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Internacionalni znanstveni simpozij International scientific symposium

*MOLEKULARNO-GENETSKA ISTRAZIVANJA DANAS I MOGUNOSTI NJIHOVE APLIKACIJE*

*MOLECULAR GENETICS RESEARCH TODAY AND IT'S APPLICATION POSSIBILITIES*

Organizator: Odsjek za biologiju, PMF ­ a i Medicinski fakultet Univerziteta u Tuzli u suradnji sa UKC Tuzla (Poliklinika za laboratorijsku dijagnostiku) i Institutom za medicinsku genetiku Klinickog centra Ljubljana (Republika Slovenija) Organizer: Department of Biology, Faculty of Science and Medical Faculty, University of Tuzla, in cooperation with UKC Tuzla (University Clinical Center Tuzla ­ Laboratory Diagnostics Polyclinic) and Medical Genetics Institute from Clinical Center Ljubljana (Slovenia)

Pokrovitelj simpozija: Akademija nauka i umjetnosti Bosne i Hercegovine Under the auspices of Academy of Sciences and Arts of Bosnian and Herzegovina

Tuzla,11. oktobar 2008. (11 October 2008)

P R O G R A M (P R O G R A M M E)

8.30 ­ 9.00 - Registracija ucesnika ­ Medicinski fakultet Tuzla (Registration of participants ­ Medical Faculty Tuzla) 9.00 ­ 9.20 ­ Otvaranje simpozija i pozdravni govor predstavnika organizatora, predstavnika pokrovitelja( akademik Ljubomir Berberovi, Akademije nauka i umjetnosti BiH) i ostalih ucesnika koji zele da se obrate skupu (Official opening with keynote spekers) 9.20 - 10.40 ­ Saopstenja (Presentations) Vrijeme trajanja saopstenja ograniceno je na 8 minuta (Presentations are limited on 8 minutes)

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Peterlin B. Bajrovi K.,Terzi R. ­ predsjedavajui (Chairmans)

Genomics in public health. Peterlin B.

Institute of medical genetics, Department of gynecology and obstetristics, University Clinical Center Ljubljana, Slovenia

Preimplantation genetic diagnosis: An experience from Institute of Medical Genetics Ljubljana. Writzl K., Veble A., Peterlin B.

Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia

Genetics aspects of spontaneous abortion. Volk M., Ostoji S., Peterlin B.

Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia

Molekularna tipizacija leukemije u BiH (Molecular typization of leukemia in BiH) Subasi ð.,

Institut za klinicku imunologiju KCU Sarajevo, BiH

Primjena HLA genotipizacije u klinickoj praksi (Application of HLA genotyping in clinical practice) Beirovi S., Berbi R., Mustedanagi-Mujanovi J., Cickusi E.

Poliklinika za laboratorijsku dijagnostiku, Univerzitetski klinicki centar Tuzla, BiH

Mogunosti detekcije i praenja hromosomskih aberacija citogenetskom i RT PCR metodom kod pacijenata sa hromicnom mijeloicnom leukemijom (Possibilities of detection and monitoring of chromosomal aberrations using cytogenetics and RT-PCR methods in patients with chronic myelogenic leukemia) Mesanovi S., Peri M., Mustedanagi-Mujanovi J., Eminovi I.

Poliklinika za laboratorijsku dijagnostiku, Univerzitetski klinicki centar Tuzla

Prednost detekcije aneuploidija sa FISH metodom u prenatalnoj dijagnostici: iskustvo u KCUS (The advantages of detecting aneuploidy by FISH (fluorescent in situ hybridization) in prenatal diagnostics: experience at the Clinical Center of the University of Sarajevo) Stomornjak M., Kurtovi A.

OJ Klinicka patologija i Citologija, KCUS

Stepen ekspresije TP53 i CDK4 gena i prognosticki znacaj kod oboljelih od karcinoma dojke (Expression and prognostic significance of cell cycle regulatory genes TP53 and CDK4 in breast cancer) Maci D.1, Rami J.1, Kapur ­ Pojski L.1, Lojo ­ Kadri N.1, Obrali N.2, Bajrovi K.1

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Institut za geneticko inzinjerstvo i biotehnologiju, Sarajevo, Bosna i Hercegovina; 2Institut za onkologiju, KCUS, Sarajevo, Bosnia and Herzegovina

Ekspresija BRCA1 I TP 53 u razlicitim tipovima tumorskog tkiva (Expression of BRCA1 and TP 53 genes in different types of tumor) Rami J.1, Kapur L. 1, Lojo ­ Kadri N.1, Maci D.1, Radi K.1, Bilalovi N.2, Bajrovi K.1

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Institut za geneticko inzinjerstvo i biotehnologiju, Sarajevo, Bosna i Hercegovina; 2Klinicki centar univerziteta u Sarajevu, Sarajevo, Bosna i Hercegovina

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Identifikacija mutacija na BRCA 1 genu u skupini pacijenata sa dijagnozom karcinoma dojke i ovarija prije 40 ­ te godine zivota (Identification of BRCA 1 mutation in breast and ovarian cancer patients diagnosed at age under 40). Lojo - Kadri N.1, Kapur L.1, Rami J.1, Beslija S.1, Obrali N.2, Bilalovi N.3, Vrani S.3, Bajrovi K1

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Institut za geneticko inzinjerstvo i biotehnologiju, Sarajevo, BiH 2Institut za onkologiju KCUS, BiH 3Institut za patologiju KCUS, BiH

Diskusija (Discussion)

10.50 ­ 11.10 ­ Koktel (Coctel) 11.10 - 12.20 ­ Saopstenja (Presentations) Peterlin B.,Bajrovi K., Terzi R. ­ predsjedavajui (Chairmans) Statistics and molecular biology: A growing success. Kastrin A., Peterlin B.,

Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia

Genetic causes of idiopatic hearing loss. Gorazd R., Vatovec J., Peterlin B.

Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia

Analiza mutacija gena za hemohromatozu u bosansko ­ hercegovackoj populaciji. (The mutation analysis of the hemochromatosis gene in bosnian - herzegovinian population) Hercegovac A.1, Teran N.2, Terzi R.1, Peterlin B.2

Univerzitet u Tuzli, PMF, Odsjek za biologiju, Bosna i Hercegovina. 2Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia

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Broj kopija DAZ gena u slovenackoj i bosansko-hercegovackoj populaciji (Copy number of DAZ genes in Slovenian and Bosnian general population) Writzl K.1, Hercegovac A. 2, Terzi R.2, Peterlin B.1

Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia 2Univerzitet u Tuzli, PMF, Odsjek za biologiju, Bosna i Hercegovina.

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Insercijski delecijski polimorfizam u genu angiotenzin konvertirajueg enzima (ACE) ­ cimbenik rizika bolesti koronarnih arterija u stanovnistvu Tuzlanske regije (BiH) (Insertion/deletion polymorphism of angiotensin-converting enzime gene-risk factor for coronary artery disease in the Tuzla region population (B&H) Terzi R.1, Letonja M.2, Terzi I.3, Meri M.4 , Kabil E.3, Hercegovac A.1, Teran N.5

Univerzitet u Tuzli, PMF, Odsjek za biologiju, Bosna i Hercegovina. 2Odjel za internu medicinu, Opsta bolnica Ptuj, Ptuj, Slovenija. Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia. 3BH Centar za srce Tuzla, BiH. 4 Kardiovaskularna klinika, UKC, Tuzla, BiH. 5Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia

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Molekularno- genetska dijagnostika neuromuskularnih bolesti u populaciji TK (Molecular ­ genetics diagnostics neuromusular diseas in Bosnia and Hercegovina population) Terzi R.1, Berbi R. 2, Hercegovac A. 1,Teran N.3, Peterlin B. 3, Sinanovi O.4

1 Univerzitet u Tuzli, PMF, Odsjek za biologiju, Bosna i Hercegovina. 2Poliklinika za laboratorijsku dijagnostiku, Univerzitetski klinicki centar Tuzla. 3Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia, 4Klinika za neurologiju, UKC Tuzla

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Molekularno-genetska dijagnostika Huntingtonove bolesti u populaciji TK (Molecular genetic diagnosis of the Huntington disease in Tuzla region population) Terzi R.1, Tupkovi E.2, Peterlin B.3,Teran N.3, Hercegovac A.1, Sinanovi O.4

Univerzitet u Tuzli, PMF, Odsjek za biologiju, Bosna i Hercegovina; 2Dom zdravlja Tuzla, Bosna i Hercegovina;3Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia;4Klinika za neurologiju, UKC Tuzla

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Cisticna fibroza u Tuzlanskom kantonu: klinicka i genetska dijagnoza, neonatalni probir, prevencija i problemi (Cystic fibrosis in Tuzla Canton: clinical genetic diagnosis, neonatal screening, prevention and problams) Hasanhodzi M.

UKC Tuzla Klinika za djecije bolesti

Diskusija (Discussion) 12.20 ­ 12.30 ­ Kafe pauza (Caffe break) 12.30 ­ 13.50 ­ Saopstenja (Presentations) Marjanovi D., Vidovi S., Petrovi D. - (Chairmans) Molekularna genetika u forenzici (Molecular genetics in forensic science) Marjanovi D., Kovacevi L.

Institut za geneticko inzinjerstvo i biotehnologiju Sarajevo, BiH

Studija ucestalosti alela15 STR genskih lokusa u populaciji Bosne i Hercegovine (Study of allele frequencies for 15 STR gene loci in population of Bosnia and Herzegovina). Berbi R., Beirovi S., Mustedanagi-Mujanovi J., Cickusi E., Hadzi N.,

Poliklinika za laboratorijsku dijagnostiku, Univerzitetski klinicki centar Tuzla.

Fragment slomljenog rebra kao strano tijelo kolona (Foreign body of the colon due to perforation by fragment of fractured rib) Zildzi M.1, Salki N.1, Eminovi I.2, Mesi D3.

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Department of Gastroenterology, Division of Medicine, University Clinical Center, Tuzla, Bosnia and Herzegovina, 2Department of Biomedical Engineering, Tuzla University School of Medicine, Tuzla, Bosnia and Herzegovina, 3Division of surgery, University Clinical Center, Tuzla, Bosnia and Herzegovina

Populaciono ­ geneticka istrazivanja u BiH na bazi molekularnih markera (Population - genetic studies in Bosnia - herzegovina based on molecular markers). Naris Pojski, Elma Silajdzi.

Institut za geneticko inzinjerstvo i biotehnologiju Sarajevo, BiH

Molekularno ­ geneticka karakterizacija krvnih grupa (Rh Faktor case ­ study) (Molecular ­ genetic characterization of blood group system (Rh blood group case study)) Lojo ­ Kadri N., Lasi L.

Institut za geneticko inzinjerstvo i biotehnologiju Sarajevo, BiH

Znacaj STR markera u identifikaciji (Importance of STR markers in Identification). Stojko Vidovi.

Katedra za humanu genetiku, Medicinski fakultet, Banja Luka, BiH

Izbor kostanih uzoraka za DNK analizu u cilju identifikacije (Selection of Bone Samples for DNA Identification) Stojko Vidovi1, Tatjana Raci2.

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Katedra za humanu genetiku, Medicinski fakultet, Banja Luka; 2 PMF, Banja Luka, BiH

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Populacono ­ geneticka analiza STR markera za bosansko ­ hercegovacku populaciju Population ­ genetics (Analysis of STR Markers for the Population of Bosnia and Herzegovina) Stojko Vidovi1, Gorana Sinik2, Irina Vuli1

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Katedra za humanu genetiku, Medicinski fakultet, Banja Luka. 2 PMF, Banja Luka, BiH

Diskusija (Discussion) 13.50 ­ 14.50 ­ Rucak (Lunch) 14.50 - 15.30 ­ Posjeta Centru za srce BiH, Tuzla (visiting BH Heart Center, Tuzla)

15.30 -16.30 - Saopstenja (Presentations) Marjanovi D., Vidovi S., Petrovi D. ­ predsjedavajui (Chairmans) Polymorphisms in the promoter region of the basic fibroblast growth factor gene are not associated with myocardial infarction in the Slovene population with type 2 diabetes. Kariz S.1, Krkovi M.2, Osredkar J.3, Petrovic D.2

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General hospital Izola, Izola, Slovenia; 2Institute of Histology and Embriology, Medical faculty, University of Ljubljana, Ljubljana, Slovenia; 3University institute for Clinical chemistry and Biochemistry, University; Medical centre Ljubljana, Ljubljana, Slovenia

Association of vascular endothelial growth factor gene polymorphism with myocardial infarction in patients with type 2 diabetes Petrovic D., Verhovec R., Globocnik Petrovic M., Osredkar J., Peterlin B.

Institute of Histology and Embriology, Medical faculty, University of Ljubljana, Ljubljana, Slovenia

K469E polymorphism of the intracellular adhesion molecule 1 (ICAM -1) gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes Globocnik Petrovic M.1, Osredkar J.2, Saraga ­ Babi M.3, Petrovic D.4

Eye Clinic, University Medical centre Ljubljana, Ljubljana, Slovenia 2University institute for Clinical chemistry and Biochemistry, University Medical centre Ljubljana, Ljubljana, Slovenia 3Department of Anatomy, Hystology and Embriology, School of Medicine, University of Split, Croatia; 4Institute of Histology and Embriology, Medical faculty, University of Ljubljana, Ljubljana, Slovenia

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The interleukin ­ 1 receptor antagonist gene and the inhibitor of kappa B ­ like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes. Terzi I.1, Kariz S.2, Terzi R.3, Peterlin B4, Petrovic D.5

1 BH Hearth Center Tuzla, BiH; 2 General hospital Izola, Izola, Slovenia; 3University of Tuzla, Faculty of science, Department of Biology, Bosnia and Herzegovina; 4Institute of medical genetics, Department of gynecology and obstetristics, University Clinical Center Ljubljana, Slovenia

Identifikacija gena kandidata metodom integrativne genomike (The identification gene candidates by integrative genomich aproach) Kari A.1, Peterlin B.2

Univerzitet u Tuzli, PMF, Odsjek za biologiju, Bosna i Hercegovina. 2Institut za medicinsku genetiku, Odjel za ginekologiju i opstetriciju, Univerzitetsko klinicki centar Ljubljana, Slovenia

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Retrospektiva molekularno ­ geneticke karakterizacije autohtonih i endemicnih salmonoidnih resursa BiH (Molecular ­ genetic characterization of autochthonous and endemic Salmonoids in Bosnia ­ Herzegovina ­ retrospective) Kalamuji B.

Institut za geneticko inzinjerstvo i biotehnologiju Sarajevo, BiH

Diskusija (Discussion)

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16.30 ­ 16.40 ­ Kafe pauza (Caffe break) 16.40 ­ 17.30 - Saopstenja (Presentations) Jerkovi A., Ballian D., Subasi Dz. ­ predsjedavajui (Chairmans) PCR detekcija bakterija u purificiranoj farmaceutskoj vodi (PCR detection of bacteria in purified pharmaceutical water) Jerkovi-Mujki A.1,Kapur L3, Isovi A.2, Rami J 3.

1 Prirodno ­ matematicki fakultet, Univerzitet u Sarajevu, 2d.d. Bosnalijek Sarajevo, 3Institut za geneticko inzinjerstvo i biotehnologiju, Sarajevo, BiH

Geneticka istrazivanja u sumarstvu i njihova primjena (Genetic researches in forestry and their appliance ) Ballian D.

Sumarski fakultet u Sarajevu, BiH

Molekularno ­ geneticka karakterizacija biospeleoloskih animalnih resursa u BiH (Molecular ­ genetic characterization of biospeleological animal resources in Bosnia ­ Herzegovina) Luki Bilela L., Kalamuji B.

Institut za geneticko inzinjerstvo i biotehnologiju Sarajevo, BiH

Optimizacija dijagnostickog testa koji je baziran na ELISA detektiranjem auto ­ antitijela protiv tumorskih antigena u ljudskom serumu (Optimization of diagnostic ELISA ­ based tests for the detection of auto-antibodies against tumor antigens in human serum) Stefati D.1,2, Riederer M.1,3, Bali M.1, Dandachi N. 1, Stanzer S. 1, Janesch B.1, Resel M. 1 , Ler D.4, Samonigg H.1, Bauernhofer T.1

Division of Oncology, Department of Internal Medicine, Medical University of Graz, Austria. 2 Institute of Molecular Biosciences, Faculty of Natural Sciences, University of Graz, Austria. 3Institute of Molecular Biology and Biochemistry, Medical university of Graz. Medical University of Graz, Austria.

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Dijagnoza hromozomopatija u prvom tromjesecju trudnoe (Diagnosis of chromosomopathis in first trimesters of pregnancy) Tinji S., Husi E.

P.Z.U. Poliklinika za neplodnost, ginekologiju i perinatologiju, Gradacac

Znacaj donosenja propisa o geneticki modificiranoj hrani u BiH (The importance of making regulations on GMOs in Bosnia and Herzegovina) Macki S., Arar K., Hajri Dz.

Agencija za sigurnost hrane BiH , Mostar

Identifikacija sojeva Listeria monocytogenes serotip 4B genetickim markerima (Identification of Listeria monocytogenes straius of serotyp 4B by genetics marcers) Hodzi S.1,Huki M2.

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Univerzitet u Tuzli, PMF, Odsjek za biologiju, Bosna i Hercegovina.2Zavod za mikrobiologiju, Klinickomedicinskog centra u Sarajevu

Diskusija (Discussion) 17.30 ­ Zatvaranje (Closing ceremony)

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