interaction in the persisten enhanced response to amphetamine in nucleus accumbens core but not shell following a single restraint stress. Neuropsychopharmacology, 32 (3): 682-692. [Epub ahead of print 19 April 2006] 10. Gioino G., Hansen C., Pacchioni A., Rocca F., Molina Barrios S., Brocca E., and Cancela L.M. (2003). "Use of HPLC with Diode-Array Detection after Primary Drug Screening in Patients Admitted to the Emergency Department". Therapeutic Drug Monitoring, 25(1):99106. 11. Pacchioni A., Gioino G., Assis A. and Cancela L. (2002)." A single exposure to restraint stress induces behavioural and neurochemical sensitization to stimulating effects of amphetamine: involvement of NMDA receptors". Annals of the New York Academy of Sciences, 965 :233-246 12. Capriles N., Pacchioni A. and Cancela L. (2002). "Influence of acute or repeated restraint stress on morphine- induced locomotion: involvement of dopamine, opioid and glutamate receptors". Behavioral Brain Research, 134: 229-238. ABSTRACTS SUBMITTED TO MEETINGS

(most recent first)

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"P-glycoprotein inhibition and risperidone-induced striatal dopamine release". Alejandra. M. Pacchioni, Alisha. Henderson, Amanda. Gabriele, Lindsay. Devane and Ronald E. See. 38th Annual Meeting of Neurosciences, Society for Neuroscience, Washington, DC, USA. November 2008. "Role of the dorsal and ventral prefrontal cortex in cue- and drug-induced reinstatement following extended access to methamphetamine". *A. Rocha, A. Pacchioni, P. W. Kalivas. 38th Annual Meeting of Neurosciences, Society for Neuroscience, Washington, DC, USA. November 2008.

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2.

Curriculum vitae

Alejandra M. Pacchioni

3. "The role of the dorsal striatum during drug-seeking after abstinence from chronic cocaine self-administration". Alejandra M Pacchioni, Amanda Gabriele and Ronald E See. 8th Annual International conference of National Hispanic Science Network on Drug of Abuse. Bethesda, MD. October 1 to 3, 2008. 4. "Deletion of neuronal Pentraxins produces differential effects on AMPA-induced locomotion and cocaine neuroadaptations. Alejandra M. Pacchioni, Patricia Steiner,Joseph Vallone, Paul F. Worley, Peter W. Kalivas. 37th Annual Meeting of Neurosciences, Society for Neuroscience, San Diego, CA, USA. November 2007. 5. "Deletion of the AMPAR-clustering protein Narp reduces cocaine-induced locomotion and increases its rewarding properties". Alejandra M. Pacchioni, Joseph Vallone, Paul F. Worley , Peter W. Kalivas . 36th Annual Meeting of Neurosciences, Society for Neuroscience, Atlanta, GA, USA. October 2006. 6. "Deletions of the AMPAR-clustering proteins Narp and NP1 increase cocaine-induced behavioral plasticity". Alejandra M. Pacchioni, Joseph Vallone, Paul F. Worley , Peter W. Kalivas . 2006 NIDA International Forum . Scottsdale (Arizona). June16-19 ,2006. 7. "Exacerbation of methamphetamine-induced behavioral and neuronal toxicity is prolonged during aging of gdnf heterozygous versus wild-type mice" H.A. Boger, L.D. Middaugh, K.S. Patrick, S. Ramamoorthy, A.M. Pacchioni, A. Granholm, J.F. McGinty. 35th Annual Meeting of Neurosciences, Society for Neuroscience, Washington, DC USA. November 2005.

8. "Nrf2 deletion gene does not sensitize mice to acute and repeated cocaine" A.M. Pacchioni, J. Vallone, R.I. Melendez, A. Shih, T.H. Murphy, P.W. Kalivas. 35th Annual Meeting of Neurosciences, Society for Neuroscience, Washington, DC USA. November 2005. 9. "Amphetamine triggers long-lasting effects in cns and is: is the proenkephalin system a possible common mediator?". M.A. Assis, M.R. Padros, M. Rosete, S. Duran, A.M. Pacchioni, C. Sotomayor, O. Vindrola, L.M. Cancela. 34th Annual Meeting of Neurosciences, Society for Neuroscience, San Diego, USA. October 2004. 10. "An acute restraint stress induces sensitization to stimulating effects of d-amphetamine and morphine on dopamine release from the shell and core of the nucleus accumbens: involvement of NMDA receptors". Pacchioni, A.M.; Capriles, N.R. and Cancela, L. 33rd Annual Meeting of Neurosciences, Society for Neuroscience, New Orleans, USA. November, 2003. 11. "Involvement of NMDA receptor in stress-induced sensitization to stimulating effects of damphetamine: microdialysis and in situ hybridization studies". AM Pacchioni and LM Cancela. "XXXIV Annual Meeting of Argentinian Society of Experimental Pharmacology". November, 2002. Tandil, Argentine. Special Mention of Argentinian Society of Experimental Pharmacology Award. 12. "Influence of NMDA/AMPA antagonists on stress-induced sensitization to stimulating effects of amphetamine: a microdialysis study". L..M. Cancela, A.M. Pacchioni, G.A.

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Curriculum vitae

Alejandra M. Pacchioni

Gioino, A.M. Basso. 32nd Annual Meeting of Neurosciences, Society for Neuroscience, Orlando, USA. November, 2002. 13. "Repeated administration of d-amphetamine facilitates stress induced immunosupression: a multiparameter T and B cells analysis by flow citometry." MA Assis, AM Pacchioni, C Collino, B Salido-Rentería, V Molina, AM Basso, C Sotomayor, L Cancela. 6th International Symposium on Predictive Oncology & Intervention Strategies. Pasteur Institute. February, 2002. Paris, France. 14. "Determinación de Anfetamina en orina por HPLC con detector fluorométrico usando un nuevo derivatizante". (Measurement of amphetamine in urine by HPLC with fluorometric detection using a new derivatizing coumpound) Gioino GA, Pacchioni AM, Suarez A y Cancela LM. XII Annual Meeting of Argentinian Toxicology Society. September, 2001. Rosario, Santa Fe, Argentina. 15. " Influence of MK-801 on stress-induced sensitization on stimulating effects of amphetamine: a microdialysis study". Pacchioni AM, Gioino GA , Assis A , Correa F y Cancela LM. Satellite Meeting of the International Society for Neurochemistry and American Society for Neurochemistry. August, 2001.Mar del Plata. Argentina. 16. "Liberación de Dopamina en Cuerpo Estriado luego de sensibilización inducida por estrés sobre anfetamina: Estudio de microdialisis". (Dopamine release from Striatum in the stress-induced sensitization of amphetamine: a microdialysis study) Pacchioni AM, Gioino GA y Cancela LM. " XV Annual Meeting of Argentine Neurochemistry Society". November, 2000.Córdoba, Argentina. 17. " Sensibilización a las propiedades estimulantes de anfetamina: participación diferencial de áreas mesocorticolímbicas". (Sensitization to the stimulating properties of amphetamine: involvement of different mesocorticolimbic areas) A. Pacchioni, N. Capriles, L. Cancela. "XXXI Annual Meeting of Argentine Society of Experimental Pharmacology". November, 1999. Mar del Plata, Argentina. (Oral Presentation) 18. " Effects of Haloperidol pretreatment in dopamine mesocorticolimbic areas on restraint stress-induced sensitization to reinforcing and locomotor stimulating properties of damphetamine".N. Capriles, A. Pacchioni, L. Ponce and LM Cancela. 21st International Summer School of Brain Research. Cognition. Amsterdam, August 23 -27, 1999.

YOUNG INVESTIGATORS PANNEL (oral presentations) "Clustering of AMPA-receptors modulates cocaine effects" Alejandra M. Pacchioni, Patricia Steiner, Joseph Vallone, Paul F. Worley , Peter W. Kalivas 7th Annual International conference of National Hispanic Science Network on Drug of Abuse. Miami Beach, Florida. September 2628th, 2007.

"Deletion of the AMPAR-clustering proteins Narp and NP1 increase cocaine rewarding properties and decrease AMPA-induced locomotion". Alejandra M. Pacchioni, Patricia Steiner, Joseph Vallone, Paul F. Worley , Peter W. Kalivas 7th Annual Argentine Neurosciences Workshop, La Falda, Cordoba, Argentina. 29-31 March 2007 5

Curriculum vitae

Alejandra M. Pacchioni

MENTORING EXPERIENCE Neurobiology of cocaine relapse after abstinence: role of dopamine in dlCPu. Kendall Ulbrich, College of Charleston Bachelor Essay. (2008-9). Mentor: Alejandra Pacchioni Neurobiology of cocaine relapse after abstinence: role of dlCPu. Laurel Black, College of Charleston Bachelor Essay. (2008-9). Mentor: Alejandra Pacchioni Deletion of the AMPAR-clustering proteins Narp reduces cocaine- and AMPA-induced locomotion. Patricia Steiner, College of Charleston Bachelor Essay. (2006-7). Mentor: Alejandra Pacchioni Chronic stress induced sensitization to amphetamine stimulant effects: rol of dopamine. Alvina Lech, School of Biology Bachelor Essay, UNC, Argentina. (2003-4). Mentor: Liliana Cancela; Co-advisor: Alejandra Pacchioni

CONVENTIONS Frontiers in Addiction Research: 2007 NIDA Mini-Convention. November 2nd, San Diego, CA, USA. November 2007. Frontiers in Addiction Research: 2006 NIDA Mini-Convention. October 13, 2006. Atlanta, GA. USA. Frontiers in Addiction Research: Washington, DC. USA. Frontiers in Addiction Research: Orleans, USA. 2005 NIDA Mini-Convention. November 11, 2005.

2003 NIDA Mini-Convention. November 7, 2003. New

SOCIETY MEMBER Society for Neurosciences: Foreign student member 2004-2005, Regular member since 2005 South Carolina Society for Neurosciences: member since 2005. National Hispanic Science Network on Drug Abuse (NHSN): Early career scientist since August 2007. TRAINING EXPERIENCE "Involvement of D1/D2 receptors in mPFC in cocaine-seeking behavior". Laboratoire de Neuropsychobiologie des Desadaptations. Université Victor Segalen Bordeaux II. Advisor: Dr. Martine Cador, October- November, 2002. Bordeaux, France.

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Curriculum vitae

Alejandra M. Pacchioni

"Microdialysis of monoamines in rat brain areas and their measurement by HPLC/ECD". Neurochemistry Division, Psychobiology Laboratory, Riberao Preto School of Philosophy Sciences and Letters, San Pablo University.. Advisor: Dr. Rodolfo Silveira, April-May, 1999. Riberao Preto, San Pablo, Brazil. Technical experience acquire during the PhD thesis: behavioral techniques (locomotor activity and place preference conditioned), microdialysis in awake animals (rats), detection of dopamine by HPLC, in situ hybridization of NMDA receptor subunits and estereotaxic surgeries for animals. Technical experience acquired during my Post-doc: behavioral studies and microdyalisis in transgenic mice; measurement of glutamate/GABA by electrochemical and fluorescence detection; western blotting; cellular subfractionation; PCR; brain dissection.

TEACHING EXPERIENCE 1994- 1998: Lecturer in Toxicology, Department of Toxicology School of Biochemical and Pharmaceutical Sciences, National University of Rosario, Santa Fe, Argentina. 1998-2004: Lecturer in Pharmacology and Toxicology, Department of Pharmacology, School of Chemical Sciences, National University of Cordoba, Cordoba, Argentina.

COURSES Graduate Courses " Molecular and analytical aspect of abuse drugs ", X Meeting of Argentinian Society of Toxicology. Advisors: Dr. A. S. Fulginiti and O. Roses. School of Pharmacy and Biochemistry, Buenos Aires University, Buenos Aires, Argentina. September, 1996. " Analytical micrography of abuse drugs", School of Pharmacy and Biochemistry, Buenos Aires University, Buenos Aires, Argentina. October, 1996. "Pharmacology", School of Pharmacy and Biochemistry, Buenos Aires University, Buenos Aires, Argentina. September-November, 1996. " Foods Toxicology and Laws". Advisors: Dr. O. Roses, School of Pharmacy and Biochemistry, Buenos Aires University, Buenos Aires, Argentina. August-September, 1996. " Animals models to physiology, pharmacology and toxicology studies". Advisors: Dr. E. Rodriguez Garay, Dra. M. C. Carrillo, Dr. A. Motino. School of Biochemical and Pharmaceutical Sciences, National University of Rosario, Santa Fe, Argentina. April-June, 1997. " Applied statistical methods". Advisor: Dr. M. Leiva. School of Biochemical and Pharmaceutical Sciences, National University of Rosario, Santa Fe, Argentina. April-August, 1997.

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Curriculum vitae

Alejandra M. Pacchioni

"I International Workshop on Risk Assessment in Developing Countries", Buenos Aires, Argentina, September, 1998. "Hormones and neuropeptides in the brain: involvement in psychopathologies". Advisor: Dr. Marta Volosín, School of Chemical Sciences, National University of Cordoba,Cordoba, Argentina. 1999. Qualification mark: 10 (ten). "Biological basis of addiction". Advisor: Dr. Liliana Cancela. School of Chemical Sciences, National University of Cordoba, Cordoba, Argentina. 1999. Qualification mark: 10 (ten). "Problems in Chemical Sciences in Argentine". Advisors: Dr. Ma. Rosa Mazzieri, Aldo Coleoni y Ana N. Santiago, School of Chemical Sciences, National University of Cordoba, Cordoba, Argentina. 2002. "Neurochemicals tools: molecular, cellular and systemic analysis of beta- endorphin knockout mice". Advisors: Dr. Hugo Carrer, Julia Cambiaso y Laura Vivas,. Mercedes and Martin Ferreyra Medical Research Institute. Cordoba, Argentina. 2003. Qualification mark: 10 (ten). Postdoctoral Courses "The responsible conduct of research". Course Director: Dr. William Boggan. Medical University of South Carolina. October 31st ­ December 5th, 2005. Teaching Techniques Course-CGS 725. Course Director: Eric R. James, Ph.D. Primary Instructor: Ruth Patterson, Ed.D. Medical University of South Carolina. January 9th-February 27. 2007

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