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P-INSULIN STRUCTURE DEVELOPMENT FROM MOMORDICA CHARANTIA LINN "THE AFRICAN CUCUMBER": A HERB USED FOR TREATMENT OF DIABETES MELLITUS

Sharon V. R. Epps Mentors: Robert P Metzger, Ph.D. and F.S.K. Tayman, Ph.D.

There has been extensive research reported on the fruit and seeds of Momordica charantia (M.c) Linn (Cucurbitaceae). The current research project studies the chemical structure and the anti-hyperglycemic activity of the polypeptide P-insulin, a mimetic of insulin reported to be present in Momordica charantia. Five fractions of plant extract were obtained from fruit and seeds of Momordica charantia and analyzed by infrared spectroscopy, 1Dimensional 1H-NMR and 1Dimensional 13C-NMR in D 2O, and uv-vis spectroscopy. The results from the NMR suggest the presence of alanine, serine, or threonine in the preparations.

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Microsoft Word - Sharon_Epps_abstract.doc