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Northwestern University Clinical and Translational Sciences Institute

NUCATS news

Winter 2010

Table of Contents

An Update from Dr. Greenland CHITREC EHR Program Bill McGaghie Paper Phil Messersmith Paper New CTI Pilot Grant Recipients Innovation Day TIPI Funding Opportunities I2C Program Science of Team Science Conference eNOTIS Launch EDW Overview Engineering Into Medicine NUCATS IT NEWSBYTES Kelly Lowry Awarded KL2 TRIP Case Study Helin Binns Awarded for Research Upcoming Events/ Announcements NUCATS' High Fives/ Service Awards 2 2 2 3 3 4 5 5 6 7 7 8 8 9 10 10 11 12

The newly awarded Chicagoland Met- President of Research, Northwestern Univerropolitan AsthmaNet Consortium (CMAC) sity, co-Center Director NUCATS Center for recently received more than $5 million in Education and Career Development and Lead funding. The effort includes Northwestern PI on the CMAC grant. "The partners involved University and Children's Memorial Hospital, have extensive experience in asthma cliniThe University of Chicago and Comer Chil- cal and translational research programs, and dren's Hospital, John H. Stroger Junior Hos- have worked together successfully on past repital and several community partners work- search initiatives. Our network in Chicago will ing together to address the high prevalence serve the city's large population of asthma of asthma in the Chicago metropolitan area. sufferers and in turn, will support the national The consortium strongly reflects the NUCATS' goals of AsthmaNet to identify approaches to mission of developing cross-disciplinary scien- better manage and treat both pediatric and tific teams focused on accelerating biomedical adult asthma." research discoveries to Successful recruitment Research teams bring extensive improve human health. is critical to the success of The CMAC is part clinical trials. The investiexpertise and leadership in asthma of a national network, gators involved have colclinical and translational research funded by NIH and laborated for more than NHLBI, developing and 10 years as part of the conducting multiple clinical trials to address American Lung Association's Asthma Clinical asthma management and new treatment ap- Research Centers program (ALA-ACRC) and proaches in pediatric and adult populations. demonstrated high success in enrolling paAsthmaNet is designed to promote coopera- tients with asthma into NIH, foundation and tion and coordination, facilitate scientific ex- industry-sponsored clinical trials, and investichange, provide training opportunities, and gator-initiated pilot studies. The consortium leverage resources. will build on this successful foundation by "The consortium builds on a history of ex- having multiple sites that together provide acpertise and innovation in approaches to the cess to patients with a wide range of asthma treatment of asthma," said Dr. Lewis Smith, severity who are ethnically/racially diverse. Professor of Medicine and Associate Vice

The Chicagoland Metropolitan AsthmaNet Consortium Combines the Strength and Resources of Major Medical Institutions

Silverman Hall Opens to Encourage Medical Discoveries at the Edges

www.nucats.northwestern.edu

New building opens to house 245 researchers in chemistry, biology and engineering.

NUCATS news

An Update from Dr. Greenland

Hello, EveryoneIt's hard to believe it is already March, isn't it? On the first of the month, we filed our Year 2 Annual Progress Report (APR). I first want to take the time to thank everyone for their efforts in completing the report--ahead of the scheduled deadline. A big note of kudos goes to Sheila Kessler for quarterbacking the project and keeping things moving, and to the core APR team comprised of Tyler Smith, Jill Bockes, Jim Bray, Brian Chamberlain, Paula Carney, Colleen DeLuca, Barbara Ferry, Tom Hancko, Elizabeth Kollross, Michelle Melin-Rogovin, Peggy Mitchell, Mary Ratliff, Thongsy Singvongsa, Latonia Trimuel, Warren Kibbe, David Were and Michael Wilson. I would also like to share a few of the highlights from the report that made me feel very proud of the progress we have made at NUCATS during our second year: Full implementation of our Enterprise Data Warehouse (EDW)-- We have made considerable progress in creating an EDW through funding from three significant NUCATS stakeholders: NMFF (Northwestern Medical Faculty Foundation), Northwestern Memorial Hospital and the Feinberg School of Medicine. This initiative will provide the NU medical enterprise with the ability to share clinical information across the research community in a safe and stable environment. It will also serve as a key enabler for research, clinical quality and healthcare operations. Complete plans to reorganize clinical research processes at Northwestern and to create a NUCATS clinical research office-- NUCATS has played a central role in developing plans to re-engineer the clinical research process across the NU medical enterprise, working jointly with NMH. A cross-functional team including researchers, process engineers, and executives conducted an analysis to determine key barriers and gaps in current infrastructure. We anticipate implementation of the newly re-engineered processes beginning Spring or Summer, 2010. Under ARRA funding, we are also able to accelerate launch of eNOTIS, our clinical research data tracking tool. Increase interactions with basic scientists throughout Northwestern University (as specified by One Northwestern planning efforts)--Collaborations across NU have increased steadily over the past year and are further enhanced by the expansion of our program of Research Team Support (RTS). The Center for Translational Innovation (CTI) also continued to provide concierge services across the University and partner institutions to match researchers with resources. Leverage our CTSA and the NUCATS Institute by developing private-University partnerships, obtaining additional grant funds outside the CTSA and increase gifts to the NUCATS Institute to accomplish our goals--Despite the continued economic pressure in hampering development efforts, NUCATS has made progress in creating alternative funding mechanisms and improving visibility with regard to development offices within Northwestern. We hired a part-time development officer to identify funding opportunities for young investigators within foundations focused on improvements in human health. We have also managed grant competitions in cooperation with corporate partners from the life sciences community.

Improve funding for K-type and T-type awards to enable us to fund additional trainees outside of the CTSA grant mechanism-- NUCATS continues to explore alternative sources of funding for K and T awards in order to expand this important pathway for young investigators interested in clinical and translational research. I also want to acknowledge the fact that we have solidified infrastructure and developed a solid base to build clinical and translational efforts at Northwestern University. During Year Two we have initiated a strong strategic planning framework in order to engage the entire Institute--and University community--around our mission and vision. Thank you for all your hard work and here is to a strong Year 3!

Chicago Health IT Regional Extension Center (CHITREC)

Northwestern University has partnered with the Alliance of Chicago Community Health Services and a number of local and national collaborators to establish the Chicago Health Information Technology Regional Extension Center, or CHITREC. The Center was funded by the federal recovery act through competitive grants. The consortium received $7.6 million in funding through the Health Information Technology Extension Program. Abel Kho, MD, MS, Associate Director of the REACH practicebased research network and Associate Director of the Medical Informatics Program in the NU Bioinformatics Center is the Principal Investigator. Dr. Kho will serve as Co-Executive Director of CHITREC in partnership with Fred Rachman, MD, CEO of the Alliance of Chicago Community Health Services. CHITREC will work with primary care physicians who practice in the City of Chicago to help them implement and use electronic health records in a meaningful way. At present only 1020% of Chicago primary care providers use an electronic health record. CHITREC aims to work with more than 80% of Chicago's primary care providers. Increasing the percentage of primary care providers using electronic health records will improve the quality, safety and value of health care in Chicago. This effort is critical in Chicago, which has a disproportionate share of the underserved, uninsured and underinsured in Illinois. Physicians interested in learning more about CHITREC, including how they can receive the technology and benefit from support, should visit the CHITREC web site at www.chitrec.org.

A Commentary Published in Science Translational Medicine by Bill McGaghie Examines Medical Education Research as Translational Science Science Translational Medicine has published a new commentary summarizing existing medical education research. Authored by Bill McGaghie, PhD, Director of NUCATS' Office of Evaluation and Jacob R. Suker, MD, Professor of Medical Education, the paper delivers a new perspective on medical educational research as a translational science, demonstrating that medical education research can influence outcomes across all three stages of translational research--in the lab, at the point of care, and ultimately in educational practices that improve patient and public health. The paper is available here and online.

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NUCATS news

NUCATS Congratulates Pilot Grant Recipient Phil Messersmith on New Published Paper

American Journal of Obstetrics and Gynecology has published new research by Phillip B. Messersmith, PhD, Professor of Biomedical Engineering, Materials Science and Engineering, and Chemical and Biological Engineering at McCormick School of Engineering with several medical and engineering collaborators in Europe and Canada. The paper, titled "Injectable candidate sealants for fetal membrane repair: bonding and toxicity in vitro" tests surgical sealants for eventual use in closing membrane defects. The research is based, in part, on pilot funding from the NUCATS Institute, which targets new high risk/high reward projects that address significant unmet needs with a direct bearing on clinical problems. Read the Northwestern News release, click here.

http://www.mccormick.northwestern.edu/grandchallenges/

Dean's Grand Challenge Lectures April 21, May 13

Dr. Phil Messersmith, Professor of Biomedical Engineering, McCormick School of Engineering and Applied Sciences and NUCATS' Pilot Grant winner was the featured lecturer during the Dean's Grand Challenge Lectures in Medicine and Engineering. He and his research group use biologically inspired strategies -- such as mimicking in a sealant the sticking power of mussels -- to develop new biomaterials for the repair, replacement or augmentation of human tissue.

NUCATS Names New CTI Pilot Grant Recipients

The Northwestern University Clinical and Translational Sciences troduction of genetic material into cells and tissues for controlling gene Institute (NUCATS) has announced the winners of the third Center for expression has significantly impacted research involving gene pathways Translational Innovation (CTI) Pilot Grant competition. Award winners and function, and provides promise for therapeutic application. The gewere selected based on the high potential of their research in solving netic level approach has inherent specificity not available with the vast unmet medical problems, and are examples of work that illustrates NU- majority of drugs, which may increase efficacy and reduce side effects. CATS' mission of accelerating the translation of research discoveries to Chad Mirkin, PhD, George B. Rathmann Professor of Chemistry improve human health. in the Weinberg College of Arts and Sciences, Professor of Medicine, ·Conrad Epting, MD, Assistant Professor of Pediatrics, Northwest- Feinberg School of Medicine, Chemical and Biological Engineering, Bioern University Feinberg School of Medicine, will lead research efforts to medical Engineering and Materials Science and Engineering, McCorcombat African trypanosomiasis (sleeping sickness) using cancer che- mick School of Engineering and Applied Sciences, and Director of the motherapy. The rapidly dividing parasite is sensitive International Institute for Nanotechnology at North"The potential scientific breakto growth arrest by anticancer drugs. Current therathroughs coming from this group of western, is collaborating with Paller on this project. pies for advanced cases are toxic and not available pilot projects is a testament to the ·Lonnie Shea, PhD, Professor of Chemical and by pill. If proven successful, use of this treatment, value of clinical and translational Biological Engineering, McCormick School of Engiwhich is well tolerated, inexpensive, and off-patent, research," said, Dr. Philip Greenland, neering and Applied Sciences, is investigating the could be a boon for the resource-challenged nations use of antigen-linked nano/micro-particles to inhibit Director of NUCATS Institute. where sleeping sickness is prevalent. This innova- "NUCATS is proud to support these antigen-specific T-cells for therapy of immune-metive approach may also be useful in treating other efforts and other collaborative health diated diseases, building on the pioneering clinical parasitic and fungal infections. stage work of his collaborator Stephen D. Miller, research initiatives across David Engman, MD, PhD, Professor, Pathology PhD. Shea and his team will develop and test the efNorthwestern University." and Microbiology-Immunology; Director, Medical ficacy of nano/micro-particles in tolerance induction Scientist Training Program, Feinberg School of Medicine, is a collabora- for prevention of diabetes and reversal of early diabetes in a mouse tor on this project. model. The research could open up islet cell transplantation on a large ·Nina Kraus, PhD, Hugh Knowles Professor, Communication Sci- scale for Type I diabetics and provide a mechanism for reversing disease ences; Neurobiology & Physiology; Otolaryngology, School of Commu- in newly diagnosed Type I diabetics. nications, is investigating a new hearing test for understanding speech Stephen D. Miller, PhD, Judy Guggenheim Research Professor of in background noise that is easy to administer and interpret, especially Microbiology-Immunology; Director, Immunobiology Center, Feinberg in older adults. It is not well understood why some older adults can School of Medicine, and Xunrong Luo, Assistant Professor, Division of hear well in noisy settings and others cannot. Dr. Kraus and her team Nephrology & Hypertension, Feinberg School of Medicine, are collabobelieve that the auditory brainstem is central to the process, and that rators on the project. the stimulus can be modulated and tested to better diagnose and treat Pilot projects are supported by NIH grant UL1 RR025741 from the the condition, perhaps leading to more effective hearing aids. National Center for Research Resources and additional funds contribut·Amy Paller, MD, Walter J. Hamlin Professor and Chair, Department ed by the Northwestern University Office for Research. For more inforof Dermatology, Professor of Pediatrics, Feinberg School of Medicine, mation on Pilot Funding or to receive updates on Pilot Grant announcewill study the potential for small interfering RNA in a noninvasive topi- ments, please contact Jim Bray, [email protected] cal treatment for melanoma, the most deadly form of skin cancer. In3

NUCATS news

WEDNESDAY, MAY 19, 2010 8:00 AM - 5:30 PM ROBERT H. LURIE MEDICAL RESEARCH CENTER 303 E. SUPERIOR STREET NORTHWESTERN UNIVERSITY CHICAGO, IL

The Center for Translational Innovation--part of Northwestern University Clinical and Translational Sciences (NUCATS) Institute--announces its second annual Innovation Day.

Commercialization Seminars Continue

Mark your calendars for the rest of the 2009-2010 academic year: Licensing University Inventions Alan Hauser, Director of Business Development, Technology Transfer Program March 22 - Lurie, Gray Room, Chicago March 23 - Tech Institute, Room L221, Evanston Legal Issues for Entrepreneurs April 2010 Esther Barron, Clinical Assistant Professor of Law, NU School of Law; and Assistant Director, Bluhm Legal Clinic's Small Business Opportunity Center (SBOC) Steve Reed, Clinical Assistant Professor of Law, NU School of Law; and Supervisor, SBOC Keep up to date on the Commercialization Seminar series at: http://www.nucats.northwestern.edu/education/seminars-lectures/commercialization/ index.html

Featuring keynote speaker Norbert Riedel of Baxter Healthcare, Innovation Day will showcase Northwestern University's advancements and projects in translational research, as well as stimulate dialogue between academic researchers, clinical affiliates, and commercial enterprises. Why attend? · This forum highlights the latest translational research and new biomedical products being developed across Northwestern's enterprise, spanning multiple campuses and clinical affiliates What is on the agenda? · Keynote speaker: Norbert Riedel, CSO of Baxter Healthcare · Presentations by and panel discussion with researchers from across the University · Pitches of late-stage commercialization projects and recent startup companies to business development professionals and early-stage investors · Details about campus grant funding programs, such as the NUCATS Center for Translational Innovation pilot program, the Dixon Family pilot programs, and the Baxter/NU Alliance program How do I register or get involved? · Visit: http://www.nucats.northwestern.edu/events/InnoDay2010/ InnovationDay2010Reg Please forward this invitation on to colleagues who may also be interested in attending the conference.

Who should attend? · Investigators, students, staff, business development professionals, and early-stage investors interested in the translational research

2010 BIO International Convention May 3-6, 2010 McCormick Place Chicago, IL http://convention.bio.org

NUCATS' Center for Translational Innovation (CTI) catalyzes biomedical innovation by fostering multidisciplinary clinical and translational research at Northwestern University through cross-college collaborations and by matching investigators with resources within the Institution and within the national CTSA network. CTI also provides pilot project funding, market research and IP analysis consultation, serves as an industry liaison, and hosts events to spur translational research and commercialization. This conference is sponsored in part by: · Baxter International, Inc. · Johnson & Johnson Corporate Office of Science & Technology · Northwestern University Office of Corporate Relations · NIH NCRR CTSA grant UL1RR025741 · Northwestern University Clinical and Translational Sciences (NUCATS) Institute 4

NUCATS news

Translational Investigator Pathway Initiative (TIPI) Connects Young Investigators with Funding Opportunities

Clinical and translational investigators take note: a new Translational Investigator Pathway Initiative (TIPI) is specifically aimed at connecting young investigators with funding opportunities. The program was just begun in May of 2009, and is led by Cynthia Csernansky, PhD, Senior Associate Director. TIPI was created as a partnership between the NUCATS Institute and the Feinberg Office for Development. The principal goal of TIPI is to match faculty with the best potential funding resources for their research, and to help prepare the most competitive application for the funding opportunities. TIPI services include identifying funding resources for pilot grants, research initiatives and career development awards, and connecting faculty with resources in the NUCATS Institute. TIPI also serves as a liaison by connecting faculty members with each other; faculty may be connected either to junior faculty who could become potential collaborators, or to senior faculty who would be interested in helping them with their work. Since its inception just nine months ago, TIPI has been very active in reaching out to young clinical and translational faculty. TIPI has helped several faculty members submit letters of intent and full proposals for foundation funding, offered assistance with career development awards, and helped with the proposal editing process. TIPI reaches out to investigators through both career development seminars and in individualized sessions with Dr. Csernansky. Recently, TIPI has created a partnership with Northwestern Memorial Foundation (NMF). NMF assists a diverse and committed group of independent foundations that provide outstanding resources to Feinberg faculty. Through this partnership, TIPI actively seeks proposals from young faculty and matches them with these grant opportunities administered through NMF. Assistance editing the proposal and presentation is available from Dr. Csernansky. What's the best tip for seeking foundation grants? Take advantage of the resources of TIPI, and speak to Dr. Csernansky or one of her colleagues in the Office of Development before approaching any foundation. Federal and nonfederal funding works very differently; therefore, it is important to have ample background on nonfederal funders before contacting them. The Office of Development will help researchers search the databases for the right foundation, since it is essential for there to be a good match between the researcher's and foundation's interests. Dr. Csernansky would be delighted to speak with any interested investigators; she can be reached at [email protected]

Innovation-to-Commercialization (I2C) Program

Northwestern's new Innovation-to-Commercialization (I2C) Program, begun in December 2009, seeks to assist medical researchers and provide experience for students. Through the I2C program, groups of graduate students provide consulting services to Northwestern faculty; services range from developing a business model to giving recommendations on the commercial potential of a proposed device. The I2C certificate program involves graduate students from all of Northwestern's graduate schools, and provides a great opportunity for them to learn about business strategy and the commercialization process. Teams of 3-5 students work closely with scientists on one project each quarter, and meet weekly with scientists to develop a recommendation. The teams are personalized for the specific project; they are composed of students with background on the industry. These teams are supervised by Kellogg professor Alicia Loffler along with other faculty, and I2C collaborates with other Northwestern departments, such as the Tech Transfer Office and Office of Research, on an extensive level. The I2C's interdisciplinary projects are presently focused on biomedical technologies, particularly for cancer drugs and treatments. Scientists may approach the I2C in need of information on patenting a technology or starting a company. Student teams will then analyze the current competition in the field, as well as market trends and growth potential. I2C teams also help scientists understand their intellectual property rights, how to avoid patent infringement, and estimate the potential commercial value of the technology. Ultimately, the I2C puts together

a recommendation for scientists on how to allocate their resources. One current project involves formalizing a business model for Dr. Thomas O'Halloran and Dr. Andrew Mazar, who started Valence Therapeutics in order to develop a cancer drug delivery technology. The I2C team is developing a recommendation on whether it would be more costeffective for Valence Therapeutics to partner with another company, form a platform company or enter clinical trials on their own. Right now, four groups are wrapping up their projects, and there are three more projects scheduled for spring quarter. Currently, I2C consists mostly of Kellogg MBA students. However, in the future, I2C hopes to involve more business, medical, engineering and law students with its interdisciplinary projects. They are also looking to expand their services and have a greater demand from the Northwestern faculty. Marta Melar-New, PhD, Project Manager of I2C, believes that the program is a "triple win situation" for Northwestern. Students receive experience in commercialization, Northwestern faculty are provided with consulting services free of charge, and the university can increase its reputation by increasing the number of start-up companies and licenses sold to other companies. The certificate is offered through the Innovation and New Ventures Office (INVO). Interested faculty and students should contact Marta Melar-New at [email protected] northwestern.edu.

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NUCATS news

Get Ready for Science of Team Science

Conference Panel Session Topics

· · · · · · A Perspective on Challenges Related to the Science of Team Science Collaborative Dynamics of Teams: Content and Connection Network Perspectives of Teams Praxis of Team Science Strategies for Facilitating Team Science Emerging Directions for the Science of Team Science and Science Policy

Contact Information Holly Falk-Krzesinski, PhD NUCATS Institute, Research Team Support (Conference Chair) Email: [email protected] Phone: 312-503-0889 http://scienceofteamscience.northwestern.edu/ Questions about registration and other conference details, please contact the Conference Coordinator, Latonia Trimuel, NUCATS Institute, Research Team Support at 312-503-2243 or [email protected] northwestern.edu.

Research Team Support (RTS) of the NUCATS Institute is pleased to announce the First Annual, International Science of Team Science Conference--Lambert Family Communication Conference, April 22-24, 2010 at the Wyndham Hotel in Chicago. The interdiscipline of the Science of Team Science promotes team-based research by empirically examining processes by which research teams organize, communicate, and conduct research. This includes understanding how teams connect and collaborate to achieve scientific breakthroughs that would not be attainable by either individual or simply additive efforts. The NUCATS Institute RTS is a champion of this emerging field of interdisciplinary study. For more information including registration, please visit: http://scienceofteamscience. northwestern.edu/. This is the first international forum dedicated to the emerging field of the Science of Team Science, intended to foster dialogue between team science investigators and practitioners/leaders of team science. It will bring together thought-leaders from a broad range of disciplines including translational research, communications, complex systems, technology, and management.It is also an opportunity to engage funding agency program staff to provide guidance on developing and managing team science initiatives. An empirical concept mapping project was employed in advance of the conference, based on open-sourced topics of interest and input for developing a roadmap to guide this emerging field of research. The results will be discussed at the conference, and published, in order to provide a framework for the field. On Saturday, April 24, a workshop to explore basic methods and impact of social network analysis for team science will also take place. Researchers representing a variety of disciplines from leading Institutions across the US are participating and attending the events. CONFERENCE SPONSORS · Research Team Support, Northwestern University Clinical and Translational Sciences (NUCATS Institute) · Bill and Sheila Lambert and the School of Communication, Northwestern University · NIH National Center for Research Resources CTSA grant UL1RR025741 · NIH, National Cancer Institute · Northwestern Institute on Complex Systems (NICO)

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NUCATS news

What you need to know about eNOTIS

A new subject enrollment tool for clinical research

eNOTIS, a new subject registration system for all IRB approved clinical research at Northwestern University is now available: http://enotis.northwestern.edu/. Developed by the NUCATS Institute's Northwestern University Biomedical Informatics Center (NUBIC), eNOTIS is designed to track participant accrual for research studies under IRB oversight, which includes any study run through NUCATS, NMH, NMFF and RIC. CMH has a separate IRB and currently the bulk of CMH clinical studies are not tracked in eIRB. eNOTIS allows researchers to see if subjects are participating in multiple studies, view accrual information and read general descriptions of studies on a current and historic basis. However, eNOTIS users only have read/write access to specific details on their own studies and subjects. eNOTIS will become the centralized repository for subject enrollment. This will provide a rich source of data for reporting and ease the management burden on researchers and administrators in tracking approach, consent, participation and completion on all IRB approved studies. The centralization of this information promotes better collaboration and compliance. This effort is in direct response to investigator requests for a coordinated, cross-institutional system and is part of the larger goal of re-engineering the clinical trial research process. The eNOTIS concept was highly-endorsed by the clinical research process taskforce. The first phase of eNOTIS is aimed at tracking research participant accrual and completion. eNOTIS offers import mechanisms to allow researches to work with other clinical trial systems, such as drug company studies, with a minimum of additional effort. However, non-anonymous tracking of participants in eNOTIS does require information such as race and ethnicity on participants to satisfy IRB periodic reviews, facilitate clinicaltrials.gov reporting and NIH requirements. The second phase of eNOTIS will include a centralized patient study calendar. Later phases will address adverse event reporting and financial billing processes. eNOTIS is supported by joint efforts across Northwestern's medical enterprise including the Office of Research, the Dean of Feinberg School of Medicine, the Dean of Research, Feinberg School of Medicine and the NUCATS Institute. If you have questions or would like more information, please contact [email protected] Over the coming weeks, more information, including training and documentation materials will be available.

8 Terabytes of Clinical Data is Now Available For Your Research with EDW

The Northwestern Medicine Enterprise Data Warehouse (NMEDW) is a Northwestern University Clinical and Translational Sciences Institute initiative funded jointly by the Northwestern Memorial Hospital, Northwestern Medical Faculty Foundation, and Northwestern University Feinberg School of Medicine. Its mission is to create a single, comprehensive, and integrated repository of all medical data sources on the campus to facilitate operational, clinical quality, and research reporting. It has data on over 2 million patients across 31 million encounters dating back to 1998. Since September of 2009, the thirteen-person EDW team has supported 246 research initiatives. EDW helps generate numbers to put in grant proposals, or more commonly provides data for projects that are funded and underway. Researchers can contact EDW with a "shopping list" of data and EDW performs the data extraction from medical records, which saves researchers time and resources. EDW is presently focused on four core service lines: oncology, cardiovascular disease, neuroscience and muscoskeletal. However, many projects have been supported beyond the basic four service lines. Current projects include liver transplant, kidney disease, asthma and thyroid disease research, among many others. There are also a handful of larger, data-intensive projects on campus that involve between one to six EDW team members. EDW is currently a complimentary service, although in the coming months there will likely be associated fees. Faculty should contact Andrew Winter, Acting Director of EDW, to make sure they incorporate budgeting for EDW into their grants. This valuable in-house service is available by consultation. Interested faculty should visit the EDW website at http://edw.northwestern.edu. The website provides a link to request data and asks for general information from the researcher; a member of the EDW team will then be in contact. Inquiries can also be directed to Andrew Winter at [email protected]

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European Bioinformatics Institute Roadshow

April 26-27, 2010

Chicago's EBI Roadshow, sponsored by the NUCATS Institute, NUBIC and the Robert H. Lurie Comprehensive Cancer Center Biostatistics Core, will be an introductory-level course directed at researchers with biological background but little or no previous knowledge of the resources to be presented. Faculty, postdoctoral fellows and graduate students are all encouraged to attend. Register at

http://ebi-roadshow.nubic.northwestern.edu/

NUCATS news

Engineering into Medicine Program

The Northwestern University Clinical and Translational Sciences (NUCATS) Institute is now offering two programs to promote interdisciplinary research between the McCormick School of Engineering and the Feinberg School of Medicine. The overarching goal is to accelerate novel discoveries and their availability for patient care by enhancing interdisciplinary collaborative innovation in engineering and medicine. Proposal submissions for the Post-Doctoral Fellowship Program and the Faculty Mini-Sabbatical Program will be accepted through April 15, 2010 at 11:59pm (CST). For additional information regarding the programs, proposal requirements and links to the required applications, please visit: http://www.nucats.northwestern.edu/centers/ cti/medicalengineering. Postdoctoral Fellowship Dr. Hyung-Do Kim is currently in the first year of his postdoctoral career in the Department of Biomedical Engineering at Northwestern University. He received a Doctorate in Biological Engineering from Massachusetts Institute of Technology. His list of publications includes articles from the following professional journals: Biophysical Journal, Molecular Systems Biology, Molecular Pharmacology, Molecular Biology of the Cell and Developmental Cell. For his NUCATS postdoctoral fellowship, Dr. Kim will be mentored by Professor Phillip B. Messersmith of the McCormick School of Engineering and Professor Vincent L. Cryns from the Feinberg School of Medicine. His project will focus on developing biomimetic hydrogels for the local delivery of a proteasome inhibitors to solid tumors. Mini-Sabbatical Program Dr. Gordon Hazen is currently Director of Graduate Studies and Professor in the Department of Industrial En-

gineering and Management Sciences at Northwestern University. He received a Master of Science in Statistics and a Doctorate in Industrial Engineering, both from Purdue University. His list of publications includes articles from the following professional journals: Medical Decision Making, Decision Analysis, Operations Research and Health Care: A Handbook of Methods and Applications, The Engineering Economist, Journal of Medical Systems, Journal of Risk and Uncertainty, and more. For his mini-sabbatical during the spring 2010 quarter, Dr. Hazen will collaborate with Professors Michael Abecassis and Daniela P. Ladner in the Feinberg School of Medicine. His project will focus on collaborative research into the impacts of transplant policy. To learn more about Dr. Hazen, please visit the following webpage: http://www.iems.northwestern.edu/people/ faculty/hazen.html. Dr. Sanjay Mehrotra is currently a Professor in the Department of Industrial Engineering and Management Sciences at Northwestern University. He received a Master of Science in Industrial Engineering and a Doctorate in Operations Research, both from Columbia University. His list of publications includes articles from the following professional journals: SIAM Journal on Optimization, Mathematical Programming, Optimization Methods and Software, Computational Optimization and Applications, Bioinformatics, and BMC BioInformatics. For his mini-sabbatical during the fall 2010 quarter, Dr. Mehrotra will collaborate with Professors Michael Abecassis, Daniela P. Ladner, David M. Liebovitz and Mark V. Williams in the Feinberg School of Medicine. His project will study the problem of managing hospital resources more efficiently and equitable organ allocation decisions. To learn more about Dr. Mehrotra, please visit the following webpage: http://www.iems.northwestern.edu/people/faculty/mehrotra.html.

NUCATS IT NEWSBYTES

· Remember to lock your computer when you step away; leaving an unlocked computer open exposes you to risk as well as the network resources we all use. · Have you used AdobeConnect? It's a great tool that you can use to enhance your presentations with offsite colleagues! Finally- Thank You! Thank you for so rapidly adopting the new ticketing system, please continue to use it regardless of the nature of your IT Support needs. If you are not sure how to request support, click on the link on your desktop entitled NUCATS_Tech_Support and login with your netid and password. If you are having any issues with it, please email me. Remember to use University Supported Web Browsers when requesting support.

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· Have you checked out the NUIT Podcasts and Tech Talks? You should, here are the links: · PODCASTS: http://www.it.northwestern.edu/security/podcast. html · TECHTALK: http://www.it.northwestern.edu/learning/techtalks/index.html

NUCATS news

CERC Seminar Series

4th Wednesdays of the Month 12-1pm Rubloff 180

March 24

Speakers:

Practice-Based Researcher is Awarded NUCATS KL2 Award

Humboldt Park: A Community United to Challenge Asthma Juana Ballesteros, Maureen Damitz, and Dr. Molly Martin

April 28

Playground Safety in Chicago: Do Disparities Exist? Speakers: Dr. Erin Allen Dr. Karen Sheehan

May 26

TBA Speakers: Elizabeth Hahn

ARCC Workshops

March 25

Journal Club: Learning from Research Literature Workshop for Community Partners Time: 9-11 am

April 28

Time:

University 101: Workshop for Community Partners 9-11 am

May 6

Lessons Learned from Longstanding Community-Based Participatory Research Partners Speakers: Carol Horowitz, MD, MPH

May 20

Successful Promotion/Tenure Strategies for Community-Engaged Faculty Speakers: Dr. Lynn Blanchard

For More Information, Please Visit: http://www.nucats.northwestern. edu/centers/cerc/seminars_and_ events.html

Kelly W. Lowry, PhD, Assistant Professor in the Department of Psychiatry and Behavioral Sciences, FSM and a psychologist in the Department of Child and Adolescent Psychiatry at Children's Memorial Hospital, has received a NUCATS KL2 Award to further her research training and to continue her research on community-based behavior change in children and families, particularly addressing the problem of pediatric obesity. Her funded research study will focus on the mediating effect of child traits and behavior on the association between parenting behaviors and child weight. Dr. Lowry currently has a Practice-Based Research Program Seed Grant to gather exploratory data on parenting style and feeding practices in partnership with Dr. David Dobkin of North Arlington Pediatrics. Dr. Lowry also is working with the Pediatric Practice Research Group at Children's Memorial Hospital to develop a program to train pediatricians to use motivational interviewing to effect behavioral changes in their patients and their families. Dr. Lowry explains the importance of her relationship with the PPRG, "I have been very fortunate to work with the PPRG. The support, mentorship, and funding opportunities have been essential to me as a new faculty member working to establish a research career. My experiences with leadership staff and clinicians in the practices have been excellent and I am excited for the possibility of additional collaborative activities in the future." Dr. Lowry has a long-standing interest in multi-disciplinary and community-engaged research, specifically related to obesity. Her dissertation examined the impact of a community participatory family-based weight management program on the self-esteem of 8-14 year olds. She also is evaluating Chicago Run, a program to support running programs in underserved Chicago elementary schools with funding from the Consortium to Lower Obesity in Chicagoland Children (CLOCC). In addition, she is studying the impact of providing cameras to patients to document their lives so that clinicians can understand the barriers to behavioral change and cultural experiences their patients face. John Lavigne, PhD, ABPP, Professor of Psychiatry and Pediatrics at NU's Feinberg School of Medicine and PI of multiple practice-based studies of child mental health will be her primary mentor. Helen Binns, MD, MPH, co-director of the Practice-Based Research Program and Katherine Kaufer Christoffel, MD, MPH, Director of the Community-Engaged Research Center will serve as co-mentors to provide assistance on medical aspects of feeding and obesity. Linda Van Horn, PhD, Professor of Preventive Medicine, and Associate Dean for Faculty Development at FSM and Lynette Craft, PhD, Assistant Professor of Preventive Medicine at FSM will serve as an advisory committee to provide scientific and career development advice. The Multidisciplinary Clinical and Translational Scientists Scholars Program is designed to support the early research career development of junior faculty who will be engaged in clinical and translational research. It provides support for up to 75% of a junior faculty member's time to pursue further research training and develop their research agenda. Dr. Lowry will use the training program to develop the scientific and research skills necessary to become an independent investigator in community-based patient-oriented research.

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NUCATS news

Is it Significant?

Ask TRIP for help with your next research project

Kenzie Cameron, PhD, MPH, a Research Assistant Professor in the Division of General Internal Medicine, was in the process of developing a grant to explore the use of "Facts & Myths" in health messages related to influenza vaccinations. The use of a "Facts & Myths" organizational pattern in persuasive health messages is common, but recent research questioned this approach, suggesting that the best option is to use "Facts only" messages. However, basic communication research suggests that a well-crafted "Facts & Myths" message that includes a refutation of the myths may be the most persuasive option. The purpose of Cameron's study was to examine the effect of four variations of messages about influenza vaccination (Facts only, Facts & Myths, Facts, Myths & Refutations, and an existing control message) to assess the effects of message content on individuals' knowledge and attitudes about influenza and influenza vaccination, and their ultimate vaccination behavior. However, with four separate messages and multiple planned comparisons, statistical analyses can get complicated quickly. By engaging with Borko Jovanovic, PhD, part of the NUCATS Translational Research Incubator Program (TRIP) which supports the development of new interdisciplinary research teams and enhances the productivity of existing research teams, Cameron was able to troubleshoot statistical analysis challenges in the grant proposal ahead of NIH review. A key component of the NIH review is to examine the statistical data behind the problem the grant examines. In Cameron's case, she needed expertise in various analytic techniques. By working with Jovanovic, Cameron could drill down on specific issues related to research design, wording and power analysis. Jovanovic was able to troubleshoot and anticipate the statistical questions a reviewer might pose and advise Cameron on her proposal. "Without the expertise available in TRIP, this process would have been very challenging and taken much longer. As a researcher you often need that additional layer of insight so the reviewer views the grant as well-written and designed. TRIP is a great example of the partnership and collaboration resources available through NUCATS," said Cameron. TRIP brings together scholars from the fields of experimental design and biostatistics, epidemiology, outcomes measurement, behavioral science, communication science, economics, decision science, community-based participatory research, research ethics, and team science to be available for consultation and collaboration. The group also holds ongoing sessions to help refine the research questions of the team and assess resource needs. TRIP assists in the development, design, and analysis of ongoing studies, new proposals, papers, and presentations of investigative teams associated with the NUCATS Institute.

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Congratulations to Helen Binns for Being Awarded the Health and Medicine Policy Research Group's Annual Award

Helen Binns, MD, MPH, codirector of the Practice-Based Re s e a rc h Program, was awarded the Health and Medicine Policy Re s e a rc h Group's annual award for research at their October 1, 2009 meeting. Misty Drake, Director of Health Support Services at Lawndale Christian Health Center, nominated Dr. Binns for her research on lead poisoning in Chicago. Dr. Binns' research on lead poisoning has ranged from studies establishing screening instruments to identify children at risk of lead poisoning to studying the impact of lead-safe home remediation and soil leadabatement in Chicago communities. Dr. Binns recognized the contribution of the community health centers in addressing the issue of lead poisoning in Chicago, stating "The great thing about it is meeting people in the community and establishing partnerships and leaving behind a legacy of people who are qualified to take the ball and run with it."

CRU Orientation Schedule for Spring 2010

Thursday, April 23 1-2:30pm Feinberg 3B Part 1: Seeing Subjects on CRU

NUCATS news

Thanks to Everyone for Making Red Day a Success

Maria Sanchez was the big winner on Red Day. We're all winners if we take care of our heart.

Welcome NUCATS New Hires!

Yves Southall Research Billing Analyst in CCR-CRU Stephen Sullivan Educational Tech Coordinator in CECD Rebecca Corona Temp Project Coordinator in CCR-CRU LaRon Hughes Postdoc Fellow in NUBIC Cara Clifford Temp Program Assistant in Admin/TIPI Christopher Mitchell Temp Project Coordinator in CCR-CRU Elizabeth Shaviers Coordinator of Clinical Research in CCR-RSP-Ext Coord Svcs Samuel Granieri Systems Analyst/Programmer in NUBIC

Kirthika Padmanabhan and Robyn Mann love a plaid red. Who can blame them.

Welcome Baby Basu, November 3, 2009! Congratulations to Siddhartha and Family!

Follow Clinical and Translational Research on Twitter

Want an easy way to keep up on Clinical and Translational research #ctresearch? Follow the conversation on Twitter. Many CTSAs are posting news, events and updates including NUCATS @NUCTSInstitute.

Q1 Birthdays

Yulia Bushmanova and Laura Wimbiscus Yoon keeping it real with red and a heart healthy lifestyle. Audra Soulias 1/16 Jim Bray 1/25 Julie Johnson 1/31 Warren Kibbe 2/11 Latonia Trimuel 2/13 Holly Falk-Krzesinski 2/14 Brian Chamberlain 2/19 Stephen Sullivan 3/1 Tyler Smith 3/4

Thanks to Kelly Carroll for organizing the Red Day event. For more information on how to take care of your heart, please visit www.americanheart.org

Sheila Kessler Rhett Sutphin Ashlee Evans Christopher Mitchell Josefina Serrato Mary Beth Gaskill Hilary Mandell

3/6 3/9 3/13 3/18 3/19 3/22 3/22

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NUCATS news

New Manager for the Clinical Research Unit

Karan Fachet is the new Manager for the Clinical Research Unit (CRU). Karan, a registered nurse, worked in critical care for seventeen years before changing her direction into research. Her previous experience includes an appointment as the Nurse Manager of the General Clinical Research Center at UIC, in which she helped develop the NIH funded clinical research center. Most recently, she worked at the Clinical Trials Unit in Bluhm Cardiovascular Institute at Northwestern. Karan was the Project Manager for two industry sponsored trials and served as the liaison between the research team and the industry sponsors. The two trials were WBC (Who Benefits from Cardiac Resynchronization Therapy), and the DETERMINE trial (Defibrillators to Reduce Risk by Magnetic Resonance Imaging Evaluation). Karan finds it very rewarding to work in clinical trials because she enjoys the complexities of facilitating research and clinical trials. It is especially fulfilling when the results of research studies she's worked with lead to new medical knowledge, therapies, or technology. Karan's role is to use the services and staff of the CRU to

facilitate research data collection for both NIH and industry sponsored research studies. The CRU is located on 10NE in the Feinberg Pavilion and supports many projects from diverse disciplines within the Northwestern research community. It provides support for over 120 active protocols from more than fourteen Feinberg School of Medicine departments or divisions. The CRU provides a centralized unit with dedicated research staff trained to assist with the research process. The unit can accommodate both inpatient studies and outpatient studies. Nurses are available to perform complex research procedures like timed blood draws, drug and chemotherapy administration and surveys. There is a bionutritionist on staff to assist with the special dietary needs of the research patient. The CRU also has a CAP/CLIA accredited Core Laboratory staffed with laboratory technicians who are available to assist researchers with their specimen processing needs. Current research studies at the CRU include traumatic brain injury, polycystic ovary syndrome, islet cell transplant and post-kidney transplant, pulmonary disorders.

NUCATS' "High-fives" Recognize Great Work Across the Institute

A new feature, each issue of NUCATSnews will publish "high-five" notes of recognition showcasing people who have done exemplary work in support of the Institute. Anyone can submit "high-fives" to Elizabeth Kollross at [email protected]

Warren Kibbe

I'd like to recognize Warren Kibbe for his work rolling out the new web based submissions process for our pilot grants. I was really pleased with it and think a lot of the users were too. We are working to have it optimized and open for other NU groups to use who have expressed an interest and also plan to pass the code onto other CTSA consortium members. Current commercial products cost $10k/yr or more and having everything done through the web relieves a big administrative burden. Warren, for making my life easier I give you a BIG high five. -Jim Bray

Ashlee Evans

A big CECD high five to Ashlee Evans in the Center for Education and Career Development on her outstanding efforts to market the CRC Basic Training Course. Ashlee's marketing research planning and implementation resulted in a 30% increase in attendees at CRC Basic Training in the month of January alone and translate to an additional $30,000 for the Center over the course of 2010. Congratulations Ashlee! Your hard work has paid off with huge results and we are so proud to have you as a CECD Team member. -Mary Ratliff

Congratulations to NUCATS NU Service Award Winners

Thank you for your exceptional work!

Brandon DeLallo Jill Bockes Francisca Crespo Colleen De Luca Sheila Kessler Latonia Trimuel

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