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PHARMACOGNOSY I

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Department offering the course: Academic year / Level: Date of specification approval: Interdisciplinary Pharmacognosy 1st professional year-1st term / 200 13/9/2009

A- Basic Information

Title: Code: Credit Hours: Lecture: Tutorial: Practical: Total: Pharmacognosy 241/8 3/week 2/week --------3/week 5/week

B- Professional Information

1 ­ Overall aims of course Upon successful completion of this course, the students should be able to illustrate the morphological and histological structures of different organs of medicinal plants such as seeds, fruits, roots and rhizomes. The students should be also able to discuss role of these medicinal plants in the treatment of different disease conditions is also studied. The student in this end of this course will be able to identify many medicinal plants microscopically in both their entire and powdered forms. 2 ­ Intended learning outcomes of course (ILOs) a- Knowledge and understanding: The student should be able to 1. Describe the histological structure of the different medicinal plant parts, seeds, fruits, roots and rhizomes.

2.

3. 4.

Give an account on the biologically active principles in each plant part (seeds, fruits, roots and rhizomes) as well as their biological activity. Define Complementary therapies, including herbal therapies. Explain the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books.

a- Intellectual skills The student should be capable of: 1. Determine unknown drugs seeds, fruits, roots and rhizomes.. (morphologically and microscopically) 2. Judge whatever the powdered drug is related to seeds, fruits, roots and rhizomes. b- Professional and practical skills The student should be capable of: 1. Use the microscope to decide a given unknown plant powder is related to seeds, fruits, roots and rhizomes. 2. Design and perform experiments for detection of adulteration 3. Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities. c- General and transferable skills The student should be able to: 1. Work effectively in team. 2. Demonstrate written and oral communication skills. 3. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. 4. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates. 3- Contents Topic

-Introduction to seeds. -Strophanthus seed. -Nux vomica seed. -Stramonium seed. -Colchicum seed. -Cardamom seed. -Nutmeg seed. -Black mustard seed. 6 2 4 6

No. of hours

6

Lecture

4

Tutorial/Practical

6

-White mustard seed. -Almond seed. -Linseed. -Fenugreek. -Plantago seed. -Castor seed. -Introduction to fruits -Umbelliferous fruits -Fennel. -Anise -Coriander -Ammi visnaga. -Ammi majus -Caraway. -Dill. -Cumin. -Celery. -Hemlock. Black pepper. -Colocynth. -Senna pod. -Juniper. -Star anise. Lemon peel. -Bitter orange peel. -Hops. -Vanilla. -Ccapsicum. -Poppy Introduction to subterranean organs (roots & rhizomes) Rhizomes: -Filix mass. -Veratrum. -Valerian. -Rhubarb. -Podophyllum. -Hydrastis. -Ginger. -Galengal. -Turmeric. -Orris. -Calmus -Colchicum. Root: -Liquorice. -Ipecacuanha -Dandelion. -Krameria. -Derris. -Rauwolfia. -Alkanna. -Senega. -Calumba. -Althea. -Marshmallow. -Gentian. -Belladonna. -Jalap. -Scammony. -Aconite. -Sasaparilla. 7 5 6

7

5

6

5 4

4 3

3 3

5

3

6

3

4­ Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs.,boards, instruments, chemicals, glasswares, equipments). 4.3- Assignments, seminars, researches and posters. 5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. 5.4- Oral exam to assess knowledge and understanding and intellectual skills.

Assessment schedule Assessment 1 Assessment 2 Assessment 3 Assessment 4 Periodic exam (Surprise Quizzes) Practical exam Written exam Oral exam Week -Week 13 Week 15 Week 15

Weighting of assessments Periodic Examination Final-Term Written Examination Practical Examination Oral Examination. Total 6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors 6.2- Essential & Recommended books Trease, G.E.& Evans, W.C.; "Pharmacognosy", W.B. Saunders Publishers, Ltd, 15th ed., 2002. 6.4- Periodicals, Web sites, ... etc http://www.pubmed.com http://www.botanical .com http://www.herbmed.com 10% 50% 20 % 20% 100%

7- Facilities required for teaching and learning

4

Study halls, Laboratories, equipment, chemicals, glasswares, books, audiovisual tools. Course coordinator: Nahla Ayoub, Ph.D., Associate Professor of Pharmacognosy Head of Department: Nahla Ayoub, Ph.D., Associate Professor of Pharmcognosy

Date: 2009/2010

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PHARMACOGNOSY II

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Department offering the course: Academic year / Level: Date of specification approval: Interdisciplinary Pharmacognosy 1st professional year-2nd term / 200 13/9/2009

A- Basic Information

Title: Code: Credit Hours: Lecture: Tutorial: Practical: Total: Pharmacognosy 232/8 3/week 2/week --------3/week 5/week

B- Professional Information

1 ­ Overall aims of course Upon successful completion of this course, the students should be able to illustrate the morphological and histological structures of different organs of medicinal plants such as herbs and unorganized drugs. The students should be also able to discuss role of these medicinal plants in the treatment of different disease conditions is also studied. The student in this end of this course will be able to identify many medicinal plants microscopically in both their entire and powdered forms. They should be also able to demonstrate knowledge of basic concepts of optimum nutrition. 2 ­ Intended learning outcomes of course (ILOs) b- Knowledge and understanding: The student should be able to 1. Describe the histological structure of the different medicinal plant parts viz. herbs and unorganized drugs.

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2. Give an account on the biologically active principles in each plant part viz. (herbs and unorganized drugs) as well as their biological activity. 3. Design a regime for optimum nutrition (minerals and vitamins). 4. Define Complementary therapies, including herbal therapies. 5. Explain the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books. c- Intellectual skills The student should be capable of: 1. Determine unknown drugs viz. herbs and unorganized drugs. (morphologically, microscopically and chemically) 2. Judge whatever the powdered drug is related to herbs and identify unorganized drugs through chemical tests. d- Professional and practical skills The student should be capable of: Use the microscope to decide a given unknown plant powder is related to herbs and unorganized drugs. Design and perform experiments for detection of adulteration. Perform some experiments to know the nature of unorganized. Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities. e- General and transferable skills The student should be able to: 1. Work effectively in team. 2. Demonstrate written and oral communication skills. 3. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. 4. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates. 3- Contents Topic

Introduction to herbs Hyoscyamus Lobelia Vinca Mentha Thyme Ergot Cannabis Diatoms Focus &laminaria Carrageen Saccharomyces. Penicillium

1. 2. 3. 4.

No. of hours

5

Lecture

3

Tutorial/Practical

6

9

6

9

7

Mushroom. Cetraria Ephedra Sabina Broom tops Introduction to unorganized drugs Opium Agar Gelatin Gambier Cutch Aloes Ehinacea Kinos Colophony Rectified oil of turpentine. Guaiacum resin Jhan resin Cannabis resin Mastic Copaiba Canada turpentine Myrrh Asafetida Galbanum Ammoniacum Olibanum Benzoin Balsam Peru Balsam Tolu Storax Gum acacia Gum tragacanth Karaya gum Manna Guar gum Simbhal Tamal Evening primrose Theobroma oil Castor oil Linseed oil Olive oil Almond oil Bees wax Carnuba wax

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4

6

8

6

6

9

6

9

8

Purified honey Royal jelly Bee propolis Bee pollen Bee venom Unorganized drugs in the Egyptian market. Vitamins and minerals 3 3 -

4­ Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glassware, equipments). 4.3- Assignments, seminars, researches and posters.

5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. 5.4- Oral exam to assess knowledge and understanding and intellectual skills. Assessment schedule Assessment 1 Assessment 2 Assessment 3 Assessment 4 Periodic exam (Surprise Quizzes) Practical exam Written exam Oral exam Week -Week 13 Week 15 Week 15

Weighting of assessments Periodic Examination Final-Term Written Examination Practical Examination Oral Examination. Total 6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors 10% 50% 20 % 20% 100%

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6.2- Essential & Recommended books Trease, G.E.and Evans, W.C.; "Pharmacognosy", W.B. Saunders Publishers, Ltd, 15th ed., 2002. 6.4- Periodicals, Web sites, ... etc http://www.pubmed.com http://www.botanical .com http://www.herbmed.com

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7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glassware, books, audiovisual tools. Course coordinator: Abdel Nasser Singab, Ph.D., Professor of Pharmacognosy Head of Department: Nahla Ayoub, Ph.D., Associate Professor of Pharmacognosy.

Date: 2009/2010

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PHARMACOGNOSY II University: Ain Shams University Faculty: Faculty of Pharmacy Department: Pharmacognosy

___________________________________________________

A- Basic Information

1. Title and code: Pharmacognosy II, (232/8) 2. Programme(s) on which this course is given: Bachelor Degree in Pharmaceutical Sciences 3. Year/ Level of programmes: 1st professional year ­ 2nd term / 200 4. Units/Credit hours: Lectures: 2 (2) Practical: 3 (1) Total: 5 (2+1)

5. Names of lecturers contributing to the delivery of the course - Abdel Nasser Singab, Ph.D., Professor of Pharmacognosy - Nahla Ayoub, Ph.D., Associate Professor of Pharmacognosy - Sherweit Hamed Elahmady, Ph.D, Lecturer of Pharmacognosy - Rola Milad, Ph.D, Lecturer of Pharmacognosy Course co-ordinator: Abdel Nasser Singab, Ph.D., Professor of Pharmacognosy External evaluator

B- Statistical Information

No. of students attending the course: No. of students completing the course: Results: Passed: No. 536 97% Failed: No. 7 3% No. No.

Grading of successful students: Excellent: No. 219 Good : No. 91 39.6% 16.5% Very Good: No. Pass: No. 24 202 4.3% 36.5%

C- Professional Information

1 ­ Course teaching Topic

Introduction to

No. of hours

3 12

Lecturer

Dr. Nahla Ayoub

herbs Hyoscyamus Lobelia Mentha Ergot Cannabis Thyme Diatoms Focus &laminaria Carrageen Saccharomyces. Penicillium Mushroom. Cetraria Ephedra Sabina Broom tops Introduction to unorganized drugs Opium Agar Gelatin Gambier Cutch Aloes Ehinacea Kinos Colophony Rectified oil of turpentine. Guaiacum resin Jhan resin Cannabis resin Mastic Copaiba Canada turpentine Myrrh Asafetida Galbanum Ammoniacum Olibanum Benzoin Balsam Peru Balsam Tolu Storax Gum acacia Gum tragacanth Karaya gum Manna Guar gum Simbhal

6

Dr. Rola Milad

4

Dr. Abdel Nasser Singab

6

Dr. Sherweit Elahmady

6

Dr. Sherweit Elahmady

13

Tamal Evening primrose Theobroma oil Castor oil Linseed oil Olive oil Almond oil Bees wax Carnuba wax Purified honey Royal jelly Bee propolis Bee pollen Bee venom Unorganized drugs in the Egyptian market. Vitamins and minerals 3 Dr. Sherweit Elahmady

Topics taught as a percentage of the content specified: >90 % 70-90 % <70%

Reasons in detail for not teaching any topic All the topics have been covered If any topics were taught which are not specified, give reasons in detail No new topics have been taught 2- Teaching and learning methods: Lectures: Practical training/ laboratory: Other assignments/homework: Presentation of different projects whether presentation or herbarium or dictionary of medicinal plants, related to the topics taught by the students who had these projects in groups composed each of 5 students.

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3- Student assessment: Method of assessment Written examination Oral examination Practical/laboratory work Periodic Examination Total Members of examination committee -Mohamed Mohamed Elazizy, Ph.D., Professor of Pharmacognosy - Abdel Nasser Singab, Ph.D., Professor of Pharmacognosy -Nahla Ayoub, Ph.D., Associate Professor of Pharmacognosy - Sherweit Hamed Elahmady, Ph.D, Lecturer of Pharmacognosy - Rola Milad, Ph.D, Lecturer of Pharmacognosy Rules applied for the selection of the committee Some members of the committee are the course instructors and some helped and participated in grading the final written exam. Role of external evaluator The external evaluator has been involved in evaluating whether: 1. The exam questions are comprehensive and match the topics taught. 2. Distribution of grades reflect the number of hours spent in teaching each topic. 3. Good quality of learning opportunities are available for teaching the course. 4. Knowledge, understanding, cognitive skills and practical skills are assessed through different exams. 5. The grading process is proper and effective in measuring the ILO's. 4- Facilities and teaching materials: Totally adequate Adequate to some extent Inadequate List any inadequacies Shortage of chemicals and microscopes for lab work

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Percentage of total 50% 20% 20% 10% 100 %

5- Administrative constraints 6- Student evaluation of the course: 7- Comments from external evaluator(s): Response of course team

Deficiency of some lab instruments Microscopes we are trying to provide the required instruments

8- Course enhancement: Progress on actions identified in the previous year's action plan: Action

Continuous updating of the course -High student denisty -The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning.

State whether or not completed and give reasons for any non-completion

Completed Completed, the students are divided into two groups. Completed

9- Action plan for academic year 2010­ 2011 Actions required

-Increase number of Microscopes

Completion date

2010/2011

Person responsible

Assoc. Prof. Nahla Ayoub

Course coordinator: Abdel Nasser Singab, Ph.D., Professor of Pharmacognosy Head of Department: Nahla Ayoub, Ph.D., Associate Professor of Pharmacognosy Signature: Date: 2009/2010

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BOTANY

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Department offering the course: Academic year / Level: Date of specification approval: Interdisciplinary Pharmacognosy Pre-pharmacy year -1st term / 100 13/9/2009

A- Basic Information

Title: Code: Credit Hours: Lecture: Tutorial: Practical: Total: Botany 141/M 3/week 2/week --------3/week 5/week

B- Professional Information

1 ­ Overall aims of course Upon successful completion of this course, the students will be able to demonstrate knowledge of basic concept in the principle of pharmacognosy and to apply this knowledge efficiently in macro- and microscopical examinations of different plants organs. They should also be able to correctly compile the course specification (Plant Taxonomy) through engagement in cooperative self-directed exercise. The students should be able to illustrate the proper collection, storage methods of medicinal plants and apply this knowledge in marketing of medicinal plants. They should be also able to demonstrate knowledge of the active constituents of the lower and higher medicinal plants (secondary metabolites) as well as their medicinal uses also the methods of propagation via seeds, factors affecting plant growth, selection and breeding of medicinal plants and preparation of drugs from plants to pharmaceutical products.

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2 ­ Intended learning outcomes of course (ILOs) a- Knowledge and understanding: The student should be able to 1. List and differentiate between plant parts; roots, stems, leaves,...etc as well as Algae and Fungi 2. Name the main elements of the studied organs (macroscopically) 3. Describe the plant taxonomy 4. List methods of collection, storage and marketing of medicinal plants 5. Enumerate the factors affecting plant growth, selection and breeding of medicinal plants and preparation of drugs from plants to pharmaceutical products b- Intellectual skills The student should be able to 1. Evaluate the histological character of each organ (microscopically). 2. Criticize different methods for the detection of adulteration of medicinal plants. 3. Evaluate the purity of medicinal drug and detection of adulteration c- Professional and practical skills The student should be able to 1. Handle of the microscope. 2. Manipulate the microscopical specimens. 3. Classify any plant taxonomically. 4. Distinguish the different method for detection of adulteration. 5. Use appropriate lab equipment and tools to evaluate the different Pharmacopoeial constants. 6. Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities. d- General and transferable skills The student should be able to: 1. Work effectively in team. 2. Demonstrate written communication skills. 3. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. 4. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates. 3- Contents Topic

-General Pharmacognosy -Cultivation of medicinal Plants.

No. of hours Lecture Tutorial/Practical

7 18 4 9

-Selection & breeding of medicinal plants. -Factors affecting plant Growth -Preparation of drugs from plants to pharmaceuticals. - Adulteration. - Secondary plant metabolites. -Dusting powder. -Hairs & Fabrics. -Plant taxonomy

7

4

9

11

8

9

15

12

9

4­ Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glassware, equipments). 4.3- Research paper. 5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. Assessment schedule Assessment 1 Assessment 2 Assessment 3 Periodic exam (Surprise Quizzes) Practical exam Written exam Week -Week 13 Week 15

Weighting of assessments Periodic Examination Final-Term Written Examination Practical Examination Oral Examination. Total 6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors. 6.2- Essential & Recommended books Trease, G.E.& Evans, W.C.; "Pharmacognosy", W.B. Saunders Publishers, Ltd, 15th ed., 2002. 10% 70% 20 % ----100%

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6.4- Periodicals, Web sites, ... etc http://www.botanical.com http://www.herbmed.com 7- Facilities required for teaching and learning Study halls, laboratories, equipment, chemicals, glassware, books and audiovisual tools. Course coordinator: Mohammed El-Azizy, Ph.D.; Professor of Pharmacognosy Head of Department: Nahla Ayoub, Ph.D.; Associate Professor of Pharmacognosy

Date: 2009/2010

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MEDICAL BOTANY

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Department offering the course: Academic year / Level: Date of specification approval: Interdisciplinary Pharmacognosy Pre-pharmacy year-2nd term / 100 13/9/2009

A- Basic Information

Title: Code: Credit Hours: Lecture: Tutorial: Practical: Total: Medical Botany 142/M 3/week 2/week --------3/week 5/week

B- Professional Information

1 ­ Overall aims of course Upon successful completion of this course, the students should be able to illustrate the morphological and histological structures of different organs of medicinal plants such as leaves, barks, woods, flowers. The students should be also able to discuss role of these medicinal plants in the treatment of different disease conditions. The student in this end of this course will be able to identify many medicinal plants microscopically in both their entire and powdered forms. 2 ­ Intended learning outcomes of course (ILOs) e- Knowledge and understanding: The student should be able to 1. Describe the histological structure of the different medicinal plant parts, leaves, barks, woods, flowers. 2. Give an account on the biologically active principles in each plant part (leaves, barks, woods, flowers) as well as their biological activity. 3. Define Complementary therapies, including herbal therapies.

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4. Explain the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books.

f- Intellectual skills The student should be capable of: 1. Determine unknown drugs, leaves, barks, barks, flowers. (morphologically and microscopically) 2. Judge whatever the powdered drug is related to leaves, barks, woods, flowers. g- Professional and practical skills The student should be capable of: 1. Use the microscope to decide a given unknown plant powder is related to leaves, barks, woods, flowers. 2. Design and perform experiments for detection of adulteration 3. Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities. h- General and transferable skills 1. 2. 3. 4. The student should be able to: Work effectively in team. Demonstrate written communication skills. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

3- Contents Topic

-Introduction to Leaves. -Senna leaf. -Digitalis leaf. -Squill leaf. -Buchu leaf. -Uva ursi leaf. -Belladonna leaf. -Stramonium leaf. -Egyptian henbane. -European henbane. -Coca leaf. -Boldo leaf. -Jaborandi leaf. -Eucalyptus leaf. -Cherry laurel leaf. -Hamammelis leaf. -Henna leaf. -Tea leaf.

No. of hours

6

Lecture

4

Tutorial/Practical

6

5

4

3

6

4

6

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-Introduction to barks -Cascara bark. -Frangula bark. -Cinchona bark. -Cinnamon bark. -Cassia bark. -Canella bark. -Quillaia bark. -Galls. -Introduction to wood. -Quassia wood. -Guaiacum wood. -Introduction to flower. -Roman chamomile. -German chamomile. -Pyrethrum -Santonica. -Saffron. -Safflower. -Calendula. -Clove. -Lavander.

4

3

3

6

4

6

5

3

6

8

6

6

4­ Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs.,boards, instruments, chemicals, glasswares, equipments). 4.3-Research paper. 5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. Assessment schedule Assessment 1 Assessment 2 Assessment 3 Periodic exam (Surprise Quizzes) Practical exam Written exam Week -Week 13 Week 15

Weighting of assessments Periodic Examination Final-Term Written Examination Practical Examination Oral Examination. Total

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10% 70% 20 % ----100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors 6.2- Essential & Recommended books Trease, G.E.& Evans, W.C.; "Pharmacognosy", W.B. Saunders Publishers, Ltd, 15th ed., 2002 6.4- Periodicals, Web sites, ... etc http://www.botanical .com http://www.herbmed.com 7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glasswares, books, audiovisual tools. Course coordinator: Nahla Ayoub, Ph.D ., Associate professor of Pharmacognosy Head of Department: Nahla Ayoub, Ph.D ., Associate professor of Pharmacognosy Date: 2009 / 2010

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CHEMISTRY OF NATURAL PRODUCTS I

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Department offering the course: Academic year / Level: Date of specification approval: Interdisciplinary Pharmacognosy 2nd professional year-2nd term / 300 13/9/2009

A- Basic Information

Title: Code: Credit Hours: Lecture: Tutorial: Practical: Total: Chemistry of Natural Products I 342/8 4week 3/week --------3/week 6/week

B- Professional Information

1 ­ Overall aims of course Upon successful completion of this course, the students should illustrate the 2ry plant metabolites (viz, carbohydrates, glycosides, tannins, bitter principles) and to apply this knowledge correctly in medicine. They should be also able to demonstrate knowledge of basic concepts of chromatography and apply the theories of chromatography independently to analyze and separate mixture of biologically active natural products 2 ­ Intended learning outcomes of course (ILOs) i- Knowledge and understanding: The student should be able to 1. Give an account on the chemistry, biological activity of carbohydrates, glycosides, tannins, bitter principles 2. Describe the mechanism of action of these biologically active components and their structure activity relation ship. 3. Design a method for separation the biologically active principles from their extract.

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4. Recognize or draw the chemical structure of such biologically active compounds. 5. Enumerate the physical and chemical properties of active and inactive chemicals (synthetic, biotech or natural) and the effect that these properties on the design and formulation of medicines. Pharmacists are expected to have a basic understanding of pharmaceutical calculations and biostatistics as well as the history of the profession and professional practice of the pharmacist. 6. Define the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books. The role of these medicinal plants in the treatment of different diseased conditions 7. Define the concepts of chemistry of biologically active natural products viz, carbohydrates, glycosides, tannins, bitter principles, alkaloids, volatile oil and unorganized drugs in addition to principle of chromatography that covers theories and applications in natural product analysis. j- Intellectual skills 1. 2. 3. 4. The student should be capable of: Analyze plant extract. Identify their biologically active constituents by different chemical and physical methods. Design and perform chromatographic technique for isolation of biologically active compounds from their natural sources. Select the appropriate methods of isolation, synthesis, purification, identification, and standardization of active substances from different origins. k- Professional and practical skills The student should be capable of: Use and design methods to separate biologically active secondary metabolites from plant extracts. Perform experiments for the detection of the biologically active secondary metabolites Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities. l- General and transferable skills 1. 2. 3. 4. The student should be able to: Work effectively in team. Demonstrate written and oral communication skills. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

.

1. 2. 3.

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3- Contents Topic Carbohydrates, introduction, classification, biosynthesis, reactions, Application of carbohydrates Anthracene glycosides , flavonoids Steroidal cardioactive glycosides Terpenoid glycosides Miscellaneous glycosides Bitter principles Tannins Chromatography (CC, TLC, PC) No. of Lecture Tutorial/ hours Practical 15 19 14 19 14 15

16

14

6

4­ Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs.,boards, instruments, chemicals, glasswares, equipments). The students were allowed to prepare the plant extracts and dry them using the rotary vaccum. 4.3- Assignments, seminars, researches and posters.

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5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. 5.4- Oral exam to assess knowledge and understanding and intellectual skills. Assessment schedule Assessment 1 Assessment 2 Assessment 3 Assessment 4 Periodic exam (Surprise Quizzes) Practical exam Written exam Oral exam Week -Week 13 Week 15 Week 15

Weighting of assessments Periodic Written Examination Practical Examination Oral Examination. Total 6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors 6.2- Essential & Recommended books Trease, G.E.and Evans, W.C.; "Pharmacognosy", W.B. Saunders Publishers, Ltd, 15th ed., 2002. 6.4- Periodicals, Web sites, ... etc http://www.pubmed.com 7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glassware, books, audiovisual tools. Course coordinator: Mohamed Mohamed elazizy, Ph.D., Professor of Pharmacognosy Head of Department: Nahla Ayoub, Ph.D , Associate Professor of Pharmacognosy 50% 20 % 20% 100%

Date: 2009 / 2010

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CHEMISTRY OF NATURAL PRODUCTS II

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Department offering the course: Academic year / Level: Date of specification approval: Interdisciplinary Pharmacognosy 3rd professional year-1st term / 400 13/9/2009

A- Basic Information

Title: Code: Credit Hours: Lecture: Tutorial: Practical: Total: Chemistry of Natural Products II 441/8 4/week 3/week --------3/week 6/week

B- Professional Information

1 ­ Overall aims of course Upon successful completion of this course, the students should illustrate the 2ry plant metabolites (viz, alkaloids & volatile oil) and to apply this knowledge correctly in phytomedicine. 2 ­ Intended learning outcomes of course (ILOs) m- Knowledge and understanding: The student should be able to 1. Give an account on the chemistry, biological activity of alkaloids and volatile oils. 2. Describe the mechanism of action of these biologically active components and their structure activity relationship. 3. Recognize or draw the chemical structure of such biologically active compounds. 4. Enumerate the physical and chemical properties of active and inactive chemicals (synthetic, biotech or natural) and the effect that these properties on the design and formulation of medicines. Pharmacists are expected to have a

29

5.

6. 7.

basic understanding of pharmaceutical calculations and biostatistics as well as the history of the profession and professional practice of the pharmacist. Define the concepts of medicinal drugs from plant kingdom; their identification as well as, their proper collection, storage and marketing according to compendial books. Define the role of these medicinal plants in the treatment of different diseased conditions Illustrate the concepts of chemistry of biologically active natural products viz, carbohydrates, glycosides, tannins, bitter principles, alkaloids, volatile oil and unorganized drugs in addition to principle of chromatography that covers theories and applications in natural product analysis.

n- Intellectual skills The student should be able to: 1. Analyze plant extract and identify their biologically active constituents by different chemical and physical methods, especially for alkaloids and volatile oils. 2. Design and perform chromatographic technique for isolation of alkaloids from their natural sources. 3. Select the appropriate methods of isolation, synthesis, purification, identification, and standardization of active substances from different origins. o- Professional and practical skills The student should be capable of: Use and design methods to separate biologically active secondary metabolites from plant extracts. Perform experiments for the detection of the biologically active secondary metabolites Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities. p- General and transferable skills The student should be able to: 1. Work effectively in team. 2. Demonstrate written and oral communication skills. 3. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. 4. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates.

1. 2. 3.

30

3- Contents Topic Alkaloids General reactions Phenylalkyl amine alkaloids Pyridine alkaloids Pyrrolizidine alkaloids Pipperine alkaloids Quinoline alkaloids Isoquinoline alkaloids Quinolizidine alkaloids Tropolone alkaloids Purine alkaloids Tropane alkaloids Volatile oils Terpenes Oxygenated terpenes Lipids & Fixed oil Fats & Waxes 4­ Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glasswares, equipments). The students were allowed to prepare a volatile oil sample by using a distillation unit. Also, the practical labs were demonstrated as powerpoint and were added on the internet site of the faculty. 4.3- Assignments, seminars, researches and posters. No. of Lecture Tutorial/ hours Practical 38 28 30

16

14

6

5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. 5.4- Oral exam to assess knowledge and understanding and intellectual skills. Assessment schedule Assessment 1 Assessment 2 Assessment 3 Assessment 4 Periodic exam (Surprise Quizzes) Practical exam Written exam Oral exam Week -Week 13 Week 15 Week 15

Weighting of assessments Periodic Examination Final-Term Written Examination Practical Examination Oral Examination. Total

31

10% 50% 20 % 20% 100%

6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors

6.2- Essential & Recommended books Trease, G.E. and Evans, W.C.; "Pharmacognosy", W.B. Saunders Publishers, Ltd, 15th ed., 2002.

6.4- Periodicals, Web sites, ... etc http://www.pubmed.com 7- Facilities required for teaching and learning

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Study halls, Laboratories, equipment, chemicals, glassware, books, audiovisual tools. Course coordinator: Abdel Nasser Singab, Ph.D, Professor of Pharmacognosy Head of Department: Nahla Ayoub, Ph.D, Associate Professor of Pharmacognosy Date: 2009/2010

33

Quality control of Herbal Products

University: Ain Shams University Faculty: Faculty of Pharmacy Course specifications

Programme(s) on which the course is given: Bachelor Degree in Pharmaceutical Sciences Major or minor element of programmes: Single Major Department offering the programme: Department offering the course: Academic year / Level: Date of specification approval: Interdisciplinary Pharmacognosy 4th professional year-1st term / 500 13/9/2009

A- Basic Information

Title: Code: Credit Hours: Lecture: Tutorial: Practical: Total: Quality control of herbal products 541/8 3/week 2/week --------3/week 5/week

B- Professional Information

1 ­ Overall aims of course After attending this course the students would be expected to deal with the general principles of quality control: definitions, documentation, environmental monitoring, packaging systems, the finished product, the quarantine, and quality control laboratory scheme including quantitative chromatographic analysis of herbal products, storage, preservation, marker determination, validation and applications of the proposed schemes. In addition students will be capable of independently using the different spectroscopic methods to elucidate the structures of pure natural products applying different methods of spectral analysis viz, UV, IR, Ms and NMR, also the application of GC and HPLC in the analysis of herbal constituents.

2 ­ Intended learning outcomes of course (ILOs) q- Knowledge and understanding: The student should be able to: 1. Give an account on the general principles of quality control, chromatographic analysis of herbal products, storage and preservation of herbal drugs, marker determination, validation and applications of analysis of herbal tea bags.

34

2. Describe the application of GC and HPLC in the analysis of herbal constituents. 3. Recognize the structure of pure active natural products applying different methods of spectral analysis viz, UV., IR, Ms and NMR. 4. Illustrate the Analytical methods embracing principles, design, development, validation, application, good laboratory practice (GLP) and good storage practice (GSP). 5. Define Complementary therapies, including herbal therapies. 6. Enumerate the concepts of chemistry of biologically active natural products viz, carbohydrates, glycosides, tannins, bitter principles, alkaloids, volatile oil and unorganized drugs in addition to principle of chromatography that covers theories and applications in natural product analysis. 7. Explain the principles of quality control of herbal products achieved by focusing on the major steps in quality control scheme including quantitative chromatographic analysis of herbal products, storage, preservation, marker determination, validation and applications of the proposed schemes. Advanced quality control applying GC and HPLC. r- Intellectual skills 1. 2. 3. 4. The student should be able to: Solve spectroscopic problems of pure natural products. Design and perform chromatographic technique for isolation of secondary metabolites from their natural sources. Apply qualitative and quantitative analytical and biological methods for QC and assay of raw materials as well as pharmaceutical preparations. Select the appropriate methods of isolation, synthesis, purification, identification, and standardization of active substances from different origins. s- Professional and practical skills The student should be able to: Analyze herbal mixtures in the lab. Use the microscope to decide the components of a given unknown herbal mixture is pure or adulterated. Determine the pharmacopoeial constants of the herbal mixture. Identify different classes of natural compounds using spectroscopic methods. apply samples to be analyzed using certain chromatographic techniques GC and HPLC. structural elucidation of samples by measuring UV absorbance of natural products using the UV spectrophotometer and they analyze it by themselves Implement/Perform standard industrial and/or pharmaceutical instrumentation and laboratory procedures and applying such skill in quality control of pharmaceuticals. Apply validation aspect effectively. Analyze herbal drugs for the purpose of using such skill in determining adulteration of herbal dugs, controlling the quality of produced medicinal agents, and discovering new drug entities. t- General and transferable skills The student should be able to:

35

1. 2. 3. 4. 5. 6. 7.

8.

1. 2. 3. 4.

Work effectively in team. Demonstrate written and oral communication skills. Performing online computer search to develop information technology skills and knowing how to retrieve information from a variety of sources. Keeping up with the pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry and appreciating the need for independent life-long continuing education, starting the day after the student graduates. 3- Contents Topic Quality control of herbal products Validation of methods 9 Gas chromatography (basis, instrumental, applications, Q.C. by finger print by GLC analysis of natural products) HPLC (basis, , instrumental, applications, Q.C. by finger print by HPLC analysis of natural products) Structural elucidation of natural products (UV, IR, 1D &2D NMR and Mass spectrometry) 11 6 8 No. of Lecture Tutorial/ hours Practical 9 9

9 11

6 8

9 9

4­ Teaching and learning methods 4.1- Lectures (Tools: board, overhead projector, data show). The lectures were added on the internet site of the faculty to be available to the students all the time as an e-learning. 4.2- Practical Session (Tools: labs., boards, instruments, chemicals, glassware, equipments). They were allowed to apply samples to the equipments available as the GLC, HPLC and UV spectrophotometers. Examine the runs and analyze the data obtained. 4.3- Assignments, seminars, researches and posters.

5- Student assessment methods 5.1- Written exam(s) to assess knowledge and understanding and intellectual skills. 5.2- Practical exam(s) to assess practical skills. 5.3- Periodic exam(s) to assess understanding and intellectual skills. 5.4- Oral exam to assess knowledge and understanding and intellectual skills. Assessment schedule Assessment 1 Assessment 2 Assessment 3 Periodic exam (Surprise Quizzes) Practical exam Written exam

36

Week -Week 13 Week 15

Assessment 4

Oral exam

Week 15

Weighting of assessments Periodic Examination Final-Term Written Examination Practical Examination Oral Examination. Total 6- List of references 6.1- Course notes Lecture and practical notes prepared by instructors 6.2- Essential & Recommended books Trease, G.E.and Evans, W.C.; "Pharmacognosy", W.B. Saunders Publishers, Ltd, 15th ed., 2002. 2D NMR spectroscopy, Silverstein. 6.4- Periodicals, Web sites, ... etc http://www.pubmed.com 10% 50% 20 % 20% 100%

7- Facilities required for teaching and learning Study halls, Laboratories, equipment, chemicals, glasswares, books, audiovisual tools.

Course coordinator: Nahla Ayoub, Ph.D., Associate Professor of Pharmacognosy Head of Department: Nahla Ayoub, Ph.D, Associate Professor of Pharmacognosy Date: 2009/2010

37

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