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`Life is no brief candle, but a splendid torch to be made burn ever more brightly'

Sir Edward `Weary' Dunlop

Annual Report July 2002 to June 2003

The Sir Edward Dunlop Medical Research Foundation

Table of Contents

Message from the Patron Message from the Minister for Veterans' Affairs Message from the Minister for Education and Training Board of Directors Report from the Chairman Medical Research Committee Report from the Chairman of the M.R.C. Summary of research supported by the Foundation Photo gallery Financial statements Independent Audit Report Prize-winning essay 4 5 6 7 8 14 15 16 21 26 37 39

Acknowledgements

The Board of Directors gratefully acknowledges the outstanding support received from the Foundation's auditors, Ernst & Young, and the Foundation's solicitors, Mallesons Stephen Jaques. The Board also acknowledges, with thanks, support from the Foundation's major bankers, The Bank of Melbourne, a division of Westpac Banking Corporation.

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The Sir Edward Dunlop Medical Research Foundation

Message from the Patron, Sir Arvi Parbo AC

The past year was one of the most active and successful in the Foundation's history. There were several new initiatives to assist with raising funds for the continued support of medical research. It is particularly pleasing to see an increasing number of younger volunteers participating in the various activities. The future of the work initiated by Sir Edward depends on the coming generations gradually taking over.

Sir Arvi Parbo AC

The inaugural Weary Dunlop Appeal in July 2003, which is to be an annual event in the future, will be supported by a distinguished group of Official Patrons. However, the success of the Appeal will depend on the efforts of a large number of volunteers, many of them new to the Foundation. The Foundation depends on volunteers in all its activities and I continue to admire the unselfish contribution of their time and energies. The Appeal, and the Secondary School Student Project combined with it, will help to commemorate and keep alive the deeds and spirit of Sir Edward as an example to us all. This is also an important purpose of the inaugural Gala Night in September 2003, in the presence of the Governor of Victoria, His Excellency John Landy AC MBE, and numerous other distinguished guests. Members of the Medical Research Committee, headed by Professor John McNeil, again made a valuable contribution in deciding which of the many research proposals received by the Foundation would be funded. I congratulate the Chairman, Mr Dino De Marchi, and the members of the Board on their outstanding leadership. I believe that the Sir Edward Dunlop Medical Research Foundation can look forward to the future with confidence.

Sir Arvi Parbo AC Patron of the Foundation

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The Sir Edward Dunlop Medical Research Foundation

Message from the Minister for Veterans' Affairs, the Hon Danna Vale MP

I am pleased to welcome readers to this annual report and to express the Australian Government's appreciation for the work of the Sir Edward Dunlop Medical Research Foundation. The work of the Foundation is always of interest to me because of its guiding principle to improve the health and well-being of the veteran community. For close to 20 years the Foundation, made up of loyal and dedicated volunteers, has aided the mental and physical health of veterans and their families through grant funding for research projects.

Hon Donna Vale MP

To date the Foundation has provided more than $1.5 million to fund medical research. Many of these projects focus on issues of great concern to the veteran community such as cardiovascular disorders and preventative medicine. The Foundation has created a wealth of knowledge on pertinent health issues that benefit not only the veteran community but all Australians. The Foundation has also been instrumental in the establishment of The Sir Edward Dunlop Medical Research Foundation Chair of Medicine. A joint venture among the Foundation, the University of Melbourne and the Heidelberg Repatriation Hospital, the Chair of Medicine will be a world-class centre of excellence in research, teaching and the clinical diagnosis, treatment and care of veteran communities around Australia. In addition to this, the mental and social health of veterans has been aided through a series of events held by the Foundation throughout the year. These events have brought together parts of the veteran community in a relaxed and convivial atmosphere. I am particularly delighted to hear of the Foundation's work with the Secondary School Student Project, `Should we remember Weary Dunlop?'. It is encouraging to see young Australians honour and remember our war heroes who have given so much to our country. The health care of the veteran community is of high importance to the Australian Government. I would like to take this opportunity to thank and commend the Board of Directors who generously donate their time to the Foundation. I wish those involved with the Foundation well in their pursuits to improve the health of veterans and the community as a whole. Danna Vale MP Minister for Veterans' Affairs

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The Sir Edward Dunlop Medical Research Foundation

Message from the Minister for Education and Training, the Hon Lynne Kosky MP In April this year I was honoured to be invited to launch the Secondary School Student Project, `Should we remember Weary Dunlop?', an initiative of the Sir Edward Dunlop Medical Research Foundation. The decision by the Foundation to expand their goals to include resources for students about his life and his Hon Lynne Kosky MP legacy was very welcome. To mention Weary Dunlop amongst my generation is to immediately conjure up an impression of a person who embodies values that every Australian should strive for: compassion for all, forgiveness, respect, resilience and commitment to furthering the opportunities and quality of life for all. The education resource developed by the Sir Edward Dunlop Medical Research Foundation will ensure that a new generation will also gain an understanding and appreciation of the contribution Weary Dunlop made to Australian life. Moreover, they will gain an understanding that each of us can make a contribution to our community through building on the values that people like Weary Dunlop stood for. Lynne Kosky

Minister for Education and Training

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The Sir Edward Dunlop Medical Research Foundation

Board of Directors

The Foundation's activities are guided by a Board of Directors. Board members 30 June 2003 were: Mr Dino De Marchi RFD, LLB (Chairman) Barrister and Solicitor Director, De Moray Pty Ltd, Transgard Pty Ltd Dr Graham W Cooper RFD, ED, MBBS, MRCP, FRACP (Vice Chairman) Physician Mr Fred A Cullen OAM (Secretary) Investor, primary producer Chairman, Mullawingee Co-operative Ltd Mrs Janice Young (Treasurer) Office Administrator, secretary/public officer of the 2/24th Australian Infantry Battalion Inc. Professor John J McNeil MBBS, MSc, PhD FRACP, FAFPHM (Medical Research Committee Chairman) Professor and Head of Department Department of Epidemiology and Preventative Medicine, Monash University Dr Mario De Luise MBBS, BmedSci, PhD, FRACP (Medical Research Committee Liaison Officer) Consultant Physician and endocrinologist, Austin & Repatriation Medical Centre Mr George McCauley War Widows' Guild representative Sir Richard Kingsland AO, CBE, DFC RAAF Association representative Retired Commonwealth department head Mr Ted Richards JP Legacy representative Director, S&H Printing Pty Ltd Mr Bill Toon Ex-Prisoners of War and Relatives Association representative Retired company director Mr Mike O'Meara Department of Veterans' Affairs VIC Branch representative Mr Raymond Gill Naval Association of Australia representative Retired bank officer Mrs Joan Johnstone Returned and Services League representative Retired bank manager Mr David Keall Retired teacher (appointed 9/7/02) Mr Grahame Thom BEc, FCPA retired DVA officer Cr Ross Smith City of Monash, former M.L.A. Mr Stephen Murby FRSA Vice President, Swinburne University of Technology

*The Board expresses its thanks to Board Director Mr Clive Smith, who resigned on 9/7/02.

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The Sir Edward Dunlop Medical Research Foundation

Report from the Chairman, Mr Dino De Marchi

Introduction

It is with great pleasure that, on behalf of the Board of Directors, I report on the various activities of the Sir Edward Dunlop Medical Research Foundation for the financial year ended June 2003. 2002­2003 was an exciting year for the Foundation. While continuing our customary work of improving the health care and quality of life of veterans and their dependants through Mr Dino De Marchi the funding of medical research, the Board also instigated important expansion in the scope and nature of our fund-raising program, the development of our profile in the community and the consolidation of our infrastructure and personnel. Plans are now well under way for an inaugural state-wide Weary Dunlop Appeal ( July 2003) and a prestigious Gala Ball (September 2003). The Foundation has also developed a Secondary School Student Project on the life of Weary Dunlop and played a crucial role in the establishment of a world-class veterans' health research centre at the Heidelberg Repatriation Hospital. In accordance with the spirit of these new initiatives and in light of the prospect of increased attention to and awareness of the Foundation, its cause and its activities, the Board opted to update the branding of the Foundation. A clear, stately new logo, featuring the image of the late Sir Edward `Weary' Dunlop, now represents the Foundation. Further, recognising the power and ubiquity of the internet as a communications tool, the Board initiated the overhaul of the Foundation's website. Now featuring the new logo and improved layout and navigation, the website allows the user to find out more about Sir Edward's life and keep up to date with the Foundation's news and activities while providing the on-line facilities to register as a Friend of the Foundation, volunteer to help with the Appeal or make a donation/ bequest to the Foundation. On the financial front, we achieved a substantial operating surplus while continuing to provide medical research grants in the amount of $150,000. This considerable growth was due not only to the diligent efforts of our fund-raising committee but to the generous groups and individuals who made donations in the amount of $24,860 and bequests totalling a staggering $345,013. I am pleased to announce the appointment of Mr David Keall, who on 9 July 2002 joined the Board of Directors as representative of the T&PI Association, where he has held office since 1994. Mr David Keall replaces the late, esteemed and greatly missed Dr Sol Rose and I wish him a successful term with the Foundation. Congratulations go to Board Directors Mrs Joan Johnstone and Mr Fred Cullen, who, on 26 January 2003 were both awarded the Centenary Medal in recognition of their tireless work for the Foundation and the community. It is very pleasing to see an official recognition of the admirable qualities and the selflessness they have evinced throughout their lives and careers. Well done!

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The Sir Edward Dunlop Medical Research Foundation

The Medical Research Committee

The Board, in consultation with the Medical Research Committee, advertised the following areas of study for the 2003 medical research grants: Cardiovascular Disease ­ causative factors, early detection, prognosis and clinical treatment Preventative Medicine ­ behavioural factors promoting health

Future Grants

The Board agreed that the funds for medical research to be made available for future financial years would be $150,000, the same as in 2002­2003.

Chair of Medicine

During the course of the year, the Board and the Medical Research Committee negotiated the Foundation's position in relation to funding of the Chair of Medicine at the Heidelberg Repatriation Hospital. In April an agreement was reached and I am most pleased to report the inauguration of the Sir Edward Dunlop Medical Research Foundation Chair of Medicine. The Chair of Medicine will be the head of a world-class Centre for Excellence in research, teaching and the clinical diagnosis, treatment and care of veteran communities around Australia. Based at the Heidelberg Repatriation Hospital and working in conjunction with Melbourne University's Faculty of Medicine, the Chair will receive $45,000 a year from the Foundation in a seven-year shortfall funding arrangement. The position of Chair of Medicine has been advertised and is expected to be filled early in the next financial year. The successful candidate will be selected by the Medical Research Committee as well as representatives of Heidelberg Hospital and Melbourne University. This is a great step for the Foundation, something that will not only garner considerable public attention, but also set high standards for, and make important progress in, the study and treatment of veterans' health problems.

New Projects

Secondary School Student Project

Here at the Foundation we believe that our work is not limited to the raising of funds in the name of Sir Edward `Weary' Dunlop. We have a strong commitment to inform others, especially our youth, about the life and qualities of the Foundation's namesake and about how this man inspired and still inspires us to continue his work. Devised in conjunction with the ANZAC Day Commemoration Committee, the Secondary School Student Project, which can be integrated into various subjects and curricula such as history, SOSE and studies of conflict, gives the student an insight into the arduous conditions that our POWs faced and the bravery and compassion that Weary Dunlop displayed to boost the morale and save the lives of hundreds of POWs.

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The Sir Edward Dunlop Medical Research Foundation

We hope that this project will encourage our youth to consider the choices that Weary Dunlop made and embrace the sense of individual responsibility and compassion that informed those choices. Ultimately we hope that lessons like these will have as tangible an effect on the whole community as the medical research we have funded for the past 17 years. Early in July 2003, the Hon Lynne Kosky MP, Minister for Education and Training, will launch the Secondary School Student Project at a media conference timed to coincide with our Commemorative Service and the inauguration of the Weary Dunlop Appeal. We are honoured to have Minister Kosky with us on this new initiative and thank her for her support.

Preparations for the Appeal

In today's competitive economic climate, the charity dollar is becoming harder and harder to come by. In light of this fact, the Board resolved that the Foundation needed to find a way of raising funds that would allow it to augment its funding of medical research in order to consolidate and secure its position as the only not-for-profit organisation specifically focused on the health of veterans. The Board decided on the concept of a two-week appeal centring on the sale of lapel pins featuring the image of Sir Edward. Under the direction of Foundation Secretary Mr Fred Cullen, the Appeal comprises a backbone of selling points in RSL Sub-Branches around Victoria in conjunction with numerous individual sellers and various selling points in Melbourne's city centre on authorised selling days. Already we have had excellent co-operation from many RSL Sub-Branches and have signed on a bevy of volunteers to operate our selling points and to help prepare and distribute the lapel pins, collection tins and display materials.

Preparations for the Gala Night

The Board decided that, in order to raise the profile of the Foundation, a premier social occasion was a necessary part of the Foundation's calendar of events. The concept was to host a black tie occasion where the Foundation could thank its volunteers, benefactors and supporters and recognise the good works being done and celebrate the life of Sir Edward `Weary' Dunlop while having an excellent night out and raising further funds for medical research. His Excellency John Landy AC MBE, the Governor of Victoria, a consistent supporter of the Foundation, graciously agreed to be the guest of honour. His presence will certainly lend weight to the occasion and we thank him for his support. Ricardo Pietropaoli, creative and artistic director and event manager with a wealth of experience in the entertainment world, joined a team of volunteers from within the Foundation to form the Gala Night Steering Committee, the group responsible for making this occasion a real event. With Ricardo Pietropaoli's artistic flair, know-how and connections, the efforts of the

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The Sir Edward Dunlop Medical Research Foundation

dedicated team of volunteers as well as the presence of the Governor, the Gala Night is shaping up to be a night to remember.

New Infrastructure and Personnel

As a result of these new initiatives, the Board created two new positions at the Foundation's office. Ms Virginia Lovig was engaged as Appeal Co-ordinator, a position involving administration, logistics and publicity as well as the management of volunteers for the Appeal. Virginia, who started as a volunteer for the Foundation, has a background in administration and marketing. Mr Stephen Willis joined the team on a part-time basis as our Information Officer, dealing with the copy writing and editing of outgoing publicity material and the Foundation's website as well as administrative support. I wish our new staff all the best and hope they enjoy their time with the Foundation.

Commemoration and fund-raising activities

Each year the Foundation hosts a number of events that serve to raise funds for Australian medical research while providing entertaining occasions and activities for veterans and their families, Board Directors, researchers and volunteers.

Cape Schanck Golf Day ­ 5 July 2002

The annual Sir Edward `Weary' Dunlop Memorial Charity Golf Day grows more popular every year. Scores of golfers hit the Cape Schanck Golf Club's championship links for a day of fine stroke-making or simply a relaxed round with friends on the stunning seaside course. Organised as usual by the indefatigable Ivor Jones, the highly successful day brought together golfers of all levels for a win-win situation ­ raising money for the Foundation and having a great golfing day. This year the Sir Edward Dunlop Trophy went to Andre Winter, who outshone his rivals with a scorching 39-point performance.

Commemorative Service ­ 12 July 2002

Each year on 12 July, the Foundation holds a memorial service for the late Sir Edward next to his statue in the King's Domain on St Kilda Road. It is a chance to remember and honour a great Australian and to reflect on his manifold kindnesses and noble deeds. Guests of honour this year were His Excellency the Governor of Victoria, Mr John Landy; Lord Mayor of Melbourne John So; the Hon Fran Bailey MP, Parliamentary Secretary to the Minister of Defence and representative of the Prime Minister; and Mr Bruce Mildenhall MP, representative of the Victorian Premier, the Hon Steve Bracks. The Weary Dunlop Scholarship, a joint initiative of the Foundation, Swinburne University of Technology and the City of Stonnington, was this year awarded during the Commemorative Service to Jane Brewer by the Governor and Dr Douglas Mitchell, Acting Chancellor of Swinburne University.

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The Sir Edward Dunlop Medical Research Foundation

A Swinburne student with an impressive track record of community service, Jane wrote an essay entitled `The life of Sir Edward Dunlop in respect of Community Service' that can be found on page 39 of this report or downloaded from the Awards and Recognition page on our website www.siredwarddunlop.com.au/awards.htm.

Back to Caulfield Races ­ 24 August 2002

Caulfield racecourse was built on a former staging ground for Australian troops in the First and Second World Wars. So now, when the Melbourne Racing Club hosts a day of races dedicated to the veteran and ex-service communities, the diggers come `Back to Caulfield'. This year's event was, as always, a most enjoyable day out. The clement weather provided a brilliant backdrop for the bands and other entertainment throughout the day. The Sir Edward Dunlop Medical Research Foundation Stakes was won by Pernod, ridden by Kerrin McEvoy and trained by Michael Moroney.

Cocktail Evening at Austin Health ­ 27 September 2002

This function is a chance for the Foundation to recognise the outstanding support provided by individuals ­ be they members of the general community or volunteers with the Foundation. This year a Certificate of Appreciation was awarded to Mr Bob Solly of the Department of Veterans' Affairs. Mr Solly has proven himself to be exceptionally committed to the Foundation and has always made himself available to help in any way, ensuring that the bond between the Department and our Foundation remains strong and dependable. Our thanks go out to you, Bob, and we wish you all the best.

Spring Luncheon ­ 27 October 2002

This afternoon luncheon with music, dancing and entertainment, held at Empire Receptions, was again conducted under the auspices of the Italian Sub-Branch of the RSL, with an increasing participation from other sub branches and the Italian ex-service organisations. A clear profit of $3,000 was again achieved from the day's activities. Guests of Honour included the Hon Gordon Rich-Phillips, member for Eumemmerring; the Hon Carlo Furletti, member for Templestowe Province; the President of the Italian Alpini Association, Mr Gaetano Tomada; and Mr Giovanni Marchese, delegate of the Bersaglieri Association of Australia.

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The Sir Edward Dunlop Medical Research Foundation

DVA Information Evening ­ 6 December 2002

This year's information evening, hosted by the Department of Veterans' Affairs, was an opportunity for people to be informed about the role that the Foundation plays in the world of medical research. The Patron of the Foundation, Sir Arvi Parbo AC, introduced guests. Professor William Louis spoke on the importance of the Medical Research Committee and fellow Committee member Professor Michael Hill spoke about his medical research project conducted with the support of the Foundation. Board Secretary Fred Cullen spoke with his usual eloquence about the plans for the upcoming inaugural Weary Dunlop Appeal.

Kilmore Race Day ­ 1 June 2003

A great opportunity to get out of the city and enjoy a good old-fashioned day at the races, Kilmore Race Day is firm favourite on the Foundation's calendar. There was an excellent turnout to enjoy the food, drinks and entertainment and watch the running of the Weary Dunlop Medical Research Foundation Handicap, taken out by Zedatzi, ridden by Vlad Duric and trained by Bill Mitchell.

Conclusion

It has given me great pleasure this year to see the Foundation flourish, consolidate and lay the foundations for further exciting development in the years to come. We now have more staff, higher turnover, a higher profile and a growing list of respected and renowned Official Patrons for the upcoming inaugural Weary Dunlop Appeal. I would like to thank all our Board Directors, Medical Research Committee Members and volunteers as well as everyone who made donations and bequests this year. As a volunteer-based, not-for-profit organisation, we rely on the generosity and goodwill of others in order to continue Sir Edward's work. With supporters like this, it seems that we can achieve anything we put our minds to. Thank you all for making 2002-2003 an extraordinary year for the Sir Edward Dunlop Medical Research Foundation and the furthering of Sir Edward's ethos of improving the health and quality of life of our veterans. Our thoughts now turn to the exciting blockbuster of a year ahead of us in 2003-2004!

Dino De Marchi RFD LLB (Melb) FRSA Chairman

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The Sir Edward Dunlop Medical Research Foundation

Medical Research Committee

The Board of Directors of the Foundation is guided on medical research matters (including funding applications) by the advice and recommendations received by its Medical Research Committee. The Committee members, as listed below, give to the Foundation freely of their time and expertise and the Board of Directors wishes to express its appreciation for their contribution.

Professor John McNeil MBBS MSc PhD FRACP FAFPHM (Chairman) Professor and Head of Department Department of Epidemiology & Preventative Medicine Monash University Vic Professor Jeffrey Zajac MBBS PhD FRACP Head of Department of Medicine Austin & Repatriation Medical Centre Heidelberg West Vic Dr Mario De Luise MBBS FRACP BmedSci PhD Endocrinologist Austin & Repatriation Medical Centre Heidelberg West Vic Dr Maurice Fabiani BSc(Hons) PhD GradDipDrugEval PharmSc MBA candidate Senior Research Fellow Department of Medicine University of Melbourne Austin & Repatriation Medical Centre Heidelberg West Vic Professor Bill Louis MBBS MD MRACP FRACP (Deputy Chairman) Professor of Clinical Pharmacology & Therapeutics, University of Melbourne Director of Hypertension Services Austin & Repatriation Medical Centre Heidelberg West Vic Professor Michael Hill PhD Associate Dean (Research) Faculty of Life Sciences RMIT University Bundoora Vic Associate Professor Bruce Jackson MBBS PhD FRACP Nephrologist and General Physician Northern Hospital Epping Vic Dr Graham Cooper MBBS FRACP MRCP(Lond) Retired Physician

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The Sir Edward Dunlop Medical Research Foundation

Report from the Chairman of the Medical Research Committee, Professor John McNeil

Professor John McNeil

The Medical Research Committee of the Sir Edward Dunlop Medical Research Foundation is chaired by Professor John McNeil, Head of the Department of Epidemiology and Preventive Medicine of the Monash Medical School, Alfred Hospital. Its other members are all distinguished medical researchers and include Professors Jeffery Zajac, William Louis, Bruce Jackson and Drs Maurice Fabiani and Mario De Luise.

The role of the Committee is to ensure that the funds of the Foundation support the most worthy projects with the greatest potential to benefit veterans' health. These projects are selected from an increasing number of applications from major teaching hospitals, universities and research institutes. Each grant is assessed and ranked by the Medical Research Committee members and a final selection made by consensus. Eight projects were selected for funding this year. Two addressed potential new treatments for prostate cancer, four were directed towards improved understanding and treatment of cardiovascular disease and the other two focused on a better understanding of wound healing and muscle wasting. All were judged as having a significant potential to improve veterans' health and all support the aims outlined in the Articles of Association of the Foundation. As Chairman of the Medical Research Committee I am grateful for the continuing commitment of the other Committee members who have assisted in selecting the final successful applicants.

John McNeil

Chairman Medical Research Committee

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The Sir Edward Dunlop Medical Research Foundation

Summary of Research supported by the Foundation

1. Dr Albert Frauman

Title: Aim: KAI1, a potential metastasis suppressor gene and the progression of primary prostatic carcinoma. Prostate cancer is a leading cause of death and illness in men due to its high incidence of spread to other organs. Our laboratory will examine whether a correlation exists between altered expression of a tumour suppressor, KAI1, and cancer aggressiveness in localised prostatic cancer. Our laboratory has shown elevated levels of KAIl gene and protein in low grade primary prostatic cancers, with reduced levels in high grade prostatic cancer, suggesting that KAIl may be responsible for restricting growth of low grade tumours, and that its loss allows for more aggressive tumour formation. This gene loss may therefore possibly allow us to anticipate which tumours are most likely to spread beyond the confines of the prostate gland. The proposed project aims to expand our findings by examining the expression of KAIl in primary prostate cancer sections stored at the Austin and Repatriation Medical Centre and correlating levels with patient outcome, including time to spread of the cancer. Furthermore, we propose to examine the effects of KAIl reintroduction into prostate cancer cells and prostate cancer animal models. This information may lead directly to improved prediction of aggressive behaviour of tumours and improved therapy of localised or spread tumours. Researcher(s): A. G. Frauman, Department of Clinical Pharmacology and Therapeutics, Austin and Repatriation Medical Centre.

Summary:

2. Dr Christopher O'Callahan

Title: Aim:

Does abnormal liver blood flow cause diabetes in patients with high blood pressure?

To identify the cause of the metabolic syndrome (hyperinsulinaemia, impaired insulin clearance, insulin resistance, dyslipidaemia, impaired fibrinolysis etc). Most heart attacks are caused by well-known risk factors for cardiovascular disease - including hypertension, high cholesterol levels and diabetes. Incredibly, these risk factors frequently occur in individual patients - and just as incredibly, some manoeuvres, such as exercise, dieting and some types of medications, can simultaneously correct each of these defects. We are investigating a novel hypothesis, developed in our laboratory, that

Summary:

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The Sir Edward Dunlop Medical Research Foundation

the metabolic disorders that cause heart attacks are ultimately caused by reduced blood flow to the liver. Researcher(s): Dr Chris O'Callaghan, Department of Clinical Pharmacology and Therapeutics, Austin and Repatriation Medical Centre.

3. Dr Ian Darby

Title: Aim:

Role of Sox Transcription Factors in Wound Healing and Angiogenesis.

This project is aimed at better understanding how blood vessels grow during wound repair. After tissue damage, new blood vessels form by a process called angiogenesis. The growth of these vessels re-establishes the blood supply to damaged areas. Some of the factors that control this process have been discovered, such as growth factors released by cells close to the site of damage. We have recently described a new factor that is involved in signalling the nucleus of cells involved in the development of new vessels. This factor was first described in embryological development where it is involved in vessel growth. It is then only switched on when it is needed in adult life, during vessel growth after tissue damage (wound healing) but also in vessels growing in tumours. As vessel growth is needed for efficient wound healing it is of great interest to know how this factor works, particularly how it controls endothelial cell function (the cells that are responsible for small vessel growth). The possibility that it could be switched on when new vessels are needed, such as in wounds or switched off in situations where vessel growth is undesirable (such as in tumours) makes it a target molecule for future treatment of diseases where angiogenesis is implicated.

Summary:

Researcher(s): Dr Ian Darby, School of Medical Sciences, RMIT University.

4. Professor Jeffrey Zajac

Title: Aim:

Prevention of Muscle Wasting in Disorders of Motor Neurones.

Our research is aimed at trying to understand the causes of the degenerative process with the long-term aim of developing appropriate therapies to prevent muscle wasting. Prevention of muscle wasting in individuals suffering from neurodegenerative disorders is a major medical problem. A group of diseases in which this is a particularly significant problem are those caused by degeneration of motor neurones. Individuals affected by conditions causing muscle wasting, particularly motor neurone diseases, suffer from weakness and inability to perform the most fundamental of

Summary:

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The Sir Edward Dunlop Medical Research Foundation

functions such as speaking, eating and walking. While physical therapy plays a role in treatment, this is insufficient to prevent the underlying causes and progression of the disease. The motor neurone disease we use as a model is Kennedy's Disease. The genetic basis of this disease is known and the function of the affected protein is well characterised. We are studying the role of this genetic mutation and the abnormal protein produced in animal models and cell culture systems with the aim of understanding the pathological mechanisms causing this form of motor neurone disease. We anticipate this will help us to understand nerve degeneration in general. Researcher(s): Professor Jeffrey D. Zajac, Department of Medicine at the Austin & Repatriation Medical Centre.

5. Dr Karin Jandeleit-Dahm

Title: Aim:

Role of advanced glycation end products for the development and progression of diabetes associated atherosclerosis and renal disease.

The aim of this proposal is to find new treatments to prevent and/or regress atherosclerosis, heart and kidney disease in diabetes thus reducing disability and death in diabetic patients, particularly in the elderly. Diabetes is associated with large and small blood vessel (macro- and microvascular) disease leading to complications including heart disease, kidney disease, stroke and gangrene. These vascular complications remain the major cause of the increased rate of disability and death in diabetic patients, particularly in the elderly. The proposed studies will determine if interventions that reduce the amount of glucose that sticks to proteins known as "glycation" can prevent or reverse the vascular complications in diabetes. We have developed a good model of diabetic atherosclerosis that closely resembles the situation seen in human diabetes, the diabetic apolipoprotein E knockout mouse. Furthermore, we have unique access to drugs that inhibit this glycation process.

Summary:

Researcher(s): Karin Jandeleit-Dahm, Terri Allen and Josephine Forbes, Danielle Alberti Centre for Diabetic Complications, The Baker Heart Research Institute.

6. Dr Michael Hill

Title: Aim:

Cellular mechanisms underlying myogenic arteriolar tone: role of Na+/ Ca2+ exchanger (NCX).

To pharmacologically demonstrate the functional significance of the NCX in arteriolar myogenic tone as well as its existence and distribution in arteriolar smooth muscle.

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The Sir Edward Dunlop Medical Research Foundation

Summary:

Small arteries, or arterioles, are vital players in the control of blood pressure and blood flow. This level of control is mediated through their ability to change their diameter, and hence resistance, in response to signals generated within the body. Such signals include both chemical entities (for example hormones and products of metabolism) and physical factors (pressure and sheer stress). While these responses are fundamental to the circulatory system their underlying mechanisms are not fully known. In addition to expanding basic knowledge delineation of these mechanisms may provide the identification of sites for pharmacological intervention appropriate for the targeted treatment of disorders including hypertension and diabetes mellitus. The studies supported by the Dunlop Foundation will use sophisticated imaging techniques in combination with modern cell/molecular biology approaches to dissect out the cellular events which enable arterioles to alter their diameter in response to a changing local environment.

Researcher(s): Professor Michael Hill, Associate Dean (Research and Development), Faculty of Life Sciences, School of Medical Sciences, RMIT University.

7. Dr Simon Louis

Title: Aim:

Expression and role of angiotensin II receptors in prostate cancer.

We believe that by activating AT2-receptors or ATIP we will slow prostate tumour growth. Alternatively, drugs that block the AT1-receptor may also inhibit prostate tumour growth. Prostate cancer accounts for 23% of all new cases of cancer in men and is a leading cause of mortality. It frequently occurs in the aging veterans' population and current treatments can have a severe impact on the patient's quality of life. Angiotensin II receptors are cell surface proteins. There are two types, AT1- and AT2-receptors. Stimulation of AT1-receptors causes the cells to divide, whereas activation of the AT2-receptor can slow cell growth and cause them to die. Recently, we identified a new protein, called ATIP, that interacts with the AT2-receptor inside the cell. This protein blocks pathways responsible for cell growth. We will examine prostate tumour cell lines and prostate tumour tissues for the presence of ATIP, AT1- and AT2-receptors. In the prostate tissues we will identify the type of cells that contain these proteins and determine whether these cells are dividing or dying. The effect of stimulation and blockade of AT1- and AT2-receptors on prostate tumour cell growth will also be examined.

Summary:

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The Sir Edward Dunlop Medical Research Foundation

Researcher:

Dr Simon Louis, Department of Clinical Pharmacology, Austin and Repatriation Medical Centre.

8. Professor William Louis

Title: Aim:

The cardioprotective effect of highly selective beta1 blockade using D140S during percutaneous coronary intervention.

To demonstrate whether use of D140S offers benefits in terms of heart rate and blood pressure control during the procedure and a reduction in myocardial damage after the procedure. Percutaneous coronary intervention (PCI) to reopen blocked coronary arteries involves inflation of a balloon catheter to widen the blocked areas and insertion of stents to keep the artery open. This procedure involves repeated balloon inflations, during which blood flow is completely stopped in the artery. This may lead to some cardiac damage as detected by raised cardiac enzymes in blood in about 20% of patients. The trial is designed to show whether a short acting specific beta-blocker, D140S, can reduce this damage by controlling heart rate and reducing myocardial oxygen demand and lead to better long-term outcomes from the procedure. D140S has been selected because of its short duration of action, which allows us to control its effects with greater safety than conventional beta-blockers and secondly because of its high specificity for the cardiac beta1 receptor, which should avoid side effects associated with actions at beta2 receptors in lung and blood vessels seen with conventional beta-blockers. As is true of the general population, the incidence of heart attack and arterial disease is increasing in the Veteran population and such treatment may greatly improve the safety and outcome of PCI treatment for Veterans.

Summary:

Researchers:

Professor W.J. Louis, M.Horrigan, B.Chan, C.J.O'Callaghan and G.P. Jackman, Department of Clinical Pharmacology & Therapeutics and Department of Cardiology, Austin & Repatriation Medical Centre.

20 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

Photo Gallery - 12 July

Greg Monks singing the national anthem

VIPs, Defence Force and Police representatives

(from left) Mr Giuseppe Gardoz, President of the Italian Sub-Branch of the RSL; Ms Jane Brewer, winner of the 2002 Weary Dunlop Scholarship; Mr Alex Dugina, Secretary of the Italian SubBranch of the RSL; and the Chairman

Ms Jane Brewer with Master of Ceremonies Mr Tony Charlton AO

(from left) Mr Peter Jones, Dr Alexander Dunlop, Mrs Amanda Dunlop with their children Edward and Diana Dunlop

Governor of Victoria John Landy AC MBE, addressing the participants of the Commemorative Service

Gunner Alwyn Barrett, 2/10 Field Regiment RAA, playing the Last Post

(from left) Mr John Deighton MC, Sir Arvi Parbo AC, the Hon Fran Bailey MP, the Hon Bruce Mildenhall MP, Governor John Landy AC MBE and the Chairman

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 21

The Sir Edward Dunlop Medical Research Foundation

Photo Gallery - Cape Shank Golf Day

The picturesque Cape Schanck Golf Course

Event organiser Mr Ivor Jones with the Chairman

Winner of the competition, Mr Ralph De Marchi

The Chairman taking aim 22 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

Photo Gallery - Back to Caulfield Races

Sir Edward Dunlop Medical Research Foundation Stakes Trophy presentation

Board Directors Mr Ray Gill and Mrs Joan Johnstone

Ms Dagma Yeaman, event facilitator

(from left) supporters Mr Serge Tribuzio, Mrs Mary Tribuzio, Mrs Carmel Lentini and Mr Sam Lentini The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 23

The Sir Edward Dunlop Medical Research Foundation

Photo Gallery - Cocktail Evening

Presentation of Certificate of Appreciation to Mr Bob Solly, Deputy Commisioner of the Department of Veterans' Affairs. (from left) Dr Alexander Dunlop, the Hon Bruce Skeggs, Mr Bob Solly and the Chairman

Ms Jennifer Williams, CEO of Austin Health

(from left) Mr Secombe, the Chairman and Sir Arvi Parbo AC

24 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

Photo Gallery - Spring Luncheon

(from left) Mr Nick Gallina, Mr Victor Sassi (and friend) from the Cavour Club

Ex-service organisation presidents supporting the Spring Luncheon

(from left) Mr George Cappellotto, Veneto Region Association Delegate; the Hon Gordon RichPhillips, Member for Eumemmerring; Mrs Julia De Marchi; the Chairman; Mr Bob Solly; and Mrs Nola Solly

(from left) Mr Ross Rosario, Mrs Pina Rosario, Ms Maria Carideo, Board Director Mr Mike O'Meara and Mrs Margaret O'Meara

(from right) Mr Alex Dugina, Secretary of the Italian Sub-Branch of the RSL; Mr Fred Cullen, Board Director and President of the Ivanhoe RSL; Professor Bill Louis, Deputy Chairman of the Medical Research Committee; Mrs Sue Louis; and friend

Mr Max Usher from the Glenroy RSL learning to belly dance

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 25

The Sir Edward Dunlop Medical Research Foundation

FINANCIAL STATEMENTS

AT 30 JUNE 2003 ABN: 92 536 010 060 ACN: 006 753 162

26 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

Directors' Report

The Directors submit their report, together with the financial statements of the Company, for the year ended 30 June 2003, in accordance with a resolution of the Directors.

1. Directors

The names of the Directors in office at the date of this report are: Mr D De Marchi, RFD, LLB, FRSA (Chairman), barrister and solicitor, director, De Moray Pty Ltd, Transgard Pty Ltd Dr G W Cooper (Vice - Chairman), RFD,ED, MBBS, MRCP, FRACP, physician Mr F A Cullen OAM (Secretary) investor, primary producer, Chairman of Mullawingee Co-Operative Ltd Dr Mario DeLuise MBBS, B MED Sc, Ph D, FRACP, consultant physician Mr Raymond Gill, Retired bank Officer Mrs J Johnstone, retired, RSL representative Sir Richard Kingsland AO, CBE, DFC, retired Commonwealth department head Mr D G Keall, retired teacher Mr G W McCauley, retired bank manager Professor J J McNeil MBBS, MSc, PhD, FRACP, FAFPHM, clinical pharmacologist, epidemiologist and general physician Mr S P Murby, Vice President Swinburne University Mr M O'Meara Department of Veteran Affairs VIC branch Mr E.I. Richards, JP, retired company director Councillor E.R Smith ­ City of Monash, Former M.L.A Mr G R Thom BEc, FCPA, retired. Mr J W H Toon, OAM, retired company director Mrs J M Young (Treasurer), Office Administrator, secretary / Public Officer of the 2/24th Australian Infantry Battalion inc.

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 27

The Sir Edward Dunlop Medical Research Foundation

2. Principal Activity

The principal activity of the Company during the financial year continued to be the promotion of medical research through the encouragement of donations and fund raising activities.

3. Surplus / Deficit

The net amount of the surplus of the Company for the financial period was $215,862 (2002 a surplus of $28,238). The Company is exempt from income tax.

4. Review of Operations a ults

Operating income for the financial year was $438,470 (2002: $210,524) from donations, interest on investments and sundry items. Total expenditure of $222,608 (2002: $182,286) included research grants of $150,000 (2002: $150,000).

5. Significant Changes in the State of Affairs

There have been no significant changes in the state of affairs for the period ended 30 June 2003.

6. Significant Events after the Balance Date

No matter or circumstance has arisen since the end of the financial year that has significantly affected or may significantly affect: (i) (ii) (iii) the operations of the company; the results of those operations; or the state of affairs of the company

in the financial year subsequent to the financial year.

7. Directors' Benefits

Since the end of the previous financial year no Director of the Company has received or become entitled to receive a benefit by reason of a contract entered into by the Company with the Director or with a firm of which he is a member, or with a Company in which he has a substantial financial interest.

8. Dividends

The Sir Edward Dunlop Medical Research Foundation is limited by guarantee and is precluded from paying dividends. On behalf of the Board

D De Marchi Chairman

Melbourne 28 October 2003

J M Young Treasurer

28 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

Directors' Declaration

In accordance with a resolution of the Directors of The Sir Edward Dunlop Medical Research Foundation we state that: In the opinion of the Directors: (a) the financial statements and notes of the company are in accordance with the Corporations Act 2001, including: (i) giving a true and fair view of the company's financial position as at 30 June 2003 and of the performance for the year ended on that date; and (ii) complying with Accounting Standards and Corporations Regulations 2001; and there are reasonable grounds to believe that the Company will be able to pay its debts as and when they become due and payable.

(b)

On behalf of the Board

D De Marchi Chairman

Melbourne 28 October 2003

J M Young Treasurer

Statement of Financial Performance for the Year Ended 30 June 2003 Note

Operating Revenue from Ordinary Activities Operating Expenses from Ordinary Activities excluding Borrowing Costs Borrowing Costs Operating Surplus before Income Tax Income Tax Attributable to Ordinary Activities Operating Surplus After Income Tax Net Increase in Asset Revaluation Reserve Total Valuation Adjustments Total Changes in Equity 2a 2b

2003 $

438,470 222,608 215,862 215,862 60,000 60,000 275,862

2002 $

210,524 182,286 28,238 28,238 28,238

1 9

The Surplus and Deficit Statement should be read in conjunction with the accompanying Notes (pages 6 to 10).

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 29

The Sir Edward Dunlop Medical Research Foundation

Statement of Financial Position at 30 June 2003

Note Current Assets

Cash assets Receivables Inventory Other financial assets Total current assets 3 4 5 4,020 11,481 44,179 1,159,664 1,219,344 1,699 7,306 991,874 1,000,879

2003 $

2002 $

Non-current assets

Other financial assets Property, plant & equipment Total non-current assets Total assets 6 7 202,150 1,085 203,235 1,422,579 142,150 1,620 143,770 1,144,649

Current Liabilities

Other payables Total current liabilities Total liabilities Net assets 8 2,068 2,068 2,068 1,420,511 1,144,649

Fund Balances

Reserves Retained surplus Total Fund Balances 9 10 100,000 1,320,511 1,420,511 40,000 1,104,649 1,144,649

The Balance Sheet should be read in conjunction with the accompanying Notes (Pages 6 to 10).

30 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

Statement of Cash Flows for the Year Ended 30 June 2003

Note Cash Flows from Fund Raising Activities

Receipts from donors Payments for research grants Interest received Fund raising expenses Payments to employees Distribution from deceased estate Sundry expenses Sundry income Net Cash Flows from Operating Activities 24,860 (150,000) 50,981 (65,826) (19,050) 345,013 (35,461) 19,593 170,110 40,482 (150,000) 37,666 (6,972) (16,724) 121,604 (6,858) 8,354 27,552

2003 $

2002 $

11(b)

Cash Flow from Investing Activities

Purchase of Plant, Property and Equipment Purchase of financial asset ­ Portrait -

Net Cash Flows from Investing Activities

Net Increase/(Decrease) in Cash Held Add Opening Cash Brought Forward Closing Cash Carried Forward 170,110 993,574 1,163,684 27,552 966,022 993,574

11(a)

The Balance Sheet should be read in conjunction with the accompanying Notes (Pages 6 to 10).

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 31

The Sir Edward Dunlop Medical Research Foundation

Notes to and Forming Part of the Financial Statements at 30 June 2003

1. Summary of SignificantAccounting Policies

The financial statements are a general-purpose financial report prepared in accordance with the requirements of the Corporations Act 2001, which includes applicable Accounting Standards. Other mandatory professional reporting requirements (Urgent Issues Group Consensus Views) have also been complied with. The financial reports have been prepared in accordance with the historical cost convention. Freehold land and buildings are measured at fair value. The accounting policies adopted are consistent with those of the previous year unless otherwise specified. Changes in Accounting Policy There have been no changes in accounting policies for the year ended 30 June 2003. Cash and Cash Equivalents Cash on hand and in banks and short-term deposits are stated at the lower of cost and net realisable value. For the purpose of the Statement of Cash Flows, cash includes cash on hand and money market investments readily convertible to cash. Revenue Recognition Revenue is recognised to the extent that it is probable that the economic benefits will flow to the Foundation and the revenue can be reliably measured. Investments Listed shares held for trading are carried at net market value. Changes in net market value are recognised as revenue or expense in the statement of financial performance for the period. Property, Plant and Equipment Freehold land and buildings and freehold land are measured on a fair value basis. At balance date the value of each asset in this class is reviewed to ensure that it does not differ materially from the asset's fair value. Property, Plant & Equipment are carried at cost or at independent valuation Major depreciation rates are: Computer, printer and fax (reducing balance) 2003 33% 2002 33%

Income Tax The Foundation is an approved research institute under the Income Tax Assessment Act and therefore is exempt from income tax.

32 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

2. Operating Deficit and Inflow of Funds from Ordinary Activities

Included in the operating surplus are the following items:

2003 $ (a) Revenues from Operating Activities

Donations Bequests from Deceased Estates Total Revenues from Operating Activities 24,860 345,013 369,873

2002 $

40,482 121,604 162,086

Revenues from non-operating activities

Interest received - other entities Other Total Revenues from Non-Operating Activities Total Revenues from Ordinary Activities 49,004 19,593 68,597 438,470 40,084 8,354 48,438 210,524

(b) Expenses

Depreciation of non-current assets Plant and equipment Total Depreciation of Non-Current Assets Employee Expenses Salaries and wages Total Employee Expenses Research grants Fundraising and other operating expenses Total Expenses from Ordinary Activities 535 535 798 798

19,050 19,050 150,000 53,023 222,608

16,724 16,724 150,000 14,764 182,286

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 33

The Sir Edward Dunlop Medical Research Foundation

3. Receivables (Current) 2003 $

Other debtors GST Receivable 3,908 7,573 11,481

2002 $

5,886 1,420 7,306

4. Inventory 2003 $

Inventory ­ Lapel pins 44,179 44,179

2002 $

-

5. Other Financial Assets (Current) 2003 $

Listed shares Short term deposits Listed shares are readily saleable with no fixed terms. 114,536 1,045,128 1,159,664

2002 $

117,664 874,210 991,874

6. Other Financial Assets (Non-current) 2003 $

Investment property - at fair value Antiques bequeathed to the Foundation Portrait The fair value of the Foundation's investment property has been determined by reference to directors valuations based on independent valuations. The most recent independent valuation was obtained as at 30 June 2003 and has been performed on an open market basis, being an assessment of the amount for which the asset could be exchanged between a knowledgeable willing buyer and a knowledgeable willing seller in an arms length transaction. 200,000 1,900 250 202,150

2002 $

140,000 1,900 250 142,150

34 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

7. Property, Plant & Equipment 2003 $

Office equipment - at cost Accumulated depreciation 6,286 (5,201) 1,085

2002 $

6,286 (4,666) 1,620

8. Other Payables (Current) 2003 $

PAYG Payable Superannuation Payable 1,122 946 2,068

2002 $

-

9. Reserves 2003 $

Asset revaluation Movement in asset revaluation reserve Balance at beginning of year Revaluation increment on revaluation on property Balance at end of year 100,000

2002 $

40,000

40,000 60,000 100,000

40,000 40,000

10. Retained Surplus 2003 $

Balance at beginning of the year Operating (deficit)/surplus Total available for appropriation 1,104,649 215,862 1,320,511

2002 $

1,076,411 28,238 1,104,649

11. Statement of Cash Flow

(a) Reconciliation of cash: Cash comprising: Cash on hand Other financial assets (Note 5)

2003 $

4,020 1,159,664 1,163,684

2002 $

1,699 991,875 993,574

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 35

The Sir Edward Dunlop Medical Research Foundation

(b) Reconciliation of surplus to net cash flow activities:

2003 $

(Deficit)/surplus Depreciation - Property, plant & equipment Changes in assets & liabilities (increase)/decrease in receivables increase/(decrease) in payables (increase)/decrease in inventory Net Cash Provided by Operating Activities 215,862 535

2002 $

28,238 798

(4,175) 2,068 (44,179) 170,110

(1,484) 27,552

12. Directors' Remuneration

No remuneration was paid to directors during the year. The Foundation has directors and officers liability insurance.

13. Related Party Disclosure

(a) The Directors of The Sir Edward Dunlop Medical Research Foundation during the financial year were: G W Cooper F A Cullen M De Luise D De Marchi R Gill J Johnstone R Kingsland G W McCauley J J Mc Neil S Murby M O'Meara E.I. Richards C J Smith (Resigned 9 July 2002) E.R Smith (appointed 27 August 2002) G R Thom J W H Toon J M Young

(b) There were no related party transactions during the financial year.

14. Financial Instruments

Cash and cash equivalents and short-term investments: The carrying amount approximates fair value because of their short term to maturity. Trade Receivables: The carrying amount approximates fair value.

15. Employees

The number of full time equivalents employed as at 30 June 2003 is 1. (2002, 1)

36 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

Independent Audit Report

The financial report and directors' responsibility The financial report comprises the statement of financial position, statement of financial performance, statement of cash flows, accompanying notes to the financial statements, and the directors' declaration for The Sir Edward Weary Dunlop Medical Research Foundation (the company), for the year ended 30 June 2003. The directors of the company are responsible for preparing a financial report that gives a true and fair view of the financial position and performance of the company, and that complies with Accounting Standards in Australia, in accordance with the Corporations Act 2001. This includes responsibility for the maintenance of adequate accounting records and internal controls that are designed to prevent and detect fraud and error, and for the accounting policies and accounting estimates inherent in the financial report. Audit approach We conducted an independent audit of the financial report in order to express an opinion on it to the members of the company. Our audit was conducted in accordance with Australian Auditing Standards in order to provide reasonable assurance as to whether the financial report is free of material misstatement. The nature of an audit is influenced by factors such as the use of professional judgement, selective testing, the inherent limitations of internal control, and the availability of persuasive rather than conclusive evidence. Therefore, an audit cannot guarantee that all material misstatements have been detected. We performed procedures to assess whether in all material respects the financial report presents fairly, in accordance with the Corporations Act 2001, including compliance with Accounting Standards in Australia, and other mandatory financial reporting requirements in Australia, a view which is consistent with our understanding of the company's financial position, and of its performance as represented by the results of its operations and cash flows. We formed our audit opinion on the basis of these procedures, which included: examining, on a test basis, information to provide evidence supporting the amounts and disclosures in the financial report, and assessing the appropriateness of the accounting policies and disclosures used and the reasonableness of significant accounting estimates made by the directors.

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 37

The Sir Edward Dunlop Medical Research Foundation

Independent Audit Report continued

While we considered the effectiveness of management's internal controls over financial reporting when determining the nature and extent of our procedures, our audit was not designed to provide assurance on internal controls.

38 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation The winner of the Weary Dunlop Scholarship for 2002-2003

The significance of the life of Sir Edward `Weary' Dunlop in respect of community service

by Jane Brewer "There was little that was for the welfare of Australians in which he was not active."

Sir Ninian Stephen, former Governor General and fellow member of the Melbourne Scots, from a tribute given at Sir Edward's State funeral (Geddes, 1996:434)

From the day he was born Sir Edward `Weary' Dunlop was destined to make a significant contribution to citizens of Australia and around the world. His family of origin led by example through their country hospitality, Christian attitude of sacrificial giving and actions of always looking after other people. As a young person, Weary demonstrated exceptional personal qualities of courage, strength, endurance and steadfast determination. These qualities were to sustain him throughout his pharmacy and medical college years, lead him to command and save his fellow diggers from their Japanese captors and meet post-war challenges through continued humanitarian service to others at home and world-wide. Weary spent his life in service to others. Renowned as `Christ of the Burma Railway' he served for four years as medical officer, leader, motivator and death defying advocate for fellow diggers during the Second World War. Weary's return to Melbourne did not deter him from his quest to serve. In addition to his large, busy surgical practice and dedication to healing, Weary became a powerful force for good. Finding it difficult to ignore requests for help he was involved in 43 different organisations at one stage. Weary served and used his influence in multiple ways as patron, chairperson, member and donor. Organisations included the Anti-Cancer Council of Victoria where he passionately sought to help veterans through medical research into causes of cancer such as post-traumatic stress and smoking; the Victorian Foundation of Alcoholism and Drug Dependence; the Prisoners of War Trust and Association; the Ex-Prisoners of War and relatives' Association; the Melbourne Council for Overseas students; Friends of Vellore; the Colombo Plan, which helped developing nations; and the Australian Asian Association. This force for good was never more evident than in Weary's capacity to forgive his Japanese captors and promote the exchange of knowledge, skills and culture through forging social and cultural links between Australian and Asian students. His philosophy regarding reconciliation following the war was. "You are better to offer friendship and understanding" (Geddes: 284) and it has provided a positive legacy to our Australian community promoting acceptance and assistance to all people irrespective of race, class or creed. His service to others continues to live on in a number of charitable activities and scholarships, These include the Sir Edward Dunlop Research Foundation set up to investigate veterans' health problems, the Weary Dunlop-Boonpong Exchange Fellowship, which provides opportunities for young Thai Surgeons to get specialist training in Australia and various others. Weary was portrayed by those who knew and loved him as a gifted and exceptional man, but by no means perfect. Weary was described as individualistic, exuding confidence in

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 39

The Sir Edward Dunlop Medical Research Foundation

his own ability, a great leader but poor follower, blessed with exceptional physical and inner strength, untiring and totally focused on whatever he did to the point of ignoring his own and others' discomfort. Margaret Geddes' (1996) book, fellow surgeons, friends, patients, veterans, students and dignitaries alike, not only testified to his remarkable endurance, thoughtful letter writing, attentive post-surgical care, generosity, humility, quiet dry wit, gentleness and determination to help others but also to his total disregard for other people's time, his occasional temper outbursts and road rage, his priority to help others over spending time with family and his depression and loneliness experienced in latter years. Thus `Weary the Hero' was also `Weary the man', and as such even today serves as an inspiration and realistic model for us all. Serving his community was not limited to organisational involvement but also to constantly opening his Toorak Road home for others to stay, come for meals and use for functions. His deep interest in people of all ages in particular the younger generation ranged widely from medical, to musical, to cultural groups. The extent of one man's impact on the lives of those he touched was never more evident than at his state funeral attended by around 10,000 people. With only a little of Weary's immense capacity, sense of duty and willingness to serve others, we too can accomplish much. With our own abilities and life experience we too can choose to serve others and create better relationships and quality of life for all. Weary's inspiring example of what an ordinary person at any age can achieve, shows us that as ordinary people, doing ordinary things, we too can make an extra ordinary difference in our community. Reference: Geddes, Margaret (1996) Remembering Weary. Sir Edward Dunlop as recalled by those whose lives he touched. Australia: Penguin Books.

40 | The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03

The Sir Edward Dunlop Medical Research Foundation

The Sir Edward Dunlop Medical Research Foundation acknowledges a debt of gratitude to all board and Committee members, all volunteers, sponsors, supporters and benefactors whose generous assistance enables the Foundation to continue its work. In the spirit of Weary Dunlop,

Thank you

The Sir Edward Dunlop Medical Research Foundation Annual Report 02­03 | 41

Heidelberg Repatriation Hospital PO Box 5444, Heidelberg West Victoria Australia 3081 Tel 03 9387 7833 or 03 93814676 Fax 03 9387 2125 Email [email protected] www.siredwarddunlop.com.au Care and knowledge through medical research

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