Read publicacionesxgrupo06-09.pdf text version

TRABAJOS PUBLICADOS POR GRUPOS DE INVESTIGACIÓN DEPARTAMENTO DE QUÍMICA BIOLÓGICA 2006-2009 Laboratorio de Biología Molecular: Transducción de señales (Silvia Moreno/ Silvia Rossi) 1. Gironella M, Malicet C, Cano C, Sandi MJ, Hamidi T, Tauil RM, Baston M, Valaco P, Moreno S, Lopez F, Neira JL, Dagorn JC, Iovanna JL. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.J Cell Physiol. 2009 Dec;221(3):594-602. 2. Ocampo J, Fernandez Nuñez L, Silva F, Pereyra E, Moreno S, Garre V, Rossi S. A subunit of protein kinase A regulates growth and differentiation in the fungus Mucor circinelloides. Eukaryot Cell. 2009 Jul;8(7):933-44. 3. Rinaldi J, Ocampo J, Rossi S, Moreno S. A novel activating effect of the regulatory subunit of protein kinase A on catalytic subunit activity. Arch Biochem Biophys. 2008 Dec 15;480(2):95-103. 4. Ocampo J, Moreno S, Rossi S.PKA from Mucor circinelloides: model to study the role of linker I in the interaction between R and C subunits. Biochem Biophys Res Commun. 2007 Oct 26;362(3):721-6. Epub 2007 Aug 20.PMID: 17761146 5. Argimón S, Galello F, Pereyra E, Rossi S, Moreno S. Mucor rouxii Rho1 protein; characterization and possible role in polarized growth. Antonie Van Leeuwenhoek. 2007 Apr;91(3):237-51. 6. Pereyra E, Ingerfeld M, Anderson N, Jackson SL, Moreno S. Mucor rouxii ultrastructure: cyclic AMP and actin cytoskeleton. Protoplasma. 2006 Sep;228(4):189-99. 7. Portela P, Moreno S, Rossi S. Characterization of yeast pyruvate kinase 1 as a protein kinase A substrate, and specificity of the phosphorylation site sequence in the whole protein. Biochem J. 2006 May 15;396(1):117-26. 8. Valacco MP, Varone C, Malicet C, Cánepa E, Iovanna JL, Moreno S. Cell growthdependent subcellular localization of p8. J Cell Biochem. 2006 Apr 1;97(5):1066-79 9. Portela P, Moreno S. Glucose-dependent activation of protein kinase A activity in Saccharomyces cersiae and phosphorylation of its TPK1 catalytic subunit. Cell Signal. 2006 Jul;18(7):1072-86. 10. Espinosa, L., Schebor, C., Buera, P., Moreno, S. and Chirife, J. Inhibition of trehalose crystallization by cytoplasmic yeast components Cryobiology , 52: 157-160, 2006.

1

11. María Pía Valacco, Cecilia L. Varone, Cédric Malicet, Eduardo T. Cánepa, Juan L. Iovanna and Silvia M. Moreno. Cell growth-dependent subcellular localization of p8. (2006) J Cell Biochem. 97: 1066-79 ISSN 0730-2312 Laboratorio de Biología Molecular: Regulación de la expresión génica y control del ciclo celular (Eduardo T. Cánepa) 1. Carcagno Abel L., María F. Ogara, Silvina V. Sonzogni, Mariela C. Marazita, Pablo F. Sirkin, Julieta M. Ceruti and Eduardo T. Cánepa. E2F1 transcription is induced by genotoxic stress through ATM/ATR activation. IUBMB Life 61 (2009), 537-543. 2. Ceruti Julieta M., María E. Scassa, Mariela C. Marazita, Abel L. Carcagno, Pablo F. Sirkin and Eduardo T. Cánepa. Transcriptional upregulation of p19INK4d upon diverse genotoxic stress is critical for optimal DNA damage response. Int. J. Biochem. Cell Biol. 41 (2009), 1344-1353 3. Cánepa Eduardo T., Maria E. Scassa, Julieta M. Ceruti, Mariela M. Marazita, Abel L. Carcagno, Pablo F. Sirkin and Maria F. Ogara. INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions. IUBMB Life 59 (2007), 419-426 4. Scassa, María E. Mariela C. Marazita, Julieta M. Ceruti, Abel L. Carcagno, Pablo F. Sirkin, Marcela González-Cid, Omar P. Pignataro, and Eduardo T. Cánepa. Cell cycle inhibitor, p19INK4d, promotes cell survival and decreases chromosomal aberrations after genotoxic insult due to enhanced DNA repair. DNA Repair 6 (2007), 626-638 5. Cánepa Eduardo T. Proliferación o quiescencia: una difícil decisión celular. Química Viva 6 (2007), publicación online Laboratorio de Biosensores y bioanálisis (Eduardo Cortón) 1. Ximena C. Abrevaya, Eduardo Cortón and Pablo J. D. Mauas. UV habitability and dM stars: an approach for evaluation of biological survival. Proceedings of the International Astronomical Union, 2009, 5, 443-445, ISSN: 1743-9213. 2. Diego J. Kormes and Eduardo Cortón. Development of a Novel Method for in vivo Determination of Activation Energy of Glucose Transport across S. cerevisiae Cellular Membrane. A Biosensor-like Approach. Sensors, 2009, 9, 1599-1608. ISSN: 1424-8220. 3. X. C. Abrevaya, H. P. Adamo, E. Cortón, P. J. D. Mauas. UV limits of life on extrasolar planets: an experiment with halophile archaeabacteria at different UV doses. Boletín de la Asociación Argentina de Astronomía, BAAA, 2008, 51, 126-130. ISSN: 1669­9521.

2

4. E. Cortón, J. A. García-Calzón, M. E. Díaz-García. Kinetics and Binding Properties of Chloramphenicol Imprinted Polymers. Journal of Non-Crystalline Solids, 2007, 353, 974980. ISSN: 0022-3093. 5. Mariela F. Martínez, Astrid Hilding Ohlsson, Alberto A. Viale and Eduardo Cortón. Membrane Entrapped Saccharomyces cerevisiae in a Biosensor-like Device as a Generic Rapid Method to Study Cellular Metabolism. Journal of Biochemical and Biophysical Methods, 2007, 70, 455-464. ISSN: 0165-022X. 6. Santiago Chiappini, Peter Hans Döhmer Pisani and Eduardo Cortón. Characterization of a First-Generation Microbial Fuel Cell and its Possible Applications in Environmental Chemistry. Proceedings del 5º Congreso Iberoamericano de Sensores, Ibersensor 2006, Montevideo, Uruguay, 27 al 29 de septiembre del 2006, 1-6. REVISTAS DE DIVULGACIÓN CIENTÍFICA 1. La Contaminación de Nuestros Ríos. Estrategias para su Estudio y Uso Racional". Eduardo Cortón. Kuxulkab, México. Volumen 12, Número 23, diciembre del 2006. ISSN: 1665-0514. 2. Solucionando Grandes Problemas Ambientales con la Ayuda de Pequeños Amigos: las Técnicas de Biorremediación". Eduardo Cortón y Alberto A. Viale. Revista electrónica Ecosistemas, año XV Nº 3 / 2006 Septiembre - Diciembre, Páginas 1-10. Asociación Española de Ecología Terrestre. ISBN: 1697-2473. 3. INFORMES TÉCNICOS, PARTICIPACIÓN EN MEDIOS MASIVOS DE COMUNICACIÓN Y ARTÍCULOS ESCRITOS POR TERCEROS 4. "Bacterias + Barro = Electricidad". Revista Exactamente, revista de divulgación científica de la FCEN, Nro. 43, septiembre 2009, páginas 18-20. Artículo escrito por Cecilia Draghi, basado en material y entrevistas proporcionadas y revisadas pro E.C. 5. "Astrobiología". Participación (entrevistas) en el programa "Recurso Natural", emitido el sábado 19 de septiembre, canal 7, de 11 a 12 hs. 6. "Transferencia de tecnología. De microscopios y fierros". Nota acerca del premio IB50K (entregado por el Instituto Balseiro, a los mejores proyectos), en Bariloche. El grupo dirigido por el Dr. Cortón recibió una mención de honor. Cable Semanal 726, 15 de septiembre del 2009, página 4. 7. "Habrá un seguimiento minucioso y con tecnología de las aguas del río Pilcomayo; descartan contaminación". Publicado en La Mañana de Formosa, diario (versión papel y electrónico) el 11-09-09. En el artículo se destaca la presentación del proyecto "Biosensores de Calidad de Agua", presentado por el Dr. Cortón el 02 de septiembre en Formosa.

3

8. "Proyectan instalar un robot para alerta temprana de contaminación. Miércoles, 02 de Septiembre de 2009". Nota publicada en la página del canal 11, Lapacho TV, acerca de las Jornadas de Calidad del Agua, desarrolladas en Formosa Capital, 02 de septiembre del 2009. 9. Participación en el programa televisivo "Aportes", en vivo, emitido el 02 de septiembre del 2009, en el canal 11, Lapacho TV, Formosa. Se presentó el proyecto Biosensores de Calidad de Agua, con la participación de Marina Jakomin (Subsecretaria de Recursos Hídricos, Nación) y el Dr. Oscar Orfeo (CECOAL, CONICET, Corrientes) y el coordinador ejecutivo de la Unidad Provincial Coordinadora de Agua (UPCA), Rafael Silva, Pcia. de Formosa. 10. Entrega de premio Innovatekne por el Dr. Lino Barañao, Ministro de Ciencia y Tecnología de la Nación. http://www.youtube.com/watch?v=d90m9dmxmz8. 11. "Convocatoria Incubacen 2009". Nota acerca del premio Incubacen 2008 recibido por el Laboratorio de Biosensores. Cable Semanal 712, 31 de marzo del 2009, pagina 7. 12. "Cosechan Energía a Partir de Bacterias". Entrevista filmada en los Laboratorios del Depto. de Química Biológica, para el programa televisivo Pura Energía (Canal Metro, dirigido por Guillermo Lobo), mayo del 2009. Emitido el 23 de julio del 2009, 8 minutos. 13. "Desarrollan un Biosensor para el Diagnóstico Rápido de Mastitis". Articulo periodístico escrito por Cecilia Draghi (incluye foto color). Diario La Nación, Edición Nacional, Suplemento Campo, página 5, sábado 10 de enero del 2009. Examinado y corregido técnicamente por E.C. 14. "Cosechan Energía a Partir de Bacterias". Radio el Mundo, AM 1070, entrevistado en el programa "Ciencia que Habla", conducido por Cecilia Farré y Gabriela Vizental. Unos 15 minutos al aire, martes 09 de diciembre del 2008. 15. "Cosechan Energía a Partir de Bacterias". Articulo periodístico escrito por Cecilia Draghi (incluye foto color), acerca del proyecto financiado por la Fundación YPF. Diario La Nación, edición Nacional, sección noticias de Ciencia/Salud. Examinado y corregido técnicamente por E.C. 17 de noviembre del 2008, página 12. 16. "CUM LAUDE. Astrid Hilding Ohlsson, UBA, Exactas". Articulo periodístico (incluye foto color), acerca del la entrega del Premio Incubacen. Diario Clarín, edición Nacional, sección Campus, del domingo 13 de julio del 2008, página 18. 17. "Galardón", Premio Incubacen. Nota periodística acerca de la entrega del premio "Mejor Plan de Negocios." Incluye foto color. El Cronista Comercial, día 05 de junio de 2008, Sección Mundo PYME, página VII. 18. "De la Idea a la Empresa". Artículo escrito por Gabriel Rocca, acerca de la entrega del premio al mejor plan de negocios, realizada por el Ministro de Ciencia y Tecnología, Dr. Lino Barañao y el Decano Dr. Jorge Aliaga. Premio recibido por el proyecto "Intensive 4

Farm Care Products", dirigido por el Dr. E.C., acerca de los trabajos realizados en el laboratorio del mismo. Examinado y corregido técnicamente por E.C. Cable Semanal 687, 28 de mayo del 2008, páginas 1-3. 19. "Ganador premio "Mejor Plan de Negocio". Nota referida al otorgamiento del premio al mejor plan de negocios por el proyecto "Intensive Farm Care Products" (proyecto mastitis). Nota en la sección Noticias, del 21/05/2008, en al página WEB del INCUBACEN, replicada en otros medios como en la página de canal-AR (22/05/2008). 20. "Emprender para Ganar". Nota referida al otorgamiento de los premios a la Mejor Idea-Proyecto (Incubacen-Innova Tekne). El grupo liderado por E.C. obtuvo el primer premio por el proyecto titulado "Desarrollo de Biosensores o Lenguas Electrónicas para el Diagnostico Rápido de Mastitis Subclínica. Septiembre 2007. Cable Semanal 664, 2 de octubre del 2007, pagina 1 y 2 21. Ámbito Financiero 10.10.2007, Ámbito Financiero - Sup. Especial - Pág. 4, Noticias, PROYECTOS PREMIADOS, Mastitis. 22. "Científicos Industria Argentina", programa de Televisión del canal 7, dirigido por el Dr. Adrián Paenza. Eduardo Cortón Científico Invitado, programa emitido lunes 24 de Septiembre del 2007. 23. "Medir con Bacterias". "Dialogo con Eduardo Cortón, Biólogo". Sección Ciencia, diario Página 12, miércoles 12 de agosto del 2007. Por Leonardo Moledo. 24. "Laboratorio de Biosensores y Bioanálisis". Artículo escrito por Patricia Olivilla, basado en entrevistas realizadas al Dr. Cortón, acerca de los trabajos realizados en el laboratorio del mismo. Examinado y corregido técnicamente por E.C. Cable Semanal 642, 11 de abril del 2007, pagina 6. 25. "Intentan Medir la Contaminación del Agua... con Bacterias". Artículo escrito por Cecilia Draghi, basado en entrevistas realizadas al Dr. Cortón, acerca de los trabajos realizados en el laboratorio del mismo. Examinado y corregido técnicamente por E.C. Publicado en el diario de edición nacional "La Nación", página 13, del 16 de junio de 2006. Artículo replicado en varios medios electrónicos, incluyendo su traducción al portugués. 26. "Cuando las bacterias "trabajan" para el hombre." Artículo escrito por Cecilia Draghi, basado en entrevistas realizadas al Dr. Cortón, acerca de los trabajos realizados en el laboratorio del mismo. Examinado y corregido técnicamente por E.C., Centro de Divulgación Científica-SEGB-FCEyN, martes 18 de julio de 2006. 27. "Pila de Microbios", articulo de divulgación en la revista "NEO", Nro. 16, julio del 2006, páginas 102-103, ISSN 1669-1687. Artículo escrito por Cecilia Draghi, basado en entrevistas realizadas al Dr. Cortón, acerca de los trabajos realizados en el laboratorio del mismo. Examinado y corregido técnicamente por E.C.

5

Laboratorio de Disturbios metabólicos por xenobióticos (Leonor San Martín de Viale/ Carlos Lantos) 1. Altuna ME, Mazzetti, M.B., Rago LF, San Martín de Viale LC and Damasco MC. Hepatic 11 beta-hydroxysteroid dehydrogenase 1 involvement in alterations of glucose metabolism produced by acidotic stress in rat . J. Physiol Biochem 65, 329-338 (2009) ISSN: 1138-7548, Official Journal of the University of Navarra, Spain 2. Lelli, S.M., Mazzetti, M.B. and San Martin de Viale, L.C. "Hepatic alteration of tryptophan metabolism in an acute porphyria model. Its relation with the gluconeogenic blockage". Biochem. Pharmacol. 75, 704-712 (2008) ISSN 006-2952, Editorial Elsevier Ireland Ltd. Co. Clare 3. Llambías, E.B.C., Mazzetti, M.B., Lelli, S.M.,. Aldonatti, C. and San Martin de Viale, "Melatonin formation in pineal glands from rats with HCB experimental porphyria" L.C. International Journal of Toxicology 26: 545-551 (2007). ISSN 1091-5818, The official Journal ofAmerican College of Toxicology, Francis & Taylor Group, London, England 4. Lelli, SM., Ceballos NR, Mazzetti, MB, Aldonatti, and San Martín de Viale, LC Hexachlorobenzene as hormonal disruptor- studies about glucocorticoid: Their hepatic receptor, adrenal synthesis and plasma levels in relation to impaired gluconeogenesis". Reino Unido. Inglaterra. Biochem Pharmacol. 73: 873-879 (2007) ISSN 006-2952. Elsevier Ireland Ltd. Co. Clare, Ireland. Laboratorio de Enzimología, Estrés oxidativo y Metabolismo (María del Carmen Ríos) 1. Causin H.F., Roberts I.N., Criado M.V., Gallego S.M., Pena L.B., Ríos M.C., Barneix A.J.Changes in hydrogen peroxide homeostasis and cytokinin levels contribute to the regulation of shade-induced senescence in wheat leaves. Plant Science 2009. doi:10.1016/j.plantsci.2009.08.014. ISSN: 0168-9452. 2. Sabatini S. E., Chaufan G., Juárez A. B., Coalova I., Bianchi L., Eppis M.R., Ríos de Molina M.C. Dietary copper effects in the estuarine crab, Neohelice (Chasmagnathus) granulata, maintained at two different salinities. Compar. Biochem. Physiol., Part C. 150 (2009) 521­527. doi:10.1016/j.cbpc.2009.07.006. ISSN: 1532-0456. 3. Sabatini S. E., Juárez A. B., Eppis M. R., Bianchi L., Luquet C. M., Ríos de Molina M. C. Oxidative stress and antioxidant defenses in two green microalgae exponed to copper. Ecotoxicol. Environ. Safety. 72 (2009) 1200-1206. doi:10.1016/j.ecoenv.2009.01.003. ISSN: 0147-6513. 4. Miller E. A., Ríos de Molina M. C., Domínguez G, Guerra L. N.Thyroid hormone effect in human hepatocytes. Redox Report, 13 (4) (2008) 185-191. ISSN 1351-0002.

6

5. Rocchetta I., Leonardi P. I., Amado Filho G. M., Rìos de Molina M.C., Conforti V. Ultraestructure and X-ray microanálisis of Euglena gracilis (Euglenophyta) under chromium stressPhycologia 46 (3) (2007) 300-306. ISSN: 0031-8884. 6. Juárez A., Aldonatti C., Vigna S., Ríos de Molina M.C.Studies on Uroporphyrinogen decarboxylase (UroD) from Chlorella kessleri (Trebouxiophyceae, Chlorophyta). Can. J. Microbiology. 53 (2) (2007) 303-315. ISSN: 1480-3275. 7. Chaufan G., Juárez A., Basack S., Ithuralde E., Sabatini S. E., Genovese G., Oneto M.L., Kesten E., Ríos de Molina M.C. Toxicity of hexachlorobenzene and its transference from microalgae (Chlorella kessleri) to crabs (Chasmagnathus granulatus). Toxicology 227 (2006) 262-270. ISSN 0300-483X. 8. Riva D.A., Ríos de Molina M.C., Rocchetta I., Gerhardt E., Coulombié F.C., Mersich S.E. Oxidative stress in Vero cells infected with vesicular stomatitis virus. Intervirology, 49 (2006) 294-298. ISSN 0300-5526/06/0495-0294 9. Rocchetta I., Ruiz L., Ríos de Molina M.C., Conforti V. Chromium toxicity to Euglena gracilis strains depending on the physicochemical properties of the culture medium. Bull. Environ. Contam. Toxicol., 76 (2006) 512-521. ISSN 0007-4861. 10. Rocchetta I., Mazzuca M., Conforti V., Ruiz L.B., Balzaretti V., Ríos de Molina M.C. Effect of chromium on the fatty acid composition of two strains of Euglena gracilis. Environmental Pollution, 141(2) (2006) 353-358. ISSN 0269-7491. 11. Julianelli Vanina L., Guerra Liliana N.*, Calvo Juan C.*. Cell-cell communication between Mouse mammary epithelial cells and 3T3-L1 preadipocytes: Effect on triglyceride accumulation and cell proliferation. Biocell, 2007, 31: 237-245. 12. L N Guerra, E. Miler, M. Moiguer, S. Karner, A. Orlando, H. Fideleff and J. Burdman Telomerase Activity in Fine Needle Aspiration Biopsy Samples: Application to Diagnosis of Human Thyroid Carcinoma. Clinica Chimica Acta, ISSN 0009-8981, 2006, 370: 180184. 13. Liliana N. Guerra, Ma del Carmen Ríos de Molina, Eliana A. Miler, Silvia Moiguer, Mirta Karner and José A. Burdman. Antioxidants and methimazole in the treatment of Graves' disease: effect on urinary maondialdehyde levels. Clinica Chimica Acta, ISSN 0009-8981, 2005, 352: 115-120. Capítulos de libros 14. Chaufan G., Juárez A. B., Sabatini S. E., Ríos de Molina M.C Impacto del hexaclorobenceno sobre el cangrejo Chasmagnathus granulatus (=Neohelice granulata) de la Bahía de Samborombón.. En: RED CYTED - Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo. 406RT0285, Fernández Reyes L., Volpedo A., Rial A. (eds.).

7

Efecto de cambios globales sobre humedales de Iberoamérica. 2008, pp. 191-205. ISBN 978-987-05-5533-9. 15. Juárez A.B., Schiariti A., Aldonatti C., Rodríguez M.C., Ríos de Molina M.C.Estudios de toxicidad celular de contaminantes ambientales. En: Herkovits J. (ed.) Salud Ambiental y Humana. Una visión Holística. Libro de SETAC (Sociedad de Toxicología Ambiental y Química) América Latina. 2006, pp. 69-72. ISBN 10: 987-05-1959-8 y ISBN 13:978-98705-1059-1. 16. Capítulo: Telomerase Activity: Application to Diagnosis of human carcinoma. Libro: DNA-Directed DNA Polymerase Editorial: Nova Science Publisher, Inc, (2009) Web: www.novapublisher.com Revistas de divulgación científica 17. Scaglia, HE; Viola, AM; Guevel, L; Guerra, LN; Mohr, AL; Jozami, LS; Aquilano, DR; Scaglia, Perfil androgenico en mujeres hirsutas. Modificaciones de sus niveles en la fase lutea. J. Revista Argentina de Endocrinología y Metabolismo, ISSN: 0326-4610, 2007, 44: 233- 241.

Laboratorio de Expresión Génica en Mama y Apoptosis (Adalí Pecci) 1. Pecci A, Alvarez LD, Veleiro AS, Ceballos NR, Lantos CP, Burton G. New lead compounds in the search for pure antiglucocorticoids and the dissociation of antiglucocorticoid effects. 2009 J Steroid Biochem Mol Biol. 113(3-5):155-62. ISSN: 0960-0760. 2. Romorini L, Coso OA, Pecci A. Bcl-XL mediates epidermal growth factor dependent cell survival in HC11 mammary epithelial cells. 2009 Biochim Biophys Acta. 1793(3):496505. ISSN 0304-4165 3. Alvarez LD, Martí MA, Veleiro AS, Misico RI, Estrin DA, Pecci A, Burton G. Hemisuccinate of 21-Hydroxy-6,19-Epoxyprogesterone: A Tissue-Specific Modulator of the Glucocorticoid Receptor. 2008 ChemMedChem. 3(12):1869-77. ISSN: 1860-7179. 4. L. Rocha Viegas, E. Hoijman, M. Beato and A. Pecci. Mechanisms involved in tissuespecific apopotosis regulated by glucocorticoids 2008 J Steroid Biochem Mol Biol. 109:273-8. ISSN:0960-0760. 5. L.D. Alvarez, M.A. Martí, A.S. Veleiro, D.M. Presman, D.A. Estrín, A. Pecci and G. Burton. Exploring the molecular basis of action of the passive antiglucocorticoid 21hydroxy-6,19-epoxyprogesterone. 2008. J Med Chem 51:1352-60. ISSN: 0022-2623.

8

6. Rodríguez Granillo, J.C. Boffi, L. Barañao, E. Kordon, A. Pecci and A. 7. Guberman. STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line. 2007 Biochem. & Bioph. Res. Comm. (356:727). ISSN:0006-291X 8. L. Rocha Viegas, G.P. Vicent, J.L. Barañao, M. Beato and A. Pecci. Glucocorticoids repress bcl-X expression in lymphoid cells through the recruitment of STAT 5 B to the distal promoter P4 2006 J. Biological Chemistry (281:33959. ISSN: 0021-9258. 9. D. Presman, E. Hoijman, N.R. Ceballos, M.D. Galigniana and A. Pecci. Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes 2006 Endocrinology (147:5452)ISSN: 0013-7227 Sistema de señales intracelulares y diferenciación celular (María del Carmen Vila) 1. Martini, Claudia. N., Romero, Damian, Yanes, Licy L. y M.C. Vila. Induction of 5aminolevulinate-synthase by activators of steroid biosynthesis. Life Sciences 81, 19-25 (2007) 2. PKA-dependent and independent cAMP signalling in 3T3-L1 fibroblasts differentiation. Martini, Claudia, Plaza, María Victoria y M.C.Vila Mol. Cell Endocrinol. 298, 42-47 (2009) 2008 Oct 25

Biología Celular y Molecular (Mario Galigniana/ Martín Monte) 1. M. Monte, M. Simonatto, L.Y. Peche, D.R. Bublik, S. Gobessi, M.A. Pierotti, M. Rodolfo and C. Schneider. MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. Proc.Natl.Acad.Sci (USA), 103: 11160-11165, 2006. 1. M. Monte, M. Simonatto, L.Y. Peche, D.R. Bublik, S. Gobessi, M.A. 2. Pierotti, M. Rodolfo and C. Schneider. MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment andconfer resistance to chemotherapeutic agents. Proc.Natl.Acad.Sci (USA),103: 11160-11165, 2006. 3. Salatino M, Beguelin W, Peters MG, Carnevale R, Proietti CJ, Galigniana MD, Vedoy CG, Schillaci R, Charreau EH, Sogayar MC, Elizalde PV. Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation. Oncogene. 2006; 25(59):7723-39. 4. Aviezer-Hagai K, Skovorodnikova J, Galigniana M, Farchi-Pisanty O, Maayan 5. E, Bocovza S, Efrat Y, von Koskull-Döring P, Ohad N, Breiman A. Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced, and bind HSP90. Plant Mol Biol. 2007 Jan;63(2):237-55. 2006.

9

6. Piwien Pilipuk G, Vinson GP, Sanchez CG, Galigniana MD. Evidence forNL1independent nuclear translocation of the mineralocorticoid receptor. Biochemistry. 2007 Feb 6;46(5):1389-97. 7. Colo GP, Rubio MF, Nojek IM, Werbajh SE, Echeverría PC, Alvarado CV, Nahmod VE, Galigniana MD, Costas MA. The p160 nuclear receptor co-activator RAC3 exerts an anti-apoptotic role through a cytoplasmatic action. Oncogene. 2008;27(17):2430-44. 8. Gallo LI, Ghini AA, Piwien Pilipuk G, Galigniana MD. Differential Recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity. Biochemistry. 2007;46(49):14044-57. 9. Echeverría PC, Mazaira G, Erlejman A, Gomez-Sanchez C, Piwien Pilipuk G, Galigniana MD. Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol. 2009; 29(17):4788-97. Regulación de la expresión génica en el crecimiento, supervivencia y diferenciación celular (Lino Barañao) 1. Scassa M.E., Fernández Espinosa D., Questa M., Videla Richardson G.,Losino N., Luzzani C., Guberman A.S., Grancelli H., Sevlever G., Miriuka S.G.. (2009) Diferenciación en cardiomiocitos a partir de células madre embrionarias humanas. Rev. Argent. Cardiol.; 77 458-464. 2. Rodríguez Granillo, A.; Boffi J. C.; Barañao L.; Kordon E., Pecci A., Guberman, A. (2007). STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line. Biochemical and Biophysical Research Communications 356 727-732. Laboratorio de Regulación génica en levaduras (Susana Correa/ Mariana Bermudez Moretti) 1. Bermúdez Moretti M., Maskin L., Gudesblat G., Correa García S. and Iusem N. ASR1, a stress-induced tomato protein, protects yeast from osmotic stress. Physiologia Plantarum 127, 111-118, 2006. 2. Luzzani, C., Cardillo, S. B., Bermudez Moretti, M. & Correa Garcia, S. New insights into the regulation of the Saccharomyces cerevisiae UGA4 gene: two parallel pathways participate in carbon-regulated transcription. Microbiology 153, 3677-84. 2007. 3. Perullini, M., Jobbágy, M., Bermúdez Moretti, M., Correa García, S. and Bilmes S.A. Optimizing silica encapsulation of living cells: in situ evaluation of cellular stress. Chem. Mater. 20 (9), 3015-3021, 2008.

10

Grupo interdisciplinario de Bioquímica Estructural (Adrián Turjanski/ Valeria Levi) 1. De Biase, P.; Alvarez Paggi, D; Doctorovich, F; Hildebrandt, P; Estrin, D. A; Murgida, D,H; Marti, M,A. Molecular Basis for the Electric Field Modulation of Cytochrome c Structure and Function. J. Am. Chem. Soc. 2009. 131 (44), 16248-56. 2. Leonardo Boechi, Pau Arroyo Mañez, Javier Luque, Marcelo A. Marti and Dario A. Es trin. Unraveling the molecular basis for ligand binding in truncated hemoglobin: the trHbO B. s ubtils case. Proteins, Struc. Func. And Bionf. 2010;78(4):962-70. 3. Ariel Lewis-Ballester, Dipanwita Batabyal, Tsuyoshi Egawa, Changyuan Lu, Yu Lin, Marcelo A. Marti, Luciana Capece, Dario A. Estrin and Syun-Ru Yeh. Evidence for a Ferryl Intermediate in a Heme-based Dioxygenase. Proc. Natl. Acad. Sci USA. 2009, 106(41) 17371-17376. 4. Ariel A. Petruk, Marcelo A. Marti, and Rosa María S. Alvarez. Thyroid Hormones Interactions with DMPC bilayers. A Molecular Dynamics Study. J. Phys. Chem B. 2009, 113(40) 13357-64. 5. Diego F. Gauto, Santiago Di Lella, Carlos M. A. Guardia, Darío A. Estrin and Marcelo A. Martí. Carbohydrate-binding proteins: Dissecting ligand structures through solvent environment occupancy. J. Phys. Chem B. 2009 113(25) 8717-8724. 6. Lama A, Pawaria S, Bidon-Chanal A, Anand A, Gelpí JL, Arya S, Martí MA, Estrin DA, Luque FJ, Dikshit KL. Role of Pre-A motif in nitric oxide scavenging by truncated hemoglobin, HbN, of mycobacterium tuberculosis. J Biol Chem. 2009 284(21), 1445714468. 7. Giordano D, Boechi L, Vergara A, Martí MA, Samuni U, Dantsker D, Grassi L, Estrin DA, Friedman JM, Mazzarella L, di Prisco G, Verde C. The hemoglobins of the subAntarctic fish Cottoperca gobio, a phyletically basal species-oxygen-binding equilibria, kinetics and molecular dynamics. FEBS J. 2009;276(8):2266-77. 8. D Alvarez Paggi, DF. Martín, A Kranich, P Hildebrandt, MA Martí,DH Murgida. Computer simulation and SERR detection of cytochrome c dynamics at SAM-coated electrodes Elctrochimica Acta. 2009, 54(21) 4963-70. 9. Marti MA, Estrin DA, Roitberg AE. Molecular Basis for the pH Dependent Structural Transition of Nitrophorin 4. J Phys Chem B.2009;113(7):2135-2142. 10. Swails JM, Meng Y, Walker FA, Marti MA*, Estrin DA, Roitberg AE. pH-dependent mechanism of nitric oxide release in nitrophorins 2 and 4. J Phys Chem B. 2009;113(4):1192-201.

11

11. Capece L, Marti MA, Bidon-Chanal A, Nadra A, Luque FJ, Estrin DA. High pressure reveals structural determinants for globin hexacoordination: Neuroglobin and myoglobin cases. Proteins. 2009, 75(4) 885-894. 12. L. Capece, D.A Estrin and M.A. Marti. Dynamical characterization of the Heme NO Oxygen binding (H-NOX) domain. Insight into soluble guanylate cyclase allosteric transition. Biochemistry 2008; 47(37):9793-802. 13. L.L. Perissinotti, M.A. Marti, F. Doctorovich, F.J. Luque and D.A. Estrin. A microscopic study of the deoxy-hemoglobin catalyzed generation of nitric oxide from nitrite anion. Biochemistry, 2008; 47(37):9793-802. 14. Marti, MC. González Lebrero, AE. Roitberg and DA Estrin. J. Bond or Cage Effect: How Nitrophorins Transport and Release Nitric Oxide MA. Am. Chem. Soc, 2008; 130(5); 1611-1618. 15. G. Pierdominici-Sottile, MA. Martí and J. Palma. The role of residue Thr122 of methylamine dehydrogenase on the proton transfer from the iminoquinone intermediate to residue Asp76. Chem Phys Lett. 2008, Vol. 456 (4), 243-246 16. Boechi L, Martí MA, Milani M, Bolognesi M, Luque FJ, Estrin DA. Structural determinants of ligand migration in Mycobacterium tuberculosis truncated hemoglobin O. Proteins. 2008 17. Alvarez LD, Martí MA, Veleiro AS, Misico RI, Estrin DA, Pecci A, Burton G. Hemisuccinate of 21-hydroxy-6,19-epoxyprogesterone: a tissue-specific modulator of the glucocorticoid receptor. ChemMedChem. 2008 (12):1869-77 18. Lautaro D. Álvarez, Marcelo A. Martí, Adriana S. Veleiro, Diego M. Presman, Darío A. Estrin, Adalí Pecci, and Gerardo Burton. Exploring the Molecular Basis of Action of the Passive Antiglucocorticoid 21-Hydroxy-6,19-epoxyprogesterone J. Med. Chem. 2008 13;51(5):1352-60. 19. MA Martí, A. Bidon-Chanal, A. Crespo, S. Yeh, V. Guallar, F. J. Luque, D. A. Estrin. Mechanism of Product Release in NO detoxification from Mycobacterium tuberculosis Truncated Hemoglobin N. J. Am. Chem. Soc. 2008; 130(5); 1688-1693. 20. Alejandro D. Nadra, Marcelo A. Martí, Alessandra Pesce, Martino Bolognesi, Darío A. Estrin. Exploring the molecular basis of heme coordination in human neuroglobin. Proteins. 2008, 71(2):695-705. 21. Tioni MF, Llarrull LI, Poeylaut-Palena AA, Martí MA, Saggu M, Periyannan GR, Mata EG, Bennett B, Murgida DH, Vila AJ. Trapping and characterization of a reaction intermediate in carbapenem hydrolysis by B. cereus metallo-beta-lactamase. J Am Chem Soc. 2008;130(47):15852-63.

12

22. Di Lella S, Marti MA, Alvarez RM, Estrin DA, Ricci JC.Characterization of the Galectin-1 Carbohydrate Recognition Domain in Terms of Solvent Occupancy. J Phys Chem B. 2007, 111, (25) 7360-7366 23. Marcelo A. Marti, Luciana Capece, Damian E. Bikiel, Bruno Falcone, and Dario A Estrin. Oxygen Affinity Controlled by Dynamical Distal Conformations: The Soybean Leghemoglobin and the Paramecium Caudatum Hemoglobin cases. Proteins 2007, 27;68(2):480-487. 24. Bidon-Chanal, Marcelo A. Martí, Darío A. Estrin, and F. Javier Luque. Dynamical Regulation of Ligand Migration by a Gate-Opening Molecular Switch in Truncated Hemoglobin-N from Mycobacterium Tuberculosis Axel J Am Chem Soc. 2007, 30;129(21):6782-6788. 25. Sebastián A. Suárez, Marcelo A. Martí, Pablo M. De Biase, Darío A. Estrin, Sara E. Bari and Fabio Doctorovich. HNO trapping and assisted decomposition of nitroxyl donors by ferric hemes Polyhedron 2007, 26(16):4673-4679. 26. Capece L, Marti MA, Crespo A, Doctorovich F, Estrin DA. Heme protein oxygen affinity regulation exerted by proximal effects. J Am Chem Soc. 2006,128(38):12455-61 27. Crespo A, Marti MA, Roitberg AE, Amzel LM, Estrin DA. The catalytic mechanism of peptidylglycine alpha-hydroxylating monooxygenase investigated by computer simulation J Am Chem Soc. 2006;128(39):12817-28. 28. Damián E. Bikiel, Leonardo Boechi, Luciana Capece, Alejandro Crespo, Pablo M. De Biase, Santiago Di Lella, Mariano C. González Lebrero, Marcelo A. Martí, Alejandro D. Nadra, Laura L. Perissinotti, Damián A. Scherlis and Darío A. Estrin. Modeling heme proteins using atomistic simulations Phys. Chem. Chem. Phys. 2006 29. Bidon-Chanal, A. Marti, MA. Crespo, A. Milani, M. Orozco, M. Bolognesi, M. Luque, FJ and Estrin DA. Ligand-induced dynamical regulation of NO conversion in Mycobacterium Tuberculosis truncated-hemoglobin N Proteins, 2006;64(2):457-64. 30. Xiong, H. Crespo, A. Marti, MA. Estrin DA, Roitberg AE. Free Energy Calculations with Non-equilibrium Methods: Applications of the Jarzynski Relationship. Theoretical Chemistry Accounts, 2006, 106, 338-346. 31. Marti MA, Crespo A, Capece L, Boechi L, Bikiel DE, Scherlis DA, Estrin DA. Dioxygen affinity in heme proteins investigated by computer simulation. J. Inorg. Biochem. 2006, 100(4):761-70. 32. Marti MA, Bikiel DE, Crespo A, Nardini M, Bolognesi M, Estrin DA. Two distinct heme distal site states define Cerebratulus lacteus mini-hemoglobin oxygen affinity. Proteins. 2006;62(3):641-8.

13

33. Capece L, Marti MA, Bidon-Chanal A, _Nadra A_, Luque FJ, Estrin DA. High pressure reveals structural determinants for globinhex acoordination: Neuroglobin and myoglobin cases". Proteins. 2008 Oct 15. 34. Marcaida MJ, Prieto J, Redondo P, _Nadra AD_, Alibés A, Serrano L, Grizot S, Duchateau P, Pâques F, Blanco FJ, Montoya G.Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering." Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16888-93. 35. Alejandro D. Nadra_, Marcelo A. Marti, Alessandra Pesce, Martino Bolognesi, and Dario A. Estrin. Exploring the molecular basis of heme coordination in human neuroglobin". _ Proteins: Structure, Function, and Bioinformatics. Proteins. 2008 May 1;71(2):695-705. 36. Bikiel DE, Boechi L, Capece L, Crespo A, De Biase PM, Di Lella S, González Lebrero MC, Martí MA, _Nadra AD_, Perissinotti LL, Scherlis DA, Estrin DA. Modeling heme proteins using atomistic simulations." Phys Chem Chem Phys. 2006 Dec 28;8(48):5611-28 37. Maia Brunstein, Luciana Bruno, Marcelo Desposito, Valeria Levi. Anomalous dynamics of melanosomes driven by myosin-V in Xenopus laevis melanophores. Biophys J 97:1548-57 2009. 38. L. Bruno, V. Levi, M. Brunstein and M. A. Despósito. Intracellular actin-based transport mediated by molecular motors: transition to superdiffusive behavior. Phys Rev E Stat Nonlin Soft Matter Phys. 80(1 Pt 1):011912. 2009. 39. Javier Baier, Cristina Gallegos, Valeria Levi and Francisco Barrantes. Cholesterol modulates nicotinic acetylcholine receptor mobility at the cell membrane. Eur Biophys J. 39(2):213-27. 2009. 40. Luciana Bruno, Mercedes Echarte and Valeria Levi. Exchange of Microtubule Molecular Motors During Melanosome Transport in Xenopus laevis Melanophores is Triggered by Collisions with Intracellular Obstacles. Cell Biochem Biophys. 52(3):191201. 2008. 41. Levi V. Villamil Giraldo A, Castello PR, Rossi JP, Gonzalez Flecha FL. Effects of phosphatidylethanolamine glycation on lipid-protein interactions and membrane protein thermal stability. Biochem J. Nov 15;416(1):145-52. 2008. 42. Levi V, Gratton E. Chromatin dynamics during interphase explored by single particle tracking. (Review) Chromosome Research and Technique 16:439-449 2008. 43. Levi V, Gratton E. Exploring dynamics in living cells by tracking single particles. (Review) Cell Biochemistry and Biophysics 48(1):1-15. 2007. 44. Levi V, Gelfand VI, Serpinskaya AS, Gratton E. Melanosomes Transported by Myosin V in Xenopus Melanophores Perform Slow 35 nm Steps. Biophys J. 90:L7-9. 2006. 14

45. Levi V, Serpinskaya AS, Gratton E, Gelfand V. Organelle transport along microtubules in Xenopus melanophores: evidence for cooperation between multiple motors. Biophys J. 90:318-327. 2006. 46. Turjanski AG, Hummer G, Gutkind JS. How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study. J Am Chem Soc. 2009 May 6;131(17):6141-8. 47. Amanda P. Skoumbourdis; Christopher A. Leclair; Eduard Stefan; Adrian G. Turjanski; William Maguire; Steven A. Titus; Ruili Huang; Douglas S. Auld; James Inglese; Christopher P. Austin; Stephen W. Michnick; Menghang Xia; Craig J. Thomas. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009. 48. Jaime G. Mayoral, Marcela Nouzova, Michiyo Yoshiyama, Tetsuro Shinoda, Salvador Hernandez-Martinez, Elena Dolghih, Adrian G. Turjanski, Adrian E. Roitberg, Horacio Priestap, Mario Perez, Lucy Mackenzie, Yiping Li, Fernando G. Noriega. Molecular and functional characterization of a juvenile hormone acid methyltransferase expressed in the corpora allata of mosquitoes. Insect Biochemistry and Molecular Biology. 2009. vol. 39 n. 1 p.31-37 ISSN 0965-1748 A. G. Turjanski, J. S. Gutkind, R. Best, G. Hummer. Binding Induced Folding of a Natively Unstructured Transcription Factor. PLOS Computational Biology, 4(4): e1000060. A. G. Turjanski, J P. Vaqué, J.S. Gutkind. MAPKs and the control of nuclear events. Oncogene. 2007 May 14;26 (22):3240-53 49. VM Sanchez, A. Crespo, JS. Gutkind, AG. Turjanski. Investigation of the Catalytic Mechanism of Farnesyl Pyrophosphate Synthase by Computer Simulation. Journal of Physical Chemistry B, 2006 Sep 14;110(36):18052-7. 50. L. Sigman, VM Sanchez, AG. Turjanski. Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics. Journal of Molecular Graphics and Modeling. 2006, 25, 345-352. 51. Clara Smal, Diana E. Wetzler, Karina I. Dantur, Lucia B. Chemes, María M. GarcíaAlai, Mariano Dellarole, Leonardo G. Alonso, Kevin Gaston and Gonzalo Prat-Gay. The human papillomavirus E7-E2 interaction mechanism reveals a finely tuned regulatory system for modulating available E7 and E2 protein levels. Biochemistry, 2009, 48 (50), pp 11939­11949 52. Diana E. Wetzler, Mariana Gallo, Riccardo Melis, Tomasso Eliseo, Alejandro D. Nadra, Diego U. Ferreiro, Maurizio Paci, Ignacio E. Sánchez, Daniel O. Cicero, Gonzalo de Prat Gay. A strained DNA binding helix is conserved for site recognition, folding nucleation, and conformational modulation. Biopolymers, 2009, 91(6), 432-443.

15

53. Diana E. Wetzler, Eduardo M. Castaño, Gonzalo de Prat-Gay. Quasi-spontaneous amyloid route in a dna binding gene regulatory domain of the papillomavirus hpv16 e2 protein. Protein Sicence, 2007, 16(4), 744-754. 54. D. E. Wetzler, D. García-Fresnadillo, G. Orellana. A Solid Reference System for Photosensitized 1O2 Production Measurements. P.C.C.P, 2006, 8, 2249-2256 55. Maria M. García-Alai, Mariana Gallo, Marcelo Salame, Diana E. Wetzler, Alison A. McBride, Maurizio Paci, Daniel O. Cicero, and Gonzalo de Prat-Gay. Molecular basis for phosphorylation dependent PEST mediated protein turnover. Structure, 2006, 14, 309-319. Capitulos de libro 56. 3-Dimensional particle tracking in a laser scanning fluorescence microscope. Valeria Levi and Enrico Gratton. En: Single Particle Tracking and Single Molecule Energy Transfer published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim ("WILEY-VCH"). (in press) 57. Exploring the Nitric Oxide Detoxification Mechanism of Mycobacterium tuberculosis Truncated Haemoglobin N, A. Bidon-Chanal, M.A. Marti, D.A. Estrin, and F.J. Luque. In Self organization of Molecular system: From Molecules and Clusters to Nanotubes and Proteins. Edited by N Russo, VY Antochenko and E Kryachko. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer 2009, p33-47. 58. NO reactivity with globins as investigated through computer simulation. M.A. Marti, L. Capece, A. Bidon-Chanal, A. Crespo, V. Guallar, F.J. Luque, and D. A. Estrin. Globins and Other Nitric Oxide-Reactive Proteins, Part B Edited by R.k Poole for Methods in Enzymology Volumen 437 Páginas 477-98 Elsevier 2008. Trabajos publicados en Revistas Nacionales o de Divulgación 59. La bioinformática estructural o la realidad virtual de los medicamentos. Marcelo A. Martí y Adrian A. Turjanski. Quimica Viva, Número 1, Año 8, Abril 2009.

Regulación de la respuesta inmune celular por proteínas de señalización (Verónica García) 1. María F. Quiroga, Virginia Pasquinelli, Gustavo J. Martínez, Javier O. Jurado, Liliana Castro Zorrilla, Rosa M. Musella, Eduardo Abbate, and Verónica E. García. Inducible Costimulator (ICOS): a modulator of IFN- production in human tuberculosis. The Journal of Immunology, 176:5965-5974. 2006. ISSN: 0022-1767.

16

2. Verónica E. García, H. Eduardo Chuluyan. SLAM and CD31: signaling molecules involved in cytokine secretion during the development of innate and adaptive immune responses. Cytokine and Growth Factor Reviews, 18(1-2): 85-96, 2007. ISSN: 1359-6101 3. Paulo C. Maffia, Sandra E. Zittermann, M. Lucila Scimone, Nancy Tateosian, Nicolás Amiano, Diego Guerrieri, Viviana Lutzky, Diego A. Rosso, Horacio E. Romeo, Verónica E. García, Andrew C. Issekutz and H. Eduardo Chuluyan. Neutrophil elatase converts immature dendritic cells into TGF-B secreting cells and reduces allostimulatory ability. The American Journal of Pathology, 2007 Sep;171(3):928-37 ISSN: 0002-9440. 4. Maria F. Quiroga, Javier O. Jurado, Gustavo J. Martínez, Virginia Pasquinelli, Rosa M. Musella, Eduardo Abbate, Andrew C. Issekutz, Peter A. Sieling, H. Eduardo Chuluyan, Verónica E. García. Cross-talk between CD31 and the signaling lymphocytic activation molecule-associated protein during interferon- gamma production against Mycobacterium tuberculosis. The Journal of Infectious Diseases, 2007, 196:1369-1378. ISSN: 0022-1899. 5. Ankita Garg, Peter F. Barnes, María F. Quiroga, Sugata Roy, Shiping Wu, Verónica E. García, Steven E. Weis, and Ramakrishna Vankayalapati. Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection. European Journal of Immunology, 2008, 38:459-69. ISSN: 0014-2980 6. Javier O. Jurado, Ivana B. Alvarez, Virginia Pasquinelli, Gustavo J. Martínez, María F. Quiroga, Eduardo Abbate, Rosa M. Musella, H. Eduardo Chuluyán, Verónica E. García. PD-1:PD-L1/PD-L2 pathway inhibits T cell effector functions during human tuberculosis". The Journal of Immunology. 2008. Vol: 181: 116-125. 7. Sonia A. Gómez, Claudia L. Argüelles, Diego Guerrieri, Nancy L. Tateosián, Nicolás O. Amiano, Ruth Slimovich, Paulo C. Maffía, Eduardo Abbate, Rosa M. Musella, Verónica E. Garcia*, H. Eduardo Chuluyan*. Secretory leukocyte protease inhibitor: a new secreted pattern-recognition receptor for Mycobacteria. * Igual contribución al trabajo. Am J Respir Crit Care Med. 2009 ;179(3):247-53. ISSN: 1073-449X 8. Virginia Pasquinelli; James C Townsend; Javier O Jurado; Ivana B Alvarez; María F Quiroga; Peter F Barnes; Buka Samten; Verónica García. IFN- production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM and CREB". Journal of Infectious Diseases. 2009;199(5):661-5. Publicaciones en revistas nacionales 9. "Contribución de la respuesta inmune del huésped al control de la infección por Mycobacterium tuberculosis". Revista Química viva. Revista Electrónica del Depto. de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina. Volumen 7. Número 2. Agosto 2008. Capítulos de libros 17

10. Verónica García, Virginia Pasquinelli, Javier Jurado, Ivana Alvarez, Darío Fernández Do Porto. En edición. 2010Fainboim- Geffner. Introducción a la Inmunología Humana. 6ta edición. Capítulo Inmunidad antibacteriana.

Cáncer de próstata: modulación génica e inmunología (Gabriel Rabinovich) a.i.1. GALECTIN-1 SUPPRESSES AUTOIMMUNE RETINAL INFLAMMATION BY PROMOTING CONCOMITANT T HELPER-2- AND T REGULATORY--MEDIATED ANTI-INFLAMMATORY RESPONSES. Marta A. Toscano, Alessandra Commadoro, Juan Ilarregui, Germán Bianco, Ana Liberman, Horacio M. Serra, Jun Hirabayashi, Luis V. Rizzo, Gabriel Rabinovich, Journal of Immunology, (2006) 176 (10)6323-6332. a.i.2. SYNTHETIC LACTULOSE AMINES: NOVEL CLASS OF ANTICANCER AGENTS THAT INDUCE TUMOR-CELL APOPTOSIS AND INHIBIT GALECTINMEDIATED HOMOTYPIC CELL AGGREGATION AND ENDOTHELIAL CELL MORPHOGENESIS. Gabriel Rabinovich, Albana Cumashi, Germán A. Bianco, Domenico Ciavardelli, Ida Iurisci, Maurizia D´Egidio, Enza Piccolo, Nicola Tinari, Nikolay Nifantiev, and Stefano Iacobelli. Glycobiology, (2006) 16: 210-220. a.i.3. OVEREXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE AND CYCLOOXYGENASE- 2 IN RAT ZINC-DEFICIENT LUNG: INVOLVEMENT OF A NFB- DEPENDENT PATHWAY. Nidia N. Gomez, Roberto C. Davicino, Veronica S. Biaggio, German A. Bianco, Silvina M. Alvarez, Patricia Fischer Lucas Masnatta, Gabriel A. Rabinovich, and María S. Gimenez. Nitric oxide, (2006) 14; 30-38. a.i.4. CIRCULATING ANTI-GALECTIN-1 AUTOANTIBODIES ARE ASSOCIATED WITH THE SEVERITY OF OCULAR DISEASE IN AUTOIMMUNE AND INFECTIOUS UVEITIS. Marta Romero, Juan.C. Muiñio, Germán A. Bianco, Mercedes Ferrero, Claudio P. Juarez, José D. Luna and Gabriel Rabinovich. Investigative Ophthalmology & Visual Sciences (2006) 47: 1550-1556. Trabajo distinguido con una editorial "Inside IOVS" de la revista IOVS. a.i.5. HOW DO PROTEIN-GLYCAN INTERACTIONS REGULATE T-CELL PHYSIOLOGY? Marta Toscano, Juan M. Ilarregui, Germán Bianco, Natalia Rubinstein, & Gabriel Rabinovich. Medicina (Buenos Aires) (2006) 2006;66:357-62. a.i.6. IMPACT OF PROTEIN-GLYCAN INTERACTIONS IN THE REGULATION OF AUTOIMMUNE AND CHRONIC INFLAMMATORY DISORDERS. Germán Bianco, Juan M. Ilarregui, Marta A. Toscano, Gabriel Rabinovich, Autoimmunity Reviews . (2006) 5: 349-356. a.i.7. LOW DOSES CYCLOPHOSPHAMIDE MODULATES EXPRESSION AND FUNCTION OF GALECTIN-1 IN AN EXPERIMENTAL LYMPHOMA MODEL. Mariano Zacarías, María J. Rico, Silvia I. Gervasoni, Juan M. Ilarregui, Marta Toscano, 18

Gabriel Rabinovich, Graciela Scharovsky. Cancer Immunoloogy and Immunotherapy. (2007) 56(2):237-48. a.i.8. FROM IMMUNE SURVEILLANCE TO TUMOR IMMUNE ESCAPE: STORY OF AN ENEMY WITH MULTIPLE COUNTERATTACK STRATEGIES. Graciela Scharovsky, Pablo Matar, Mariano Zacarías, María J. Rico, and Gabriel A. Rabinovich. Invitado por la revista Inmunología (España) (2006) 2006; 25(2)101-114. a.i.9. ROLE OF GALECTINS IN CHRONIC INFLAMMATORY MICROENVIRONMENTS.Greg Parsonage, Emily Trebilcolck, Marta Toscano, Germán Bianco, Juan Ilarregui, Christopher Buckley, Gabriel Rabinovich. Future Rheumatology. (2006) 1(4) 441-454. a.i.10. IMMUNOSUPPRESSIVE STRATEGIES THAT ARE MEDIATED BY TUMOR CELLS. Gabriel A. Rabinovich, Dmitry Gabrilovich and Eduardo Sotomayor. Annual Reviews Immunology. (2007) 25: 267-96. a.i.11. A NOVEL FUNCTION FOR GALECTIN-1 AT THE CROSSROAD OF INNATE AND ADAPTIVE IMMUNITY: GALECTIN-1 REGULATES MONOCYTE/ MACROPHAGE PHYSIOLOGY THROUGH A NON-APOPTOTIC ERK-DEPENDENT PATHWAY. Paula Barrionuevo, Macarena Beiger-Bompadre, Juan M Ilarregui, Marta Toscano, Germán Bianco, Martín Isturiz, Gabriel Rabinovich. Journal of Immunology, 2007 178: 436-445. a.i.12. TGF-1 REGULATES GALECTIN-1 EXPRESSION IN METASTATIC MAMMARY ADENOCARCINOMA CELLS: IMPLICATIONS FOR TUMOR-IMMUNE ESCAPE. M. Cecilia Daroqui, Juan M. Ilarregui, Natalia Rubinstein, Mariana Salatino, Marta Toscano, Paula Vazquez, Lidia Puricelli, Elisa Bal de Kier-Joffe, Gabriel Rabinovich,Cancer Immunology and Immunotherapy, 2007 Apr;56(4):491-9. a.i.13. ALTERED EXPRESSION OF GALECTIN-3 INDUCES CORTICAL THYMOCYTE DEPLETION AND PREMATURE EXIT OF IMMATURE THYMOCYTES DURING TRYPANOSOMA CRUZI INFECTION. Elizangela SilvaMonteiro, Luciana Reis-Lorenzato, Oscar Kenji-Nihei, Mara Junqueira, Gabriel A. Rabinovich, Dan Hsu, Fu-Tong Liu, Wilson Savino, Roger Chammas, Dea M. Serra VillaVerde. American Journal of Pathology, 2007;170:546-556. a.i.14. COMPARATIVE STUDY OF THE ANTIINFLAMMATORY, ANTICOAGULANT AND ANTIANGIOGENIC ACTIVITIES OF SELECTED FUCOIDANS ISOLATED FROM BROWN SEAWEEDS. Albana Cumashi, Natalia A. Ushakova, Marina E. Preobrazhenskaya, Armida D'Incecco, Antonio Piccoli, Licia Totani, Nicola Tinari, Galina E. Morozevich, Albert E. Berman, Maria I. Bilan, Anatolii I. Usov, Nadezhda E. Ustuzhanina, Craig J. Sanderson, Maeve Kelly, Gabriel Rabinovich, Stefano Iacobelli, and Nikolay E. Nifantiev. Glycobiology, 2007, 2007 May;17(5):541-52. a.i.15. DISSECTING THE PATHOPHYSIOLOGIC ROLE OF ENDOGENOUS LECTINS: GLYCAN-BINDING PROTEINS WITH CYTOKINE-LIKE ACTIVITY? 19

Marta A. Toscano, Juan M. Ilarregui, Germán Bianco, Diego Croci Russo, Leonardo Campagna, , Mariana Salatino, Gabriel Rabinovich. Cytokines and Growth Factors Reviews 2007; 18, 57-71. a.i.16. CYTOKINES COMING OF AGE IN SOUTH AMERICA. Gabriel Rabinovich. Cytokines and Growth Factors Reviews 2007; 18, 1-3. a.i.17. GALECTINS: MATRICELLULAR GLYCAN-BINDING PROTEINS LINKING CELL ADHESION, MIGRATION AND SURVIVAL. Maria T. Elola, Carlota W. Todel, Gerardo Vasta, Gabriel Rabinovich. Cellular and Molecular Life Sciences 2007 ;64:1670700. a.i.18. DYNAMIC CROSS-TALK BETWEEN TUMORS AND IMMUNE CELLS IN ORCHESTRATING THE IMMUNOSUPPRESSIVE NETWORK AT THE TUMOR MICROENVIRONMENT. Diego O. Croci, Mariano Zacarías Fluck, María J. Rico, Pablo Matar, Gabriel A. Rabinovich, and O. Graciela Scharovsky. Cancer Immunology & Immunotherapy (2007) 56:1687-700. a.i.19. DIFFERENTIAL GLYCOSYLATION OF TH1, TH2 AND TH17 EFFECTOR CELLS SELECTIVELY REGULATES SUSCEPTIBILITY TO CELL DEATH. Marta A. Toscano, Germán A. Bianco, Juan M. Ilarregui, Diego Croci, Jorge Correale, Joseph Hernandez, Norberto W. Zwirner, Francoise Poirier, Eleanor Riley, Linda G. Baum, Gabriel A. Rabinovich. Nature Immunology(2007) 8(8) 825 ­ 834. a) Distinguido como feature article por Nature (www.nature.com). Mes de julio 2007. b) Destacado en la Sección "Research Highlights"(Nature Reviews Immunology 2007;7, 579. c)Distinguido en el sitio "Faculty of 1000 biology" como "Must Read". Top 10 articles. d) Distinguido como ARTICULO DEL MES (agosto 2007) en Nature Glycomics (www.nature.com/glycomics). e) Distinguido en el TOP 10 del sitio de Nature Immunology (Septiembre 2007). a.i.20. AN EMERGING ROLE FOR GALECTINS IN TUNING THE IMMUNE RESPONSE: LESSONS FROM EXPERIMENTAL MODELS OF INFLAMMATORY DISEASE, AUTOIMMUNITY AND CANCER. G. A. Rabinovich, F.T. Liu, M. Hirashima, A. Anderson. Scandinavian Journal of Immunology 2007; 66143-158. a.i.21. TOLERANCE SIGNALING MOLECULES AND PREGNANCY: IDO, GALECTINS AND THE RENAISSANCE OF REGULATORY T CELLS. P. Terness, A. Mellor, G. Chaouat, G. Rabinovich, A. Betz, S. Saito, D. Clarck. American Journal of Reproductive Immunology. 2007;58:238-54. a.i.22. NEURO-ENDOCRINE-IMMUNE DISEQUILIBRIUM AND ENDOMETRIOSIS: AN INTERDISCIPLINARY APPROACH Nadja Tariverdian Theoharis C. Theoharides, Friederike Siedentopf, Gabriela Gutiérrez, Udo Jeschke, Gabriel A. Rabinovich, Sandra M. Blois and Petra C. Arck Seminars in Immunopathology 2007; 29(2) 193-210. a.i.23. Galectin-1 expression in human glioma cells: modulation by ionizing radiation and effects on tumor cell proliferation and migration. Herwig M. Strik, Katharina Schmidt, Paul

20

Lingor, Lars Tonges, Wilfried Kugler, Mirko Nitsche, Gabriel A. Rabinovich, Mathias Bähr. Oncology Reports, 18:483-488. a.i.24. THE AP1-DEPENDENT SECRETION OF GALECTIN-1 BY REEDSTERNBERG CELLS FOSTERS IMMUNE PRIVILEGE IN CLASSICAL HODGKIN LYMPHOMA . Przemyslaw Juszczynski, Jing Ouyang, Jeffery Kutok, Stefano Monti, Wen Chen, Paola Dal Cin, Jeremy Abramson, Kunihiko Takeyama, Todd Golub, Jon Aster, Gabriel Rabinovich, Margaret Shipp. Proceedings of the National Academy of Science USA. (2007) 104: 13134-13139 (Agosto 1 early online publication). a.i.25. INTEGRATING THE UNIVERSE OF REGULATORY CELLS IN CANCER: A MAJOR HURDLE FOR SUCCESSFUL IMMUNOTHERAPY. J. M. Ilarregui, D.O. Croci, M. Salatino, G.A. Bianco, M.A. Toscano and G.A. Rabinovich. Medicina (B Aires)2007;67:25-31. a.i.26. GALECTIN-CARBOHYDRATE LATTICES DURING INNATE AND ADAPTIVE IMMUNE RESPONSES. Gabriel Rabinovich, Marta Toscano, Gerardo Vasta. Current Opinion Structural Biology 2007 17(5):513-520. a.i.27. A PIVOTAL ROLE FOR GALECTIN-1 IN FETO-MATERNAL TOLERANCE. Sandra M. Blois, Juan M. Ilarregui, Mareike Tometten, Mariana García, Arif Suphi Orsal, Rosalia Cordo-Russo, Marta A Toscano, Germán Bianco, Bori Handjiski, Irene Tirado, Udo R. Markert, Francoise Poirier, Julia Szekeres-Bartho, Petra C Arck, Gabriel Rabinovich. Nature Medicine. (2007) 13:1450-1457.a) Distinguido como FEATURE ARTICLE en el area de Inmunología (Diciembre 2007) por Nature (www.nature.com). b) Distinguido con un RESEARCH HIGHLIGHT de Nature Reviews Immunology (mes de Enero 2008) (www.nature.com/nri). c) Distinguido en Nature Functional Glycomics como ARTICULO DEL MES (www.nature.com/glycomics). a.i.28. GALECTINS AS THERAPEUTIC TARGETS IN INFLAMMATORY DISEASES AND CANCER. Mariana Salatino, Diego Croci, Germán Bianco, Juan Ilarregui, Marta Toscano, Gabriel Rabinovich. Expert Opinion Biological Therapies. 2008 8(1):45-57. a.i.29. CONTROL OF DENDRITIC CELL MATURATION AND FUNCTION BY TRIIODOTHYRONINE (T3). Iván Mascanfroni, S. Susperreguy, Juan M. Ilarregui, Susana Montesinos, Laura Cervi, Ana Repiso, Hector Targovnik, Gabriel Rabinovich, Claudia Pellizas. FASEB Journal. (2008); 22:1032-1042. a.i.30. CRITICAL ROLE OF GALECTIN-1 IN THE CONTROL OF PLATELET ACTIVATION. Natalia Pacienza, Roberto G Pozner , Germán A. Bianco, Lina Paola D'Atri, Diego O. Croci, Soledad Negrotto, Elisa Malaver, Ricardo M. Gómez, Mirta Schattner, Gabriel A. Rabinovich. FASEB Journal (2008) 22: 1113-1123. TRABAJO DISTINGUIDO POR 1000 FACULTY BIOLOGY (Junio 2008). a.i.31. GALECTINS: STRUCTURE, FUNCTION AND THERAPEUTIC POTENTIAL. Ri-Yao Yang, Gabriel A. Rabinovich, and Fu-Tong Liu. Expert Reviews Molecular Medicine (2008) 10 doi: 10.1017/S1462399408000719. 21

a.i.32. INTRACELLULAR RETENTION OF MICA IN MELANOMAS PREVENTS RECOGNITION BY NK CELLS: NOVEL TUMOR IMMUNE ESCAPE MECHANISM. Mercedes B Fuertes, Luciana L Molinero, María V Girart, Carolina Domaica, Marcela Barrio, José Mordoh, Gabriel A Rabinovich and Norberto W Zwirner. Journal of Immunology- 2008; 180:4606-4614. a.i.33. APOPTOSIS RESISTANCE IN HIV-1 PERSISTENTLY-INFECTED CELLS IS INDEPENDENT OF ACTIVE VIRAL REPLICATION AND INVOLVES MODULATION OF THE APOPTOTIC MITOCHONDRIAL PATHWAY. Pablo Nicolás Fernández Larrosa, Diego Croci, Diego Riva, Mariel Bibini, Renata Luzzi, Mónica Saracco, Susana Mersich, Gabriel A. Rabinovich, Liliana Martínez Peralta. Retrovirology (2008), 5:19doi:10.1186/1742-4690-5-19. http://www.retrovirology.com/content/5/1/19. a.i.34. AP-1-DEPENDENT GALECTIN-1 EXPRESSION DELINEATES CLASSICAL HODGKIN AND ANAPLASTIC LARGE CELL LYMPHOMAS FROM OTHER TUMORS WITH SHARED MOLECULAR FEATURES. Scott J. Rodig, Jing Ouyang, Przemyslaw Juszczynski, Treeve Currie, Kenneth Law, Donna S. Neuberg, Gabriel A. Rabinovich, Margaret A. Shipp and Jeffery L. Kutok. Clinical Cancer Research (2008) 14: 3338-3344. a.i.35. PROTEIN-GLYCAN INTERACTIONS IN THE CONTROL OF INNATE AND ADAPTIVE IMMUNE RESPONSES. Yvette van Kooyk and Gabriel A. Rabinovich. Nature Immunology, (2008)9,593-601. a.i.36. SILENCING SURVIVIN GENE EXPRESSION INHIBITS PROLIFERATION AND PROMOTES APOPTOSIS OF BREAST CANCER CELLS BY A CASPASEINDEPENDENT PATHWAY. Diego O. Croci, Ingrid S. Cogno, Natalia B. Rumie Vittar, Edgardo Salvatierra, Osvaldo L. Podhajcer, Eduardo Osinaga, Viviana A. Rivarola, Gabriel Rabinovich. Journal of Cellular Biochemistry 2008; 105: 2:381-390. a.i.37. IMMUNOLOGY SOUTH OF THE EQUATOR IN THE AMERICAS. Gabriel A. Rabinovich, Alexis Kalergis, Norberto W. Zwirner, Wilson Savino. Nature Immunology, 2008, 9(10):1087-1090. a.i.38. CRITICAL ROLE OF THE SOLVENT ENVIRONMENT IN GALECTIN-1 BINDING TO ITS SPECIFIC DISACCHARIDE LACTOSE. Santiago Di Lella, Lu Ma, Juan C. Diaz-Ricci, Gabriel A. Rabinovich, Sanford A. Asher, and R. Maria S. Alvarez. Biochemistry, (2009) 48(4):786-91. a.i.39. SYNTHETIC INHIBITORS OF GALECTINS-1 AND -3 SELECTIVELY MODULATE DIFFERENT STEPS OF TUMOR PROGRESSION. Ida Iurisci , Albana Cumashi, , Andrei A. Sherman, Nicola Tinari, Enza Piccolo, Maurizia D'Egidio, Yury E. Tsvetkov, Gabriel A. Rabinovich, Nikolay E. Nifantiev Stefano Iacobelli. Anticancer Research, 2009, 29:1 403-410.

22

a.i.40. DUODENAL INTRAEPITHELIAL INTESTINAL LYMPHOCYTES FROM FOOD ALLERGY PATIENTS SELECTIVELY BIND THE GLYCAN-BINDING PROTEIN GALECTIN-3. Natalia Mercer, Ricardo Drut, Cueto Rua, Liliana Guzman, Marta Toscano, Gabriel Rabinovich, Guillemo H Docena International Journal of Immunopathology and Pharmacology, 2009 22(1):207-217. a.i.41. TURNING `SWEET' ON IMMUNITY: GALECTIN-GLYCAN INTERACTIONS IN IMMUNE TOLERANCE AND INFLAMMATION. Gabriel A. Rabinovich and Marta A Toscano. Nature Reviews Immunology, 2009; 9(5): 338-352. a.i.42. GALECTIN-3 INDUCES A DISTINCTIVE PATTERN OF CYTOKINE AND CHEMOKINE PRODUCTION IN RHEUMATOID SYNOVIAL FIBROBLASTS VIA SELECITVE SIGNALLING PATHWAYS. Andrew D. Filer, Magdalena Bik, Greg N. Parsonage, John Fitton, Emily Trebilcock, Katherine Howlett, Karin Raza, David L. Simons, Mike Salmon, Dagmar Scheel-Toellner, Janet M. Lord, Gabriel A. Rabinovich, Christopher D. Buckley. Arthritis & Rheumatism 2009 60(6):1604-1614. a.i.43. GUIDELINES FOR THE USE AND INTERPRETATION OF ASSAYS FOR MONITORING CELL DEATH IN HIGHER EUKARYOTES. Lorenzo Galluzzi, John Abrams, Emad S. Alnemri, Eric H. Baehrecke, Mikhail V. Blagosklonny, Catherine Brenner, Maria Castedo, Ruggero de Maria, Wafik S. El-Deiry, Simone Fulda, Carmen Garrido, Pierre Golstein, Douglas R. Green, Hinrich Gronemeyer, Michael Hengartner, Marja Jäättelä, Oliver Kepp, Daniel J. Klionsky, Richard A. Knight, Sally Kornbluth, Peter H. Krammer, Sharad Kumar, Stuart A. Lipton, Frank Madeo, Walter Malorni, Patrick Mehlen, Gerry Melino, Eugenia Morselli, Pierluigi Nicotera, Gabriel Nuñez, Josef Penninger, Marcus E. Peter, Mauro Piacentini, Gabriel A. Rabinovich, Guy S. Salvesen, Luca Scorrano, Hans-Uwe Simon, Andreas Strasser, Jürg Tschopp, Peter Vandenabeele, Andreas Villunger, Junying Yuan, Boris Zhivotovsky and Guido Kroemer. Cell Death and Differentiation, 2009, 16(8):1093-107. a.i.44. TUMOR EXPERIENCED-ACTIVATED T CELLS MODULATE NKG2D- AND NKp46-DEPENDENT NK CELL FUNCTIONS THROUGH TROGOCYTOSIS OF SPECIFIC LIGANDS FROM THE TUMOR CELL SURFACE. Carolina I. Domaica, Mercedes Fuertes, Maria V. Girart, Lucas Rossi, Damián Avila, Gabriel Rabinovich and Norberto Zwirner. EMBO Reports (2009) 10: 908­915. a.i.45. CONVEYING GLYCAN-CONTAINING INFORMATION INTO T-CELL HOMEOSTATIC PROGRAMS: A CHALLENGING ROLE OF GALECTIN-1 IN INFLAMMATORY AND TUMOR MICROENVIRONMENTS. G.A. Rabinovich and J.M. Ilarregui Immunological Reviews (2009) 230: 144-159. a.i.46. EMERGING CONCEPTS IN TOLERANCE AND AUTOIMMUNITY: NOVEL THERAPEUTIC APPROACHES. Esteban Ciliberti, Leandro Carambia, Sebastian Cavallin, Osvaldo L. Cerda, Juan J. Poderoso and Gabriel A. Rabinovich. Medicina (B Aires) 2009; 69(4): 460-465.

23

a.i.47. TOLEROGENIC SIGNALS DELIVERED BY DENDRITIC CELLS TO T CELLS VIA A GALECTIN-1-DRIVEN IMMUNOREGULATORY CIRCUIT INVOLVING IL-27AND IL-10. Juan M. Ilarregui, Diego O. Croci, Germán A. Bianco, Marta Toscano, Mariana Salatino, Mónica Vermeulen, Jorge Geffner, Gabriel Rabinovich. Nature Immunology, (2009) 10(9): 981 ­ 991. Distinguido por 1000 Faculty Biology (sitio donde se destacan los mejores trabajos del año en cada área) como EXCEPCIONAL (Puntaje 9.0). Seleccionado entre los Top 10 Articles por Nature Immunology a.i.48. Gérard A, Ghiotto M, Fos C, Guittard G, Compagno D, Galy A, Lemay S, Olive. D, Nunès JA. Dok-4 is a novel negative regulator of T cell activation.(2009) J Immunol, 182(12):7681-7689. Laboratorio de Estudios de estrés osmótico en bacterias Gram positivas (Carmen Sánchez/ Sandra Ruzal) 1. Palomino MM, Sanchez Rivas C and SM Ruzal. High salt stress in Bacillus subtilis: Involvement of PBP4* as a peptidoglycan hydrolase Research in Microbiology (2009) 160:117-124 2. Prado-Acosta M, Palomino MM, Allievi MC, Sanchez Rivas C and SM Ruzal. The Slayer of Lactobacillus acidophilus ATCC 4356 shows Murein Hydrolase Activity Applied and Environmental Microbiology (2008) 74:7824­7827 3. Lopez CS, Alice AF, Heras H, Rivas EA, Sanchez-Rivas C Role of anionic phospholipids in the adaptation of Bacillus subtilis to high salinity. Microbiology. (2006) 152:605-16. Genética y Ecología Microbianas (Beatriz Mendez/ Julia Pettinari) 1. Ayub, N. D.; Pettinari, M. J.; Méndez, BS and N. I. López. 2006.Impaired polyhydroxybutyrate biosynthesis from glucose in Pseudomonas sp. 14-3 is due to a defective beta-ketothiolase gene. FEMS Microbiology. Letters 264:125131. 2. Ruiz J. A, Fernández R. O, Nikel P.I, Méndez B.S & Pettinari M.J. 2006 dye (arc) mutants: insights into an unexplained phenotype and its suppression by the synthesis of poly (3-hydroxybutyrate) in Escherichia coli recombinants. FEMS Microbiol. Lett. 258: 55-60. 3. Nikel P.I, Pettinari M.J, Galvagno M.A and Méndez B.S. 2006. Poly(3 hydroxybutyric Acid) Synthesis by Recombinant Escherichia coli arcA mutants in microaerobiosis. Appl. Environ. Microbiol. 72: 2614-2620. 4. Nikel Pablo Iván, Alejandra de Almeida, Evelia Melillo, Miguel Ángel Galvagno and Ma. Julia Pettinari.(2006). New recombinant Escherichia coli strain tailored for the 24

production of poly(3-hydroxybutyrate) from agroindustrial by-products. Applied and Environmental Microbiology. 72: 3949-3954. 5. de Almeida Alejandra, Beatriz S. Méndez y M. Julia Pettinari (2006) Nuevas oportunidades para productos bacterianos. Revista Industria y Química. 354: 22-25 6. de Almeida Alejandra, Pablo I. Nikel, Andrea M. Giordano, and M. Julia 7. Pettinari (2007). Effects of Granule-Associated Protein PhaP on Glycerol-Dependent Growth and Polymer Production in Poly(3-Hydroxybutyrate)-Producing Escherichia coli. Applied and Environmental Microbiology. 73: 7912-7916. 8. Ayub, N.D., Pettinari, M.J. , Méndez B.S. & N.I. López. 2007. The polyhydroxyalkanoate genes of a stress resistant Antarctic Pseudomonas are situated within a genomic island. Plasmid 58:240-248. 9. Pettinari, M.J., Nikel. P.I., Ruiz, J.A. and Méndez, B. S. 2008. ArcA redox mutants as a source of reduced bioproducts. J. Molec. Microbiol. Biotechnol. 15: 41-47. (review upon invitation by the editors). 10. Nikel. P.I., Pettinari, M.J., Ramírez, C., Galvagno, M. A. and Méndez, B. S. 2008. Escherichia coli arcA mutants: metabolic profile characterization of microaerobic cultures using glycerol as a carbon source. J. Molec. Microbiol. Biotechnol. 15: 48-54. 11. Nikel P.I., Pettinari, M.J., Galvagno, M. A. and Méndez B. S. 2008. Poly(3hydroxybutyrate) synthesis from glycerol by a recombinant Escherichia coli arcA mutant in fed-batch microaerobic cultures Appl. Microbiol. Biotechnol, 77: 1337-1343. 12. Nikel. P.I., de Almeida A, Pettinari, M.J. and Méndez B. S. 2008. The Legacy of HfrH: Mutations in the Two-Component System CreBC are responsible for the Unusual Phenotype of an Escherichia coli arcA Mutant. J.Bacteriol.190: 3004-3007. 13. Nikel. P.I,. Zhu J, San K-Y, Méndez, B. S, and Bennett, G.N. 2009. Metabolic Flux Analysis of Escherichia coli creB and arcA Mutants Reveals Shared Control of Carbon Catabolism under Microaerobic Growth Conditions. J. Bacteriol. 5538-5548. 14. López, N.I., Pettinari, M.J., Stackebrandt, E., Tribelli, P.M.,Potter, M., Steinbüchel, A. and B.S. Méndez 2009. Pseudomonas extremaustralis sp. nov. a polyhydroxybutyrateproducer isolated from Antarctic environments. Current Microbiology 59: 514-519.

Laboratorio de Biotecnología Ambiental y Ecología Bacteriana (Nancy Lopez) 1. Ayub, N.D., Tribelli,P.M. and N.I. López. 2009. Polyhydroxyalkanoates are essential for maintenance of redox state in the Antarctic bacterium Pseudomonas sp. 14-3 during low-temperature adaptation. Extremophiles, 13:59-66. 25

2. Raiger Iustman, L.J. y N.I. López. 2009. Los biosurfactantes y la industria petrolera. Revista Química Viva. Número 3, año 8, Diciembre . Revista electrónica del Departamento de Química Biológica. FCEyN. UBA. ISSN 1666-7948. www.quimicaviva.qb.fcen.uba.ar.

Laboratorio de Fisiología celular de la Eritropoyetina (Alcira Nesse) 1. Pregi N, Wenker S, Vittori D, Perez Leiros C, Nesse A (2009). TNF-alpha-induced apoptosis is prevented by erythropoietin treatment on SH-SY5Y cells. Exp Cell Res 315:419-431. 2. Pregi N, Vittori D, Perez G, Perez Leiros C, Nesse A. (2006) Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells. Biochim Biophys Acta 1763: 238-246. 3. Callero M, Pérez G, Vittori D, Pregi N, Nesse A. Modulation of tyrosine phosphatase 1B by erythropoietin in UT-7 cell line. Cell Physiol Biochem 20:319-28, 2007. ISSN: 1015­8987. 4. Pérez G, Romero MC, Trigo P, Lendoire J, Imventarza O, Nesse A. Polineuropatía amiloidótica familiar tipo I. Diagnóstico en la Argentina. Medicina (Bs As) 68:273-81, 2008. ISSN 0025-7680. 5. Calafat M, Larocca L, Roca V, Hauk V, Pregi N, Nesse A, Pérez Leirós C. Vasoactive intestinal peptide inhibits TNF--induced apoptotic events in acinar cells from non obese diabetic mice submandibular glands. Arthritis Research & Therapy 11(2):1-10, 2009 (http://arthritis-research.com/content/11/2/R53). ISSN 1478-6354. Laboratorio de Apoptosis en el Sistema Nervioso-Nanooncología (Mónica Kotler) 1. Magariños, M.P.; Sánchez-Margalet, V.; Kotler, M.L.; Calvo, J.C. & Varone, C.L. Leptin promotes cell proliferation and survival of trophoblastic cells Biol. Reprod. (2007) 76 (2) 203-210. 2. Gonzalez, L.E., Juknat A.A., Venosa A., Verrengia N. & Kotler M.L Manganese activates the mitochondrial apoptotic pathway in rat astrocytes by modulating the expression of proteins of the Bcl-2 family Neurochem. Int. (2008) 53, 408-415. 3. Llansola Portolés, M.; Rodriguez Nieto, F.; Soria, D.; Amalvy, J.; Peruzzo, P.; Mártire, D.; Kotler, M.L.; Holub, O; Gonzalez, M. Photophysical properties of blue ­ emitting silicon nanoparticles The Journal of Physical Chemistry C (2009) 113 (31), 13694­13702.

26

Laboratorio de Apoptosis y Cáncer (Elba Vázquez/ Adriana De Siervi) 1. Gueron G, De Siervi A, Ferrando M, Salierno M, De Luca P, Elguero B, Meiss R, Navone N, Vazquez ES. Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells. 2009 Mol Cancer Res. 7(11):1745-55. 2. Becher E., Toblli J., Castruonovo C., Nolazco C., Rosenfeld C., Grosman H., Vazquez E., Mazza O. Expression of caveolin-1 in penile cavernosal tissue in a denervated animal model after treatment with sidenafil citrate. 2009 J. Sex. Med. 6: 1587-93. 3. Li ZG, Mathew P, Yang J, Starbuck M, Zurita A, Liu J, Sikes Ch., Multani A, Efstathiou E, Lopez A, Wang J, Fanning T, Prieto V, Kundra V, Vazquez E, Troncoso P, Raymond R, Logothetis C, Lin S-W, Maity S, Navone N. Androgen Receptor­Negative Human Prostate Cancer Cells Induce Osteogenesis through FGF9- Mediated Mechanisms. 2008 J. Clin. Invest. 118: 2697-2710. 4. Li ZG, Yang J, Vazquez ES, Rose D, Vakar-Lopez F, Mathew P, Lopez A, Logothetis CJ, Lin S-H & Navone NM. Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone 2008 Oncogene 27: 596-603 5. Sacca P., Meiss R., Casas G., Mazza O., Calvo JC., Navone N., Vazquez E. Nuclear translocation of heme oxygenase-1 is associated to prostate cancer. 2007 Br. J. Cancer 97: 1683-9. 6. Castronuovo C., Sacca P., Meiss R., Caballero A., Batlle A. & Vazquez E. Homeostatic response under carcinogen withdrawal, heme oxygenase 1 expression and cell cycle association. 2006 BMC Cancer 6, 286-295. 7. Byun JS, Wong MM, Cui W, Idelman G, Li Q, De Siervi A, Bilke S, Haggerty CM, Player A, Wang YH, Thirman MJ, Kaberlein JJ, Petrovas C, Koup RA, Longo D, Ozato K, Gardner K. Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes. Proc Natl Acad Sci USA. 106(46):19286-91 (2009). 8. De Siervi A, De Luca P, Moiola C, Gueron G, Tongbai R, Chandramouli GV, Haggerty C, Dzekunova I, Petersen D, Kawasaki E, Kil WJ, Camphausen K, Longo D, Gardner K. Identification of new Rel/NFkappaB regulatory networks by focused genome location analysis. Cell Cycle. 8(13):2093-100 (2009). 9. Macias E, Miliani de Marval PL, De Siervi A, Conti CJ, Senderowicz AM, RodriguezPuebla ML. CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development. Am J Pathol. 173(2):526-35 (2008). 10. Ge Y, Byun JS, De Luca P, Gueron G, Li QQ, Yabe IM, Sadiq-Ali SG, Figg WD, Quintero J, Haggerty CM, De Siervi A, Gardner K. Combinatorial anti-leukemic disruption of oxidative homeostasis and mitochondrial stability by the redox reactive thalidomide CPS49 and flavopiridol. Mol Pharmacol. 74(3):872-83 (2008).

27

Laboratorio de Biología tumoral (Rosa Wainstok) 1. Gazzaniga S., Bravo A.I., Mordoh J., Wainstok R. Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma. Acta Bioquím Clin Latinoam 40, 463467; 2006 2. Gazzaniga S., Bravo A. I., Guglielmotti A., van Rooijen N., Maschi F.,Vecchi A., Mantovani A., Mordoh J., Wainstok R. Targeting Tumor-Associated Macrophages and Inhibition of MCP-1 Reduce Angiogenesis and Tumor Growth in a Human Melanoma Xenograft. Journal of Investigative Dermatology 2007, 127(8):2031-41. 3. Von Euw E., Barrio M.M., Furman D., Bianchini M., Levy E.M., Yee C., Li Y., Wainstok R., Mordoh J. Monocyte- derived dendritic cells loaded with a mixture of apoptotic/necrotic melanoma cells efficiently cross-present gp100 and MART-1antigens to specific CD8+ T lymphocytes. Journal of Translational Medicine 2007, 5:19 4. Von Euw E., Barrio M.M., Furman D., Levy E.M., Bianchini M., Peguillet I., Lantz O., Vellice A., Kohan A., Chacón M., Yee C., Li Y., Wainstok R., Mordoh J.A fase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogenic apoptotic/ necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10-1082 promoter genotype as predictor of disease progression. Journal of Translational Medicine 2008, 6: 6

Laboratorio de Hemostasia y Trombosis (Lucía Kordich) 1. Quintana IL, Oberholzer MV, Kordich L, Lauricella AM. Impaired fibrin gel permeability by high homocysteine levels. Thrombosis Research. 2009 Sep 9.ISSN 00493848, DOI: 10.1016/j.thromres.2009.08.013. 2. Ana María Rojas, Lucía Kordich, Ana María Lauricella. Homocysteine modifies fibrin clot deformability. Another possible explanation of harm. Biorheology. 2009; 46(5): 37987. 3. Lauricella AM, De Panis DN, Arín A, Rosa G. Importancia de la estructura de la fibrina en su lisabilidad: Estudio en distintas situaciones patológicas" Hematológica (ISSN 1138-0381) (ed. esp.). 2009, 94 (Extraordinario Nº 1) 428-432. 4. Trimarchi H, Duboscq C, Genoud V, Lombi F, Muryan A, Young P, Schwab M, Castanon M, Rodriguez-Reimundes E, Forrester M, Pereyra H, Campolo-Girard V, Seminario O, Alonso M, Kordich L. Plasminogen activator inhibitor-1 activity and 4G/5G polymorphism in hemodialysis. The Journal of Vasccular Access. 2008 Apr-Jun;9(2):1427.

28

5. Quintana I., Lauricella A., Castañon M., Genoud V., Sassetti B., Kordich L. Trombosis: Conocerla para evitarla. Revista Industria y Química. 2008; 357: 9-11. 6. Castañon MM, Gamba C, Kordich L. Insight into the profibrinolytic activity of dermatan sulfate: effects on the activation of plasminogen mediated by tissue-type and urinary-type plasminogen activator. Thrombosis Research 2007; 120, 745-752. 7. Castañon MM, Lauricella AM, Kordich L, Quintana I. Plasma homocysteine cut-off values associated to venous thrombosis. Clinical Chemistry and Laboratory Medicine 2007; 45 (2): 232-6. 8. Lauricella AM. Variabilidad de las Redes de Fibrina. Acta Bioquímica Clínica Latinoamericana (ISSN 0325- 2957) 2007; 41 (1): 7- 19. 9. Ciancia M, Quintana I, Vizcargüénaga MI, Kasulin L, De Dios A, Estevez J Cerezo A. Polysaccharides from the green seaweed Codium fragile and C. vermilara with controversial effects on hemostasis. Internacional Journal of Biological Macromolecules (ISSN 0141- 8130) 2007; 41 (5): 641- 649. 10. Lauricella A, Quintana I, Castañon M, Sassetti B, Kordich L. Influence of Homocysteine on fibrin network lysis. Blood Coagulation and Fibrinolysis 2006, 17: 181186 11. Castañon M., Lauricella AM., Genoud V., Quintana I. Importancia de la Determinación de Homocisteinemia y MTHF Reductasa. Acta Bioquímica Clínica Latinoamericana (ISSN 0325- 2957) 2006; 40 (3): 335-339. 12. Ana María Lauricella. La Homocisteína Modifica las Redes de Fibrina. Revista Química Viva. Diciembre 2006, vol. 5, Número 003, pp. 56-72. Universidad de Buenos Aires. 13. Ciancia M, Quintana I, Vizcargüénaga MI, , Kasulin L, De Dios A, Estevez J Cerezo A. Polysaccharides from the green seaweed Codium fragile and C. vermilara with controversial effects on hemostasis. Internacional Journal of Biological Macromolecules (ISSN 0141- 8130) 2007; 41 (5): 641- 649.

Laboratorio de Inmunofarmacología (Claudia Perez Leirós) 1. Roca V, Calafat M, Larocca L, Ramhorst R, Farina M, Franchi AM, Perez Leiros C (2009). Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice. Reproduction 138:733-742. 2. Fraccaroli L, Alfieri J, Leiros CP, Ramhorst R (2009). Immunomodulatory effects of chemokines during the early implantation window. Front Biosci (Elite Ed). 1:288-298.

29

3. Calafat M, Larocca L, Roca V, Hauk V, Pregi N, Nesse, A, Perez Leiros C (2009). Vasoactive intestinal peptide inhibits TNF-¦Á-induced apoptotic events in acinar cells from nonobese diabetic mice (NOD) submandibular glands. Arthritis Res Ther. 11:R53 (pp1-10). 4. Fraccaroli L, Alfieri J, Larocca L, Calafat M, Roca V, Lombardi E, Ramhorst R, Perez Leiros C (2009). VIP modulates the pro-inflammatory maternal response inducing tolerance to trophoblast-cells. Br J Pharmacol 156:116-126 5. Fraccaroli L, Alfieri J, Larocca L, Calafat M, Mor Gil, Perez Leiros C, Ramhorst R. (2009) A potential tolerogenic immune mechanism by trophoblast cells through the activation of chemokine-induced T cell death and regulatory T cell modulation. Human Reproduction 24:166-175. 6. Larocca L, Ramhorst R, Roca V, Calafat M, Aisemberg J, Franchi A, Perez Leiros C (2008). Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: focus on macrophage activation. Neuroimmunomodulation 15:84-90. 7. Calafat M, Larocca L, Roca V, Perez Leiros C (2007). NOD mice exocrinopathy: towards a neuroimmune link. Neuroimmunomodulation. 14:175-181. 8. Larocca L., Calafat M, Roca V, Franchi, A, Perez Leiros C (2007). VIP limits LPSinduced nitric oxide production through IL-10 in NOD mice macrophages. Int. Immunopharmacol. 7:1343-1349. 9. Roca V, Larocca L, Calafat M, Aisemberg J, Meiss R, Franchi AM, Perez Leiros C (2006). Reduced nitric oxide synthase and cyclo-oxygenase activity in the uterus of NOD mice. Reproduction 132: 931-938, 2006. 10. Rosignoli F, Torroba M, Juarranz Y, Garcia Gomez M, Martinez C, Gomariz RP, Perez Leiros C, Leceta J (2006). VIP tolerante induction in autoimmunity. Ann N Y Acad Sci USA 1070:525-530.

Laboratorio de Metabolismo del hemo: Porfirias y enfermedades relacionadas (Victoria Parera/ María Victoria Rossetti) 1. Lavandera, J.; Parera, V.; Batlle, A. & Buzaleh, A.M. CYP2D6 polymorphisms in patients with porphyrias. Mol. Med. 12 (9-10) (2006):259-263. 2. Lavandera, J.; Batlle, A. & Buzaleh, A.M. Metabolization of porphyrinogenic agents in brain: involvement of the Phase I drug metabolizing system. A comparative study in liver and kidney Cell. Mol. Neurobiol. 27 (2007) 717-729 3. Buzaleh, A.M.; Morán-Jiménez, M.J.; García-Bravo, M.; Sampedro, A.; Batlle A., Enríquez de Salamanca R. & Fontanellas, A. Induction of Hepatic Aminolevulinate Acid

30

Synthetase Activity by Isoflurane in a Genetic Model for Erythropoietic Protoporphyria. Cell. Mol. Biol 55 (1) (2009), 38-44 4. Lavandera, J.; Fossatti, M.; Azcurra, J.; Batlle, A. & Buzaleh, A.M. Glutamatergic System: another target for the action of porphyrinogenic agents. Cell. Mol. Biol 55 (1) (2009) 23-28. 5. Martinez, M. del C.; Afonso, S.G.; Meiss, R.; Buzaleh, A.M. & Batlle, A. Hepatic damage and oxidative stress induced by griseofulvin in mice. Cell. Mol. Biol 55 (2) (2009) 121-133 6. Sampayo, R.; Lavandera, J.; Batlle, A. & Buzaleh, A.M. Sevoflurane: its action on heme metabolism and Phase I drug metabolizing system. Cell. Mol. Biol 55 (2) (2009) 134-140. Corresponding author: Buzaleh A.M. 7. Melito, V.; Rossetti, M.V.; Parera, V. y Batlle, A. Porfirias poco frecuentes. Casos detectados en la población argentina. Revista Argentina de Dermatología 87 (2006), 248263. 8. Melito, V.; Parera, V.; Rossetti, M.V. y Batlle, A. Manifestación de porfiria cutánea tardía en pacientes infectados con el virus de la inmunodeficiencia humana. Acta Bioquím Clín Latinoam 40 (2006), 29-34. 9. Rossetti, M.V.; Parera,V; Melito, V y Batlle, A. Porfiria Congénita Eritropoyética en la Argentina: 4 niños y un caso de manifestación tardía. Acta Bioquím Clín Latinoam 41 (2007), 1-9. 10. Granata, B.; Parera,V; Melito, V; Teijo, M.J.; Batlle, A. y Rossetti, M.V The very first description of a patient with Hepatoerythropoietic Porphyiria in Argentina. Biochemical and molecular studies. Cell Mol Biol (Noisy-le-grand) 2009 Feb 16; 55(1):61-5. 11. Martinez M. del C., Afonso S.G.; Meiss R.P, Buzaleh, A.M.; Batlle, A. HEPATIC DAMAGE AND OXIDATIVE STRESS INDUCED BY GRISEOFULVIN IN MICE. Cell Mol Biol (Noisy-le-grand). 2009 Jul 1; 55(2):127-39. ISSN: 1165-158X 12. Diez B, Cordo Russo R, Teijo MJ, Hajos S, Battle A, Fukuda, H. ROS production by endogenously generated Protoporphyrin IX in murine leukemia cells. Cellular and Molecular Biology. (2009) 55:15-19 13. Alvarez MG, Milanesio ME, Rivarola V, Durantini E, Batlle A, Fukuda H. Endogeneous and exogeneous porphyrins as photosensitizers in the HEP-2 human carcinoma cell line. Cellular and Molecular Biology. (2009) 55:8-14 14. Di Venosa G, Hermida L, Fukuda H, Defain MV, Rodriguez L, Mamone L, MacRobert A, Casas A, Batlle A. Comparation of liposomal formulations of ALA Undecanoyl ester for its use in photodynamic therapy. J Photochem Photobiol B: Biol (2009) 96:152-158 31

15. Casas A, Battah S, Di Venosa G, Dobbin P, Rodriguez L, Fukuda H, Batlle A, MacRobert AJ. Sustained and efficient porphyrin generation in vivo using dendrimer conjugates of 5-ALA for photodynamic therapy. J Control Release (2009) 135 (2) 136-143 16. Di Venosa G, Hermida L, Batlle A, Fukuda H, Defain MV, Mamone L, Rodriguez L, MacRobert A, Casas A. Characterization of liposomes containing aminolevulinic acid and derived esters. J Photochem Photobiol B: Biol (2008) 92(1) 1-9 17. Alvarez MG, Lacelli S, Rivarola V, Batlle A, Fukuda H. 5-aminolevulinic acidmediated photodynamic therapy on Hep-2 and MCF-7c3 cells. Journal Environmental Pathology, Toxicology and Oncology. (2007) 26 (2):75-82 18. Fukuda H, Casas, Batlle A. Use of ALA and ALA derivatives for optimizing ALAbased Photodynamic Therapy: a review of our experience. Journal Environmental Pathology, Toxicology and Oncology (2006) 25 (1-2):127-143 19. Di Venosa G, Batlle A, Fukuda H, MacRobert A, Casas A. Distribution of 5aminolevulinic acid derivatives and induced porphyrin kinetics in mice tissues. Cancer Chemoter Pharmacol (2006) 58(4):4784-86. 20. Di Venosa G, Fukuda H, Batlle A, MacRobert A, Casas A. Photodynamic Therapy: Regulation of porphyrin synthesis and hydrolysis from ALA esters. J Photochem Photobiol B: Biol (2006) 83:129-136 21. Di Venosa G, Casas A, Battah S, Dobbin P, Fukuda H, MacRobert A, Batlle A. Investigation of a novel dendritic derivative of aminolevulinic acid for photodynamic therapy. Int J Biochem Cell Biol (2006) 38: 82-91 22. CICCARELLI A., ARAUJO L., BATLLE A. & LOMBARDO E. Effect of haemin on growth, protein content and the antioxidant defence system in Trypanosoma cruzi. Parasitology (2007) 134: 959-965. 23. CICCARELLI A, BOLLINI M.,BRUNO A., BATLLE A. & LOMBARDO E. Caracterización de la actividad tripanomicida del derivado M129 de imidazoisoquinolinona. Medicina (2007) 67 Supl. III. Comun. 118. 24. CICCARELLI A, BATLLE A & LOMBARDO E. Efecto de la vitamina B12 sobre cultivos de epimastigotes de Trypanosoma cruzi. Medicina (2008) 68 Supl. II. Comun. 128. Laboratorio de Química de Proteoglicanos y Matriz Extracelular (Juan C. Calvo/ Cecilia Varone) 1. Zallocchi Marisa L., Maria C. Damasco, Juan C. Calvo, Carlos P. Lantos and Laura B. Matkovic'"MDCK cells express 5HT-regulable 11ß-hydroxysteroid dehydrogenase type 2". Biocell 30:469-477. 2006. 32

2. Marisa L. Zallocchi, Maria C. Damasco, Juan C. Calvo, Carlos P. Lantos and Laura B. Matkovic. MDCK cells express 5HT-regulable 11ß-hydroxysteroid dehydrogenase type 2 Biocell 30 (3): 469-477, 2006 3. Magariños MP, Sanchez-Margalet V, Kotler M, Calvo JC, Varone C. Leptin promotes cell proliferation and survival of trophoblastic cells. Biology of Reproduction 76 (2): 203210, 2007 4. Julianelli VL, Guerra LN, Calvo JC Cell-cell communication between mouse mammary epithelial cells and 3T3- L1 preadipocytes: effect on triglyceride accumulation and cell proliferation. Biocell 31 (2): 237-245, 2007 5. Cynthia F. Zizola, Vanina Julianelli, Gabriel Bertolesi, Masaki Yanagishita, Juan Carlos Calvo.Role of PG-M proteoglycan and hyaluronic acid that accompany the differentiation of 3T3-L1 preadipocytes with isobutylmethylxanthine, dexamethasone and insulin.Matrix Biology 26 (6): 419-430, 2007 6. P Sacca, R Meiss, G Casas, O Mazza, JC Calvo, N Navone and E Vazquez Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer. British Journal of Cancer 97 (12): 1683-1689, 2007 7. Eleonora Pagano, Omar Coso and Juan Carlos Calvo. Down-modulation of erbB2 activity is necessary but not enough in the differentiation of 3T3-L1 preadipocytes.Journal of Cellular Biochemistry, 104 (1): 274-285, 2008 8. M Romanato, V Julianelli, M Zappi, L Calvo and JC Calvo. The presence of heparan sulfate in the mammalian oocyte provides a clue to human sperm nuclear decondensation in vivo. Human Reproduction 23(5):1145-1150, 2008 9. Perez-Perez, Antonio; Maymó, Julieta; Dueñas, José Luis; Goberna, Raimundo; Calvo, Juan; Varone, Cecilia; Sanchez-Margalet, Victor.Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway. Archives of Biochemistry and Biophysics, 477(2):390-5, 2008 10. Julieta L. Maymó, Antonio Pérez Pérez, Víctor Sánchez-Margalet, José L. Dueñas, Juan Carlos Calvo and Cecilia L. Varone. Upregulation of placental leptin by human chorionic gonadotropin. Endocrinology 150(1):304-13 (2009) 11. Paula Alejandra Sacca, Virginia Pistone Creydt, Amelia Julieta Tesone, Juan Carlos Calvo. A novel and alternative in vitro method using microwave to study the epithelialstromal interactions. Scientific Research and Essay 4(12): 1487-1495 (2009) 12. María Paula Magariños, Víctor Sánche-Margalet, Mónica Kotler, Juan Carlos Calvo and Cecilia L. Varone. Leptin promotes cell proliferation and survival of trphoblastic cells. (2007). Biol. of Reprod.76:203-210 ISSN: 1529-7268 33

13. Antonio Pérez-Pérez, Julieta Maymó, José L. Dueñas, Raimundo Goberna, Juan Carlos Calvo, Cecilia Varone and Víctor Sánchez-Margalet. Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway. (2008) Arch of Biochem. and Biophys. 477: 390-395 ISSN 0003-9861 14. Julieta L. Maymó, Antonio Pérez Pérez, Víctor Sánchez-Margalet, José L. Dueñas, Juan Carlos Calvo and Cecilia L. Varone. Upregulation of placental leptin by human chorionic gonadotropin. (2009) Endocrinology. 150:304-13 ISSN 0013-7227 15. Antonio Pérez Pérez, Julieta L. Maymó, Yésica Gambino, José L. Dueñas, Raimundo Goberna, Cecilia L. Varone, Víctor Sánchez-Margalet. Leptin stimulates protein synthesis activating translation machinery in human trophoblastic cells. Biology of Reproduction (2009) 81:826-832 Laboratorio de estrés ambiental antropogénico (Norma Casabé) 1. Casabé, N.; Piola, L.; Fuchs, J.; Oneto, M. L.; Pamparato, L.; Basack, S.; Giménez, R.; Massaro, R.; Papa, J. C.; Kesten, E. Ecotoxicological assessment of the effects of glyphosate and chlorpyrifos in an argentine soya field. JSS- Journal of Soils & Sediments, 7 (4), 232-239, 2007. 2. Giménez, R.; Massaro, R.; Papa, J. C.; Fuchs, J.; Piola L.; Casabé, N.; Oneto, M. L.; Basack, S.; Pamparato, L.; Kesten E. Impacto del uso de agroquímicos y actividad biológica de organismos del suelo. En Capítulo 3: Toxicología Experimental del 3º Libro SETAC LA "Química y Toxicología Ambiental en América Latina. Desafíos, perspectivas y nuevos enfoques". Editorial SETAC, Editor: Jorge Herkovits, Buenos Aires, 70-72, 2009. 3. Piola, L.; Fuchs, J.; Basack S.; Oneto M. L.; Pamparato L.; Kesten E.; Casabé, N. Efectos subletales en lombrices Eisenia fetida andrei expuestas a suelos agrícolas tratados con glifosato y clorpirifos. En Capítulo 3: Toxicología Experimental del 3º Libro SETAC LA "Química y Toxicología Ambiental en América Latina. Desafíos, perspectivas y nuevos enfoques". Editorial SETAC, Editor: Jorge Herkovits, Buenos Aires, 79-82, 2009 4. Piola, L.; Fuchs, J.; Oneto M. L.; Basack S.; Giménez, R.; Massaro, R.; Papa J. C.; Kesten E.; Casabé, N.; Pesquisa. Biomarkers for the assessment of chlorpyrifos effects on earthworms and on soil functional parameters. Agropecuária Brasileira, 44 (8), 874-880, 2009.

Laboratorio de Toxicología y Química Legal: Destino y efectos de contaminantes químicos (Noemí Verrengia) 1. Kristoff Gisela, Noemi Verrengia Guerrero, Ana María Pechén de D´Angelo, Adriana Cochón Inhibition of cholinesterase activity by azinphos-methyl in two freshwater 34

invertebrates: Biomphalaria glabrata and Lumbriculus variegatus.. Toxicology 222 (2006) 185-194. 2. Cochón Adriana C., Angela B. Della Penna, Gisela Kristoff, María N. Piol, Leonor C. San Martín de Viale, Noemí R. Verrengia Guerrero.Differential effects of paraquat on oxidative stress parameters and polyamine levels in two freshwater invertebrates. Ecotoxicology and Environmental Safety 68 (2007) 286-292. 3. Kristoff Gisela, Noemí R. Verrengia Guerrero, Adriana C. Cochón.Effects of azinphosmethyl exposure on enzymatic and non-enzymatic antioxidant defenses in Biomphalaria glabrata and Lumbriculus variegatus. Chemosphere. 72 (2008) 1333-1339. 4. Verrengia Guerrero N. R. (2007).Predicting the uptake and bioaccumulation of organic pollutants from natural sediments.En: Environmental Pollution: New Research, R. H. Plattenberg (editor), Editorial Nova Science Publishers, Nueva York. Chapter 5, pp. 141184. 5. Guerrero N.R. Verrengia and P.E. Lombardi (2009).Is ALA-D activity a useful biomarker of lead exposure for field monitoring programs? En: Aquatic Ecosystem Research Trends, G.H. Nairne (editor), Editorial Nova Science Publishers, New York. Chapter 7, pp. 217-261. 6. Miño L.A., S. Folco, A.M. Pechén de D'Angelo, N.R. Verrengia Guerrero (2006). Modeling lead bioavailability and bioaccumulation by Lumbriculus variegatus. Potential use in chemical remediation processes. Chemosphere 63: 261-268. 7. Kristoff G., N. Verrengia Guerrero, A.M. Pechén de D'Angelo, A.C. Cochón (2006).Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus.Toxicology 222, 185-194. 8. Ansaldo M., D.E. Nahabedian, E. Holmes-Brown, M. Agote, C.V. Ansay, N.R.Verrengia Guerrero, E.A. Wider (2006).Potential use of glycogen level as biomarker of chemical stress in Biomphalaria glabrata.Toxicology 224, 119-127. 9. Piol M.N.. A.G. López, L.A., Miño, M. dos Santos Afonso, N.R. Verrengia Guerrero (2006). The impact of particle-bound cadmium on bioavailability and bioaccumulation: A pragmatic approach. Environmental Science and Technology 40, 6341-6347. 10. Verrengia Guerrero N.R., M.G. Taylor, K. Simkiss (2007).Modelling 2,4dichlorophenol bioavailability and bioaccumulation by the freshwater fingernail clam Sphaerium corneum using artificial particles and humic acids. Environmental Pollution 145, 238-244. 11. Cochón A.C., A.B. Della Penna, G. Kristoff, M.N. Piol, L.C. San Martín de Viale, N.R. Verrengia Guerrero (2007) Differential effects of paraquat on oxidative stress parameters and polyamine levels in two freshwater invertebrates. Ecotoxicology and Environmental Safety 68, 286-292. 35

12. Kristoff G., N.R. Verrengia Guerrero, A.C. Cochón (2008)Effects of azinphos-methyl exposure on enzymatic and non-enzymatic antioxidant defenses in Biomphalaria glabrata and Lumbriculus variegatus. Chemosphere 72, 1333-1339. 13. Gonzalez L.E., A.A. Juknat, A.J. Venosa, N. Verrengia, M.L. Kotler (2008).Manganese activates the mitochondrial apoptotic pathway in rat astrocytes by modulating the expression of proteins of the Bcl-2 family Neurochemistry International, 53, 408-415. 14. Kristoff G., N.R. Verrengia Guerrero, A.C. Cochón. Inhibition of cholinesterases and carboxylesterases of two invertebrate species, Biomphalaria glabrata and Lumbriculus variegatus, by the carbamate pesticide carbaryl.Aquatic Toxicology 96, 115-123. 15. Verrengia Guerrero N.R., N.B. Casabé, M.L. Oneto, E.M. Kesten (2006). Capacitación en Toxicología Ambiental ¿Por qué, cómo, cuándo? Boletín de la Asociación Toxicológica Argentina. Año 20, Nº 74: 11-16. 16. "Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus." Kristoff, G., Verrengia Guerrero, N.R., Pechén DÁngelo, A.M. and Cochón, A. Toxicology 222: 185-194, 2006. 17. "Differential effects of paraquat on oxidative stress parameters and polyamine levels in two freshwater invertebrates." Cochón, A., Della Penna, A.B., Kristoff, G., Piol, M.N., San Martín de Viale, L.C. and Verrengia Guerrero, N.R. Ecotoxicology and Environmental Safety, 68: 286-292, 2007. 18. Effects of azinphos-methyl exposure on enzymatic and non-enzymatic antioxidant defenses in Biomphalaria glabrata and Lumbriculus variegatus." Kristoff, G.; Verrengia Guerrero, N., Cochón, A. Chemosphere, 72: 1333-1339, 2008. Laboratorio de Toxicología de Mezclas Químicas (Marcelo Wolanksy) 1. Wolansky, M., Gennings, C., Crofton, K. Cumulative risk of pyrethroids: Relative potencies for acute effects on motor function in rats. Toxicol. Sci. 89 (1): 271-7, 2006. 2. Crofton, K., Harrill, J.A Wolansky, M. Comments on: Prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cythochrome P450s in the brain and liver of offsprings [Johri et al. Toxicol. Appl. Pharmacol. 214: 279-289, 2006], Toxicol. Appl. Pharmacol. 218 (1): 96-97; author reply 98. 3. Wolansky, M., McDaniel, K., Moser, V.C., Crofton, K.M. Influence of dose volume on the neurotoxicity evoked by bifenthrin. Neurotoxicology and Teratology 29 (3): 377-84, 2007. 4. Wolansky, M., Harrill, J.A. Neurobehavioral toxicology of pyrethroid insecticides in adult animals: A critical review. Neurotoxicology and Teratology 30 (2): 55-78, 2008. 36

5. Wolansky, M.J., Gennings, C., DeVito, M.J., Crofton, K.M. Evidence for Dose Additive Effects of Pyrethroids on Motor Activity in Rats. EHP 117 (10): 1563-1570, 2009.

Bioquímica y Biología del virus Junin (Nélida Candurra) 1. Martinez M.G. , S. M. Cordo, N.A. Candurra Characterization of Junín arenavirus cell entry Journal of General Virology, 88: 1776-1784, 2007. 2. Martinez M.G. , S. M. Cordo, N.A. Candurra. Involvement of cytoskeleton in Junin virus entry. Virus Research, 138: 17-25, 2008. 3. Martinez,M.G. M. B. Forlenza, N.A. Candurra. Involvement of cellular proteins in Junin arenavirus entry. Biotechnol. J, 4: 866-870, 2009 Libros 1. Coto C. C. y N. A. Candurra. Cultivos celulares: que saber y como hacer Editado por la Federación Bioquímica de la Provincia de Buenos Aires, Acta Bioquímica Clínica Latinoamericana. Sup. Nro. 1, Año 2006. 2. Coto, C. E Candurra, N. A. En el libro: Cultivos celulares: qué saber y qué hacer. (Ed). Editado por la Federación. Bioquímica de la Provincia de Buenos Aires, Acta Bioquímica Clínica Latinoamericama. Sup. Nro. 1, Marzo de 2006. Capítulos: 6,7, 13 y 15, p. 53-62, 95-98 y 103-116. 3. Candurra N.A., - En el libro: "Microbiología Biomédica", J.A. Basualdo, C.E. Coto y R.A. de Torres (Ed.), Editorial Atlante, Buenos Aires, Segunda edición. 2006. Capítulo: Cultivo de Virus. p. 676-690. Laboratorio de Virología: Agentes antivirales y citoprotectores (Laura Alché) 1. Barquero A.A., Michelini F.M. and Alché L.E.. "1-cinnamoyl-3,11dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor kB modulating properties". Biochemical and Biophysical Research Communications 344: 955962 (2006). 2. Ramírez Javier, Andrea Bruttomesso, Flavia Michelini, Sofía Acebedo, Laura Alché and Lydia Galagovsky. Syntheses of immunomodulating androstanes and stigmastanes. Comparison of their TNF- inhibitory activity". Bioorganic and Medicinal Chemistry 15: 7538-7544 (2007). 3. Michelini Flavia M., Alejandro Berra and Laura E. Alché. The in vitro immunomodulatory activity of a synthetic brassinosteroid analogue would account for the 37

improvement of herpetic stromal keratitis in mice". The Journal of Steroid Biochemistry and Molecular Biology 108: 164-170 (2008). 4. Michelini Flavia M., Javier A. Ramírez, Alejandro Berra, Lydia R. Galagovsky and Laura E. Alché.Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23dihydroxylated stigmastane derivatives". The Journal of Steroid Biochemistry and Molecular Biology 111: 111-116 (2008). 5. Careaga Valeria P., Carlos Bueno, Claudia Muniain, Laura Alché, Marta S. Maier. Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog" Chemotherapy 55: 60-68 (2009). 6. Bueno Carlos A., Andrea A. Barquero, Hernán di Cónsoli, Marta S. Maier and Laura E. Alché. A natural tetranortriterpenoid with immunomodulating properties as a potential antiHSV agent". Virus Research 141: 47-54 (2009). 7. Petrera E., Coto, CE. The synergistic effect of IFN-alpha and IFN-gamma agaisnt HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3,11dihidroxymeliacarpin. Virol.J. 2006.Jun 13. 3: 45. 8. Petrera E and Coto CE. Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection. Phytother Res. May 13. [Epub ahead of print]. 2009. 9. Diana L. Vullo, Helena M. Ceretti, María A. Daniel, Silvana A.M. Ramirez y Anita Zalts. Cadmium, zinc and copper biosorption mediated by Pseudomonas veronii 2E, Bioresource Technology 99: 5574-5581, Elsevier Science, ISBN: 0960-8524, 2008. Libros o capítulos de libros: 10. Heavy metals and microorganisms in the environment: taking advantage of reciprocal interactions for the development of a wastewater treatment. Diana L. Vullo, Helena M. Ceretti, Silvana A. M. Ramírez y Anita Zalts, Progress in Environmental Microbiology, Capítulo III, pág. 111-149, Editado por Myung-Bo Kim Nova Science Publishers, Inc. ISBN: 1-60021-940-3, 2007. 11. Cinética de crecimiento celular (Capítulo 9), Procesos Industriales (Capítulo 10) y Inmovilización de células y enzimas (Capítulo 11), Diana L. Vullo. Cultivos celulares: qué saber y cómo hacer, Celia Coto y Nélida Candurra (editoras), Acta Bioquímica Latinoamericana ISSN: 0325-2957, Pág. 66-88, 2006. 12. Laura E. Alché. "Retroviridae" Capítulo 93 del libro "Microbiología Biomédica" pp. 918930. Editado por los Dres. J.A. Basualdo, Celia E. Coto y R.A. de Torres. Editorial Atlante S.R.L., Buenos Aires, 2006.

38

Laboratorio de Virología: Estrategias antivirales (Elsa Damonte) 1. C.A. Pujol, L.A. Scolaro, M. Ciancia, M.C. Matulewicz, A. Cerezo, E.B. Damonte. Antiviral activity of a carrageenan from Gigartina skottsbergii against intraperitoneal murine Herpes simplex virus infection. Planta Medica 72: 121-125, 2006. 2. P.C.S.F-Tischer, L.B. Talarico, M.D. Noseda, S.M.P.B. Guimaraes, E.B. Damonte, M.E.R. Duarte. Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus. Carbohydrate Polymers 63: 459-465, 2006. 3. C.C. García, M. Djavani, I. Topsirovic, K.L.B. Borden, M.S. Salvato, E.B. Damonte. Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds. Journal of General Virology 87: 1217-1228, 2006. 4. U. Adhikari, C.G. Mateu, K. Chattopadhyay, C.A. Pujol, E.B. Damonte, B. Ray. Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum. Phytochemistry 67: 2474-2482, 2006. 5. L.B. Talarico, E.B. Damonte. Interference in dengue virus adsorption and uncoating by carrageenans. Virology 363: 473-485, 2007. 6. K. Chattopadhayay, C.G. Mateu, P. Mandal, C.A. Pujol, E.B. Damonte, B. Ray. Galactan sulfate of Grateloupia indica: isolation, structural features and antiviral activity. Phytochemistry 68: 1428-1435, 2007. 7. A.T. Fazio, M.T. Adler, M.D. Bertoni, C.S. Sepúlveda, E.B. Damonte, M.S. Maier. Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities. Zeitschrift Naturforsch [C] 62c: 543-549, 2007. 8. P. Mandal, C.G. Mateu, K. Chattopadhyay, C.A. Pujol, E.B. Damonte, B. Ray. Structural features and antiviral activity of sulfated fucans from the brown seaweed Cystoseira indica. Antiviral Chemistry and Chemotherapy 18: 153-162, 2007. 9. L.B. Talarico, M.E.R. Duarte, R.G.M. Zibetti, M.D. Noseda, E.B. Damonte. An algal derived DL-galactan hybrid is an efficient preventing agent for in vitro dengue virus infection. Planta Medica 73: 1464-1468, 2007. 10. E.G. Acosta, V. Castilla, E.B. Damonte. Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis. Journal of General Virology 89: 474-484, 2008. 11. C.S. Sepúlveda, M.L. Fascio, M.B. Mazzucco, M.L. Docampo Palacios, R.F. Pellón, C.C. García, N.B. D'Accorso, E.B. Damonte. Synthesis and evaluation of N-substituted acridones as antiviral agents against hemorrhagic fever viruses. Antiviral Chemistry and Chemotherapy 19: 41-47, 2008. 39

12. P. Mandal, C.A. Pujol, M.J. Carlucci, K. Chattopadhyay, E.B. Damonte, B. Ray. Antiherpetic activity of sulfated xylomannan from Scinaia hatei. Phytochemistry 63: 21932199, 2008. 13. K. Chattopadhyay, C.A. Pujol, M.J. Carlucci, E.B. Damonte, B. Ray. Polysaccharides from Gracilaria corticata: structural features and anti-HSV activity. International Journal of Biological Macromolecules 43: 346-351, 2008. 14. J.S. Barradas, M.I. Errea, N.B. D'Accorso, C.S. Sepúlveda, L.B. Talarico, E.B. Damonte. Synthesis and antiviral activity of azoles obtained from carbohydrates. Carbohydrate Research 343: 2468-2474, 2008. 15. J.E.F. Cassolato, M.D. Noseda, C.A. Pujol, F.M. Pellizari, E.B. Damonte, M.E.R. Duarte. Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma. Carbohydrate Research 343: 3085-3095, 2008. 16. C.C. García, P.C. Ellenberg, M.C. Artuso, L.A. Scolaro, E.B. Damonte. Characterization of Junin virus particles inactivated by a zinc-finger reactive compound. Virus Research 143:196-113, 2009. 17. T. Ghosh, C.A. Pujol, E.B. Damonte, P. Karmakar, B. Ray. Sulphated xylomannans from the red seaweed Sebdenia polydactyla: structural features, chemical modification and antiviral activity. Antiviral Chemistry and Chemothearpy 19: 235-242, 2009. 18. E.G. Acosta, V. Castilla, E.B. Damonte. Alternative infectious entry pathways for dengue virus serotypes into mammalian cells. Cellular Microbiology 11: 1533-1549, 2009. 19. M.C. Artuso, P.C. Ellenberg, L.A. Scolaro, E.B. Damonte, C.C. García. Inhibition of Junín virus replication by small interfering RNAs. Antiviral Research 84: 31-37, 2009. 20. Linero FN, Scolaro LA. Participation of the phosphatidylinositol 3-kinase/Akt pathway in Junín virus replication in vitro. Virus Res. 145(1):166-70, 2009. 21. Ellenberg PC, Linero FN and Scolaro LA. Superinfection exclusion in a BHK-21 cell line persistently infected with Junin virus. Journal of General Virology, 88:2730-2739, 2007. 22. Linero FN and Scolaro LA. Junin virus Cba IV4454 S RNA segment. GenBank, bankit 831547, 2006. 23. Pujol CA, Scolaro LA, Ciancia M, Matulewicz MC, Cerezo AS and Damonte EB. Antiviral activity of a carrageenan from Gigartina skottsbergii against intraperitoneal murine Herpes simplex virus infection. Planta Medica, 72:121-125, 2006.

40

24. Talarico Laura B., Viviana Castilla, Javier A. Rámirez, Lydia R. Galagovsky and Mónica B. Wachsman. "Synergistic in vitro interactions between (22S,23S)-3bromo-522,23-trihydroxystigmastan-6-one and foscarnet against herpes simples virus type 1"Chemotherapy , 52: 38-42, 2006. 25. Romanutti Carina, Viviana Castilla, Celia E. Coto and Mónica B. Wachsman Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells".International Journal of. Antimicrobial Agents, 29: 311-316, 2007. 26. Todorov Svetoslav, Brink Marelize, Guigas C, Schillinger Ulrich, Wild Ian, Wachsman Mónica, Holzapfel Wilhelm, Dicks Leon. Boza a natural source of probiotic lactc acid bacteria"Journal of Applied Microbiology 104: 465-477, 2008. Ed: Blackwell. 27. Acosta Eliana G., Andrea C. Bruttomesso, Juan A. Bisceglia, Mónica B. Wachsman, Lydia R. Galagovsky and Viviana Castilla. Dehydroepiandrosterone, epiandrosterone and synthetic derivatives inhibit Junin virus replication in vitro Virus Research., 135: 203-212, 2008 Elsevier UK. 28. Romanutti Carina, Andrea C. Bruttomesso, Juan A. Bisceglia, Viviana Castilla, Lydia R. Galagovsky and Mónica B. Wachsman. In vitro antiviral activity of dehydroepiandrosterone and synthetic derivatives against vesicular stomatitis virus"The Veterinary Journal, 182: 327-335,2009. Elsevier UK. 29. Diana L. Vullo, Helena M. Ceretti, María A. Daniel, Silvana A.M. Ramirez y Anita Zalts. Cadmium, zinc and copper biosorption mediated by Pseudomonas veronii 2E, Bioresource Technology 99: 5574-5581, Elsevier Science, ISBN: 0960-8524, 2008. 30. Helena M. Ceretti, Diana L. Vullo, Anita Zalts y Silvana A. Ramírez. Cadmium Complexation in culture media, Electroanalysis (ISSN: 1040-0397), 18(5): 493-498, 2006. Trabajos de actualización en publicaciones periódicas 31. C.C. García, E.B. Damonte. Zn finger containing proteins as targets for the control of viral infections. Infectious Disorders-Drugs Targets 7: 204-212, 2007. 32. C.A. Pujol, M.J. Carlucci, M.C. Matulewicz, E.B. Damonte. Natural sulfated polysaccharides for the prevention and control of viral infections. Topics in Heterocyclic Chemistry 11: 259-281, 2007. 33. E.A. Acosta, L.B. Talarico, E.B. Damonte. Cell entry of dengue virus. Future Virology 3: 471-479, 2008.

Trabajos de divulgación científica

41

34. E.B. Damonte. Dengue: Un viejo y nuevo desafío para la quimioterapia antiviral. Química Viva vol 5, num 2, 52-62, www.qb.fcen.uba.ar, 2006. 35. M.C. Matulewicz, E.B. Damonte. Perspectivas de los polisacáridos sulfatados de algas marinas como agentes antivirales. Industria y Química 354: 3-7, 2006. Capítulos de libros 36. E.B. Damonte. Estructura y clasificación de virus, p. 665-675. 37. E.B. Damonte. Multiplicación viral, p. 691-707. 38. E.B. Damonte, S.E. Mersich. Genética de virus animales, p. 708-719. 39. En: Microbiología Biomédica, Basualdo J.A., Coto C.E., de Torres R.A. (Ed.), primera edición, Editorial Atlante, Buenos Aires, Segunda edición, 2006. 40. Heavy metals and microorganisms in the environment: taking advantage of reciprocal interactions for the development of a wastewater treatment. Diana L. Vullo, Helena M. Ceretti, Silvana A. M. Ramírez y Anita Zalts, Progress in Environmental Microbiology, Capítulo III, pág. 111-149, Editado por Myung-Bo Kim Nova Science Publishers, Inc. ISBN: 1-60021-940-3, 2007. 41. Cinética de crecimiento celular (Capítulo 9), Procesos Industriales (Capítulo 10) y Inmovilización de células y enzimas (Capítulo 11), Diana L. Vullo. Cultivos celulares: qué saber y cómo hacer, Celia Coto y Nélida Candurra (editoras), Acta Bioquímica Latinoamericana ISSN: 0325-2957, Pág. 66-88, 2006. Laboratorio de Metabolismo del hemo en condiciones normales y patológicas (Horacio Sancovich) 1. A.M.Ferramola de Sancovich y H.A.Sancovich. Interacciones de las radiaciones electromagnéticas y especies reactivas del Oxígeno sobre la piel. Rev. Argent. Dermatol 87 No 2,113-120, (2006). 2. N.L.Pauza, M.J.Pérez Cotti, .L.Godar, Y.E.Sopena, A.M.Ferramola de Sancovich y H.A.Sancovich. Manifestaciones cutáneas como parámetro de teratogenicidad en la intoxicación con metales pesados. Rev. Argent.Dermatol 88, Nº 1, 28-37, (2007). 3. Y.E. Sopena, A.M. Ferramola de Sancovich and H.A. Sancovich. Hexachlorobenzene treatment on hepatic mitochondrial function parameters and intracellular Coproporphyrinogen Oxidase location. Int. J. Toxicol. 27 Nº 6, 455-465 (2008). Laboratorio de Expresión Génica en Mama y Apoptosis (Edith Kordon)

42

1. Quaglino A., Salierno M., Pellegrotti J., Rubinstein N. and Kordon E. Mechanical strain induces involution-associated events in mammary epithelial cells. BMC Cell Biol. 10:55, 2009 2. Kordon E. MMTV-induced Pregnancy-dependent Mammary Tumors. Early History and New Perspectives. J Mammary Gland Biol Neoplasia 13: 289-97, 2008. 3. Quaglino A., Schere-Levy C., Romorini L., Meiss RP and Kordon E. Mouse mammary tumors display LIF signaling dependent Stat3 activation. Breast Cancer Res. 2007 Oct 9;9(5):R69. 4. Rodriguez Granillo A.; Boffi JC; Barañao JL; Kordon E.; Pecci A. and Guberman A.S. STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line. Biochem. Biophys. Res. Comm. 356:727-32, 2007. 5. Gattelli A., Zimberlin M., Castilla L. and Kordon E. Selection of early occurring mutations dictates hormone-independency progression in mouse mammary tumor lines. J Virol. 80: 11409­15, 2006. 6. Rubio M., Werbajh S., Cafferata E., Quaglino A., Coló G., Nojek I., Kordon E., Nahmod V., and Costas M. TNF-a enhances estrogen-induced cell proliferation of estrogendependent breast tumor cells through a complex containing Nuclear Factor-kappa B. Oncogene 25, 1367-77, 2006. Federico Coluccio Leskow 1. Siliceo M, Garcia-Bernal D, Carrasco S, Diaz-Flores E, Leskow FC, Teixido J, Kazanietz MG, Merida I. Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells. J Cell Sci. 2006 Jan 1;119(Pt 1):14152. 2. Dekanty A, Sauane M, Cadenas B, Coluccio Leskow F, Barrio M, Casala J, Paciencia M, Rogers F, Coso O, Piwien-Pilipuk G, Rudland PS, de Asua LJ Leukaemia inhibitory factor (LIF) induces DNA synthesis in swiss mouse 3T3 cells independently of cyclin D1 expression through a mechanism involving MEK/ERK 1/2 activation. J Biol Chem. 2006 Mar 10;281(10):6136-43. 3. Federico Coluccio Leskow, Beth A. Holloway, HongBin Wang, Mary C. Mullins and Marcelo G Kazanietz. The zebrafish homologue of mammalian chimaerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5373-8. 4. HongBin Wang, Chengfeng Yang, Federico Coluccio Leskow,Jing Sun, Bertram Canagarajah,James H. Hurley, and Marcelo G. Kazanietz. Phospholipase 43

Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J. 2006 May 17;25(10):2062-74. 5. Francheska Colon-Gonzalez, Federico Coluccio Leskow and Marcelo G. Kazanietz. Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac- GAP alpha 2-chimaerin. J Biol Chem. 2008 Dec 12;283(50):35247-57. 6. Yongsu Jeong, Federico Coluccio Leskow, Kenia El-Jaick, Erich Roessler, Maximilian Muenke, Anastasia Yocum, Christele Dubourg, Xue Li, Xin Geng, Guillermo Oliver and Douglas J. Epstein. Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein. Nature Genetics 2008 Nov;40(11):1348-53. Omar Pignataro 1. Repetto EM, Pannunzio V, Astort F, Martinez Calejman, C, Besio Moreno M, Pignataro OP, Cymeryng CB Characterization of L-arginine transport in adrenal cells: Effect of ACTH. Am J Physiol (Endocrinol and Metab). 291(2):E291-7, 2006. 2. Biron VA, Iglesias MM, Troncoso M, Besio-Moreno M, Patrignani ZJ, Pignataro O, Wolfenstein-Todel, C. Galectin-1: Negative modulation of steroidogenic capacity and biphasic regulation of growth and adhesion of Leydig tumor cells Glycobiology, 16(9):81021, 2006. 3. Mondillo C, Falus A, Pignataro OP, Pap E (Directores con igual mérito) Prolongued histamine deficiency in histidine decarboxilase gene knockout mice affects regulation of Leydig cell function by LH/hCG Journal of Andrology, 28(1):86-91, 2007. 4. Grion N, Repetto EM, Pomeraniec Y, Calejman CM, Astort F, Sanchez R, Pignataro OP, Arias P, Cymeryng CB Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: involvement of both signaling systems in the modulation of ACTH-dependent steroid production.J Endocrinol. 2007 Jul;194(1):1120. 5. de la Torre E, Genaro AM, Ribeiro ML, Pagotto R, Pignataro OP, Sales ME Proliferative actions of muscarinic receptors expressed in macrophages derived from normal and tumor bearing mice Biochim Biophys Acta-Molecular Basis of Disease 2008;1782 (2):82-9. 6. Mondillo C; Pagotto RM; Piotrkowski B; Reche CG; Patrignani ZJ; Cymeryng C; Pignataro OP Involvement of Nitric Oxide Synthase in the Mechanism of HistamineInduced Inhibition of Leydig Cell Steroidogenesis via Histamine Receptor Subtypes in Sprague-Dawley Rats Biology of Reproduction 2009; 80:144-152. 7. Astort F, Repetto EM, Martínez Calejman C, Cipelli JM, Sánchez R, Di Gruccio JM, Mercau M, Pignataro OP, Arias P, Cymeryng CB. High glucose-induced changes in steroid 44

production in adrenal cells Diabetes/Metabolism Research And Reviews 2009; 25:477486. 8. Piotrkowski B, Monzon C, Pagotto RM, Reche C, Besio M, Cymeryng C, Pignataro OP Effects of heme oxygenase isozymes on Leydig cells steroidogenesis. Journal of Endocrinology 2009; 203:155-165

Alfonso JC Soler Bistué: 1. Soler Bistué AJ, Martín FA, Vozza N, Ha H, Joaquín JC, Zorreguieta A, Tolmasky ME. Inhibition of aac(6')-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13230-5. 2. Soler Bistué AJ, Birshan D, Tomaras AP, Dandekar M, Tran T, Newmark J, Bui D, Gupta N, Hernandez K, Sarno R, Zorreguieta A, Actis LA, and Tolmasky ME. Klebsiella pneumoniae multiresistance plasmid pMET1: similarity with the Yersinia pestis plasmid pCRY and integrative conjugative elements. PLoS ONE 2008 Mar 19;3(3):e1800 3. Quiroga MP, Andres P, Petroni A, Soler Bistué AJ, Guerriero L, Vargas LJ, Zorreguieta A, Tokumoto M, Quiroga C, Tolmasky ME, Galas M, Centrón D. Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. Antimicrob Agents Chemother. 2007 Dec;51(12):4466-70. 4. Soler Bistue AJ, Ha H, Sarno R, Don M, Zorreguieta A, Tolmasky ME. External guide sequences targeting the aac(6')-Ib mRNA induce inhibition of amikacin resistance. Antimicrob Agents Chemother. 2007 Jun;51(6):1918-25. 5. Soler Bistue AJ, Martin F, Petroni A, Faccone D, Galas M, Tolmasky ME, Zorreguieta A. Vibrio cholerae InV117, a class 1 integron harboring aac(6')-Ib and blaCTX-M-2, is linked to transposition genes. Antimicrob Agents Chemother. 2006 May;50(5):1903-7. Rita Ulloa 1. P Gargantini, S Gonzalez-Rizzo, D Chinchilla, M Raices, , V Giammaria, R Ulloa, F Frugier, M Crespi.A CDPK isoform regulates nodule number in Medicago truncatula, (2006). Plant J. 48, 843-856 2. Delphine Chinchilla, Florian Frugier, Marcela Raices, Francisco Merchan, Veronica Giammaria, Pablo Gargantini, Silvina Gonzalez-Rizzo, Martin Crespi and Rita Ulloa A mutant Ankyrin Protein Kinase affects Arabidopsis adventitious rooting" (2008) Functional Plant Biology 35, 92-101

45

3. P Gargantini, V Giammaria, C Grandellis, S Feingold, S Maldonado, R Ulloa Functional and genomic characterization of StCDPK1, (2009) Plant Mol. Biol. 70, 153172 , Marta Tesone 1. Vitale, D. Abramovich, M. Peluffo, G. Meresman, M. Tesone. Effect of gonadotropinreleasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells. Fertility and Sterility Abril, vol 85 (4): 1064-7 2006 ISSN 00150282 2. Abramovich, F. Parborell, M. Tesone. Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropintreated prepubertal rats. Biol Reprod 75(3):434-41 2006 ISSN 0006-3363 3. Marina C. Peluffo, Leonardo Bussmann, Richard L. Stouffer and Marta Tesone. Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle. Reproduction 132: 465-475 2006. ISSN: 1470-1626 4. Mariela Bilotas, Rosa Inés Barañao, Ricardo Buquet, Carlos Sueldo, Marta Tesone and Gabriela Meresman. Effect of GnRH analogues on apoptosis and expression of Bcl-2, Bax, Fas and FasL in endometrial epithelial cultures from patients with endometriosis and controls. Human Reproduction 22 (3), 644-653, 2007 5. G. Irusta, F. Parborell, M. Tesone. Inhibition of cytochrome P450C17 enzyme by a GnRH agonist in ovarian follicles from gonadotropin- stimulated rats. American J. Physiol. 292: E1456-E1464 2007 ISSN 0193-1849 6. Peluffo, Marina; Stouffer, Richard; Tesone, Marta. Activity and expression of different members of the caspase family in the rat corpus luteum (CL) during pregnancy and postpartum. Am J Physiol Endocrinol Metab. 2007, 296 (5): E1215-23 ISSN 0193-1849 7. Fernanda Parborell, Griselda Irusta, Alejandra Rodriguez Celin and Marta Tesone. Regulation of ovarian angiogenesis and apoptosis by GnRH-I analogs. Molecular Reproduction and Development 2008, 75 (4): 623-31 ISSN 1040-452X. 8. Parborell Fernanda, Abramovich Dalhia and Tesone Marta. Intrabursal administration of the Antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of bcl2 related genes. Biol Reprod. 2008, 78 (3), 506-13. ISSN 0006-3363 9. Olivares C, Bilotas M, Buquet R, Borghi M, Sueldo C, Tesone M, Meresman G Effects of a selective cyclooxygenase-2 inhibitor on endometrial epithelial cells from patients with endometriosis. Hum Reprod. 2008 23 (12):2701-2708 PMID: 18716040 ISSN: 0268-1161

46

10. Tesone M, Bilotas M, Barañao RI, Meresman G. The role of GnRH analogues in endometriosis-associated apoptosis and angiogenesis. Gynecol Obstet Invest. 2008;66 Suppl 1:10-8. Epub 2008 Oct 21. PMID: 18936547 ISSN: 0378-7346 11. Abramovich D, Rodríguez Celin A, Hernandez F, Tesone M, Parborell F Spatiotemporal analysis of the protein expression of angiogenic factors and their related receptors during folliculogenesis in rats with and without hormonal treatment. Reproduction. 2009, 137(2):309-20. 2008. PMID: 18996974 ISSN: 1470-1626 12. Abramovich D, Irusta G, Parborell F, Tesone M. Intrabursal injection of vascular endothelial growth factor trap in eCG-treated prepubertal rats inhibits proliferation and increases apoptosis of follicular cells involving the PI3K/AKT signaling pathway. Fertil Steril. 2009 Mar 26. ISSN 0015-0282 13. Andreone L, Velásquez EV, Abramovich D, Ambao V, Loreti N, Croxatto HB, Parborell F, Tesone M, Campo S. Regulation of inhibin/activin expression in rat early antral follicles. Mol Cell Endocrinol. 2009 Oct 15;309(1-2):48-54. Epub 2009 May 21. PMID: 19464342 ISSN: 0303-7207 14. Hernandez F, Peluffo MC, Bas D, Stouffer RL, Tesone M. Local effects of the sphingosine 1-phosphate on prostaglandin F2alpha-induced luteolysis in the pregnant rat. Mol Reprod Dev. 2009 Jul 30; 76 (12) 1153- 64 [Epub ahead of print] PMID: 19645054 ISSN: 1040-452X

Ana María Stella 1. ZULPA, GLORIA; ACOSTA, TATIANA; ZACCARO, MARÍA C.; STELLA, ANA M.; STORNI, MÓNICA M. Cianobacterias en el proceso de compostaje. 2009. En el libro: Libro del resúmenes de la VII Reunión Nacional Científico Técnica de Biología del Suelo y Fijación Biológica del Nitrógeno. Compiladores: Carlos Bellone, Josefina Amigo y Patricia Lindón. Universidad Nacional de Tucumán. p. 192. ISBN 978-950-554-613-8 2. ESTOMBA, D.; MATTES FERNANDEZ, H.; STELLA, A. M. Actividad antioxidante y contenido de pigmentos en Adesmia boronioides, Larrea divaricada y Atriplex lampa cultivadas in Vitro. 2009. En el libro: La biotecnología y los futuros escenarios mundiales. Coordinadora: Silvia Arranz. UNR Editora. Universidad Nacional de Rosario. p. 94. ISBN 978-950-673-729-0 3. LÓPEZ AGÜERO, L.; STORNI, M. M.; ZACCARO, C.; STELLA, A. M.; ZULPA, G. Cultivo semicontinuo de Spirulina sp. en un fotobiorreactor. 2009. En el libro: La biotecnología y los futuros escenarios mundiales. Coordinadora: Silvia Arranz. UNR Editora. Universidad Nacional de Rosario. p. 124. ISBN 978-950-673-729-0 4. DIVO DE SÉSAR, MARTA; D`AMBROGIO, ANA; GRONDONA, MERCEDES; BARDON FONT, FERNANDA; VILELLA, FERNANDO; STELLA, ANA. Variación en 47

el contenido de polifenoles y antocianinas en frutos de los géneros Vaccinium y Rubus asociada a diversos factores condicionantes. 2008. En el libro AVANCES EN CULTIVOS FRUTALES NO TRADICIONALES. Ed. DIVO DE SESAR, MARTA; ROCCA, MARGARITA; VILELLA, FERNANDO. Editorial Facultad de Agronomía, UBA. p153. ISBN 978-950-29-1065-9 5. DIVO DE SÉSAR, MARTA; D`AMBROGIO, ANA; GRONDONA, MERCEDES; BARDON FONT, FERNANDA; VILELLA, FERNANDO; STELLA, ANA. Estudios fisicoquímicos e histológicos del proceso de enraizamiento de estacas estuvales de Vaccinium corymbossum suplementadas con citoquinas. 2008. En el libro AVANCES EN CULTIVOS FRUTALES NO TRADICIONALES. Ed. DIVO DE SESAR, MARTA; ROCCA, MARGARITA; VILELLA, FERNANDO. Editorial Facultad de Agronomía, UBA. p21. ISBN 978-950-29-1065-9

María Teresa Téllez-Iñón 1. Capiati DA, País SM, Téllez-Iñón MT (2006) "Wounding increases salt tolerance in tomato plants. Evidence on the participation of calmodulin-like activities in cross-tolerance signaling". J Exp Bot 57(10):2391-400. 2. País SM, González MA, Téllez-Iñón MT, Capiati DA (2009) "Characterization of potato (Solanum tuberosum) and tomato (Solanum lycopersicum) protein phosphatases type 2A catalytic subunits and their involvement in stress responses". Planta 230(1):13-25. 3. País SM, Téllez-Iñón MT, Capiati DA (2009) "Serine/Threonine Protein Phosphatases type 2A and their roles in stress signaling". Plant Signal Behav 11(4): 1013-1015.

48

TRABAJOS PUBLICADOS POR GRUPOS DE INVESTIGACIÓN DEPARTAMENTO DE QUÍMICA BIOLÓGICA 2000-2005

Laboratorio de Biología Molecular: Transducción de señales (Silvia Moreno) 1. Mucor rouxii ultrastructure: cAMP and actin cytoskeleton. Pereyra,E., Ingerfeld, M., Anderson, N., Jackson, S.L., Moreno, S. Protoplasma, en prensa, 2005. 2. Cell-growth dependent subcellular localization of p8. Valacco, P., Varone, C. Malicet, C., Cánepa, E., Iovanna, J.L., Moreno, S. J. Cell. Biochem., en prensa, 2005. 3. Glucose dependent activation and phosphorylation of protein kinase A in Saccharomyces cerevisiae. Portela, P., Moreno, S. Cellular Signal., en prensa, 2005. 4. Combined strategy using pure enzymes and whole cells as biocatalysts in the preparation of 2-hydroxyesters and gamma-butyrolactones from 2-oxoglutaric acid. Rustoy, E.M., Pereyra, E., Moreno, S. and Baldessari, A. Tetrahedron Asymmetry, 15: 3763-.3768, 2004. 5. Protein kinase A is involved in the control of morphology and branching during aerobic growth in Mucor circinelloides. Lübbehüsen, T.*, González Polo, V.* (equal contribution), Rossi, S. Nielsen, J., Moreno, S., McIntyre, M. and Arnau, J. Microbiology (UK), 150: 143-150,2004. 6. RGD-containing peptides and cAMP have antagonistic roles in the morphology of Mucor rouxii. Pereyra, E., Argimón, S., Jackson, SL and Moreno, S. Protoplasma. 222: 23-30, 2003. 7. Activation state of Protein Kinase A as measured in permeabilised Saccharomyces cerevisiae cells correlates with PKA-controlled phenotypes in vivo. Portela, P.,Van Dijck, P., Thevelein, J. and Moreno, S. FEMS Yeast Research, 3: 119-126, 2003. 8. In vivo and in vitro phosphorylation of two isoforms of yeast pyruvate kinase by protein kinase A. Portela, P., Howell, S., Moreno, S. and Rossi, S. J.Biol.Chem., 277: 30477-30487, 2002.

49

9. The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation-domain interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter . Hoffmeister, A., Ropolo, A., Vasseur, S., Mallo, G.V., Bodeker, H., Ritz-Laser, B., Dressler, G.R., Vaccaro, M.I., Dagorn, J.C., Moreno, S. and Iovanna, J.L. J.Biol.Chem. 277: 22314-22319, 2002. 10. Chemo- and stereoselective reduction of beta-keto esters by spores and various morphological forms of Mucor rouxii. Mangone, C., Pereyra, E. , Argimon, S., Moreno, S. and Baldessari, A. Enzyme Microbial Technol. 30: 596-601, 2002. 11. Protein kinase A activity in permeabilized cells as an approximation to in vivo activity. Sorol, M.R., Pereyra, E., Mizyrycki, C., Rossi, S. and Moreno, S. Exp.Cell Res. 271: 337-342, 2001. 12. TGFb-1 enhances the Smad transcriptional activity through activation of p8 gene expression. García-Montero,AC, Vasseur,S., Giono, L., Cánepa, E., Moreno, S., Dagorn, JL and Iovanna, JL. Biochem. J. 357: 249-253, 2001. 13. Overexpression of regulatory subunit of protein kinase A in Saccharomyces cerevisiae: genetic and biochemical considerations. Portela, P.*, Zaremberg, V.* and Moreno, S. (* equal contribution) Microbiology, 147, 1149-1159, 2001. 14. Structural studies of human p8, a HMG-like protein , with DNA binding activity enhanced by phosphorylation. Encinar, J., Mallo, GV, Mizyrycki, C., Giono, L., GonzálezRos, JM, Rico, M, Cánepa, E., Moreno, S., Neira, JL and Iovanna, JL. J.Biol.Chem, 276: 2742-2751, 2001. 15. Structural and functional analysis of the cAMP binding domain from the regulatory subunit of Mucor rouxii protein kinase A. Sorol, M.R., Pastori, R., Muro,A., Moreno, S. and Rossi,S. Arch.Biochem. Biophys., 382: 173-181, 2000 16. The mechanism of activation of cAMP-dependent protein kinase. In Mucor rouxii the apparent specific activity of the cAMP activated holoenzyme is different to that of its free catalytic subunit. Zaremberg V., Donnella-Deana A., and Moreno S. Arch.Biochem.Biophys., 381: 74-82, 2000. 17. Threshold level of protein kinase A activity and polarized growth in Mucor rouxii. Pereyra, E., Mizyrycki, C. and Moreno,S. Microbiology, 146: 1949-1958, 2000. 50

Capítulos de libros 1. Biochemistry and molecular biology of the stress-associated protein p8 J.L.Iovanna, S.Vasseur, and S.Moreno Recent Res.Devel.Biochem. 3 (2002): 393-407. Research Signpost , Kerala, India. Laboratorio de Biología Molecular: Regulación de la expresión génica y control del ciclo celular (Eduardo T. Cánepa) 1. "Cell growth-dependent subcellular localization of p8" María P. Valacco, Cecilia L. Varone, Cedric Malicet, Eduardo T. Cánepa, Juan L. Iovanna, and Silvia Moreno J. Cell. Biochem. 97 (2006), 1066-1079. 2. "Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells" Julieta M. Ceruti, María E. Scassa, Juan M. Fló, Cecilia L. Varone, and Eduardo T. Cánepa Oncogene 24 (2005), 4065-4080. 3. "Repression of 5-aminolevulinte synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways" Alejandra S. Guberman, María E. Scassa, and Eduardo T. Cánepa Arch. Biochem. Biophys. 436 (2005), 285-296. 4. "Hepatic nuclear factor 3 and nuclear factor 1 regulate 5-aminolevulinate synthase gene expression and are involved in insulin repression" María E. Scassa, Alejandra S. Guberman, Julieta M. Ceruti, and Eduardo T. Cánepa J. Biol. Chem. 279 (2004), 28082-28092. 5. "Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of CBP coactivator" Alejandra S. Guberman, María E. Scassa, Luciana E. Giono, Cecilia L. Varone, and Eduardo T. Cánepa J. Biol.. Chem. 278 (2003), 2317-2326 6. "Phosphatidylinositol 3-kinase and Ras/Mitogen activated protein kinase signaling pathways are required for the regulation of 5-aminolaevulinate synthase gene expression by insulin" María E. Scassa, Alejandra S. Guberman, Cecilia L. Varone and Eduardo T. Cánepa Exp. Cell Res. 271 (2001), 201-213. 7. "TGF-1 enhances the Smad transcriptional activity through activation of p8 gene expression".

51

Andrés G. Montero, Sophie Vasseur, Luciana Giono, Eduardo Cánepa, Silvia Moreno, Jean Dagorn and Juan Iovanna. Biochem. J. 357 (2001), 249-253 8. "Human p8 is a HMG-I(Y)-like protein with DNA binding activity enhanced by phosphophorylation" José Encinar, Gustavo Mallo, Cynthia Mizyrycki, Luciana Giono, José González-Ros, Manuel Rico, Eduardo Cánepa, Silvia Moreno, José Neira and Juan Iovanna. J. Biol. Chem. 276 (2001), 2742-2751. 9. "5-aminolaevulinate synthase gene promoter contains two cAMP-response element (CRE)-like sites that confer positive and negative responsiveness to CRE-binding protein (CREB)" Luciana E. Giono, Cecilia L. Varone and Eduardo T. Cánepa Biochem J. 353 (2001), 307-316.

Laboratorio de Biosensores y bioanálisis (Eduardo Cortón) 1. Learning Stoichiometry with Hamburger Sandwiches. Liliana Haim, Eduardo Cortón, Santiago Kocmur, and Lydia Galagovsky. J. Chemical Education, 2003, 80, 1021. 2. Rapid identification of viable Escherichia coli subspecies with an electrochemical screen-printed biosensor array. Peter Ertl, Melany Wagner, Eduardo Cortón, Susan R. Mikkelsen. Biosensors and Bioelectronics, 2003, 18, 907-916. 3. Use of a CO2 electrode to monitor fermentations that use xenobiotic compound as source of carbon. P. Englebienne, M.G. López, E. Cortón and A. A. Viale. Revista Argentina de Microbiología, 2002, 34, 74-76. 4. A Non-radioctive Simulation of the Viking Mission Labeled Released (LR) Experiment: A Search for Evidence of Life. Eduardo Cortón, Liliana Haim, Santiago Kocmur, Guillermo J. Visbeek and Lydia A. Galagovsky. J. Chemical Education, 2002, 79, 11051108. 5. Effect of milk proteins on the behavior of a biosensor based on poly(allylamine) containing an osmium complex wired to redox enzymes. 2. Bienzymatic Configuration. Eduardo Cortón y Fernado Battaglini. J. Electroanalytical Chemistry, 2001, 511, 08-12. 6. Effect of milk proteins on the behavior of a biosensor based on poly(allylamine) containing an osmium complex wired to redox enzymes. 1. Monoenzymatic Configuration. Eduardo Cortón y Fernado Battaglini. J. Electroanalytical Chemistry, 2001, 511, 01-07. 7. A Novel Electrochemical Method for the Identification of Microorganisms, Eduardo Cortón, Diego Raffa, and Susan R. Mikkelsen. Electroanalysis, 2001, 13, 999-1002.

52

8. Potentiometric Determination of CO2 Concentration in the Gaseous Phase: Applications in Different Laboratories Activities. Eduardo Cortón, Santiago Kochmur, Liliana Haim and Lydia A. Galagovsky. J. Chemical Education, 2000, 77, 1188-1191. 9. Characterization of Lactobacillus Carbohydrate Fermentation Activity Using Immobilized Cell Technique. Eduardo Cortón, Mariana Piuri, Fernando Battaglini and Sandra M. Ruzal. Biotechnol. Progress, 2000, 16, 59-63. Artículos de divulgación científica 1. Ruedas Terrestres sobre Otros Mundos. Eduardo Cortón. Ciencia Hoy, 2002, 12, 12-17. 2. La Búsqueda de Vida en Marte. Eduardo Cortón. Ciencia Hoy, 2000, 10, 58-66. Libros 1. Química Bioanalítica. Traducción realizada por el autor hispano-parlante (EC) de la obra "Bioanalytical Chemistry", versión en castellano terminada al 10/05, esta siendo evaluada por McGraw-Hill para su publicación en América y España. Susan R. Mikkelsen y Eduardo Cortón 2. Bioanalytical Chemistry. Susan R. Mikkelsen and Eduardo Cortón. Junio 2004, WileyInterscience, ISBN 0-471-62386-5. Edición electrónica, Libro de texto, 384 paginas 3. Bioanalytical Chemistry. Susan R. Mikkelsen and Eduardo Cortón. Febrero 2004, WileyInterscience, ISBN 0-471-54447-7. Libro de texto, 384 paginas. 4. Problemática Ecológica y Ambiental. Capítulo denominado "Ecología del Ecosistema Antártico y de las Regiones Polares, páginas 209-222, por Hernán Sala y Eduardo Cortón. Editores José Luis Parada, Fernando H. Larrumbe y Eduardo A. Baldi. Editorial Dunken, 2004, 408 páginas. ISBN 987-21290-0-2, primera edición. 5. Temas de Ecología. Volumen 3. Eduardo Cortón y Elizabeth Robello. Editora Universidad Libros, Bs. As., Argentina, 2001, ISBN 987-9465-24-5, Primera Edición 2000 ejemplares. 68 pp. 6. Temas de Ecología. Volumen 2. Eduardo Cortón y Liliana Richner. Editora Universidad Libros, Bs. As., Argentina, 2000, ISBN 987-9465-14-8, Primera edición 2000 ejemplares. 79 pp. 7. Temas de Ecología. Volumen 1. Eduardo Cortón y Liliana Richner. Editora Universidad Libros, Bs. As., Argentina, 2000, ISBN 987-98030-1-9, Primera Edición 2000 ejemplares. 70 pp.

53

Laboratorio de Disturbios metabólicos por xenobióticos en modelos experimentales (Leonor San Martín de Viale) 1. A.C Cochón, MB Mazzetti and LC San Martin de Viale. "How hexachlorobenzene impacts biochemistry - Recent studies in several tissues". Trends in Cell and Molecular Biology vol. 1(In press), 2005. 2. Lelli, SM., San Martín de Viale, LC. and Mazzetti, MB. "Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species". Toxicology 216: 4858, 2005. 3. G. Chaufan, M. Corvi, L. San Martín de Viale, M. L. Cárdenas and M.C. Ríos de Molina. "Abnormal kinetic behaviour of Uroporphyrinogen decarboxylase obtained from rats with hexachlorobenzene induced porphyria". J. Biochem. Mol. Toxicol. 19: 19-24, 2005. 4. S. Billi , A. Faletti, F. Fuentes, L. San Martin de Viale and A. Cochón. "Hepatic arachidonic acid metabolism is disrupted after hexachlorobenzene treatment". Toxicol. Appl. Pharmacol. 204: 187-195, 2005. 5. M.C. Taira, M.B. Mazzetti, S.M. Lelli y L.C. San Martín de Viale. "Glycogen metabolism and glucose transport in experimental porphyria". Toxicology 197: 164-174, 2004. 6. M.B. Mazzetti, M.C. Taira, S.M. Lelli E. Dascal.; J.C. Basabe and L.C. San Martín de Viale. "Hexachlorobenzene impairs glucose metabolism in a rat model of porphyria cutanea tarda: a mechanistic approach". Archives of Toxicology 78: (1) 25-33, 2004. 7. E. B. C. Llambías, C. Aldonatti and L. C. San Martín de Viale. "Tryptophan metabolism via serotonin in rats with hexachlorobenzene experimental porphyria". Biochem. Pharmacol. 66:35-42, 2003. 8. G. Chaufan, M. Corvi, A. Armesto, L.C. San Martín de Viale, C Luquet and M. C. Ríos de Molina. "Comparison between crab hepatopancreas and rat liver uroporphyrinogen decarboxylase". Comp. Biochem. Physiol. B Biochem Mol Biol 133(2): 251-256, 2002. 9. M.C. Rios de Molina, M.B. Mazzetti, M. Galigniana, C. Aldonatti, M.J. Tomio and L.C. San Martín de Viale. "The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage". Braz. J. Med. Biol. Res , 35 (11): 1273-1283, 2002. 10. A.C. Cochón, N. González and L.C. San Martín de Viale. "Effects of the porphyrinogenic compounds hexachlorobenzene and 3,5-diethoxycarbonyl-1,4-dihydrocollidine on polyamine metabolism". Toxicology 176: 209-219, 2002. 11. A.C. Cochón, L.C. San Martín de Viale and S.C. Billi de Catabbi. "Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain dependent and porphyria independent". Comp. Biochem and Physiol. Part C130: 199-207, 2001. 54

12. G. Chaufan, M.C. Rios de Molina and L.C. San Martín de Viale. "How does hexachlorobenzene treatment affect liver uroporphyrinogen decarboxylase". Int. J. Biochem. Cell Biol.33: 621-630, 2001. 13. S. Billi de Catabbi, C. Aldonatti and L. C. San Martín de Viale. "Heme metabolism after discontinued hexachlorobenzene administration in rats: possible irreversible changes and biomarkers for hexachlorobenzene persistence". Comparative Biochem and Physiol. Part C,127:165-175, 2000. 14. S. Billi de Catabbi, P. Setton-Advruj. N. Sterin Speziale, L. C. San Martín de Viale and A. C. Cochon. "Hexachlorobenzene induced alterations on neutral and acidic sphingomyelinases and serine palmitoyltransferase activities. A time course study in two strains of rats". Toxicology 149:89-100, 2000. 15. M. C. Fernandez-Tomé, S. Billi de Catabbi, C. Aldonatti, L. C.San Martín de Viale and N. Sterin Speziale. "Heme metabolism and lipid peroxidation in rat kidney hexachlorobenzene (HCB) induced porphyria. A compartmentalized study of biochemical pathogenic mechanisms". Kidney and Blood Pressure Research 23:20-26, 2000. Laboratorio de Enzimología, Estrés oxidativo y Metabolismo (María del Carmen Ríos) 1. Chemicals that modulate vesicular stomatitis virus (-VSV-) infection in Vero cells. Riva D, Ríos de Molina MC, Rocchetta I, Coulombié FC, Mersich SE. (aceptado para su publicación en Intervirology) 2. Chromium toxicity to Euglena gracilis strains depending on the physicochemical properties of the culture medium. Rocchetta I, Ruiz L, Ríos de Molina MC, Conforti V. (aceptado para su publicación en Bulletin of Environmental Contamination and Toxicology) 3. Effect of chromium on the fatty acid composition of two strains of Euglena gracilis. Rocchetta I, Mazzuca M, Conforti V, Ruiz LB, Balzaretti V, Ríos de Molina MC. Environmental Pollution, 2005, Oct.3 (epud ahead of print). 4. Abnormal kinetic behavior of Uroporphyrinogen decarboxylase obtained from rats with hexachlorobenzene-induced porphyria. Chaufan G, Corvi M, San Martín de Viale MC, Cárdenas ML, Ríos de Molina MC. J. Biochem. Mol. Toxicol. 19, 2005: 19-24. 5. Antioxidants and methimazole in the treatment of Graves disease: Effect on seric and urinary malondialdehyde levels. Guerra L, Ríos de Molina MC, Miler A, Moiguer S, Karner M, Burdman J. Clin Chim Acta, 352, 2005:115-120.

55

6. Niveles de TBARS plasmáticas y urinarios en pacientes hipertiroideos, pretratamiento y postratamiento con antioxidantes. Guerra L, Moiguer S, Karner M, Sreder C, Burdman J, Ríos de Molina MC. Rev Cub Invest Bioméd 23(2) 2004: 105-8. 7. Effects of sublethal concentrations of copper on three strains of green microalgae under autotrophic and mixotrophic culture conditions. Schiariti A., Juárez A., Rodriguez MC. Archiv fur Hydrobiologie, Algological Studies 114 (2004): 143-147. 8. Estudio del estrés oxidativo en 2 cepas de Euglena Gracilis. Rocchetta I., Ruiz L., Conforti V., Ríos de Molina M. C. Rev Cub Invest Biomédicas, 22(2) (2003) 105-108. 9. El estrés oxidativo y el destino celular. Ríos de Molina M.C. Química Viva, 2 (1) (2003). Revista electrónica. 10. Estrés oxidativo inducido por cobre en cultivos de microalgas verdes. Schiariti A., Juárez A., Rodriguez MC. En: J. Herkovitz (ed.) Toxicologia y Quimica Ambiental. Contribuciones para un desarrollo sustentable. SETAC LA, Instituto de Cs. Ambientales y Salud, Fundación PROSAMA, 2003: 156-158. 11. The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardles of hepatic damage. Ríos de Molina M. C., Mazzetti M.B., Galigniana M., Aldonatti C., Tomio J.M. y San Martín de Viale L. C. Braz. J. Med. Biol. Res. 35(11) (2002) 1273-1283. 12. Comparison between crab hepatopancreas and rat liver uroporphyrinogen decarboxylase. Chaufan G., Corvi M., Armesto A., San Martín de Viale L. C., Luquet C., Ríos de Molina M. C. Comparative Biochemistry and Physiology, Part B. 133/2 (2002) 251-256. 13. Antioxidants in the treatment of Graves disease. Guerra L. N., Moiguer S., Karner M., Ríos de Molina M. C., Sreider C. M. and Burdman J. A. IUBMB Life 52 (2001) 1-5. 14. How does hexachlorobenzene affect Uroporphyrinogen decarboxylase? Chaufan G., Ríos de Molina M. C. y San Martín de Viale L. C. Int. J. Biochem. Cell. Biol. 33 (2001) 621-630. 15. Co-cultivo de Micobacterias y Cyanobacterium Minervae (COP.) Komárek and Anagnostidis (Cianoprokariota). Squadrone M. J., Wenzel M. T., Ríos de Molina M. C. Dominguezia 16(1) (2000) 5-14. Laboratorio Expresión Génica en Mama y Apoptosis (Adalí Pecci) 1. "6,19-Sulfur-bridged Progesterone analogues with antiimmunosuppressive activity". A.S. Veleiro, A. Pecci, M.C. Monteserín, R. Baggio, M.T. Garland, C.P. Lantos and G. Burton. J. of Medicinal Chemistry (2005). 48:5675-83. 56

2. "Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) Via Jak and Src-Dependent Mechanism in Breast Cancer Cells". C. Proietti, M. Salatino, C. Rosemblit, R. Carnevale, A. Pecci, A.R. Kornblihtt, A.A. Molinolo, I. Frahm, E.H. Charreau, R. Schillaci and P. V. Elizalde. Mol. Cell. Biol. (2005). 25:482640. 3. "The GnRH antagonist Antide inhibits apoptosis of preovulatory follicle cells in rat ovary". F. Parborell, G. Irusta, A. Vitale, O. Gonzalez, A. Pecci y M. Tesone. Biol. Reprod., (2005). 72:659-66. 4. "Steroid hormones induce bcl-X gene expression through direct activation of distal promoter P4". L. Rocha Viegas, G.P. Vicent, J.L. Barañao, M. Beato and A. Pecci. J. Biol. Chem. (2004) 279:9831-9. 5. "Involvement of Bax protein in the prevention of glucocorticoid-induced thymocytes apoptosis by melatonin". E. Hoijman, L. Rocha Viegas, M.I. Keller Sarmiento, R.E. Rosenstein and A. Pecci. Endocrinology. (2004) 145:418-25. 6. "Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires a functional ErbB-2 and MAPK activation in breast cancer cells". L. Labriola, M. Salatino, A. Pecci, O.A. Coso, A.R. Kornblihtt, C. Proietti, E.H. Charreau and P.V. Elizalde. Mol. Cell Biol. (2003). 23:1095-1111. 7. "Differences in nuclear binding characteristics of agonist-activated glucocorticoid receptor would determine specific responses". G.P. Vicent, , A. Pecci, A. Ghini, G. Piwien-Pilipuk and M. D. Galigniana. Exp. Cell Res. (2002). 276:142-154. 8. "Effect of a gonadotropin-releasing hormone agonist on rat ovarian follicle apoptosis: Regulation by EGF and the expression of bcl-2-related genes". F. Parborell, A. Pecci, O. Gonzalez, A. Vitale and M. Tesone. Biol. Reprod., (2002). 67:481-486. 9. "Promoter choice influences alternative splicing and determines the balance of isoforms expressed from the mouse bcl-x gene". Pecci A., L. Rocha Viegas, J.L. Barañao and M. Beato. J. Biol. Chem. (2001). 276:21062-9. Capítulos de libros 1. "Mecanismos de acción celular de los glucocorticoides y de los mineralocorticoides".A. Sánchez-Pacheco, A. Pecci y G.P. Vicent. En "Actualizaciones en Endocrinología", Mon. No. 6: "Glándulas Suprarrenales". Cap. 2:35-46, R. Yturriaga Matarranz; C. Pavía Sesma y C. Dieguez. Ed. Mc. GrawHill/Interamericana. Madrid, España. (2000). María del Carmen Vila

57

1. C.N. Martini, S.G. Vaena de Avalos y M.C. Vila. ACTH stimulates the release of alkaline phosphatase through Gi-mediated activation of a phospholipase C and the release of inositolphosphoglycan. Molecular and Cellular Biochemistry (2004) 258, 191-199.

Laboratorio de Regulación génica en levaduras (Susana Correa) 1. Bermúdez Moretti, M., Perullini AM., Batlle A and Correa García S. Expression of the UGA4 gene encoding the -aminolevulinic and -aminobutyric acids permease in Saccharomyces cerevisiae is controlled by amino acid-sensing systems. Archives of Microbiology, 2005. En prensa. 2. S. Correa García, A. Casas, C. Perotti, A. Batlle and M. Bermúdez Moretti. Mechanistic studies on -aminolevulinic acid uptake and efflux in a mammary adenocarcinoma cell line. British Journal of Cancer 89, 173-177, 2003. 3. M. Bermúdez Moretti*, S. Correa García*, C. Perotti, A. Batlle and A. Casas.aminolevulinic acid transport in murine mammary adenocarcinoma cells is mediated by BETA transporters. British Journal of Cancer 87, 471-474, 2002. * MBM and SCG contributed equally to this work. 4. M. Bermúdez Moretti, A. Batlle and S. R. Correa García. UGA4 gene encoding the aminobutyric acid permease in Saccharomyces cerevisiae is an acid expressed gene. Int. J. Biochem. Cell Biol. 33 (12), 1202-1207, 2001. 5. M. Bermúdez Moretti, S. Correa García and A. Batlle. Porphyrin biosynthesis intermediates are not regulating -aminolevulinic acid transport in Saccharomyces cerevisiae. Biochem. Biophys. Res. Comm. 272 (3) 946-950, 2000. 6. Susana R. Correa García, Mariana Bermúdez Moretti and A. Batlle. The constitutive expression of UGA4 gene in Saccharomyces cerevisiae depends on two positive-acting proteins, Uga3p and Uga35p. FEMS Microbiology Letters. 184, 219-224, 2000. Laboratorio de Química de Proteoglicanos y Matriz Extracelular (Juan C. Calvo) 1. Heparin increases the adhesion of murine mammary adenocarcinoma cells (LM3). Correlation with the presence of heparin receptors on cell surface. G. Bertolesi, A.M. Eijan, J.C. Calvo, L. Lauria de Cidre. Journal of Biological Regulators and Homeostatic Agents 19 (1-2): 33-40, 2005

58

ISSN: 0393-974X MEDLINE Abbr: J Biol Regul Homeost Agents NLM Unique ID: 8809253 Place: Italy 2. Further evidence on the role of heparin sulfate as protamine acceptor during the decondensation of human spermatozoa in vivo. Marina Romanato, Eleonora Regueira, Mónica S. Cameo, Consuelo Baldini, Lucrecia Calvo and Juan Carlos Calvo. Human Reproduction 20 (10): 2784-2789, 2005. pISSN: 0268-1161 eISSN: 1460-2350 MEDLINE Abbr: Hum Reprod Publisher: Oxford University Press, Country: England JRK: 0.94 JIF: 2.09 3. Exogenous interferon- alters murine inner cell mass and trophoblast development. Effect on the expression of ErbB1, ErbB4 and heparin sulfate proteoglycan (perlecan) Vanina Fontana, Virginia Choren, Liliana Vauthay, Juan Carlos Calvo, Lucrecia Calvo and Monica Cameo. Reproduction 128 (6): 717-725, 2004. pISSN: 1470-1626 eISSN: 1741-7899 MEDLINE Abbr: Reproduction Publisher: Published for the Society for Reproduction and Fertility by BioScientifica, Country: England JIF: 2.606 4. Circulating immunoglobulins that inhibit the binding of follicle stimulating hormone to its receptor. A putative diagnostic role in resistant ovary syndrome? Violeta A. Chiauzzi, M.Sc., Leonardo Bussmann, Ph.D., Juan Carlos Calvo, Ph.D., Victoria Sundblad, M.Sc., Eduardo H. Charreau, Ph.D. Clinical Endocrinology (Oxf) 61 (1): 46-54, 2004. pISSN: 0300-0664 eISSN: 1365-2265 MEDLINE Abbr: Clin Endocrinol (Oxf) Publisher: Blackwell Publishing, Country: England JRK: 0.76 JIF: 2.38 5. Adrenal gland involvement in the regulation of renal 11ß-hydroxysteroid dehydrogenase 2. Marisa Zallocchi, Laura Matkovic, Juan Carlos Calvo and María Cristina Damasco. Journal of Cellular Biochemistry 92 (3): 591-602, 2004.

59

pISSN: 0730-2312 eISSN: 1097-4644 MEDLINE Abbr: J Cell Biochem Publisher: Liss, Country: United States JRK: 0.79 JIF: 3.47 6. ErbB2 and EGFR are downmodulated during the differentiation of 3T3-L1 preadipocytes. Eleonora Pagano and Juan Carlos Calvo Journal of Cellular Biochemistry 90(3):561-72, 2003. pISSN: 0730-2312 eISSN: 1097-4644 MEDLINE Abbr: J Cell Biochem Publisher: Liss, Country: United States JRK: 0.79 JIF: 3.47 7. TRPC3-like protein is involved in the capacitative cation entry induced by 1,25dihydroxy-vitamin D3 in ROS17/2.8 osteoblastic cells. Baldi Carolina, Vazquez Guillermo, Calvo Juan Carlos and Boland Ricardo. Journal of Cellular Biochemistry 90:197-205, 2003. pISSN: 0730-2312 eISSN: 1097-4644 MEDLINE Abbr: J Cell Biochem Publisher: Liss, Country: United States JRK: 0.79 JIF: 3.47 8. Heparan sulphate: a putative decondensing agent for human spermatozoa in vivo. Romanato M, Cameo Mónica S, Bertolesi GE, Baldini C, Calvo JC and Calvo L. Human Reproduction 18: 1868-1873, 2003. Nota: en el manuscrito figura que JCC y LC tuvieron igual participación en el diseño experimental y en la confección del manuscrito. La ubicación de los autores fue decisión personal. pISSN: 0268-1161 eISSN: 1460-2350 MEDLINE Abbr: Hum Reprod Publisher: Oxford University Press, Country: England JRK: 0.94 JIF: 2.09 9. Mechanisms of brush border Na+/H+ exchanger activation by corticosteroids. Marisa Zallocchi, Pilar Igarreta, Juan Carlos Calvo, Nancy Amaral Reboucas, María Cristina Damasco. Medical Science Monitor 9 (2): 85-90, 2003. pISSN: 1234-1010 eISSN: 1643-3750 60

MEDLINE Abbr: Med Sci Monit Publisher: Medical Science International, Country: Poland 10. Effect of Leptin on progesterone, human Chorionic Gonadotropin (hCG) and Interleukin-6 (IL-6) secretion by human term trophoblast cells in culture. Paula Cameo, Paul Bischof, Juan Carlos Calvo. Biology of Reproduction 68: 472-477, 2003. pISSN: 0006-3363 eISSN: 1529-7268 MEDLINE Abbr: Biol Reprod Publisher: Society for the Study of Reproduction Country: United States JRK: 0.82 JIF: 2.81 11. Changes in IGF-I receptor and IGF-I mRNA during differentiation of 3T3-L1 preadipocytes. Cynthia F. Zizola, María E. Balañá, Marcela Sandoval, Juan C. Calvo. Biochimie 84: 975-980, 2002. ISSN: 0300-9084 MEDLINE Abbr: Biochimie Publisher: Editions Scientifiques Elsevier Country: France JRK: 0.49 JIF: 1.57 12. Heparin and heparinase activity detection on polyacrylamide gel electrophoresis using the fluorochrome tris (2,2'-bipyridine) ruthenium (II). Gabriela I. Rozenberg, Jesús Espada, Lilia Lauria de Cidre, Ana M Eiján, Juan C. Calvo and Gabriel E. Bertolesi. Electrophoresis 22: 3-11, 2001. ISSN: 0173-0835 MEDLINE Abbr: Electrophoresis Publisher: Vch Publishers Country: Germany JRK: 0.91 JIF: 2.63 13. Autoinmunidad y falla ovárica. Charreau, E.H.; Chiauzzi, V.; Bussmann, L.; Calvo, J.C.; Cortelezzi, M.; del Castillo, E. La Prensa Médica Argentina 87: 624-629, 2000. pISSN: 0032-745X MEDLINE Abbr: Prensa Med Argent Publisher: Prensa Medica Argentina Country: Argentina 14. Kinetic properties of microsomal 3 hydroxysteroid dehydrogenase-isomerase from the testis of Bufo arenarum H. AG Pozzi, LF Canosa, JC Calvo, NR Ceballos. 61

Journal of Steroid Biochemistry and Molecular Biology 73: 257-264, 2000. ISSN: 0960-0760 MEDLINE Abbr: J Steroid Biochem Mol Biol Publisher: Pergamon Press Country: England JRK: 0.79 JIF: 1.74 Artículos de divulgación científica 1. Calvo J.C. Evaluación de un sistema hormona-receptor. Separata 2004: Fisiología Endocrina. Bioquímica y Métodos Diagnósticos. Fascículo II. 54-59. Directores: M. A. Pisarev y R. S. Calandra. Coordinadores: M.O. Suescun y G.J. Juvenal. ISSN 1515-3878. Publicada por Química Montpellier S.A. Buenos Aires, Argentina. 2. Calvo J.C. El círculo de la vida. Revista QuímicaViva Número 1, año 3, abril 2004 Número especial: la clonación humana. Recuperable de http://www.quimicaviva.qb.fcen.uba.ar ISSN 1666-7948 3. Calvo J.C. Una nueva visión del ARN: los ARN de interferencia. ¿Un nuevo genoma? QuímicaViva (QV) 2003; 2 (3). Recuperable de http://www.quimicaviva.qb.fcen.uba.ar ISSN 1666-7948 4. Calvo J.C. Proteínas a medida. QuímicaViva (QV) 2003; 2 (2). Recuperable de http://www.quimicaviva.qb.fcen.uba.ar ISSN 1666-7948 5. El Genoma Humano: ¿un libro abierto o un rompecabezas para armar? Juan Carlos Calvo. Ciencia e Investigación 54, 9-17, 2002 ISSN-0009-6733 Laboratorio de Bioquímica y biología del virus Junín en infecciones agudas y persistentes (Nélida Candurra) 1. Probing the interaction between vesicular stomatitis virus and phosphatidylserine. Carneiro, F.; Lapido-Loureiro, P.; Cordo, S. M.; Stauffer, F.; Weissmüller, G.; Bianconi, M. L.; Juliano, M.; Juliano, L.; Bisch, P.; Da Poian, A Special issue of European Biophysical Journal entitled Biophysics meets Molecular Medicine. Manuscript No. EBJ-05-0050.R1. En prensa 2. Inhibition of cell fusion in Junin virus-infected cells by sera from Argentine hemorrhagic fever patients. Castilla, V.; Contigiani, M.; Mersich, S. E. Journal of Clinical Virology. 32: 286-288, 2005 . 3. Polarized entry and release of Junín virus, a New Word arenavirus. Cordo, S. M.; Cesio y Acuña, M.; Candurra, N. A. Journal of General Virology 86: 1475-1479, 2005. 4. Resistance to superinfection of Vero cells persistently infected with Junin virus. Ellenberg, P. C.; Edreira, M.; Scolaro, L.A. Archives of Virology 149: 507-522, 2004

62

5. Intermediate filament integrity is required for Junin virus replication. Sandra M Cordo, Nélida A. Candurra. Virus Research, 97: 47-55, 2003. 6. Synthesis and expression of viral antigens in Vero cells persistently infected with Junin virus. Ellenberg PC, Edreira MM, Lozano ME, Scolaro LA. Arch Virol. 147 (8):1543-57, 2002. 7. Effect of fatty acids on arenavirus replication: inhibition of virus production by lauric acid. S. Bartolotta, C. C. García, N. A. Candurra, E .B. Damonte. Archives of Virology, 146: 777-790, 2001. Libros Candurra, N. A.; Coto, C. E. Cultivos celulares: qué saber y qué hacer. Editado por la Federación Bioquímica de la Provincia de Buenos Aires como suplemento del Acta Bioquímica Clínica Latinoamericama. En prensa. Scolaro, L. A., Claus J. D. Capítulo 8. Control de calidad de los cultivos celulares. Nélida A. Candurra, Sandra .M. Cordo, Erina Petrera y Luis A. Scolaro. Capítulo 15.Protocolos Candurra N. A. Capítulo 6: Características de los cultivos celulares. Capítulo 7: Técnicas generales de cultivo. Capítulo 13: Diagnóstico Virológico Capítulos de libros Microbiología Biomédica, Editorial Atlante, Buenos Aires, Argentina. Editor: Celia E. Coto, Ramón de Torres y Juan A. Basualdo. Segunda edición. ISBN: 950-9539-30-9 En prensa. Weber, L.; Scolaro, L. A. Agentes infecciosos no convencionales. Castilla, V; Enría, D. Arenaviridae. Candurra, N. A. Cultivo de virus

Laboratorio de Virología: Agentes antivirales y citotóxicos (Laura Alché y Celia Coto) 1. "Synergistic in vitro interactions between (22S,23S)-3-bromo-5,22,23trihydroxystigmastan-6-one and foscarnet against herpes simples virus type 1". Laura B. Talarico, Viviana Castilla, Javier A. Ramírez, Lydia R. Galagovsky and Mónica B. Wachsman. Chemotherapy 52: 38-42, (2006). 2. "Antiviral mode of action of a synthetic brassinosteroid against Junín virus replication". Viviana Castilla, Mariano Larzábal, Natalia Aguirre Sgalippa, Mónica B. Wachsman and Celia E. Coto. Antiviral Research 68: 88-95, (2005). 3. A Simple Laboratory Exercise for Etanol Production by Immobilized Bakery Yeasts (Saccharomyces cerevisiae). Diana L. Vullo and Mónica B. Wachsman

63

Journal of Foof Science Education 4: 53-55, (2005). 4. "An antibacterial and antiviral peptide produced by Enterococcus mundii ST4V isolated from soy beans". Todorov Svetoslav D, Wachsman Mónica B., Knoetze Hendriette, Meincken Martina and Dicks Leon M. T. International Journal of. Antimicrobial Agents 25: 508-513, (2005). 5. "In vitro and in vivo antiherpetic activity of three new synthetic brassinosteroid analogues". Michelini F., Ramírez J., Berra A., Galagovsky L. and Alché L.. Steroids 69: 713-720 (2004). 6. "Antiviral Activity of Natural and synthetic Brassinosteroids". Wachsman, Monica B., Ramirez Javier A., Talarico Laura B., Galagovsky Lydia R., Coto Celia E. Current Medicinal Chemistry ­ Antiinfective Agents 3: 163-179, (2004). 7. "Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus". V.C.Albiol Matanic and V. Castilla. International Journal of. Antimicrobial Agents 23: 382-389, (2004). 8. "Block of VSV endocytic and exocytic pathways by 1- cinnamoyl-3,11dihydroxymeliacarpin, a tetranortriterpenoid of natural origin". Andrea A. Barquero, Laura E. Alché and Celia E. Coto. Journal of General Virology 85: 483-493 (2004). 9. "Antiherpetic mode of action of (22S,23S)-3-bromo-5,22,23-trihydroxystigmastan 6one in-vitro". Wachsman MB, Castilla V, Talarico LB, Ramirez JA, Galagovsky LR, Coto CE. International Journal of. Antimicrobial Agents, 23: 525-527, (2004). 10. "Enterocin CRL35 inhibits late stages of HSV-1 and HSV-2 in vitro multiplication". Mónica B. Wachsman, Viviana Castilla, Aida P. De Ruiz Holgado, Ramón A. de Torres. Fernando Sesma and Celia E. Coto. Antiviral Research 58: 17-24, (2003). 11. "Antiherpes virus activity of new 6-19 carbon-bridged steroids and some synthetic precursors". Petrera, E., Joselevich, M., Ghini, A., Burton, G. and Coto C.E. Antiviral Chemistry and Chemotherapy. 14: 243-248, (2003). 12. "Effect of meliacine, a plant derived antiviral, on tumor necrosis factor alpha". Petrera, E and Coto C.E. Fitoterapia 74: 77-83, (2003). 13. "Hippocampal infection with HSV-1-derived vectors expressing an NMDAR1 antisense modifies behavior". M. F. Adrover, V. Guyot-Revol, V. T. Cheli, , C. Blanco, R. Vidal, L. Alché, E. Kornisiuk, A. L. Epstein and D. Jerusalinsky. Genes, Brain and Behavior 2: 10313, (2003). 14. "An antiviral meliacarpin from leaves of Melia azedarach L.". Alché L.E., Assad Ferek G., Meo M., Coto C.E. and Maier, M.S.. Zeitschrift für Naturforschung Section C 58c (3/4): 215-219 (2003). 64

15. "Structure-activity relationship studies in a set of new brassinosteroid derivatives assayed against herpes simples virus type 1 and 2 in cell cultures" Talarico Laura B., Ramirez Javier A., Galagovsky Lydia R. and Wachsman Mónica B. Medicinal Chemistry Research, 11: 434-444, (2002). 16. "Gene transfer of NMDAR1 subunit sequences to the rat CNS using Herpes Simplex Virus vectors interfered with habituation".V. T. Cheli, M. F. Adrover, C. Blanco, E. Rial Verde, V. Guyot-Revol, R. Vidal, E. Martin, L. Alché, G. Sanchez, M. Acerbo, A. L. Epstein and D. Jerusalinsky. Cellular and Molecular Neurobiology 22: 303-14 (2002). 17. "Therapeutic action of meliacine, a plant-derived antiviral, on HSV-induced ocular disease in mice".María Paula Pifarré, Alejandro Berra, Celia E. Coto and Laura E. Alché. Experimental Eye Research 75: 327-334, (2002). 18. "An antiviral principle present in a purified fraction from Melia azedarach L. leaf aqueous extract restrains Herpes simplex virus type 1 propagation". Laura E. Alché, Andrea A. Barquero, Norberto A. Sanjuan and Celia E. Coto. Phytotherapy Research 16: 348-352, (2002). 19. "Antiviral activity of brassinosteroid derivatives against Measles virus replication". Mónica B. Wachsman, Javier A. Ramírez and Lydia Galagovsky. Antiviral Chemistry and Chemotherapy 13: 61-66, (2002). 20. "Actividad antiviral en productos naturales: Melia azedarach L. Efecto sobre la multiplicación del virus Junín, agente de la fiebre hemorrágica argentina y acción terapéutica sobre la queratitis estromal del ratón causada por herpes simplex." Celia E. Coto, Laura E. Alché, Viviana Castilla. Anales Academia Nacional de Ciencias Exactas, Físicas y Naturales 53: 161-177, (2001). 21. "Involvement of vacuolar proton ATPase on Junin virus multiplication." Viviana Castilla, Laura M. Palermo, Celia .E. Coto. Archives of Virology 146: 251-263, (2001). 22. "Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral". Laura E. Alché, Alejandro Berra and Celia E. Coto. International Antiviral News 9: 132-135, (2001). Publicado por invitación del Dr. Derek Kinchington, Scientific Writer/Editor International Medical Press. 23. "Antiviral effect of brassinosteroids against herpes and arenaviruses".. Mónica B. Wachsman, Elsa M.F. López, Javier A. Ramirez, Lydia R. Galagovsky y Celia E. Coto. Antiviral Chemistry and Chemotherapy 11: 71-77, (2000). 24. "Treatment with meliacine, a plant derived antiviral, prevents the development of herpetic stromal keratitis in mice". Alché L.E., Berra A., Veloso M.J. and Coto C.E. Journal of Medical Virology 61: 474-480, (2000).

65

Laboratorio de Apoptosis y virus (Susana Mersich y Félix Coulombié) 1. Título: Oxidative stress in Vero cells infected with Vesicular Stomatitis virus. Año: 2005. Aprobado para su publicación En pruebas de galera. País: Suiza. Nombre: Intervirology. ISBN: 0304-8608. Idioma : Inglés. Autores: Riva D, Ríos de Molina MC , Rocchetta I, Gerhardt E, Coulombié F, Mersich S. 2. Título: Inhibition of cell fusion in Junín-virus infected cells by sera from Argentine Hemorrhagic fever patients. Año: 2005. País: Holanda. Nombre: Journal of Clinical Virology. 32:286-288. ISBN: 1386-6532. Idioma: Inglés. Autores: Castilla V, Contigiani M, Mersich S. 3. Título: Early activation of the mitochondrial apoptotic pathway in Vesicular Stomatitis virus-infected cells. Año: 2004. País: Holanda Nombre de la revista: Virus Research. 109:65-69. ISBN: 0168-1702 Idioma: Inglés. Autores: Gadaleta P, Perfetti X, Mersich S, Coulombié F. 4. Título: Influenza circulating strains exhibit differential induction of cytotoxicity and caspase-3 in vitro. Año: 2004. País: Holanda. Nombre de la revista: Journal of Clinical Virology. 31:134-139. ISBN: 1386-6532. Idioma: Inglés. Autores: Mersich S, Baumeister E, Riva D, Lewis A, Cadario S, Pontoriero A, Savy V. 5. Título: Virucidal activity activity present in Trichilia glabra leaves. Año: 2004 País: Argentina. Nombre de la revista: Revista Argentina de Microbiología. 36: 136-138. ISBN: 0325-7541. Idioma: Inglés. ( Artículos preferentemente en Castellano) Autores: Cella M, Riva D, Coulombié F, Mersich S.

66

6. Título: Vesicular stomatitis virus induces apoptosis at early stages in the viral cycle and does not depend on virus replication. Año: 2002 País: Holanda. Nombre de la revista: Virus Research 86(1-2): 87-92. ISSN: 0168-1702. Idioma: Inglés. Autores: Gadaleta P. , Vacotto M., Coulombié P. 7. Título: Antiviral activity of an acidic polysaccharides fraction extracted from Cedrela tubiflora leaves. Año: 2001 País: Holanda Nombre de la revista: Fitoterapia 72(2): 113-9. ISSN: 0367-326X Idioma: Inglés. Autores: Craig MI, Benencia F., Coulombié F. 8. Título: In vivo and in vitro immunomodulatory activities of Trichilia glabra aqueous leaf extracts. Año: 2000 País: Irlanda Nombre de la revista: J. Ethnopharmacology 69(3): 199-205. ISSN: 0378-8741 Idioma: Inglés. Autores: Benencia F, Courreges MC, Coulombié F. 9. Título: Anti-inflammatory activities of Trichilia glabra aqueous leaf extract. J Ethnopharmacol. 2000 Jul;71(1-2):293-300. Año: 2000 País: Irlanda Nombre de la revista: J. Ethnopharmacology 71(1-2): 293-300. ISSN: 0378-8741 Idioma: Inglés. Autores: Benencia F, Courreges MC, Coulombié FC. Capítulos de libros 1. Título del Libro: Microbiología Biomédica. Unico libro de texto de origen Latinoamericano que forma parte del PAL:TEX. Programa ampliado de Libros de Texto y materiales de instrucción de la OPS, en Area de Microbiología. Título: Respuesta inmune y Patogenia. Cap 64. Año: 2005. (en prensa). Reedición actualizada de 1996. País: Argentina. Editorial Atlante. Buenos Aires. Ed. J. Basualdo y R. de Torres. ISBN: 950-9539-30-9 Autores: Coulombié, F.

67

2. Título del Libro: Microbiología Biomédica. Título: Agentes inactivantes de virus. Cap 63. Año: 2005. (en prensa). Reedición actualizada de 1996. País: Argentina. Editorial Atlante. Buenos Aires. Ed. J. Basualdo y R. de Torres. ISBN: 950-9539-30-9 Autores: Mersich, S. 3. Título del Libro: Microbiología Biomédica. Título: Genética de virus Animales. Cap. 62. Año: 2005. (en prensa). Reedición actualizada de 1996. País: Argentina. Editorial Atlante. Buenos Aires. Ed. J. Basualdo y R. de Torres. ISBN: 950-9539-30-9 Autores: Damonte E, Mersich S. Otros Trabajos 1. Título: Nuevas estrategia terapéuticas basadas en apoptosis y virus. Año: 2003 País: Argentina. Nombre de la revista: Acta de Bioquímica Clínica Latinoamericana. 2003. 37:13-19. Gráfico incluido en la tapa del ejemplar 37. ISBN: Castellano ISSN 0325/2957 Idioma: Castellano Autores: Gadaleta P, Mersich S. 2. Título: Vaccine production in Argentina: a decision that cannot be postponed Año: 2003. País : Argentina Nombre de la revista: Medicina (B Aires). 2003;63(5):457-8. ISSN: Desconocido Idioma. Español. Autores: Airaldi , MG, ......, Gadaleta P. et al 3. Título: La apoptosis en las infecciones virales en humanos. Año: 2000. País: Argentina. Nombre de la revista: Reseñas de Infectología y Vacunas. (Bs.As).Vol 7, 11-17 ISSN desconocido Idioma: Castellano Autores: Mersich S. Laboratorio de Virología: Estrategias antivirales (Elsa Damonte) 1. M.C. Rodríguez, E.R. Merino, C.A. Pujol, E.B. Damonte, A.S. Cerezo, M.C. Matulewicz. Galactans from cystocarpic plants of the red seaweed Callophylis variegata (Kallymeniaceae, Gigartinales). Carbohydrate Research, 2005 (en prensa). 68

2. P.C. de S.F-Tischer, L.B. Talarico, M.D. Noseda, S.M.P.B. Guimaraes, E.B. Damonte, M.E.R. Duarte. Chemical strcuture and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus. Carbohydrate Polymers, 2005 (en prensa). 3. C.A. Pujol, L.A. Scolaro, M. Ciancia, M.C. Matulewicz, A. Cerezo, E.B. Damonte. Antiviral activity of a carrageenan from Gigartina skottsbergii against intraperitoneal murine herpes simplex virus infection. Planta Medica, 2005 (en prensa). 4. B. Matsuhiro, A.F. Conte, E.B. Damonte, A.A. Kolender, M.C. Matulewicz, E.G. Mejías, C.A. Pujol, E.A. Zúñiga. Structural analysis and antiviral activity of a sulfated galactan from the red seaweed Schizymenia binderi (Gigartinales, Rhodophyta). Carbohydrate Research 340: 2392-2402, 2005. 5. C.B. Duschatzky, M.L. Possetto, L.B. Talarico, C.C. García, F. Michis, N.V. Almeida, M.P. de Lampasona, C. Schuff, E.B. Damonte. Evaluation of chemical and antiviral properties of essential oils from South American plants. Antiviral Chemistry and Chemotherapy 16: 247-251, 2005. 6. M.A. Martins Alho, M.I. Errea, V.L. Sguerra, N.B. D'Accorso, L.B. Talarico, C.C. García, E.B. Damonte. Synthesis and antiviral evaluation of some carbonucleoside analogues. Journal of Heterocyclic Chemistry 42: 979-983, 2005. 7. L.B. Talarico, C.A. Pujol, R.G.M. Zibetti, P.C.S. Faría, M.D. Noseda, M.E.R. Duarte. E.B. Damonte. The antiviral activity of sulfated polysaccharides against dengue virus is dependent on virus serotype and host cell. Antiviral Research 66: 103-110, 2005. 8. P. Ghosh, U. Adhikari, P.K. Ghosal, C.A. Pujol, M.J. Carlucci, E.B. Damonte, B. Ray. In vitro anti-herpetic activity of sulfated polysaccharide fractions from Caulerpa racemosa. Phytochemistry 65: 3151-3157, 2004. 9. M.J. Carlucci, L.A. Scolaro, M.D. Noseda, A.S. Cerezo, E.B. Damonte. Protective effect of a natural carrageenan on genital herpes simplex virus infection in mice. Antiviral Research 64: 137-141, 2004. 10. L.A. Scolaro, C.A. Pujol, M.J. Carlucci, E.B. Damonte. Perspectivas de los carragenanos para la prevención de enfermedades de transmisión sexual. Sociedad Iberoamericana de Información Científica, recuperable de <http:// www.siicsalud.com/ dato/dat039/ 04823000.htm, SIIC Salud, 2004. 11. L.B. Talarico, R.G.M. Zibetti, P.C.S. Faria, L.A. Scolaro, M.E.R. Duarte, M.D. Noseda, C.A. Pujol, E.B. Damonte. Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata. International Journal of Biological Macromolecules 34: 63-71, 2004.

69

12. M.E.R. Duarte, J.P. Cauduro, D.G. Noseda, M.D. Noseda, A.G. Goncalvez, C.A. Pujol, E.B. Damonte, A.S. Cerezo. The structure of the agaran sulfate from Acantophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans. Carbohydrate Research 339: 335-347, 2004. 13. C.C. García, L. Talarico, N. Almeida, S. Colombres, C. Duschatzky, E.B. Damonte. Virucidal activity of essential oils from aromatic plants of San Luis, Argentina. Phytotherapy Research 17: 1073-1075, 2003. 14. C.C. García, B.N. Brousse, M.J. Carlucci, A.G. Moglioni, M. Martins Alho, G.Y. Moltrasio, N.B. D'Accorso, E.B. Damonte. Inhibitory effect of thiosemicarbazone derivatives on Junin virus replication in vitro. Antiviral Chemistry and Chemotherapy 14: 99-105, 2003. 15. G.A. Garrido Santos, A.P. Murray, C.A. Pujol, E.B. Damonte, M.S. Maier. Synthesis and antiviral activity of sulfated and acetylated derivatives of 2,3-dihydroxy-5cholestane. Steroids 68: 125-132, 2003. 16. C.C. García, N.A. Candurra, E.B. Damonte. Differential inhibitory action of two azoic compounds against arenaviruses. International Journal of Antimicrobial Agents 21: 319324, 2003. 17. N.M.A. Ponce, C.A. Pujol, E.B. Damonte, M.L. Flores, C.A. Stortz. Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies. Carbohydrate Research 338: 153-165, 2003. 18. R. Torres, B. Modak, A. Urzúa, F. Delle Monache, E. Damonte, C.A. Pujol. Propiedades antivirales de compuestos naturales y semi-sintéticos de la resina de Heliotropim filifolium. Bolsín de la Sociedad Chilena de Química 47: 259-263, 2002. 19. S. Mazunder, P.K. Ghosal., C.A. Pujol, M.J. Carlucci, E.B. Damonte, B. Ray. Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta). International Journal of Biological Macromolecules, 31: 8795, 2002. 20. C.C. García, N.A. Candurra, E.B. Damonte. Mode of inactivation of arenaviruses by disulfide-based compounds. Antiviral Research 55: 437-446, 2002. 21. C.A. Pujol, J. Estévez, M.J. Carlucci, M. Ciancia, A. Cerezo, E.B. Damonte. Novel DL-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus. Antiviral Chemistry and Chemotherapy 13: 8389, 2002. 22. M.J. Carlucci, L.A. Scolaro, E.B. Damonte. Herpes simplex virus type 1 variants arising after selection with an antiviral carrageenan: lack of correlation between drugsusceptibility and syn phenotype. Journal of Medical Virology 68: 82-91, 2002.

70

23. C.C. García, M.L. Rosso, M.D. Bertoni, M.S. Maier, E.B. Damonte. Evaluation of the antiviral activity against Junin virus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis coridifolia. Planta Medica 68: 209-212, 2002. 24. M.S. Maier, A.J. Roccatagliata, A. Kuriss, H. Chludil, A.M. Seldes, C.A. Pujol, E.B. Damonte. Two new cytotoxic and virucidal trisulfated triterpene glycosides from the Antartic sea cucumber Staurocucumis liouvillei. Journal of Natural Products 64: 732-736, 2001. 25. M.E.R. Duarte, D.G. Noseda, M.D. Noseda, S. Tulio, C.A. Pujol, E.B. Damonte. Inhibitory effect of sulfated galactans from the marine alga Bostrychia montagnei on herpes simplex virus replication in vitro. Phytomedicine 8: 53-58, 2001. 26. N. López, L. Scolaro, C. Rossi, R. Jácamo, N. Candurra, C. Pujol, E.B. Damonte, M.T. Franze-Fernández. Homologous and heterologous glycoproteins induce protection against Junin virus challenge in guinea pigs. Journal of General Virology 81: 1273-1281, 2000. 27. C.C. García, N.A. Candurra, E.B. Damonte. Antiviral and virucidal activities against arenaviruses of Zinc-finger active compounds. Antiviral Chemistry and Chemotherapy 11: 231-238, 2000. 28. P.J. Cáceres, M.J. Carlucci, E.B. Damonte, B. Matsuhiro, E.A. Zúñiga. Carrageenans from Chilean samples of Stenogramme interrupta (Phyllophoraceae): structural analysis and biological activity. Phytochemistry 53: 81-86, 2000. Trabajos de actualización en publicaciones periódicas y/o libros 1. E.B. Damonte, C.C. García. Perspectives for the therapy against arenavirus infections. En: Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats, P.F. Torrence (Ed), J. Wiley & Sons, New York, p. 115-138, 2005. 2. E.B. Damonte, C.A. Pujol, C.E. Coto. Prospects for the therapy and prevention of dengue virus infections. Advances in Virus Research 63: 239-285, 2004. 3. E.B. Damonte, M.C. Matulewicz, A.S. Cerezo. Seaweed sulfated polysaccharides as antivirals. Current Medicinal Chemistry 11: 2399-2419, 2004. 4. E.B. Damonte, C.E. Coto. Treatment of arenavirus infections: from basic studies to the challenge of antiviral therapy. Advances in Virus Research 58: 125-155, 2002. 5. E.B. Damonte. Junin virus. En: Encyclopedia of Molecular Medicine, T.E. Creighton (Ed), J. Wiley & Sons, New York, p.1844-1846, 2002. 6. M.C. Matulewicz, E.B. Damonte, A.S. Cerezo. Estructura y actividad antiviral de polisacáridos sulfatados de algas. Naturalia patagónica 1: 1-21, 2002.

71

Laboratorio Toxicología y Química Legal: Bioindicadores de estrés ambiental antropogénico (Eva Kesten) 1. Oneto M. L., Basack S.B., Casabé N.B., Fuchs J.S., Kesten E.M. (2005) "Biological responses in the freshwater bivalve Corbicula fluminea and the earthworm Eisenia fetida exposed to fenitrothion"; Fresenius Environmental Bulletin, , vol. 14, Nº 8, 716-720. 2. Fuchs J., Casabé N., Oneto M.L., Di Lello A., Lami M., Bongiovanni D., Vaccarezza M., Gómez Segura O., Vázquez C., Sánchez-Rivas C., Kesten EM (2003). "Ensayos de biorremediación de un suelo contaminado con trinitrotolueno (TNT)". En "Toxicología y Química Ambiental. Contribuciones para un desarrollo sustentable", SETAC Press, Buenos Aires, Argentina, 244-246. 3. Prieto González E.A., Fuchs J., Casabé N., Oneto M.L., Kesten E. (2003) "Ensayo cometa en celomocitos de lombrices (Eisenia fetida) expuestas a 2,4,6-trinitrotolueno (TNT)". En "Toxicología y Química Ambiental. Contribuciones para un desarrollo sustentable", SETAC Press, Buenos Aires, Argentina, 164-166. 4. Casabé N.B., Oneto M.L., Fuchs J.S., Sánchez-Rivas C., Kesten E.M. (2003) "Nitrocompuestos aromáticos explosivos: biotransformación, toxicidad y remediación". Acta Bioquím. Clín. Latinoam. 37, 47-58. 5. Gürtler, R.E; Oneto, M.L.; Cecere; M.C; Castañera, M.B., Canale, D.M. (2001) "A simple method to identify triatomine feces in sensing devices used in vector surveillance programs" J. Med. Entomol., 38 (2), 147-152. 6. Fuchs J.S., Oneto M.L., Casabé N.B., Gómez Segura O., Tarulla R., Vaccarezza M., Sánchez-Rivas C., Kesten E.M., Wood E.J. (2001) "Ecotoxicological Characterization of a Disposal Lagoon from a Munition Plant". Bull. Environ. Contam. Toxicol. 67, 696-703.

Laboratorio de Inmunoquímica: Inmunología de mucosas (Ernesto Massouh) 1. "Expression of IL-15, IL-18 and NOS.II in contralateral eyes of BALB/c mice during the development of HSV-induced keratitis. Cavalieri, H.;Gamba,G.;Courreges,M.;Massouh,E.;Benencia,F. Immunology Letters,96:295-298,2005 2. " Nitric oxide modulation of the immune response against cholera toxin-adjuvanted ovalbumin administered by the intranasal route" Gamba.G.;Bonorino,P.;Gonzalez,R.;Benedetti,R.;Cavalieri,H.;Courreges,M.;Masouh,E.;Be nencia,F. Immunology Letters,92:245-252,2004. 3. "Early inhibition of nitric oxide production increase HSV-1 intranasal infection " 72

Gamba,G.;Cavalieri,H.;Courreges, M.;Massouh,E.;Benencia,F. J. Med. Virol.,73:313-322,2004. 4. "Nitric oxide and herpes simplex virus vaginal infection in Balb/c mice". Benencia, F.;Gamba, G.;Cavalieri,H.;Courreges,M.;Benedetti,R.;Villamil,M.;Massouh,E. Virology, 309:75-84,2003. 5. "Effect of undernourishement on HSV-1 ocular infection in the rat model". Benencia,F;Courreges,M.;Benedetti,R.;Gamba,G.;Cavalieri,H.;Massouh,E. International Journal of Experimental Pathology, 83:57-66,2002. 6. "Intranasal infection with HSV-1 in undernurrished rats" Benencia, F.;Gamba,G.; Courreges, M.; Benedetti,R.; Massouh,E. Nutrition Research ,21:1435-1446,2001. 7. "Effect of Aminoguanidine, a nitric oxide synthase inhibitor, on ocular infection with Herpes Simplex virus in Balb/c mice" Benencia, F.;Gamba, G.; Courreges, M. ;Massouh ,E. Investigative Ophthalmology and Visual Science,42:6,1277-84,2001. Laboratorio de Genética y Ecología Microbianas (Beatriz Méndez) 1. Pablo I. Nikel, M. Julia Pettinari, Beatriz S. Méndez, Miguel A. Galvagno. Statistical optimization of a culture medium for biomass and poly(3-hydroxybutyrate) production by a recombinant Escherichia coli strain using agroindustrial by-products. International Microbiology 8: 243-250. 2005 2. Nicolás D. Ayub, M.Julia Pettinari, Jimena A. Ruiz and Nancy I. López. A polyhydroxybutyrate- producing Pseudomonas sp. Isolated from Antactic environments with high stress resistance. Current Microbiology 49: 170-174. Springer Verlag New York 2004 3. Ruiz, J.A., López, N.I,Pettinari, M.J. and Méndez, B.S. Role of polyhydroxyalkanoates (PHAs) in bacterial stress resistance. Proceedings of the International Symposium on Biotechnology. San Miguel de Tucumán, 2004. 4. Ruiz,J.A., López, N.I. and Mendez, B.S. rpoS gene expression in carbon-starved cultures of the polyhydroxyalkanoate accumulating species Pseudomonas oleovorans. Current Microbiology. 48: 396-400. 2004. 5. López, NI, Austin, A., Sala, O. and Méndez, B.S. Controls on nitrification in a water-limited ecosystem: experimental inhibition of ammonia-oxidising bacteria in the patagonian steppe. Soil Biol. Biochem.35: 1609-1613. 2003

73

6. Costa, C.S., Pettinari, M.J., Méndez, B.S. and Antón, D.N. Null mutations in the essential gene yrfF (mucM) are not lethal in rcsB, yojN or rcsC strains of Salmonella enterica serovar Typhimurium.FEMS Microbiol Lett. 222:25-32.2003 7. Vazquez, G.J., Pettinari, M.J. and Méndez, B.S. Evidence of an association between Poly (3-hydroxybutyrate) accumulation and phosphotransbutyrylase expression in Bacillus megaterium. Int. Microbiol. 6: 127-129. 2003. 8. Pettinari, M.J.,Chanetón,L.,Vazquez,G.J., Steinbüchel,A. and Méndez,B.S.Insertion sequence - like elements associated with putative polyhydroxybutyrate regulatory genes in Azotobacter sp. FA8. Plasmid 50: 36-44. 2003 9. Pettinari, M. J., Vazquez, G. J ., Silberschmidt,D., Rehm B., Steinbüchel A. and Méndez,B.S. Poly(3-hydroxybutyrate) genes in Azotobacter sp. FA8.Appl. Environ.Microbiol. 67: 5331-5337. 2001 10. Giacomodonato, M.N., Pettinari, M.J., Souto, G., Méndez, B.S. and López, N.I. A PCR ­ based method for the screening of bacterial strains with antifungal activity in suppressive soybean rhizosphere. World J. Microbiol. Biotechnol.17: 51-55. 2001 11. Ruiz,J.A., López N.I., Fernández, R. and Méndez B.S Polyhydroxyalkanoate degradation is associated with nucleotide accumulation and enhaces stress resistance and survival of Pseudomonas oleovorans in natural water microcosms. Appl. Environ. Microbiol 67: 225-230. 2001 12. Vazquez, G.J., Pettinari, M.J. and Méndez, B. S Phosphotransbutyrylase expression in Bacillus megaterium. Curr. Microbiol. 42: 345- 349. 2001 Publicaciones electrónicas 1. Pseudomonas oleovorans rpoS gene for RNA polymerase sigma factor. ACCESSION AJ519340. 2002 2. Azotobacter sp. FA8 phaF gene, phaP gene, phaR gene, ORFB and ORFA. EMBL nucleotide accession number AJ496234. 2002 ( incluida en la publicación 8) 3. Azotobacter sp. FA8 phbA gene for beta-ketothiolase and phbC gene for PHB synthase EMBL nucleotide accession number AJ319748.2001( incluida en la publicación 9) 4. Azotobacter sp. FA8 phaB gene for acetoacetyl-CoA reductaseEMBL nucleotide accession number AJ311166 .2001.( incluida en la publicación 9) 5. Bacillus megaterium ptb gene for phosphotransbutyrylase. EMBL nucleotide accession number AJ278958. 2000 (Incluida en la publicación12) 6. EMBL nucleotideaccession number: AJ277459. Unidentified ammonia oxidizing bacterium UBA6-1 partial amoA gene for ammonia monooxigenase. 2000 74

Artículos de divulgación científica 1. Méndez, B. S. ...las cosas por su nombre. Tarea harto difícil si de bacterias se trata. Boletín de la Asociación Argentina de Microbiología. 2003 2. Stoppani, A., Méndez, B. S. and Sordelli, D. Remembering a Microbiologist: Alfredo Sordelli. Enviado a publicación a International Microbiology. 4: 237-238. 2001.

Laboratorio de Análisis Biológicos (Alcira Nesse) 1. "Homeostasis del hierro. Mecanismos de absorción, captación celular y regulación". Actualización. Pérez, G; Vittori, D; Pregi, N; Garbossa, G; Nesse, A. Acta Bioquím Clín Latinoamer, ISSN 0325-2957, Vol. 39, N°3, 2005. En prensa. 2. "Aluminum exposure affects transferrin-dependent and -independent iron uptake by K562 cells". Pérez G, Pregi N, Vittori D, Di Risio C, Garbossa G, Nesse A. Biochim Biophys Acta Elsevier, ISSN 0005-2736, 1745:124-130, 2005. 3. "The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor". Vittori D, Pregi N, Pérez G, Garbossa G, Nesse A. Biochim Biophys Acta, Elsevier, ISSN 0005-2736, 1743:29-36, 2005. 4. "Aluminio: culpable o inocente?". Nesse A, Garbossa G, Pérez G. Vittori D, Pregi N. Química Viva Año 1, número 2, 2003. Revista electrónica con referato nacional, del Depto. de Química Biológica, FCEN, UBA (www.quimicaviva.fcen.uba.ar). ISSN 1666-7948. 5. "Tamm-Horsfall protein excretion to predict the onset of renal insufficiency". Romero MC, Zanaro N, González L, Trigo P, Imventarza O, Nesse A. Clin Biochem, Elsevier, ISSN 0009-9120, 35:65-68, 2002. 6. "Human erythroid cells are affected by aluminium. Alteration of membrane band 3 protein". Vittori D, Garbossa G, Lafourcade C, Pérez G, Nesse A. Biochim Biophys Acta, Elsevier, ISSN 0005-2736, 1558:142-150, 2002. 7. "Toxicidad del aluminio sobre el sistema eritropoyético. Mecanismos involucrados". Actualización. Pérez G, Vittori D, Garbossa G, Nesse A. Acta Bioquím Clín Latinoamer, ISSN 0325-2957, 36:41-50, 2002.

75

8. "Disturbance of cellular iron uptake and utilisation by aluminium". Pérez G, Garbossa G, Di Risio C, Vittori D, Nesse A. J Inorg Biochem, Elsevier, ISSN 0162-0134, 87:21-27, 2001. 9. "Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies". Lauricella AM, Garbossa G, Nesse A. Int Immunopharmacol, Elsevier, ISSN 1567-5769, 1:1725-1732, 2001. 10. "Lipoproteínas de baja densidad modificadas en pacientes con insuficiencia renal. Detección por electroforesis". Lauricella AM, Elbert A, Beresán H, Nesse A. Nefrol Latinoamer, Sociedad Latinoamericana de Nefrología, 7:27-34, 2000. Capítulos de libros 1. Aluminium toxicity in erythropoiesis. Mechanisms related to cellular dysfunction in Alzheimer's Disease. Nesse A, Garbossa G. En Aluminium and Alzheimer's Disease. The Science that describes the Link. C Exley (ed.), Elsevier, Amsterdam, cap. 13, pp.261-278, 2001. ISBN 0 444 50811 2. Artículos de divulgación científica 1. "La otra cara del aluminio". Entrevista, realizada por Cecilia Draghi, al grupo de investigación dirigido por la Dra. Alcira Nesse: Revista "Exactamente" de la Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, ISSN 1514-920X, vol. 10 (27):30-33, 2003.

Laboratorio de Inmunofarmacología (Claudia Pérez Leirós) 1. Rosignoli F, Roca V., Meiss R., Receta J., Gomariz R.P., Pérez Leirós C. (2005). A defective signalling in salivary glands precedes the autoimmune response in the NOD mouse model of sialadenitis. Clin Exp Immunol (en prensa). 2. Roca V, Rosignoli F, Calafat M, Pérez Leirós C (2004). Lack of nitric oxide-mediated regulation of amylase secretion stimulated by VIP in parotid glands of NOD mice. Int. Immunopharmacol 4/14:1837-1844. 3. Rosigmoli F, Roca V, Meiss R, Pregi N, Pérez Leirós C. (2004). Inhibition of calciumcalmodulin kinase restores nitric oxide production and signaling in submandibular glands of a mouse model of salivary dysfunction. Br J Pharmacol 143: 1058-1065 4. Rosignoli F, Pérez Leirós C. (2002). Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice. J Neuroimmunol 130: 109-116. 5. Rosignoli F, Pérez Leirós C. (2002). Activation of nitric oxide synthase through muscarinic receptors in rat parotid gland. Eur J Pharmacol 439:27-33. 76

6. Rosignoli F, Goren N, Pérez Leirós C. (2001). Alterations in the activity and expression of NOS in submandibular glands of NOD mice. Clin Immunol 101: 86-93. 7. Pérez Leirós C, Rosignoli F, Genaro A, Sales ME, Sterin Borda L, Borda E. (2000) Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands. J Aut Nerv Sys 79: 99-107.

Laboratorio de Estudios de estrés osmótico en bacterias Gram positivas (Carmen Sánchez) 1. López CS, Alice A., Heras H. Rivas EA. & Sanchez-Rivas C. (2005) "Role of the anionic phospholipids in the adaptation of Bacillus subtilis to high salinity." Microbiology en revision 2. Prado Acosta M, Valdman E., Battaglini F., Leite S.G.F. and Ruzal S. (2005) "Biosorption of copper by Paenibacillus polymyxa cells and their exopolysaccharide World Journal of Microbiology and Biotechnology 21 en prensa ISSN: 0959-3993 3. Piuri M., Sanchez-Rivas C., Ruzal S.M. (2005) Cell wall modifications during osmotic stress in Lactobacillus casei Journal of Applied Microbiology 98(1):84-95 (ISI Impact factor JCR2003: 1.743) Blackwell Publishing ISSN 1365-2672 4. Alice AF, G. Pérez-Martinez & C. Sanchez-Rivas (2003) "Phosphoenolpyruvate phosphotransferase system and N-acetyl glucosamine metabolism in Bacillus sphaericus." Microbiology; 149: 1687-1698 5. Casabé Norma, María Luisa Oneto, Julio Fuchs, Carmen Sánchez-Rivas y Eva Kesten (2003). " Nitrocompuestos aromáticos explosivos: biotransformación, toxicidad y remediación Acta Bioquímica clínica LatinoAmericana. Vol XXXVII- nº1 6. Piuri M., C. Sanchez-Rivas and S.M. Ruzal. (2003) Adaptation to high salt in Lactobacillus: Role of peptides and proteolytic enzymes Journal of Applied Microbiology 95(2)372-379 (ISI Impact factor JCR2003: 1.743) Blackwell Publishing ISSN 1365-2672 7. Ruzal S.M. and Sanchez-Rivas C. (2003) Effect of Glutamate Synthase (Gogat) Activity In Bacillus subtilis Spore Properties." Current Microbiology 47(3):208-13 (ISI Impact factor JCR2002: 1.21) Springer-Verlag ISSN 0343-8651 8. Alice A., G Perez Martinez & C Sánchez de Rivas (2002). "Existence of a true Phosphofructokinase in Bacillus sphaericus: cloning and sequencing of the pfk gene". Applied and Environmental Microbiology vol 68 (12) 6410-6415 77

9. S. Fuchs, M.L. Oneto, N.B. Casabé, O. Gómez Segura, R. Tarulla, M. Vaccarezza, C. Sánchez-Rivas, E.M. Kesten and E.J Wood (2001) - "Ecotoxicological Characterization of a Disposal Lagoon from a Munition Plant" Bulletin of Environmental Contamination and Toxicology. Vol. 67, 696-703 10. Priano G., Ruzal SM and F. Battaglini (2001) "Evaluation of an electrochemiluminescent method for the detection of microorganism resistance to ßlactam antibiotics. Analytical Biochemistry 290(2):379-82 (ISI Impact factor JCR2002: 2.37) Elsevier ISSN 0003-2697 11. Lopez C.S., Heras H., Garda H., Ruzal S., Sanchez-Rivas C. and Rivas E. (2000). "Biochemichal and biophysical studies of Bacillus subtilis envelopes under hyperosmotic stress". Internatinal Journal of Food Microbiology, 55: 137-142 (ISI Impact factor JCR2003: 2.26) Elsevier ISSN: 0168-1605 12. Cortón E, M. Piuri, F. Battaglini and S.M. Ruzal (2000) "Characterization of Lactobacillus Carbohydrate Fermentation Activity using Immobilised Cell Technique" Biotechnology Progress, 16(1): 59-63 (ISI Impact factor JCR2001: 1.821) American Chemical Society ISSN 8756-7938 Capítulos de libros 1. En « Toxicología y Química ambiental : Contribuciones para un desarrollo sustentable » de SETAC LA Editor: J. Hercovits. 2003 pp.244-246 "Ensayos de biorremediación de un suelo contaminado con trinitrotolueno (TNT)." Fuchs, J., Casabé N., Oneto M.L., Di Lello A., Lami M., Bongiovanni D., Vaccarezza M., Gómez Segura O., Vázquez C., Sánchez-Rivas C. y Kesten E.

Laboratorio de Metabolismo del hemo: Porfirias y enfermedades relacionadas (Victoria Parera y María Victoria Rossetti) 1. Design of a novel dendritic derivative of aminolevulinic acid to improve the outcome of photodynamic therapy" Di Venosa G, Casas A., Battah S, Dobbin P, Fukuda H, MacRobert A, Batlle A. Int. J. Biochem. Cell Biol., 38: 82-91 (2006). 2. The role of inherited and acquired factors in the development of Porphyria Cutanea Tarda in the Argentinean population. M Mendez, MV Rossetti, AM. del C Batlle , VE Parera. Journal of the American Academy of Dermatology. 52 (3) 417-424 (2005) 3. A spectrophotometric method for estimating hemin in biological systems. Lombardo M.E., Araujo L.S., Ciccarelli A.B. & Batlle A. Anal. Biochem. (2005) 341: 199-203

78

4. Sensitivity to ALA-PDT of cell lines with different nitric oxide production and resistance to nitric oxide cytotoxicity". Di Venosa,G.; Perotti,C.; Fukuda,H.; Batlle,A. & Casas, A. J. Photochem. Photobiol. B, 80: 195-202(2005). 5. Aminolevulinic acid: from its unique biological function to its star role in photodynamic therapy. Fukuda H, Casas A & Batlle A" Int. J. Biochem. Cell Biol, 37: 272-276 (2005). 6. No cross resistance between ALA-PDT and Nitric Oxide" Di Venosa G, Casas A, Fukuda H, Perotti C & Batlle A. Nitric Oxide Biol. Chem,13: 155-162 (2005). 7. Glutathione depletion and anaesthesia in mice alter heme and drug metabolising enzymes. Buzaleh, A.M. & Batlle, A. Biochim. Biophys. Acta 1723 (2005) 128-134 8. Efecto de la administración de los anestésicos Enflurano e Isoflurano a ratones con niveles inducidos y deprimidos de Citocromo P450. Estudios sobre el sistema enzimático metabolizante de drogas. Martínez, M. del C.; Buzaleh, A.M. & Batlle, A. Acta Bioquím. Clin. Latinoam. 39 (2005) 37-42 9. Effects of repeated administration with CP-55,940, a cannabinoid CB1 receptor agonist on the metabolism of the hepatic heme. A. Fontanellas, A.; Manzanares, J.; García-Bravo, M., Buzaleh, A.M.; Méndez, M.; Oliva, J.M.; Batlle, A. ; Palomo, T. & Enriquez de Salamanca, R. Int. J. Biochem. Cell Biol. 37 (2005) 1620-1625 10. Heme oxytenase, aminolevulinate acid synthetase and the antioxidant system in the brain of mice treated with porphyrinogenic drugs. Rodríguez, J.L.; Martínez, M. del C.; Gerez, E.; Batlle, A. & Buzaleh, A.M. Cell. Mol. Biol. 51 (2005) 487-494 11. Volatile anaesthetics induce biochemical alterations in the heme pathway in a Blymphocyte cell line established from hepatoerythropoietic porphyric patients (LBHEP) and in mice inoculated with LBHEP cells. Buzaleh, A.M; García Bravo, M.; Navarro, S.; Moran Jimenez, M.J., Méndez, M.; Batlle, A.; Fontanellas, A. & Enríquez de Salamanca, R. Int. J. Biochem. Cell Biol.36 (2004) 216-222 12. A method for separating ALA from ALA derivatives using ionic exchange chromatography". Di Venosa G, Fukuda H, Perotti C, Batlle A & Casas A. J. Photochem. Photobiol B.,75:157-63 (2004). 13. Porphyrin synthesis from ALA derivatives for Photodynamic therapy. In vitro and in vivo studies". Perotti C, Fukuda H, Di Venosa G, MacRobert A, Batlle A & Casas A. Br J. Cancer, 90: 1660-1665 (2004). 14. Acute Porphyrias in the Argentinean population: A Review. VE Parera, A De Siervi, L Varela, MV Rossetti, AM. del C Batlle Cellular and Molecular BIology 49 (4) 493-500 (2003) 15. 5-Aminolevulinic acid synthesis in epimastigotes of Trypanosoma cruzi. Lombardo M.E., Araujo L.S. & Batlle A. Int. J. Biochem. Cell Biol. (2003) 35: 1263-1271. 79

16. Dietary and sexual correlates of carotenoid pigment expression in dove plumage. Mahler B., Araujo L.S. & Tubaro P.L. The Condor (2003) 105: 258-267. 17. Topical application of ALA and ALA hexyl ester on a subcutaneous mammary adenocarcinoma: tissue distribution". C. Perotti, A.Casas, H. Fukuda, P. Sacca & A. Batlle. Br J. Cancer , 88: 432-437 (2003). 18. Estudios genéticos de las porfirias agudas en Argentina. Adriana De Siervi, Manuel Méndez, Laura Varela, María Victoria Rossetti, Victoria Parera, Alcira. Acta Bioquímica Clínica Latinoamericana XXXVI (5) 505-513 (2002). 19. 5-aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines. Adriana De Siervi, Laura Varela, María Victoria Rossetti, Alcira Batlle. BMC Cancer 6-12 (2002) 20. Saccharomyces cerevisiae 5-aminolaevulinate dehydratase (HEM2) gene, promoter and partial cds. Laura Varela, Adriana De Siervi , María Victoria Rossetti, Alcira Batlle. NCBI AF349727 (2002) 21. Photodynamic Therapy of activated and resting lymphocytes and its antioxidant adaptive response". A.Casas, C.Perotti, H. Fukuda & A. Batlle. Lasers Med. Sci. 17: 42-50 (2002). 22. ALA and ALA hexyl ester in free and liposomal formulations for the photosensitisation of tumour organ cultures."A. Casas, C. Perotti, M. Saccoliti, P. Sacca, H. Fukuda, & A. Batlle. Br J. Cancer, 86: 837-842 (2002). 23. Scavengers protection of cells against ALA-based Photodynamic Therapy induced damage". C. Perotti, H. Fukuda, A. Casas & A. Batlle. Lasers Med. Sci, 17: 229-229 (2002). 24. ALA and ALA hexyl ester induction of porphyrins after their systemic administration to tumour bearing mice. C.Perotti, A. Casas, H. Fukuda, P.Sacca & A. Batlle. Br. J. Cancer, 87: 790-795 (2002). 25. In vitro photosensitisation of a murine mammary adenocarcinoma with Verteporfin". A.Casas, G.Di Venosa, A.Batlle & H.Fukuda. Cell. Mol. Biol, 48: 931-937 (2002). 26. The effects of some porphyrinogenic drugs on the brain cholinergic system. Rodríguez, J.L.; Buzaleh, A.M.; Fossati, M..; Azcurra, J. & Batlle, A.M. del C. Cell. Mol. Biol. 48 (2002) 103-110 27. Diagnosis of latent acute intermittent porphyria by genetic analysis. De Siervi A, Varela LS, Méndez M, Parera VE, Batlle AM del C, Rossetti MV. Ann. Clin. Biochem 38 149-152 (2001)

80

28. Photosensitisation and mechanism of cytotoxicity induced by the use of ALA derivatives in photodynamic therapy. A. Casas, H. Fukuda, G. Di Venosa & A. Batlle. Br J. Cancer 85: 279-284 (2001). 29. ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitisation. A. Casas, C. Perotti, H. Fukuda, L. Rogers, A. Butler & A. Batlle. Br J. Cancer, 85: 1740-1800 (2001). 30. Two new mutations (H106P and L178V) in the protoporphyrinogen oxidase gene in Argentinean patients with Variegate Porphyria. Adriana de Siervi, Victoria E Parera, Alcira M Del C. Batlle, María V Rossetti. Human Mutation. Mutation and Polymorphism Report 16 (6) 532 (2000) 31. Porfiria Variegata: signos cutáneos, agudos y bioquímicos. Primer estudio genético en pacientes argentinos. Adriana de Siervi, Victoria E Parera, Laura Varela, Alcira M Del C. Batlle, María V Rossetti. Rev Argent Dermatol 81 94-100 (2000) 32. Mutations in Familial Porphyria Cutanea Tarda: two novel and two previously described for Hepatoerythropoietic Porphyria. Manuel Mendez, María Victoria Rossetti, Adriana De Siervi , Alcira M. Del C. Batlle, Victoria Parera. Human Mutation, Mutation in Brief 16 (3) 269-270 (2000) 33. A novel mutation (1320InsT) identified in two Argentine families with Variegate Porphyria. Adriana de Siervi, Victoria E Parera, Laura S Varela, Alcira M del C Batlle, María V Rossetti. Human Mutation. Mutation and Polymorphism Report 16 (1) 96 (2000) 34. Identification and Characterization of two novel mutations that produce Acute Intermittent Porphyria: a 3-base deletion (841-843delGGA) and a missense mutation (T35M). A De Siervi, DE Weiss Cádiz, VE Parera, A M del C Batlle, Rossetti MV. Human Mutation, Mutation in Brief 16 (4) 373 (2000) 35. Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase.Buzaleh, A.M & Batlle, A. Pharmacol. Rev. Commun. 11 (2000) 39-47 36. The relevance of P-450 levels on enflurane and isoflurane action action in mice. Studies on heme pathway. Buzaleh, A.M & Batlle, A. Clin. Exp. Pharmacol. Physiol. 27 (2000) 796-800

Laboratorio de Metabolismo del hemo en condiciones normales y patológicas (Horacio Sancovich) 1. "Disturbances on delta aminolevulinate dehydratase (ALA-D) enzyme activity by Pb 2+, Cd2+, Cu2+; Mg2+, Zn2+, Na+, K+ and Li+: analysis based on coordination geometry and acid-

81

base Lewis capacity". N:L: Pauza, J. Pérez Cotti, L. Godar, A:M. Ferramola de Sancovich y H.A. Sancovich. J.Inorg.Biochem. 99 No 2, 409-414, (2005). 2. "Estudios in vivo de la toxicidad del Pb2+, Cd2+ y Cu2+ y sus consecuencias en la biosíntesis del hemo". N:L: Pauza, Y:E: Sopena de Kracoff, A:M. Ferramola de Sancovich y H.A. Sancovich. Rev. Argent. Dermatol. 85, 154-163, (2004). 3. "Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity and phosphotyrosine content in rat liver". Andrea S. Randi, Horacio A. Sancovich, Ana M. Ferramola de Sancovich, Andrea I. Loaiza, Rodolfo A. Kölliker Frers, María F. Spinelli and Diana L. Kleiman de Pisarev. Biochem. Pharmacol, 65, 1495-1506, (2003). 4. "Ontogeny of 5-aminolevulinic dehydratase and porphobilinogen deaminase activities in the yolk sac membrane and liver of chick embryos". N:L: Pauza, Y:E: Sopena de Kracoff, A:M. Ferramola de Sancovich and H.A. Sancovich. British Poultry Sci. 43, 196-203 (2002). 5. "Ontogenia y algunas propiedades de la enzima -aminolevúlico dehidrasa de embriones de pollo: modelo para el estudio de la actividad porfirinogénica de drogas".N.L.Pauza, Y.E.Sopena de Kracoff, A.M.Ferramola de Sancovich y H.A.Sancovich. Rev. Argent. Dermatol. 82, 76-86 (2001). Laboratorio de Hemostasia y Trombosis (Lucía Kordich y Beatriz Sassetti) 1. Influence of homocysteine on fibrin networks lysis. Lauricella AM, Quintana IL, Sassetti B, Castañon M, Kordich L. Trabajo enviado a Blood Coagulation & Fibrinolysis. Código de recepción: BCF- 05147. Estado actual: en corrección según las observaciones de los referees. 2. Thrombotic events of arteriovenous fistulae in hemodialysis patients related to the C677T thermolabile variant of methylene tetrahydrofolate reductase. Trimarchi H, Genoud V, Schropp J, Castañon M, Freixas E, Forrester M, Pereyra H, Kordich L. The Journal of Vascular Access 2004; 5: 83-88 3. Associated thrombophilic defects in essential thrombocythaemia: Their relationship with clinical manifestations Kornbliht L, Heller P, Correa G, Castañon M, Genoud V, Vassallu P, Sarano J, Kordich L, Molinas F Thromb Res. 2003; 112(3):131-135. 4. Effects of homocysteine thiol group on fibrin networks: another possible mechanism of harm. Lauricella AM, Quintana IL, Kordich LC. 82

Thromb Res. 2002; 107(1-2):75-79. 5. Markers of platelet, endothelial cell and blood coagulation activation in leprosy patients with antiphospholipid antibodies. Martinuzzo ME, de Larranaga GF, Forastiero RR, Pelegri Y, Farina MH, Alonso BS, Kordich LC, Carreras LO. Clin Exp Rheumatol. 2002; 20(4):477-83. 6. Unsuspected hyperhomocysteinemia in chronically anticoagulated patients. Murua A, Quintana I, Galarza C, Alfie J, Kordich L. Blood Coagul Fibrinolysis. 2001; 12(1):79-80. 7. Low plasma protein Z levels in patients with antiphospholipid antibodies. B. Steffano, R. Forastiero, M. Martinuzzo, L. Kordich. Blood Coagul Fibrinolysis. 2001; 12(5):411-412. 8. Increased lipid peroxidation correlates with platelet activation but not with markers of endotelial cell and blood coagulation activation in patients with antiphospholipid antibodies. Martinuzzo MM, Forastiero RR, Kordich LC, Carreras LO Br J Haematol. 2001; 114 (4):845-51. 9. Prevalence of hyperhomocyteinemia in an elderly population. Janson J., Murúa A., Quintana I., Galarza C., Pzygoda P., Waisman G., Cámera L., O'Flaherty M., Kordich L., Morales M. Cámera M. American Journal of Hypertension 2001; 15(5): 394-397 10. Nitric oxide and its relationship with biochemical parameters in liver transplantation. NL Zanaro, MC Romero, F Duek, O Imvertarza, J Lendoire, B Sassetti. Clinical Chemistry and Laboratory Medicine 39:932-936, 2001. 11. Endothelial dysfunction, nitric oxide and platelet activation in Hypertensive and diabetic type II patients. MS.Ouviña, NL Zanaro, RD La Greca, B. Sassetti. Thrombosis Research, 102: 107-114, 2001. 12. Prevalence of three prothrombotic polymorphisms. Factor V G1691A, factor II G20210A and methylenetetrahydrofolate reductase (MTHFR) C 677T in Argentina. On behalf of the Grupo Cooperativo Argentino de Hemostasia y Trombosis. Genoud V, Castanon M, Annichino-Bizzacchi J, Korin J, Kordich L. Thromb Res. 2000; 100(3):127-31 13. Validation of an enzyme immunoassay for the determination of total homocysteine in plasma. Quintana I, Freeman D, Galarza C, Murua A, Spence JD, Kordich L. Blood Coagul Fibrinolysis. 2000; 11(3):235-8. 14. Plasmatic homocysteine response to vitamin supplementation in elderly people. 83

Murua AL, Quintana I, Janson J, Batista M, Camera MI, Kordich LC. Thromb Res. 2000; 100(6):495-500. Publicaciones en revistas nacionales 1. Hiperhomocisteinemia. ¿Factor de riesgo trombótico? Quintana Irene. Acta Bioquímica Clínica Latinoamericana (ISSN: 0325-2957) 2005; Sup. Nº 1:1-76. Edición especial de la revista con la publicación exclusiva. 2. Efecto de la concentración de citrato de sodio sobre las pruebas de hemostasia. Duboscq C., Kordich L.C. Acta Bioquímica Clínica Latinoamericana. 2005; Vol. 39 N°1, 87-92. 3. Comparación de parámetros de actividad antitrombótica entre dos productos de enoxaparina. Korin J.D., Porterie P., Kordich L.C. Hematología. 2004; Vol. 8, 1: 9-13. 4. Endotelina-1, óxido nítrico y Factor von Willebrand en pacientes hipertensos diabéticos tipo 2. Ouviña SM, Palmer L, Sassetti B. Acta Bioquímica Clínica Latinoamericana, 38(4): 471476, 2004. 5. Homocisteinemia de la población de Buenos Aires: Una realidad alejada de la idealidad. Quintana I., Castañon M., Murúa A., Kordich L. Hematología (ISSN 0329-0379) 2002; 6 (1): 2-7. 6. The C677T Thermolabile variant of Methilene Tetra Hydrolfolate Reductase on Homocysteine, Folate and Vitamin B12 in a Hemodialysis Center. Trimarchi H., Genoud V., Schiel A., Castañon M.M., Freixas E., Diaz M.L., Schropp D., Pereyra H., Kordich L. Medicina (Buenos Aires) 2002; 62: 149-153. 7. El óxido nítrico y las enzimas en trasplante hepático: perfiles evolutivos. Zanaro NL, Romero MC, Imvertarza O, Sassetti B. Acta Bioquímica Clínica Latinoamericana, 4: 575-581, 2002. 8. El camino L-arginina-óxido nítrico y su rol en presencia de injuria de células endoteliales vasculares. NL Zanaro, MV Silva, SM Ouviña, AS Haedo, B Sassetti. Anales de la Fundación Alberto J Roemmers. 14: 593-607, 2001. 9. Acción del clonixinato de lisina sobre la función plaquetaria. EH. Kramer, B. Sassetti, A. Kaminker, AR. De Los Santos, ML. Martí, G. Di Girolamo. Medicina 60: 301-307, 2001.

84

10. Hiperhomocisteinemia: Un factor de riesgo para enfermedad coronaria, cerebral y periférica, muy común, fácilmente corregible, pero aún no reconocido. Galarza C., Murúa A., Janson J, Quintana I., Kordich L,Cámera M. Revista Argentina de Medicina (ISSN 1515-3460) 2000; II-2: 83-97 Libros 1. Fundamentos para el manejo práctico en el laboratorio de hemostasia. Editado por el Grupo Cooperativo Argentino de Hemostasia y Trombosis. 2003. ISBN 987-21580-0-2. Editora en jefe: Lucía C. Kordich (Diferentes capítulos desarrollados por el Grupo de Investigación: Beatriz Sassetti, Irene Quintana, Ana María Lauricella, M. Mercedes Castañon)

Laboratorio de Apoptosis y Cáncer (Elba Vázquez y Mónica Kotler) 1. Personalized therapy: an interdisciplinary challenge. Vazquez E. Personalized Medicine 1 (2004) 127-130. Invitada a escribir un artículo para el fascículo de lanzamiento). 2. Immunohistochemical analysis of HO1 in preneoplastic and neoplastic lesions during chemicl hepatocarcinogenesis. Caballero F, Meiss R, Gimenez A, Batlle A & Vazquez E Int J Exp Pathol 85 (2004) 213-222. 3. Cell cycle arrest and modulation of HO1 expression induced by acetylsalicylic acid in hepatocarcinogenesis. Sacca P., Caballero F., Batlle A. & Vazquez E. Int. J. Biochem. Cell Biol. 36 (2004) 1945-1953. 4. p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells. Martinez L., Yang J., Vazquez E., Rodriguez-Vargas M, Olive M., Hsieh J., Logothetis C & Navone N. Carcinogenesis 23 (2002) 1289-1296. 5. 5-aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines. De Siervi A., Vazquez E., Rezaval C., Rossetti MV. & Batlle A. BMC Cancer 2 (2002) 6-12. 6. Interaction of cimetidine with P450 in a mouse model of hepatocarcinogenesis initiation. Caballero F., Gerez E., Batlle A. & Vazquez E. Br. J. Cancer 86 (2002)630-635. 7. On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by pdimethyl-aminoazobenzene in CF1 mice. Caballero F., Gerez E., Oliveri L., Falcoff N., Batlle A. & Vazquez E. Int. J. Biochem. Cell Biol. 33 (2001) 681-690 8. Preventive aspirin treatment of streptozotocin induced diabetes: blockage of oxidative status and revertion of heme enymes inhibition. Caballero F., Gerez E.; Batlle A. & Vazquez E. Chemico-Biological Interactions 126 (2000) 215-225 85

9. A strategy for introducing undergraduate students to protein structure. Noriega G. & Vazquez, E. Biochememistry and Molecular Biology Education 28 (2000) 200-202 Capítulos de libros 1. On the promoting action of tamoxifen in the p-dimethylaminoazobenzene induced hepatocarcinogenesis CF1 mice model and the cytoprotective role of heme oxygenase. E. Vazquez, E. Gerez, F. Caballero, L. Oliveri, N. Falcoff, M.L. Tomaro & A. Batlle. En: Heme Oxygenase in Biology and Medicine (Eds. N.G.Abraham, J. Alan, K. Nath) Kluwer Academic/Plenum. (2002) pp 469-480. Revisión de material didáctico Multimedia in Biochemistry: BioRom 2005 (Software Review) Vazquez E. Biochem. Molec. Biol. Educ.32 (2004) 419.

Laboratorio de Toxicología y Química Legal: Destino y efectos de contaminantes químicos (Noemí Verrengia) 1. Influence of humic acids on the toxicity of cadmium to Lumbriculus variegatus. M.N. Piol A.G. López, L.A. Miño, M. dos Santos Afonso, N.R. Verrengia Guerrero. Revista de la Sociedad de Toxicología Brasilera. En etapa de revisión, por correcciones menores. 2. Influence of artificial particles on lead bioavailability and bioaccumulation by Lumbriculus variegatus. Potential use in chemical remediation processes. L.A. Miño, S. Folco, A.M. Pechén de D'Angelo. N.R. Verrengia Guerrero. Journal: Chemosphere. 2005, publicado en la Web desde el 16/9/2005. 3. Comparative study on two freshwater invertebrates for monitoring environmental lead exposure. J. Aisemberg, D.E. Nahabedian, E.A. Wider, N.R. Verrengia Guerrero (2005). Toxicology Vol. 210: 45-53. 4. Influence of particle characteristics and organic matter content on the bioavailability and bioaccumulation of pyrene by clams. N.R.Verrengia Guerrero, M.G. Taylor, E.A. Wider, K. Simkiss (2003). Environmental Pollution Vol. 121: 115-122. 5. Evidence of differences in the biotransformation of organic contaminants by aquatic invertebrates. N.R.Verrengia Guerrero, M.G. Taylor, N.A. Davies, M.A.M. Lawrence, P.A. Edwards, K. Simkiss, E.A. Wider (2002). Environmental Pollution Vol. 117: 523-530 6. Modeling pentachlorophenol (PCP) bioavailability and accumulation by the freshwater fingernail clam Sphaerium corneum using artificial particles and humic acids.

86

N.R.Verrengia Guerrero, M.G. Taylor, E.A. Wider, K. Simkiss (2001). Environmental Toxicology and Chemistry Vol. 20: 2757-2763. 7. Analysis of some factors that may modify the bioavailability of cadmium and lead by Biomphalaria glabrata. N.R.Verrengia Guerrero, D.E. Nahabedian, E.A. Wider (2000). Environmental Toxicology and Chemistry Vol. 19: 2762-2768. Artículos de divulgación científica 1. Biomphalaria glabrata. Utilización de sistemas mixtos para evaluación de riesgo. E. A. Wider, N.R. Verrengia Guerrero (2000). Acta Toxicológica Argentina, Vol. 8: 27-28. Laboratorio de Biología Tumoral (Rosa Wainstok) 1. Innate NKT Lymphocytes Confer Superior AdaptiveImmunityVia Tumor Capturing Dendritic Cells. Liu K., Idoyaga J., Charalambous A., Fujii S., Bonito A., Mordoh J., Wainstok R., Bai X., LiuY., Steinman R. The Journal of Experimental Medicine (2005) Aceptado para su publicación 2. Isolation and molecular characterization of a mouse renal microvascular endothelial cell line. Gazzaniga S., Gonzalez L., Mantovani A., Vecchi A., Wainstok R In Vitro Cellular and Developmental Biology- Animal 40: 82-88 (2004). 3. Tissue expression of platelet endothelial cell adhesion molecule-1 and pre and postnatal murine development. Calabrese G., Wainstok R. BIOCELL 28: 251-258 (2004) 4. Dendritic cells charged with apoptotic tumor cells induce long- lived protective CD4+ and CD8+ T cell immunity against B16 melanoma. Goldszmid R., Idoyaga J., Bravo A.I., Steinman R., Mordoh J., Wainstok R. J. of Immunology 171: 5940-5947 (2003) 5. Inflammatory changes after cryosurgery- induced necrosis in human melanoma xenografted in nude mice. Gazzaniga, S.N., Bravo, I., Goldszmid, S.R., Maschi, F., Martinelli, J., Mordoh, J., Wainstok, R. Journal of Investigative Dermatology 116 (5) : 664 (2001) Artículos de divulgación científica 1. Quimioquinas, proteinas atractivas y promiscuas que empiezan a destacarse en el escenario de la inflamación y la inmunidad. Wainstok R. Química Viva, año 2, Vol 2 (2003)

Grupo interdisciplinario de investigación de Fisiología del metabolismo oxidativo (Evi Wider y Martín Ansaldo) 87

1. Comparative study on two fresh water invertebrates for monitoring environmental lead exposure. J. Aisemberg, D. Nahabedian, E. Wider & N. Verrengia Guerrero. Toxicology (2005). 210(1): 45-53. 2. Chemical and biochemical changes of pumpkin (Cucumis Moschata, Duch.) tissue in relation to osmotic stress. M F de Escalada Pla, N.M.A:Ponce, E.A.Wider, C. Stortz, A M.Rojas & L. N.Gerchenson. Journal of the Science of Food and Agriculture. (2005) 85(11):1852-1860. ISSN 1097-0010. 3. Oxidative stress generated by diesel seawater contamination on the digestive gland of the Antarctic limpet Nacella cocinna. M. Ansaldo, R. Najle and C.M. Luquet. Marine Environmental Research. (2005). 59: 381-390. 4. Oxidative stress generated by diesel seawater contamination on the digestive gland of the Antarctic limpet Nacella cocinna. M. Ansaldo, R. Najle and C.M. Luquet. Marine Environmental Research. (2005). 59: 381-390. 5. Differential growth of the barnacle Notobalanus flosculus (Archaeobalanidae) onto artificial and live substrates in the Beagle Channel, Argentina. Leonardo A. Venerus, Javier A. Calcagno, Gustavo A. Lovrich and Daniel E. Nahabedian. Helgoland Marine Research. 2005. 59:196 ­ 205. ISSN: 1438-387X . 6. Modeling pyrene bioavailability and accumulation by Sphaerium corneum using artificial particles and humic acids. N.R.Verrengia Guerrero, M.G. Taylor, E.A. Wider K. Simkiss. Environmental Pollution. (2003). 121(1): 115-122. 7. Evidence of differences in the biotransformation of organic contaminants in three species of freshwater invertebrates. N.R. Verrengia Guerrero, M.G. Taylor, N.A. Davies, M.A.M. Lawrence, P.A.Edwards, K. Simkiss, E.A. Wider. Environmental Pollution (2002).117(3): 523-530. 8. Acute and chronic effects of cadmium on blood homeostasis of an estuarine crab, Chasmagnathus granulata, and the modifying effect of salinity". E.M. Rodriguez, R. Bigi, D.A. Medesani, V.S. Stella, L.S. Lopez, P.A. Rodriguez Moreno, J.M. Monserrat, G.N. Pellerano and M. Ansaldo. Brazilian Journal of Medical and Biological Research. (2001) 34:509-518. 9. Analysis of some factors that may modify the bioavailability od cadmium and lead by Biomphalaria glabrata. N.R. Verrengia Guerrero, D.E. Nahabedian y E.A. Wider. Environ Toxicol & Chem.. (2000)19:2762-2768. 10. Histopathological changes in gills of the estuarine crab Chasmagnathus granulata (Crustacea-Decapoda) following acute exposure to ammonia". M. de Freitas Rebelo, E.M. Rodriguez, E.A. Santos y M. Ansaldo. Comp. Biochem. and Physiology. (2000) C125: 157164.

88

11. Bimodal breathing in the estuarine crab Chasmagnathus granulata Dana 1851. Physiological and morphological studies. J. Halperin, M. Ansaldo, G.N. Pellerano and C.M. Luquet. Comp. Biochem. and Physiology (2000) A126: 341-349. 12. Antioxidant levels from different Antarctic fish caught around South Georgia's Islands and Shag Rocks". M. Ansaldo, P.A. Evelson, C.M. Luquet, J.M. Polo, S. Llesuy. Polar Biology. (2000) 23, 3: 160-165.

89

Information

89 pages

Report File (DMCA)

Our content is added by our users. We aim to remove reported files within 1 working day. Please use this link to notify us:

Report this file as copyright or inappropriate

922927

Notice: fwrite(): send of 214 bytes failed with errno=104 Connection reset by peer in /home/readbag.com/web/sphinxapi.php on line 531