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Principal Investigator/Program Director (Last, first, middle): Blumhardt, Ralph

BIOGRAPHICAL SKETCH

Provide the following information for the key personnel in the order listed for Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME Ralph Blumhardt EDUCATION/TRAINING

postdoctoral training.)

POSITION TITLE Professor And Vice Chairman

(Begin with baccalaureate or other initial professional education, such as nursing, and include

INSTITUTION AND LOCATION Letterman Army Medical Center - San Francisco, CA. William Beaumont Army Hospital - El Paso, TX. Madigan Army Hospital - Ft. Lewis, WA. Tripler Army Medical Center - Honolulu, HI. Hahnemann Medical College Philadelphia, PA. Rutgers University - New Brunswick, NJ.

DEGREE Residency Fellowship Residency Internship MD

YEAR(s) 1976-1978 1971-1973 1964-1967 1963-1964 1963 1956-1959

FIELD OF STUDY Diagnostic Radiology Nuclear Medicine Internal Medicine Medicine

NOTE: The Biographical Sketch may not exceed four pages. Items A and B (together) may not exceed two of the four-page limit. Follow the formats and instructions on the attached sample. A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List any honors. Include present membership on any Federal Government public advisory committee. Positions and Employment 1987 to Present 1982 to 1987 1976 to 1977 1974 to 1978 1962 to 1982 Honors 01/1996 01/1990 01/1985 Professor, Vice Chairman, Radiology, Medical School, The University of Texas Health Science Center at San Antonio, San Antonio, TX Associate Professor, Radiology, Medical School, The University of Texas Health Science Center at San Antonio, San Antonio, TX Adjunct Professor, Department of Pharmacology, University of Pacific, San Francisco, CA Adjunct Professor, George Washington University School of Medicine and Health Sciences, Washington, DC Medical Corps Officer, Government, US Army

Teacher of the Year Award, Academic Year 1995-96, Dept. of Radiology, UTHSCSA Inducted as Fellow, American College of Radiology Teacher of the Year Award, Academic Year 1984-85, Dept. of Radiology, UTHSCSA

01/1982 01/1981 01/1970 01/1969 01/1957

Legion of Merit, By the Commander, US Army Health Services Command Awarded "A Prefix" in Radiology, Army Equivalent of Professorship by the Surgeon General of the Army. Inducted as Fellow, American College of Physicians Army Commendation Medal with Oak Leaf Cluster, By the Secretary of the Army Beta Beta Beta Biological Society, Undergraduate Honor Society

B. Selected peer-reviewed publications (in chronological order). Do not include publications submitted or in preparation. Phillips WT, Andrews T, Liu H, Klipper R, Landry AJ, Blumhardt R, Goins B. Evaluation of [(99m)Tc] liposomes as lymphoscintigraphic agents: comparison with [(99m)Tc] sulfur colloid and [(99m)Tc] human serum albumin. Nucl Med Biol 2001 May;28(4):435-444. Hander TA, Lancaster JL, Kopp DT, Lasher JC, Blumhardt R, Fox PT. Rapid objective measurement of gamma camera resolution using statistical moments. Med Phys 1997 Feb;24(2):327-334. Goins B, Klipper R, Rudolph AS, Cliff RO, Blumhardt R, Phillips WT. Biodistribution and imaging studies of technetium-99m-labeled liposomes in rats with focal infection. J Nucl Med 1993 Dec;34(12):2160-2168. Metter D, Blumhardt R, Metter DF. Tc-99m renal scan demonstrating growth in a pediatric renal transplant. Clin Nucl Med 1993 Sep;18(9):796-796. Phillips WT, Rudolph AS, Goins B, Timmons JH, Klipper R, Blumhardt R. A simple method for producing a technetium-99m-labeled liposome which is stable in vivo. Int J Rad Appl Instrum B 1992 Jul;19(5):539-547. Blumhardt R, Chakeres DW, Vasila M, Schmalbrock P. Biologic Effects and Safety Issues of Magnetic Resonance In: Findamentals of Magnetic Resonance Imaging. Baltimore, MD: Chakeres DW and Schmalbrock P, Eds. Williams and Wilkins; 1992. Lasher JC, Blumhardt R, Phillips WT. The accuracy of quantitative analysis of stress/delayed thallium-201 myocardial tomograms. J Nucl Med 1991 Apr;32(4):749-750. Phillips WT, Schwartz JG, Blumhardt R, McMahan CA. Linear gastric emptying of hyperosmolar glucose solutions. J Nucl Med 1991 Mar;32(3):377-381. Bergh JR, Phillips WT, Blumhardt R. Unusual Case of Entire Lung Ventilation Perfusion Mismatch. In: Yearbook of Nuclear Medicine. Hoffer PB et al., eds; Mosby Yearbook; 1991. Starling MR, Blumhardt R. Radionuclide Imaging of Resting Cardiac Function: State of the Art In: Radionuclide Imaging of the Heeart, Contemporary Issues in Nuclear Medicine. New York: Guiberteau MR, ed., Churchill Livingstone; 1990. Miller DD, Scott RA, Riesmeyer JS, Chaudhuri TK, Blumhardt R, Boucher CA, O`Rourke RA. Acute hemodynamic changes during intravenous dipyridamole thallium imaging early after infarction. Am Heart J 1989 Oct;118(4):686-694. Bauman JM, Bergh JR, Blumhardt R, Byrd BF, Cawthon MA, Gonzales AC, Hartshorne MF, Heironimus JD, Jackson RE, Lasher JC. Rotating slanthole collimater SPECT revisited. J Nucl Med 1989 Oct;30(10):1737-1737. Bergh JR, Phillips W, Blumhardt R. Unusual cause of entire lung ventilation-perfusion mismatch. Clin Nucl Med 1989 Jun;14(6):464-467. Lasher JC, Lancaster JL, Chang W, Blumhardt R. Chapter 4: Limited Angle Slant Hole Tomography In: Tomographic Methods in Nuclear Medicine. Boca Raton, FL: Ahulwalia BD, ed., CRC Press Inc.; 1989. Starling MR, Gross MD, Walsh RA, Mancini GB, Blumhardt R. Radionuclide determination of the relationship between left ventricular contractile state and ejection fraction. Am Heart J 1988 Sep;116(3):790-798.

Starling MR, Gross MD, Walsh RA, Dell'Italia LJ, Montgomery DG, Squicciarini SA, Blumhardt R. Assessment of the radionuclide angiographic left ventricular maximum time-varying elastance calculation in man. J Nucl Med 1988 Aug;29(8):1368-1381. Lancaster JL, Kopp DT, Lasher JC, Blumhardt R. Distance and depth measurements of radioactive objects utilizing rotating slant-hole collimators. Med Phys 1988;15(4):642-647. Starling MR, Walsh RA, Lasher JC, Lancaster JL, Blumhardt R. Quantification of left-ventricular regional dyssynergy by radionuclide angiography. J Nucl Med 1987 Nov;28(11):1725-1735. Starling MR, Walsh RA, Dehmer GJ, Lasher JC, Blumhardt R. Value of tomographic thallium201 imagining in patients with chest pain following coronary artery bypass grafting. Clin Nucl Med 1987 Feb;12(2):134-139. Pohl HA, Phillips WT, Blumhardt R. Evidence of AC Fields from Living Biological Cells. In: Energy Transfer Dynamics, Studies amd Essays in Honor of Herbert Frolich.. Barrett TW, Phl HA, eds. Springer-Verlag; 1987. Blumhardt R. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Invest Radiol 1986 Dec;21(12):940-942. Lancaster JL, Starling MR, Kopp DT, Lasher JC, Blumhardt R. Effect of errors in reangulation on planar and tomographic thallium-201 washout profile curves. J Nucl Med 1985 Dec;26(12):14451455. Dell'Italia LJ, Starling MR, Blumhardt R, Lasher JC, O'Rourke RA. Comparative effects of volume loading, dobutamine, and nitroprusside in patients with predominant right ventricular infarction. Circulation 1985 Dec;72(6):1327-1335. Starling MR, Dehmer GJ, Lancaster JL, Lasher JC, Walsh RA, Weiland FL, Uhl GS, Blumhardt R. Segmental coronary artery disease: detection by rotating slant-hole collimator tomography and planar thallium 201 myocardial scintigraphy. Radiology 1985 Oct;157(1):231-237. Dell'Italia LJ, Starling MR, Walsh RA, Badke FR, Lasher JC, Blumhardt R. Validation of attenuation-corrected equilibrium radionuclide angiographic determinations of right ventricular volume: comparison with cast-validated biplane cineventriculography. Circulation 1985 Aug;72(2):317-326. Beck RN, Blumhardt R, Bennett W, Cable H, McCauley R, Telepak RJ, Pacheco J, Phillips L. Gallium-67 scintigraphy in well-differentiated lymphocytic lymphoma of the skin. Clin Nucl Med 1985 Aug;10(8):589-591. Lancaster JL, Kopp DT, Lasher JS, Blumhardt R. Practical gamma camera quality control with a four-point phantom. J Nucl Med 1985 Mar;26(3):300-307. Lasher JC, Blumhardt R, Lancaster JL. The digital computer: the role of functional imaging in radiology. Radiology 1984 Oct;153(1):69-72. Kuzbary Y, Lasher JC, Blumhardt R, Vicks B. Renal transplant extravasation of urine through a chest tube: an unusual appearance on radionuclide imaging. Nucl Med Commun 1984 Oct;5(10):655-659. Benedetto AR, Harrison CR, Blumhardt R, Trow LL. Tc-99m red blood cells for the study of rapid hemolytic processes associated with heterologous blood transfusions. Clin Nucl Med 1984 Oct;9(10):561-564. Blumhardt R, Growcock G, Lasher JC. Cortical necrosis in a renal transplant. AJR Am J Roentgenol 1983 Jul;141(1):95-96. Lecklitner ML, Blumhardt R. Radiology of the bile ducts. A symposium on the use of new modalities for diagnosis and treatment. Radiology 1983 Jun;147(3):887-888. Telepak RJ, Bunker SR, Lancaster JL, Hartshorne MF, Blumhardt R. Another use for the sevenpinhole collimator. Routine nontomographic imaging of the thyroid. Clin Nucl Med 1983 Apr;8(4):163-164. Nusynowitz ML, Blumhardt R. Proceedings: Estimation of true red cell volume from RISA red cell volume. Am J Roentgenol Radium Ther Nucl Med 1974 Mar;120(3):549-552.

Nusynowitz ML, Blumhardt R, Volpe J. Plasma volume in erythremic states. Am J Med Sci 1974 Jan;267(1):31-34. Blumhardt R, Nusynowitz ML. A guide to bone scanning. Am Fam Physician 1974 Jan;9(1):153157. Lull RJ, Strader WJ, Blumhardt R. Tests of vitamin B 12 absorption. Southwest Med 1971 Oct;52(10):198-200. Blumhardt R, Pappano JE, Moyer DG. Depression of poison ivy skin tests by measles vaccine. JAMA 1968 Dec;206(12):2739-2741. Lorelius LE, Benedetto AR, Blumhardt R, Gaskill HV, Lancaster JL, Stridbeck H. Enhanced drug retention in VX2 tumors by use of degradable starch microspheres. Invest Radiol ;19(3):212215. Lancaster JL, Kopp DT, Lasher JC, Blumhardt R. Distance and depth measurements of radioactive objects utilizing rotating slant-hole collimators. Med Phys ;15(4):642-647. Gleason NN, Fisher GU, Blumhardt R, Roth AE, Gaffney GW. Plasmodium ovale malaria acquired in Viet-Nam. Bull World Health Organ ;42(3):399-403. C. Research Projects: 07/01/1985 -- 01/01/1987 Vestar Corporation Grant Evaluation of VS 102 (Indium-111 Vesicles) as a Tumor Imaging Agent Role:Co-Principal Investigator 07/01/1984 -- 06/01/1989 National Institute of Health Grant Clinical Application of End-Systolic P-V Relations Role:Consultant

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