Read Product Data Sheet - Sudantha text version

PRODUCT DATA SHEET

1. Product Name: 2. General Introduction: The Traditional Medical System of Sri Lanka has evolved throughout the centuries, and benefited by a Royal sponsorship from the time of King Budhadasa onwards (circa 400 A.D). The King was himself an accomplished physician, and through his active participation developed an organized medical system throughout the island which enjoyed full state recognition. A special feature of the indigenous system of medicine of today as it has evolved from the time of King Buddadasa, is that it is a synthesis of a number of systems that existed in the South Asian region, - viz: the dominant Ayurvedic system originating in the Indian sub-continent, the Unani system of Greco- Arabian origin, the Siddha system of Dravidian origin, and the Deshiya Chikitsa system, which prevailed in our little island prior to the progressive introduction and influence of Ayurveda, and the other systems. Thus the Sri Lankan indigenous system, which is a composite blend also bears a uniqueness where some of the constituent plant species utilized in the poly-prescriptions are endemic ones, similar to the species utilized in the other aforementioned systems. Oral hygiene is much valued in Ayurvedic health care. A healthy oral condition is an indication of good health; bad breath on the other hand stems from inter-alia faulty oral hygiene. The Link Sudantha tooth paste has been formulated with the idea of presenting the benefits from a mixture of medicinal plants which have been used in Ayurveda for keeping teeth and gums healthy. It uses a total extract of nine specially selected plant species to formulate a regular modern herbal toothpaste. Link Sudantha therefore, has healing effects on many conditions of gums and mouth and prevents bacterial infections, tartar build-up, sensitivities and bad breath. In short, daily use of Link Sudantha safeguards oral health and acts as a mouth cleansing agent, with an acceptable taste and flavour, leaving a refreshing after-taste following use. 3. Presentation: Link Sudantha is presented as a modern herbal medicinal toothpaste, in plastic tubes of 45 g and 80 g.

LINK SUDANTHA

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4. Constituents: Name given in Scientific name of plant Acacia chundra Willd. (Fabaceae) Adhatoda vasica Nees. (Acanthaceae ) Mimusops elengi L.( Sapotaceae) Piper nigrum L.( Pipperaceae) Pongamia pinnata(L.) Pirerre (Fabaceae) Quercus infectoria Olivier.( Fagaceae) Syzygium aromaticum L. (Myrtaceae) Terminalia chebula Retz.( Combretaceae) Zingiber officinale Rosce.( Zingiberaceae) Name in English Vasaka Bullet wood tree Black pepper Indian beech Gall oak Clove Myrobalan Ginger SLAP.* Rathkihiriya Adatoda Moonamal Gammiris Karanda Masakka Karabunati Aralu Inguru Plant part utilised. Dried heartwood Dried leaf Dried bark Dried seed Dried root Dried gall Dried flower bud Dried fruit Dried rhizome

* Sri Lanka Ayurveda Pharmacopoeia, 2 nd edition, 1994

5. Therapeutic effects: The plant extracts incorporated into Link Sudantha are well known in Ayurveda to promote oral hygiene and provide relief from various oral care problems. They exhibit a combination of antibacterial actions, anticarious and anti-inflammatory effects. In addition these plant extracts have been used for countering pyorrhoea, toothache, bleeding of gums, sensitivity of teeth and sore throat. This specific combination acts synergistically to strengthen the gums, clean the teeth, prevent caries and to remove bad breath. 6. Indications: Use Link Sudantha to ensure complete oral hygiene. Link Sudantha exerts healing effects on bleeding gums, gingivitis, ulceration of mouth and pyorrhoea. Link Sudantha will also combat the problems of tartar build-up, bad breath, and tooth decay. Link Sudantha leaves behind a refreshing after-taste in the mouth. Its usage is most warranted in the cases aforementioned as well as in combating all unhealthy conditions of the mouth, gums and teeth.

7. Directions for use: Use a pea sized (1 cm on brush) amount of tooth paste and brush your teeth at least twice a day, once in the morning and once before you go to bed.

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8. Literature and Technical information

TECHNICAL DATA SHEET

1.Analytical profile: Physical description : a. Appearance b. Odour c. Flavour Moisture content (%w/w) Volatile oil content (% w/w) Chloroform soluble extractives(% w/w) Ethyl Acetate soluble extractives(% w/w) :Yellowish paste :Spicy and mint :Spicy, minty and mildly pungent :15 ­ 25 : 1.0 ­ 2.0 : not less than 0.15 : not less than 0.44

Cohesiveness Density at 30 0C pH of aqueous solution(10g/45 ml) Fineness a) particles retained on 75 µm sieve(% w/w) b) particles retained on 150 µm sieve(% w/w) Abrasion Test Ease of extrusion Stability a) 0 0 C for 1 hr b) 45 0C for 72 hr

: not less than 15 s :1.60 - 1.65 g/ml : 6-7 : not more than 0.05 :not more than 1.0

:Passed (No scratches) :95 ­ 98 :stable (no change) :stable (no change)

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II.Chromatographic profile : Chromatographic "finger prints" :

TLC profile of Ethyl Acetate extract of Link Sudantha

Densitogram of Ethyl Acetate extract of

Sudantha

GLC Profile of volatile oil fraction of Sudantha

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III. Microbiological assessment : : Less than 105 per gram : Less than 103 per gram

a) Total viable aerobic count (cfu) b) Total fungal count (cfu)

9. Pharmacological activities of the constituent plants of Link Sudantha:

Constituent plant species Terminalia chebula Retz.

Reported relevant bioactivity anti-bacterial1, anti-microbial2, anti-caries3, cures bleeding and heals ulceration of gums4. has growth inhibitory activity against oral pathogens5, antiseptic6,anti-bacterial6, anti-fungal6, anti-viral6, spasmolytic6 , local anaesthetic6, countering pyorrhoea, toothache7. anti-microbial on gingival inflammation8, counter to pyorrhoea, and bleeding from mouth9 anti-microbial, anti- parasitic, local anesthetic, analgesic10, tumour inhibitory activity11, dentrifice12. tumor inhibitory activity13, sialagogue14, desensitizer15. reduces tooth hypersensitivity16, sponginess of gums17, relieves sore throat17, bleeding17 , ulceration of gums17. protection of gums and teeth15, strengthens the gums18, gargle for throat18 ,relaxes uvula18. cleanses the teeth15, anti-inflammatory19, analgesic19. gargle for sore throat20, obtunds sensitive dentine21 , toughens mucous membrane21.

Syzygium aromaticum (L.) Merry & Perry

Adhatoda vasica Nees.

Piper nigrum L.

Zingiber officinale Rosc.

Acacia chundra Willd.

Mimusops elengi L.

Pongammia pinnata (L.) Pierre. Quercus infectoria Oliver.

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10. References : 1. Malekzadeh, F., Ehsanifar, H., Shahamat, M., Levin, M., & Colwell, R.R., 2001, Int. J Antimicrob. Agents, 18, 1, 85 ­ 88 2. Sato, Y., Oketani, H., Singyouchi, K., Ohsub, T., Kihara, M., Shibata, H., and Higuti,T., 1997,Biol. Pharm. Bull , 20,4, 401 ­ 4 3. Jagtap, A. G., Karkera, S.G.,1999, J Ethnopharmacol , 68, 1 ­ 3, 299 ­ 306 4. The Wealth of India, 1989, Council of Scientific & Industrial Research, New Delhi, vol x, p 171 - 177 5. Cail, Wu C.D., 1996, J Nat. Prod, 59,10, 987 ­ 90 6. Physicians Desk Reference (PDR) for Herbal Medicines, 2000, 2nd edition, Medicinal Economics Company, U.S.A., p 196 7. Farooqi, A. H.A., Jain, S.P., Shukla, Y.N., Ansari, S.R., and Kumar, S., 1998, J of Med. and Aromatic Plant Sciences, 20 , 441 ­ 450 8. Patel, V.K., Venkatakrishna ­ Bhatt, H., 1984, Indian J Med. Sci, 38, 4, 70 ­ 2 9. Doshi, V.K., Patel V,K., Venkatakrishna ­ Bhatt, 1983, Int. J. Crude Drug Res. 21 , 4, 173 ­ 176 10. Johri, R.K., Zutshi, U.,1992, J. Ethnopharmacol. 37, 85 ­ 91 11. Physicians Desk Reference (PDR) for Herbal Medicines, 2000, 2nd edition, Medicinal Economics Company, U.S.A., p 103 12. Farooqi, A. H.A., Jain, S.P., Shukla, Y.N., Ansari, S.R., Kumar, S., 1998, J of Med. and Aromatic Plant Sciences, 20 , 441 ­ 450 13. Keum, Y. S., Kim, J., Lee, K. H., Park, K. K., and Surh, Y.J., 2002 , Cancer Lett, 8, 177, 1, 41 - 7 14. S. Joshi, 2000, Medicinal Plants, Oxford & IBH Publishing Co. Pvt.Ltd, India, p 413 15. Prescott, J., Stevenson, R. J., 1996, Physiol Behav , 60,6, 1473 ­ 80 16. Farooqi, A. H.A., Jain, S.P., Shukla, Y.N., Ansari, S.R.,and Kumar, S., 1998, J of Med. and Aromatic Plant Sciences, 20 , 441 ­ 450 17. Atta ­ Ur ­ H.M. Said and Ahmad ,V. U.., 1986, Pakistan Encyclopoedia Planta Medica, Vol ­ 1, Hamdard Foundation Press, Pakistan, p 51 ­ 52

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18. Perry, L. M., 1980, Medicinal Plants of East & Southeast Asia, Attributed properties Uses, Judith Metzger, MIT Press, p 376 19. Singh, R. K., Nath, G., Acharya, S. B.,& Goel, R.K., 1997, Indian J Exp. Biol ,35, 8, 831­ 6 20. Chatterjee , A., Pakrashi, S. C., 1992, The Treatise on Indian Medicinal Plants, vol­ 2, Publications & Information Directorate, p111 21. David, M.R., 1927, A Manual of Materia Medica & Pharmacology, 7th edition, p 360 - 365

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Product Data Sheet - Sudantha

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