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Ross V. Weatherman, Ph.D.

Associate Professor Department of Chemistry and Biochemistry Rose-Hulman Institute of Technology Terre Haute, Indiana USA Professional website: http://www.rose-hulman.edu/~weatherm

Academic Record

Ph.D. 1996 Department of Chemistry, University of Wisconsin-Madison A.B. 1991 Wabash College, Chemistry major, graduated summa cum laude

Academic Appointments

Associate Professor, Rose-Hulman Institute of Technology, Department of Chemistry and Biochemistry, 2011-present Assistant Professor, Rose-Hulman Institute of Technology, Department of Chemistry and Biochemistry, 2009-2011 Assistant Professor, Purdue University, Department of Medicinal Chemistry and Molecular Pharmacology, 2001-2009. American Cancer Society Postdoctoral Fellow, University of California, San Francisco, Department of Pharmaceutical Chemistry, 1997­2001.

Awards and Honors

2007 2004 1997-2000 1995-1991 Purdue Seeds for Success Award AACP-AFPE Pharmacy Faculty New Investigator Award American Cancer Society, California Division Postdoctoral Fellow Hoechst-Celanese Outstanding Graduate Student in Organic Chemistry, Amoco Graduate Fellowship, NIH Biotechnology Predoctoral Fellowship, Wisconsin Alumni Research Foundation Fellowship

Professional Memberships

American Chemical Society, Sigma Xi, Phi Beta Kappa, Alpha Chi Sigma Chemistry Fraternity, Phi Lambda Sigma Pharmaceutical Chemistry Fraternity

Published Work

Peer-Reviewed Research Articles (* denotes corresponding author) 1. Shah, V. P.; Chegini, H. A.; Vishneski, S. R.; Weatherman, R. V.; Blackmore, P. F.; Dobrydneva, Y. Tamoxifen promotes superoxide production in platelets by activation of PI3Kinase and NADPH oxidase pathways. Thrombosis Research, 2012, 129, 36­42. 2. Rickert, E.L.; Oriana, S.; Hartman-Frey, C.; Long, X.; Webb, T.T.; Nephew, K.P.; *Weatherman, R.V. Synthesis and characterization of fluorescent 4-hydroxytamoxifen conjugates with unique antiestrogenic properties. Bioconjugate Chemistry. 2010 21, 903-10 3. Rickert, E. L.; Trebley, J. P.; Peterson, A. C.; Morrell, M. M.; *Weatherman, R. V., Synthesis and Characterization of Bioactive Tamoxifen-conjugated Polymers. Biomacromolecules. 2007 8, 3608-12. 4. *Dobrydneva, Y.; Weatherman, R. V.; Trebley, J. P.; Morrell, M. M.; Fitzgerald, M. C.; Fichandler, C. E.; Chatterjie, N.; Blackmore, P. F., Tamoxifen Stimulates Calcium Entry into Human Platelets. Journal of Cardiovascular Pharmacology. 2007 50, 380-390. 5. Fan, M., Rickert, E. L., Chen, L., Aftab, S. A., Nephew, K. P., and *Weatherman, R. V. Characterization of molecular and structural determinants of selective estrogen receptor downregulators. Breast Cancer Research and Treatment. 2007. 103, 37-44 6. *Johnson, M.D.; Zuo H.; Lee. K-H; Trebley. J.P.;Rae, J.M.; Weatherman. R.V.; Zeruesanay, D.; Flockhart. D.A.; Skaar, T.A.; "Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen." Breast Cancer Research and Treatment 2004, 85, 151-159. 7. Weatherman, R. V.; Chang, C-Y.; Clegg, N. J.; Carroll, D. C.; Day, R. N.; Baxter, J. D.; Weatherman 1

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McDonnell, D. P.; Scanlan, T. S.; *Schaufele, F. Ligand-selective Interactions of ER Detected in Living Cells by FRET. Molecular Endocrinology. 2002, 16, 487-496. Weatherman, R. V.; Carroll, D.C.; *Scanlan, T. S. Activity of a Tamoxifen-Raloxifene Hybrid Ligand for Estrogen Receptors at an AP-1 Site. Bioorganic & Medicinal Chemistry Letters. 2001, 11, 3129-3131. Weatherman, R. V.; Clegg, N.; *Scanlan, T. S. Differential SERM Activation of the Estrogen Receptors (ERalpha and ERbeta) at AP-1 sites. Chemistry & Biology. 2001, 8, 427-436. Weatherman, R. V.; *Scanlan, T. S. Unique Protein Determinants of the Subtype-Selective Ligand Responses of Estrogen Receptors (ERalpha & ERbeta) at AP-1 Sites. Journal of Biological Chemistry. 2001, 276, 3827-3832. Webb, P.; Nguyen, P.; Valentine, C.; Weatherman, R. V; Scanlan, T. S.; *Kushner, P.J. An Antiestrogen Responsive Estrogen Alpha Mutant (D351Y) Shows Weak AF-2 Activity in the Presence of Tamoxifen. Journal of Biological Chemistry. 2000, 275, 37552-37558 Weatherman, R. V.; *Kiessling, L. L. Fluorescence Anisotropy Assays Reveal Affinities of Cand O-Glycosides For Concanavalin A. Journal of Organic Chemistry. 1996, 61, 534-538. Weatherman, R. V.; Mortell, K. I.; Chervenak, M.; Kiessling, L. L.; *Toone, E. J. Specificity of C-Glycoside Complexation By Mannose Glucose Specific Lectins. Biochemistry 1996, 35, 3619-3624. Mortell, K. H.; Weatherman, R. V.; *Kiessling, L. L. Recognition Specificity of Neoglycopolymers Prepared By Ring-Opening Metathesis Polymerization. Journal of the American Chemical Society. 1996, 118, 2297-2298. *Olsen, J. A.; Weatherman, R. V. Characterization of an ATPase Associated With the Lipid Body Membrane of Germinating Rapeseed. Phytochemistry. 1992, 31, 411-412.

Conference Proceedings 1. Trebley, J.P.; Rickert, E.L.; Reyes, P.T.; *Weatherman, R.V.; "Tamoxifen-Based Probes for the Study of Estrogen Receptor-Mediated Transcription." Ernst Schering Research Foundation Workshop in Chemical Genomics. 2006, 76-86. Review Articles/Book Chapters 1. *Weatherman, R. V., Hormone Signaling. In Wiley Encyclopedia of Chemical Biology, 2008, Begley, T. P., Ed. John Wiley & Sons, Inc.: DOI: 10.1002/9780470048672.wecb229. 2. *Weatherman, R. V., Untangling the Estrogen Receptor Web: Tools to Selectively Study Estrogen binding Receptors. In Nuclear Receptors as Drug Targets, Ottow, E.; Weinmann, H., Eds. Wiley-VCH, 2008, 47-64. 3. *Weatherman RV: Chemical approaches to studying transcription. Organic & Biomolecular Chemistry. 2003, 1, 3257-3260. 4. Weatherman, R. V.; Fletterick, R. J.; *Scanlan, T. S. Nuclear Receptor Ligands and Ligand Binding Domains. Annual Reviews in Biochemistry. 1999, 68, 559­582. Commentaries/Book Reviews 1. *Weatherman, R. V.. Review of "Cancer Drug Discovery and Development-Hormone Therapy in Breast and Prostate Cancer. Edited by V. Craig Jordan and Barrington JA Furr." ChemMedChem 2010, 5, 1152 ­ 1154. 2. *Weatherman, R. V. Sensing Estrogen's Many Pathways. ACS Chem. Biology, 2008, 3, 33840. 3. *Weatherman, R. V., A triple play for thyroid hormone. ACS Chemical Biology 2007, 2, 377-9. 4. *Weatherman, R. V., Untangling the estrogen receptor web. Nature Chemical Biology 2006, 2, 175-6.

Invited lectures

1. 2. "Fluorescent Conjugates for Studying Rapid Steroid Signaling" invited talk at International Symposium on Rapid Steroid Signaling, Crete, Greece, September 2011. "Chemical Biology of Estrogen Signaling in Breast Cancer", Feb. 22, 2010, Manchester College Departments of Chemistry and Biology.

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"Chemical Biology of Estrogen Signaling in Breast Cancer", 2009, Rose-Hulman Institute of Technology, Department of Chemistry and Biochemistry. 4. "Antiestrogenic Conjugates as New Breast Cancer Chemoprevention Agents." Cancer Prevention and Control Group. Purdue Oncological Sciences Center, February 2007. 2. "Bioconjugation for the Study of Hormone Signaling". Bindley Bioscience Center Workshop on Bioconjugation, Purdue University, September, 2005 3. "Integrated Study of Integrated Hormone Signaling." American Association of Colleges of Pharmacy National Meeting, July 2005. 4. "Chemical Genomics of Integrated Hormone Crosstalk", Schering Foundation Workshop on Chemical Genomics, Berlin, Germany, April 2005. 5. "Chemical Biology of Integrated Estrogen Signaling", Department of Basic Medical Sciences, Indiana University-Bloomington, April 2005 6. "Chemical Biology of Steroid Hormone Signaling" Nuclear Receptor Drug Discovery Session, American Chemical Society Central Region meeting, Indianapolis, June 2004 7. "Chemical Biology of Steroid Hormones" Lyon College, March 2003. 8. Chemical Biology of Steroid Hormones" Manchester College, April 2002. 9. "Chemical Biology of Estrogen Signaling", Indiana University School of Medicine and Indiana Cancer Center, March 2002. 10. "Chemical Biology of Steroid Hormone Signaling." Truman State University, November 2001. 11. "Chemical Biology of Steroid Hormone Signaling." Wabash College, November 2001 12. "Chemical Biology of Steroid Hormone Signaling." Department of Chemistry, Purdue University, October 2001.

Research Grants and Awards

Current Awards Agency: National Institute of Diabetes and Digestive and Kidney Diseases Title: Novel Bioconjugates as Probes of Estrogen Receptors Duration: 5/1/07-4/30/12 Total Amount of Award: $1,410,000 Role: Principal Investigator with subcontract to Ken Nephew, Indiana University Past Awards Agency: U.S. Army Medicinal Research and Materiel Command Idea Award Title: Chemical Probes of Rapid Estrogen Signaling in Breast Cancer Treatment Duration: 1/1/04-12/31/06 Total Amount of Award: $478,000 Role: Principal Investigator Agency: Purdue Cancer Center/Indiana U. Cancer Center Collaborative Pilot Grant Title: Chemical Probes of Mechanistically Distinct Antiestrogens Duration: 7/1/04-6/30/05 Total Amount of Award: $30,000 Role: co-PI with Ken Nephew, Indiana University Agency: Showalter Foundation Title: Development of Intelligent, Nanotechnology-based Materials for the Prevention and Treatment of Osteoporotic Bone Duration: 7/1/04-6/30/06 Total Amount of Award: $60,000 Role: co-PI with Tom Webster, Alan Friedman & Jim Fleet, Purdue University Agency: Amer. Assoc. of Colleges of Pharmacy New Investigator Program Title: Chemical Probes of Rapid Estrogen Signaling Duration: 12/1/03-11/30/04 Total Amount of Award: $10,000 Role: Principal Investigator Agency: American Cancer Society Institutional Junior Research Grant Title: Chemical Probes of Estrogen's Effects on Cell Death in Breast Cancer Duration: 8/1/01-7/31/02 Total Amount of Award: Direct: $20,000 Role: Principal Investigator

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Awards and Grants to Students Emily Rickert 2007-2008 Purdue Research Foundation Fellowship 2007 ACS Medicinal Chemistry Travel Award Joseph Trebley 2004-2006 NSF Integrative Graduate Education & Research Fellowship Priscilla Reyes 2002-2004 NIGMS Minority Access to Research Careers Predoctoral Fellowship

Evidence of National/International Recognition

Grant application review panels Army Breast Cancer Program, Cancer Experimental Therapeutics study section (2003-2010), Cancer Experimental Therapeutics Concept Award (2006-2010) National Institutes of Health, ad hoc reviewer for Molecular Endocrinology (2010) Susan G. Komen Foundation, Tumor Cell Biology Study Section (2007), System-based Therapeutics (2008) National Institutes of Health, Synthetic & Biological Chemistry A, ad hoc reviewer (2007) Meeting Sessions organized Co-organizer of session on selective estrogen receptor modulators at the American Chemical Society meeting in Anaheim, California, April 2004 Founding member, Faculty of 1000 Literature Alerting Service Member of Macromolecular Chemistry section of Chemical Biology Faculty since 2001. Submitted over 120 paper highlights. Paper Reviewer Journal of the American Chemical Society, Nature Chemical Biology, ACS Chemical Biology, Chemistry and Biology, Proceedings of the National Academy of Sciences, Journal of Medicinal Chemistry, Bioconjugate Chemistry, Chem Communications, Organic & Biomolecular Chemistry, ChemMedChem, Molecular Biosystems, Bioorganic and Medicinal Chemistry Letters, Analytical Chemistry, Journal of Organic Chemistry, Current Topics in Medicinal Chemistry

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