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VETERINARY VACCINES

MCP-1129

CONTENTS

1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS...............................................1

Study Reliability and Reporting Limitations ................................. 1 Disclaimers..................................................................................... 2 Data Interpretation & Reporting Level .......................................... 3 Quantitative Techniques & Analytics ........................................ 3 Product Definitions and Scope of Study........................................ 3 A. Companion Animal Vaccines ................................................ 4 B. Livestock Vaccines................................................................. 4 Porcine Vaccines..................................................................... 4 Bovine Vaccines ..................................................................... 4 Poultry Vaccines ..................................................................... 4 Ovine Vaccines ....................................................................... 4 Equine Vaccines...................................................................... 5 Other Animal Vaccines........................................................... 5 Veterinary Vaccines ­ An Essential Component of Animal Health Care ...............................................................................13 What Does A Veterinary Vaccine Do?.....................................14 Classification of Veterinary Vaccines ......................................14 Companion Animals Vaccines ..............................................14 Canine Vaccines ................................................................14 Feline Vaccines..................................................................16 Livestock Vaccines................................................................17 Bovine Vaccines ................................................................17 Poultry Vaccines ................................................................18 Ovine Vaccines ..................................................................18 Porcine Vaccines................................................................19 Equine Vaccines ................................................................19 Aquaculture Vaccines ........................................................19 A Tabular Analysis on Select Animal Diseases Controlled by Vaccines..............................................20 Vaccination and Its Reactions...................................................20 Veterinary Vaccines- Latest Breakthroughs.............................20 Marker vaccines ....................................................................20 DNA vaccines........................................................................20 Gene-deleted vaccines...........................................................21 Viral-vectored vaccines.........................................................21

2. INDUSTRY OVERVIEW & OUTLOOK........................6

Global Animal Health Care Industry - A Brief Review ................ 6 Table 1: Global Animal Health Products Market by Region (2008): Percentage Share Breakdown by Value Sales for North America, Europe, Latin America and Rest of World (includes corresponding Graph/Chart) ..................................................... 6 Table 2: Global Animal Health Products Market by Product Group (2008): Percentage Share Breakdown by Value sales for Parasiticides, Vaccines, Anti-Infectives, Medical Feed Additives and Other Pharmaceuticals (includes corresponding Graph/Chart) ..................................................... 6 Animal Healthcare Market Grows Amidst Recession................... 7 Veterinary Vaccines Industry Posts Moderate Growth ................. 7 Poultry Vaccines Industry: A Global Scenario .......................... 7 Improved Manufacturing Techniques ........................................ 8 Improved Analysis...................................................................... 8 Scope of the Report........................................................................ 8

5. NOTES ON SELECT ANIMAL DISEASES.................22

Brucellosis ....................................................................................22 Tuberculosis..................................................................................22 Johne's disease .............................................................................22 Spirochete Associated Diseases ...................................................22 Respiratory Disease in Goats, Sheep, and Cattle .........................23 Porcine Respiratory Diseases .......................................................23 Mastitis .........................................................................................23 African Swine Fever.....................................................................23 Avian Influenza ............................................................................24 East Coast Fever ...........................................................................24 Hemorrhagic Septicemia ..............................................................24 Foot-And-Mouth Disease .............................................................24 Japanese Encephalitis ...................................................................24 Rift Valley Fever ..........................................................................25 Equine Virus .................................................................................25

3. MARKET TRENDS & ISSUES........................................9

Companion Animal Vaccines: Trailing on a High Growth Track.............................................................................. 9 OTC Market: A Potential Threat for Veterinarians....................... 9 Small Animal Practitioners Feel the Pinch of Recession .............. 9 Parasiticides, Systemic Agents To Drive The Market................... 9 Taxonomy of Vaccines .................................................................. 9 Bird Flu ­ The Aftermath............................................................. 10 Vaccination ­ Critical for Controlling Avian Influenza Virus ....... 10

6. PRODUCT INNOVATIONS/INTRODUCTIONS........26

Intervet/Schering-Plough Animal Health Introduces a New Web Site for Innovax recombinant Vaccines Product Line...........................................................26 Pfizer Animal Health Introduces the First E. Coli Bacterial Extract Vaccine .........................................................................26 Intervet Schering-Plough Animal Health Re-Launches EQUILIS® StrepE for Horses ..................................................26 Boehringer Ingelheim Vetmedica Launches Single Shot 3FLEX combination package PL .....................................26 Pfizer Animal Health Launches INFORCETM 3 ..........................26 Boehringer Ingelheim Introduces Ingelvac CircoFLEX® in Russia ....................................................................................27 Pfizer Animal Health Introduces Bopriva® for Bull and Beef Market in NZ ....................................................................27 GALVmed, Inter-African Bureau for Animal Resources Launch ECF Vaccine ................................................................27 BIVI launches Five New Variants of Vetera® Vaccines ............28

4. PRODUCT OVERVIEW ................................................11

Vaccines - An Evolutionary Scan ................................................ 11 Contribution of Animal Research to Vaccine Production ........... 11 Veterinary Medicines- A Brief Review ....................................... 12 Preventive Medicines ............................................................... 12 Therapeutic Medicines ............................................................. 12 Others........................................................................................ 12 Development of Vaccines ............................................................ 12 Production of Vaccines ................................................................ 13

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Hipra Announces Launch of Suiseng® ....................................... 28 Aceto Corporation Receives Approval to Sell Suppliera[euro]TM in the US ..................................................... 28 Intervet Schering-Plough Unleashes NOBIVAC Lyme Vaccine for Dogs ...................................................................... 29 Intervet Schering-Plough Animal Health Introduces PORCILIS PCV Vaccine ......................................................... 29 Lohmann Launches AviPro® MEGAN®VAC Vaccination for Salmonella Disease ............................................................. 29 Intervet Schering Plough Animal Health Introduces Circovirosis Vaccine................................................................. 29 Pfizer Animal Health Develops Inovocox® Vaccine.................. 29 Intervet/Schering-Plough Animal Health Launches Bravoxin 10 .............................................................................. 30 Bioject and Merial Rolls Out Derma-Vac NF ............................. 30 Defra to Launch Bovine Tuberculosis Vaccine........................... 30 Intervet International Develops Bluetongue Vaccine.................. 31 Hester Biosciences Unveils Anti-Coryza Vaccine ...................... 31 Intervet/Schering-Plough Animal Health Introduces Bovilis BTV8 Vaccine ............................................................. 31 Tecnovax Develops Vaccine for Salmon Virus........................... 31 Tamil Nadu Veterinary and Animal Science University and The Indian Veterinary Research Institute Develop Vaccine ...... 31 Lohmann Animal Health Develops AviPro IBD Xtreme............ 31 Intervet/Schering-Plough Animal Health Launches EquiRabTM ................................................................................ 32 Lohmann Animal Health Introduces Larger Doses of AviPro® ViBursa CE ............................................................... 32 Lohmann Animal Health International Rolls Out AviBlue......... 32 Fort Dodge Animal Health Unveils West Nile-Innovator DNA................................................................. 33 Univet Agricultural Products Introduces Coglapest .................... 33 Intervet/Schering-Plough Animal Health Launches Porcilis® COLI 6C ................................................................... 33 Pfizer Animal Health Unveils FluSure® XP Defense System ........................................................................ 33 Pfizer Animal Health Launches Improvac® ............................... 34 Intervet/Schering-Plough Animal Health Develops OnsetTM 5 Intranasal (IN) Vaccine ........................................... 34 Merial Rolls Out BTVPUR AlSap 8............................................ 34 Pfizer Animal Health Introduces FarrowSure® GOLD and FarrowSure® GOLD B...................................................... 35 Schering-Plough Animal Health Unveils CAVALRY 9............. 35 Lohmann Animal Health Develops BTO2 REO Vaccine ........... 35 Merial Limited Gets USDA Approval for DNA Vaccine for Melanoma in Dogs ..............................................................37 Embrex's Poultry Vaccine Inovocox Gets USDA Approval....................................................................................38 Skystar Bio-Pharmaceutical Develops Avian Influenza Vaccine......................................................................................38 United States Department of Agriculture Grants Conditional License for Necrotic Enteritis Vaccine.....................................38 Fort Dodge Receives USDA License for Pyramid®10 ...............39 USDA Licenses Use of Fort Dodge's Suvaxyn® PCV2 Vaccine in Pigs..........................................................................39 USDA Grants Conditional License to Pfizer's New Canine Vaccine .........................................................................39

8. RECENT INDUSTRY ACTIVITY ................................40

Centegen Enters into Licensing Partnership with Merial ............40 The Ugandan Government Enters into Partnership with Brentec Vaccines International.................................................40 Pfizer Animal Health Kicks Off Equine Business Unit...............40 Pfizer Animal Health Acquires Microtek ....................................40 GenVec Enters into Collaboration with Merial to Develop and Commercialize FMD Vaccine ...........................................41 Pfizer Animal Health Inks Global Licensing Deal with Epitopix.............................................................................41 Indian Immunologicals Intends to Establish a New Facility in Hyderabad .............................................................................41 Pfizer Phases out Animal Vaccine Manufacturing Unit of Wyeth in the Netherlands .....................................................41 Vivalis Signs Commercial License for EB66® Cell Line Platform.....................................................................................42 Ibio Grants Rights of iBioLaunch platform to Government Funded Project ..........................................................................42 Intervet/Schering-Plough Animal Health Unveils Production Center at Boxmeer..................................................42 Globion India Announced Plans to Develop Eight New Vaccines ...........................................................................42 Veterinary Services Department Intends to Upgrade VRI ..........42 VIVALIS Grants Rights of EB66® Cell Line To KYOTO BIKEN .......................................................................43 Vical Enters Into Agreement with GenomIdea for Development of DNA Vaccine.................................................43 Intervet/Schering-Plough Animal Health Unveils the New Freeze-drying and Specialized Central Filling Unit ............................................................................43 Him Electronics Enters into Partnership with Hester Bioscience to Produce Animal Vaccines..................................44 Intervet/Schering-Plough Animal Health Receives Approval for Nobivac Lepto4 ...................................................................44 Biolex Enters into Collaboration With Merial for Research and Development ......................................................44 Intervet/Schering-Plough Animal Health Receives Full License from USDA for Nobivac® Vaccine ....................45 Intercell Inks License Agreement with Boehringer .....................45 Intervet/Schering-Plough Recalls PreveNile West Nile Virus Vaccine in the US ...................................................45 Merial Gains Full License of ONCEPTTM from USDA ..............45 Virbac Acquires Veterinary Assets from Pfizer...........................46 Harbin Pharmaceutical Group Holding Acquires Animal Vaccine Business From Pfizer..................................................46

7. PRODUCT INNOVATIONS/INTRODUCTIONS IN RECENT PAST - A PERSPECTIVE BUILDER ..........36

Agroinsuvet Introduces New Vaccines........................................ 36 Merial Rolls Out Vaxxitek® HVT+IBD Hatchery Vaccine for Poultry Industry .................................................................. 36 Intervet & Friedrich-Loeffler-Institute Develop Dual Vaccine Prototype for Birds ..................................................... 36 Schering-Plough Receives USDA License for its RhusigenTM Erysipelas Vaccine ............................................... 36 USDA Approves Use of PreveNileTM Vaccine for Horses ......... 37 Fort Dodge Animal Health Develops Reverse Genetics Avian Vaccine .......................................................................... 37 Boehringer Ingelheim's Swine Vaccine Gains Approval in Australia................................................................................ 37

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Boehringer Ingelheim Acquires Certain Cattle Vaccines from Fort Dodge ....................................................................... 46 Virbac Acquires 30% Share in Santa Elena................................. 46 Merck and Sanofi-Aventis to Merge their Animal Health Business ........................................................................ 46 Elanco to Take Over Pfizer's Animal Health Products Portfolio ..................................................................... 47 Boehringer Ingelhei to Acquire Pfizer's Fort Dodge Animal Health Unit .................................................................. 47 ImmunoVaccine Inks Deal with Pfizer........................................ 47 Merck Merges with Schering-Plough .......................................... 48 Pfizer Acquires Wyeth ................................................................. 48 Merial Receives Marketing License for BTVPUR AlSap 8 Vaccine ....................................................................... 48 Epitopix Obtains Approval to Sell Siderophore Receptor and Porin Vaccine..................................................................... 48 Phibro Animal Health Acquires Animal Health Division of Abic ....................................................................... 49 Fort Dodge Animal Health and Vivalis Sign Commercial License Deal ............................................................................. 49 Hester Biosciences Expands Gujarat Based Facility ................... 49 Intervet/Schering-Plough Animal Health Replaces Bovilis® IBR Vaccine with Bovilis® IBR Marker Live......................... 50 Tangshan Yian Biological Engineering Wins Approval from Ministry of Agriculture of China..................................... 50 Lohmann Animal Health International Signs an Agreement with Celldex Therapeutics........................................................ 50 Intervet/Schering-Plough Animal Health Starts New Manufacturing Facility ............................................................. 50 Laprovet Commences New Facility............................................. 51 ImmunoVaccine Technologies and La Jolla Institute for Allergy & Immunology Enter into an Agreement ................... 51 Merial Signs a Toll Distribution and Manufacturing Agreement with Newport Laboratories.................................... 51 BOEHRINGER INGELHEIM Animal Health Signs Research License Deal with Vivalis......................................... 52 AviTech Selects Merial as a Distributor and Service Provider......... 52 Bayer Inks Agreement with Juvaris............................................. 52 Pfizer Inks Agreement with ImmunoVaccine Technologies....... 52 BioVet Inaugurates BSL-4 Production Unit in India .................. 53 Vaxine to Take over Protein Sciences ......................................... 53 Pfizer Inaugurates a New Development Facility for Veterinary Vaccines ................................................................. 53 Merial to Establish Animal Vaccine Manufacturing Plant.......... 53 BNC Bioniche Life Sciences Bags Approval to Sell Econiche Vaccines.................................................................... 53 Hind Bio-Pharmaceuticals to Establish Animal Vaccines Division..................................................................... 54 Pfizer's Animal Health Unit Acquires Schering-Plough's Product License in Europe........................................................ 54 Grupo Mathiesen Takes Over Centro de Diagnostico Veterinario ................................................................................ 54 Harbin Veterinary Research Institute Opens Animal Vaccine Manufacturing Base ................................................... 54 Bioject Medical Technologies Enters into a Long-Term Supply, Development and License Contract with Merial ........ 55 Vivalis SA Signs Letter of Intent with Intervet/ Schering-Plough ....................................................................... 55 Biochemiq Enters into Partnership with Labovet........................ 55 Microbix Biosystems Purchases Production Plant.......................55 Beijing Veterinary Biological Product Factory Starts Operation in New Plant.............................................................55 Changzhou Tongtai Biopharmaceutical Sets Up Rabies Vaccine Facility ........................................................................56 Schering-Plough to Sell Health Products of Animals to Pfizer and Virbac ......................................................................56 Pfizer Group Establishes a Veterinary Vaccines Development Center .................................................................56 Phylaxia to Acquire Gazdasagi Radio and Kozep-europai Gazterminal Zrt .........................................................................56 Bayer HealthCare AG's Animal Health Unit Enters into Licensing Agreement with Juvaris BioTherapeutics................57 Vivalis Enters into a Commercial License Contract with Virbac................................................................................57 ImmunoVaccine Technologies Signs Licensing Agreement with Pfizer Animal Health ........................................................57 Kaketsuken and Vivalis Extends Research Collaboration...........57 Heska Amends Distribution Contract with Agri Laboratories ....57 Prevtec Microbia and Saskatchewan Research Council Receives Approval to Market and Manufacture Coliprotec.....58 Imugene and Merial Enter into an Agreement.............................58 Celldex Therapeutics Merges with AVANT Immunotherapeutics' Subsidiary ..............................................58 Ceva Sante Animale Acquires Delvet..........................................58 Inovio Biomedical Signs Merger Agreement with VGX Pharmaceuticals ........................................................................59 Environmental Risk Management Authority Approves equine Influenza Vaccine..........................................................59 Functional Technologies Commences Operations of Phyterra Bio ..............................................................................59 Summit VetPharm Enters into Distribution Partnership with Webster Veterinary Unit...................................................59 PerOs Receives Establishment and Bacterin License from USDA ...............................................................................60 Wyeth's Fort Dodge Animal Health Unit Acquires Poultry Vaccines .......................................................................60 Boehringer Ingelheim Vetmedica Receives Approval for Express® FP and Express® Vaccines from the USDA ...........60

9. CORPORATE ACTIVITY IN RECENT PAST A PERSPECTIVE BUILDER.........................................61

Merial Bags Major Australian Contract .......................................61 United States Department of Agriculture Approves Intervet Vaccine ........................................................................61 Merial Pockets Ancare .................................................................61 Heska Revises Distribution Agreement with AgriLabs...............61 Animal Health International Acquires Kane Veterinary Supplies...................................................................62 Industrial Equity Investments Pockets Arysta LifeScience................................................................................62 Henry Schein Acquires W&J Dunlop ..........................................62 Tecnovax Establishes New Facility .............................................62 Pingtung Agricultural to Set Up an Exclusive Veterinary Park .........................................................................62 Ouro Fino To Expand Veterinary Product Suite..........................62 Alpharma Acquires Yantai Jinhai ................................................62 Pfizer Animal Health Acquires Embrex ......................................63 Schering-Plough Acquires Intervet ..............................................63

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Schering-Plough Acquires Organon BioSciences ....................... 63 Intervet Sets Up New Animal Vaccine Production Facility in Boxmeer................................................................................ 63 Crucell Licenses PER.C6® Technology to Pfizer Animal Health........................................................................... 64 Central Veterinary Research Laboratory to Synthesize New Animal Vaccines .............................................................. 64 Pfizer to Shut Down Omaha Animal Vaccine Center ................. 64 IGI Licenses Novasomes to Novavax.......................................... 65 Bogor Agricultural Institute Collaborates with Shigeta Animal Pharmaceuticals........................................................... 65 Suguna Poultry Steps into Livestock Vaccine Production Business ................................................................. 65 European Medicines Agency Grants Community Authorization for Nobilis Influenza H7N1 .............................. 65 AVANT Immunotherapeutics & Pfizer Collaborate to Develop Animal Vaccines........................................................ 66 Intervet International Acquires FMD Vaccine Production Facility from Bayer Healthcare ................................................ 66 Canadian Food Inspection Agency Authorizes Bioniche E. Coli O157:H7 Cattle Vaccine for Field Use........................ 66 Hemispherx Biopharma Acquires DOGS Molecule Patent ........................................................................ 67 Hind Industries to Establish Animal Vaccine Formulations Plant at Patiala.................................................... 67 Cryosite and Animal Health Australia Form Partnership............ 67 Hester Pharmaceuticals Plans Capacity Expansion..................... 67 Biovet to Set up Animal Vaccine Plant in Karnataka ................. 67 Bogor Institute of Agricultureand Shigeta Establish JV for Production of CLOSE 5.1 Vaccine..................................... 67 IPB Shigeta Acquires Bird Flu Vaccine Rights from MedImmune.............................................................................. 68 Bioject Medical Technologies Signs Three Agreements With Merial ............................................................................. 68 PetCARE Television Network signs Distribution Agreement with Butler Animal Health Supply........................................... 68 Poultry Vaccine to be produced in Vladimir ............................... 68 CEL-SCI's CEL-1000 Peptide Shows Adjuvant Activity ...........73 Progress in Vaccine for Canine Cancer........................................73

11. FOCUS ON SELECT GLOBAL PLAYERS .................74

Bayer HealthCare AG (Germany)................................................74 Biogenesis-Bago (Argentina) .......................................................74 Boehringer Ingelheim GmbH (Germany) ....................................74 Heska Corporation (US) ...............................................................75 Imugene Limited (Australia) ........................................................75 Indian Immunologicals Ltd (India) ..............................................75 Lohmann Animal Health (US) .....................................................76 Merck & Co., Inc. (US) ................................................................76 Intervet/Schering-Plough Animal Health (The Netherlands) .....77 Merial Ltd. (US) ...........................................................................77 Pfizer, Inc. (US)............................................................................77 Embrex, Inc. (US) .....................................................................78 Fort Dodge Animal Health (US)...............................................78 Protein Sciences Corporation (US) ..............................................79 Virbac Corporation (US) ..............................................................79

12. GLOBAL MARKET PERSPECTIVE ...........................80

Table 3: World Recent Past, Current & Future Analysis for Veterinary Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ..............................80 Table 4: World Historic Review Veterinary Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart)........................................81 Table 5: World 11-Year Perspective for Veterinary Vaccines by Geographic Region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015(includes corresponding Graph/Chart) ........82 Table 6: World Recent Past, Current & Future Analysis for Companion Animal Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).................83 Table 7: World Historic Review for Companion Animal Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).................84 Table 8: World 11-Year Perspective for Companion Animal Vaccines by Geographic Region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart) ................................................................................85 Table 9: World Recent Past, Current & Future Analysis for Companion Animal Vaccines by Product Segment- Canine Vaccines & Feline Vaccines Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ................................................................................86

10. RESEARCH AND DEVELOPMENT IN RECENT PAST................................................................69

Scientists Develop New Vaccine Against Disease Related to PCV2 ....................................................................... 69 Auburn University and Vaxin Researchers Develop Avian Flu Vaccine .................................................................... 69 UK Researchers Develop In-Shell Vaccine for Chicks............... 69 Researchers in Vietnam Decode the H5N1 Virus Gene.............. 70 Pittsburgh Researchers Create Avian Flu Vaccine from H5N1 Virus............................................................................... 70 University of Warwick Develops Protecting Virus Method ....... 70 New Treatment Measure Against Ovine Salmonella & Brucellosis ................................................................................ 71 ICAR Develops Indigenous Bird Flu Vaccine ............................ 71 St. Jude Develops Flu Virus Vaccine through Reverse Genetics .................................................................................... 71 Researchers Develop Vaccine for Swine Disease ....................... 71 Researchers Develop Experimental Vaccine Against 1918 Influenza Virus ......................................................................... 72 Study Proves Effectiveness of Intradermal Vaccine Administration in Rabbits......................................................... 72

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Table 10: World Historic Review for Companion Animal Vaccines by Product Segment- Canine Vaccines & Feline Vaccines Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ....................................... 87 Table 11: World 11-Year Perspective for Companion Animal Vaccines by Product Segment ­ Percentage Breakdown of Dollar Sales for Canine Vaccines & Feline Vaccines Markets for Years 2005, 2010 & 2015.............. 87 Table 12: World Recent Past, Current & Future Analysis for Canine Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ....................................................... 88 Table 13: World Historic Review for Canine Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ....................................... 89 Table 14: World 11-Year Perspective for Canine Vaccines by Geographic region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart)................................................................................ 90 Table 15: World Recent Past, Current & Future Analysis for Feline Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ................ 91 Table 16: World Historic Review for Feline Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ....................................... 92 Table 17: World 11-Year Perspective for Feline Vaccines by Geographic Region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015(includes corresponding Graph/Chart) ....................................................... 93 Table 18: World Recent Past, Current & Future Analysis for Livestock Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ....................................................... 94 Table 19: World Historic Review for Livestock Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ....................................... 95 Table 20: World 11-Year Perspective for Livestock Vaccines by Geographic Region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart) ....................................................... 96 Table 21: World Recent Past, Current & Future Analysis for Livestock Vaccines by Product Segment ­ Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ................................................................................97 Table 22: World Historic Review for Livestock Vaccines by Product Segment ­ Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines & Other Animal Vaccines Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ................................................................................98 Table 23: World 11-Year Perspective for Livestock Vaccines by Product Segment ­ Percentage Breakdown of Dollar Sales for Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines & Other Animal Vaccines Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart) ................................................................................99 Table 24: World Recent Past, Current & Future Analysis for Porcine Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart)...............100 Table 25: World Historic Review for Porcine Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart)......................................101 Table 26: World 11-Year Perspective for Porcine Vaccines by Geographic Region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart) ..............................................................................102 Table 27: World Recent Past, Current and Future Analysis for Bovine Vaccines by Geographic Region ­ US, Europe & Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart)......................................103 Table 28: World Historic Review for Bovine Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart)......................................104 Table 29: World 11-Year Perspective for Bovine Vaccines by Geographic region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015(includes corresponding Graph/Chart) .....................................................105 Table 30: World Recent Past, Current & Future Analysis for Poultry Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart)...............106

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Table 31: World Historic Review for Poultry Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ..................................... 107 Table 32: World 11-Year Perspective for Poultry Vaccines by Geographic region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart).............................................................................. 108 Table 33: World Recent Past, Current & Future Analysis for Ovine Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) .............. 109 Table 34: World Historic Review for Ovine Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ..................................... 110 Table 35: World 11-Year Perspective for Ovine Vaccines by Geographic region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015(includes corresponding Graph/Chart) ..................................................... 111 Table 36: World Recent Past, Current & Future Analysis for Equine Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ..................................................... 112 Table 37: World Historic Review for Equine Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ..................................... 113 Table 38: World 11-Year Perspective for Equine Vaccines by Geographic region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart) ..................................................... 114 Table 39: World Recent Past, Current & Future Analysis for Other Animal Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) .............. 115 Table 40: World Historic Review for Other Animal Vaccines by Geographic Region ­ US, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ..................................... 116 Table 41: World 11-Year Perspective for Other Animal Vaccines by Geographic region ­ Percentage Breakdown of Dollar Sales for US, Europe and Rest of World Markets for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart) ..................................... 117

13. THE UNITED STATES ................................................118

A. Market Analysis ...................................................................118 Current & Future Analysis ..................................................118 H5N1 Virus: A Conundrum for the US Industry ............118 Rabies Cases in the US........................................................118 B. Market Analytics..................................................................119 Table 42: US Recent Past, Current & Future Analysis for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ..............................................119 Table 43: US Historic Review for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ..............................................120 Table 44: US 11-Year Perspective for Veterinary Vaccines by Product Group/Segment ­ Percentage Breakdown of Dollar Sales for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets for 2005, 2010 & 2015 (includes corresponding Graph/Chart) ..............................121

14. EUROPE.........................................................................122

Market Analysis........................................................................122 Table 45: European Recent Past, Current & Future Analysis for Veterinary Vaccines by Geographic Region ­ France, Germany, Italy, United Kingdom and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ..............................................122 Table 46: European Historic Review for Veterinary Vaccines by Geographic Region ­ France, Germany, Italy, United Kingdom and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).......................................................................123 Table 47: European 11-Year Perspective for Veterinary Vaccines by Geographic Region ­ Percentage Breakdown of Dollar Sales for France, Germany, Italy, United Kingdom and Rest of Europe for Years 2005, 2010 & 2015 (includes corresponding Graph/Chart) ..............................................124

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Table 48: European Recent Past, Current & Future for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) .............................. 125 Table 49: European Historic Review for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ...................................................................... 126 Table 50: European 11-Year Perspective for Veterinary Vaccines by Product Group/Segment ­ Percentage Breakdown of Dollar Sales for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets for Years 2005, 2010 & 2015(includes corresponding Graph/Chart) ...................................................................... 127

14b. GERMANY..................................................................131

Market Analysis ....................................................................131 Table 54: German Recent Past, Current & Future Analysis for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines and Equine Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart).......................................................................131 Table 55: German Historic Review for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines and Equine Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart)........132 Table 56: German 11-Year Perspective for Veterinary Vaccines by Product Group/ Segment ­ Percentage Breakdown of Dollar Sales for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines and Equine Vaccines) Markets for 2005, 2010 & 2015 (includes corresponding Graph/Chart) ..............................................133

14a. FRANCE ......................................................................128

Market Analysis .................................................................... 128 Table 51: French Recent Past, Current & Future Analysis for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines and Equine Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) .............................. 128 Table 52: French Historic Review for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, and Equine Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart).............................................. 129 Table 53: French 11-Year Perspective for Veterinary Vaccines by Product Group/Segment ­ Percentage Breakdown of Dollar Sales for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines and Equine Vaccines) Markets for 2005, 2010 & 2015 (includes corresponding Graph/Chart) ...................................................................... 130

14c. ITALY ..........................................................................134

Market Analysis ....................................................................134 Table 57: Italian Recent Past, Current & Future Analysis for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) .....................134 Table 58: Italian Historic Review for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ..............................................135 Table 59: Italian 11-Year Perspective for Veterinary Vaccines by Product Group/Segment ­ Percentage Breakdown of Dollar Sales for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets for 2005, 2010 & 2015 (includes corresponding Graph/Chart).......................................................................136

© Global Industry Analysts, Inc., February 2011

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VETERINARY VACCINES

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CONTENTS

14d. THE UNITED KINGDOM.........................................137

Market Analysis .................................................................... 137 Table 60: UK Recent Past, Current & Future Analysis for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) .............................. 137 Table 61: UK Historic Review for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ....... 138 Table 62: UK 11-Year Perspective for Veterinary Vaccines by Product Group/Segment ­ Percentage Breakdown of Dollar Sales for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets for 2005, 2010 & 2015 (includes corresponding Graph/Chart) .............................. 139 Table 65: Rest of Europe 11-Year Perspective for Veterinary Vaccines by Product/Segment ­ Percentage Breakdown of Dollar Sales for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets for 2005, 2010 & 2015 (includes corresponding Graph/Chart) ........144

15. REST OF WORLD ........................................................145

A. Market Analysis ...................................................................145 Current & Future Analysis ..................................................145 Focus on Select Regions .....................................................145 Canada..............................................................................145 Overview of Canadian Animal Health Industry ..........145 Import and Manufacture of Veterinary Biologics .......145 First to Access E. coli 0157:H7 Vaccine .....................145 China ................................................................................146 A Glance at the Animal Vaccine Market in China ......146 China Initiates Mass Vaccination Campaign Against Bird Flu Virus .............................................147 Australia ...........................................................................147 A Note on Australian Veterinary Therapeutics Market .......................................................................147 India .................................................................................147 ICAR Develops Indigenous Bird Flu Vaccine ............147 Thailand ...........................................................................147 Japan & Thailand to Cooperate for Developing Bird Flu Vaccine.......................................................147 Taiwan..............................................................................148 Taiwan's Animal Healthcare Industry Under Scan................................................................148 Malaysia ...........................................................................148 Malaysia Initiates Measures to Deal with Potential Flu Pandemic.............................................148 Kazakhstan.......................................................................148 Kazakhstan Takes Proactive Measures Against Bird Flu .....................................................................148 North Korea .....................................................................149 North Korea Develops Bird Flu Vaccine.....................149 Vietnam............................................................................149 Vietnam Imports Bird Flu Vaccines ............................149 Egypt ................................................................................149 Egypt Reports H5N1 Infection in Vaccinated Flocks........................................................................149 Kenya ...............................................................................149 Kenya Mass-Manufactures Vaccines Against Rift Valley Fever ......................................................149 B. Market Analytics..................................................................150 Table 66: Rest of World Recent Past, Current & Future Analysis for Veterinary Vaccines - by Product Group/ Segment for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) ..............................150

14e. REST OF EUROPE ....................................................140

A. Market Analysis................................................................... 140 Current & Future Analysis.................................................. 140 A Note on Danish Veterinary Services............................... 140 The 2002 Standards of Danish Medicines recommend test for antibody inducing fragments in veterinary vaccines.................................................................... 141 Hungary Vaccinates Birds Across Zoos ............................. 141 Russia Mass-Produces Vaccines Against Avian Flu.......... 141 B. Market Analytics ................................................................. 142 Table 63: Rest of Europe Recent Past, Current & Future Analysis for Veterinary Vaccines ­ by Product Group/ Segment for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2007 through 2015 (includes corresponding Graph/Chart) .............................. 142 Table 64: Rest of Europe Historic Review for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) ...................................................................... 143

© Global Industry Analysts, Inc., February 2011

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Table 67: Rest of World Historic Review for Veterinary Vaccines by Product Group/Segment ­ Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart) .............................. 151 Table 68: Rest of World 11-Year Perspective for Veterinary Vaccines by Product Group/Segment ­ Percentage Breakdown of Dollar Sales for Companion Animal Vaccines (Canine Vaccines and Feline Vaccines) and Livestock Vaccines (Porcine Vaccines, Bovine Vaccines, Poultry Vaccines, Ovine Vaccines, Equine Vaccines and Other Animal Vaccines) Markets for 2005, 2010 & 2015 (includes corresponding Graph/Chart).......................................................................152

COMPETITIVE LANDSCAPE

Total Companies Profiled: 69 (including Divisions/Subsidiaries - 97) Region/Country The United States Canada Japan Europe France Germany The United Kingdom Italy Rest of Europe Asia-Pacific (Excluding Japan) Latin America Africa Middle-East Players 30 5 3 28 3 8 1 2 14 22 5 1 3

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