Read AFIP 07-08 text version


AFIP 2007-2008

Conference 15, Slide 3 Tissue from a dog.

· 6 yo female lab cross. · History of atopy, managed with cyclosporine, prednisone, shampoo baths, and immunotherapy.

What is the tissue? What is abnormal?

Haired skin. Too cellular in dermis (too blue).

Acanthosis ­ thickening of stratum spinosum. Orthokeratosis ­ thickening of the corneum layer without retention of nuclei.

Inflammatory cells: neutrophils, macrophages, and plasma cells predominate.


What are these??

Protozoal pseudo cysts! Differentials include: 1) Sarcocystis 2) Toxoplasma 3) Neospora 4) Trypanosoma Immunohistochemistry was positive for Neospora, Neospora titer was high, and PCR on tissue samples was positive for Neospora.

Contributor morphological diagnosis: 1. Moderate to severe, chronic, follicular and epidermal hyperplasia and hyperkeratosis with intra-keratinocyte protozoal pseudocysts DDx: Neospora, 2. Moderate to marked, diffuse, interstitial pyogranulomatous dermatitis with intrahistiocytic, intraendothelial and free protozoal zoites: DDx: Neospora

Cutaneous Neosporosis is an unusual presentation, which might have occurred in this patient secondary to the immunosuppressive therapy used to control her atopy. Neospora is more commonly associated with neurological signs in dogs and abortion in cattle.

Neospora life cycle

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AFIP 07-08

11 pages

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