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Coagulation Cascade

Intrinsic Pathway

Contact System

High MW Kininogen Kallikrein

AT III

Extrinsic Pathway

Cellular Injury

Prekallikrein Factor XII

Subendothelium

Factor XII

Tissue Factor Factor X Factor VIIa

++ Ca

Factor XI

Factor XI a Soluble Kininogen Soluble Factor XIa

++ Ca

Factor VII

AT III

++ Ca

Factor IX Factor VIIIa Factor VIIIa

Tissue Factor

Factor IX a

AT III

Activated Platelet . Surface

Prothrombin

++ Ca

Platelet Phospholipids

Factor IX a-Factor VIIIa

++ Platelet Phospholipids Ca

Factor Xa Factors Xa- Va Complex

Factor X

Factor Xa

Factors Xa- Va Complex

AT III

Factor Va

Factor V

++ Ca

Factor V Activated Protein C Protein S Complex

Factor Va

AT III

Factor XIII

Thrombin

AT III

Factor XIIIa

++ Ca

Protein C

Activated Protein C

Protein S

Fibrinogen Plasminogen

Fibrin

Fibrin Cross linked

Thrombin Thrombomodulin Complex

Thrombomodulin

TPA, Urokinase, Streptokinase

Plasmin

AT III

Endothelium

Common Pathway

Protein binding/interaction

Fibrin Degradation

Action of an enzyme Enzymatic conversion of substrate to product

Inhibition Thrombin feedback activity

Information

Coagulation Cascade Pathway

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