Read Microsoft Word - Oral Toxicity Classifications_06.30.09 text version

Results of Required EPA Companion Animal Safety Studies confirm that both Hartz Active Ingredients and Product Formulations are Classified among the Lowest Categories for Potential Oral Toxicity

Executive Summary

· According to EPA's classification of toxicity, where category I is considered the most toxic and category IV is the least toxic; o The active ingredients in Hartz® topical treatments for both dogs and cats are among the least toxic of any pet pesticide active ingredient on the market, whether sold in retail outlets or in the veterinarian's office.

·

Hartz® UltraGuard® topical cat formula is classified in the lowest EPA toxicity category available, category IV, requiring no signal word on the packaging label. o Scientific and long-term usage studies have shown that etofenprox, the active ingredient in Hartz Flea and Tick Topical Treatment for Cats, has a low oral and dermal toxicity. The attached chart illustrates that the formula for Hartz® UltraGuard Pro® Flea & Tick Drop for Cats is categorized in a lower toxicity category than the competitive commercial formulas listed.

o

·

Hartz® flea and tick products for dogs contain highly effective, low toxicity ingredients to provide effective flea and tick control with a low incidence of adverse events. o Hartz® UltraGuard Plus® and UltraGuard Pro® Flea & Tick Drops for Dogs have been rated by EPA as having the lowest oral toxicity rating, category IV. d-Phenothrin is one of a class of pyrethroid compounds. Pyrethroids are synthetic compounds based largely on pyrethrins, which are found naturally in chrysanthemum flowers.

o

o

Similar to the Cat Topical Formula Toxicity Chart, the information below illustrates that the formula for Hartz® UltraGuard Pro® Flea & Tick Drop for Dogs and Puppies is categorized as equal to or of a lower toxicity category than competitive commercial formulas.

2

Results of Required EPA Companion Animal Safety Studies confirm that both Hartz Active Ingredients and Product Formulations are Classified among the Lowest Categories for Potential Oral Toxicity

According to EPA's classification of toxicity, where category I is considered the most toxic and category IV is the least toxic, the active ingredients in Hartz® topical treatments for both dogs and cats are the least toxic of any pet pesticide active ingredient on the market, whether sold in retail outlets or in the veterinarian's office. Hartz® UltraGuardTM Topical Treatments for Cats Hartz® UltraGuard Plus® and UltraGuard Pro® Flea & Tick Drop for Cats were developed with etofenprox, an active ingredient that provides safe and effective control of fleas, ticks and mosquitoes when applied directly to the cat's skin. Etofenprox is an adulticide that is effective against adult fleas and mosquitoes and 3 of the 4 tick life stages; it affects the parasite's nervous system, exciting its nerve cells to bring about the death of the pest. Scientific and long-term usage studies have shown that etofenprox has a low oral and dermal toxicity. Hartz® UltraGuard® topical cat formula is classified in the lowest EPA toxicity category available, category IV, requiring no signal word on the packaging label. Conversely, the leading brands sold by veterinarians are classified in EPA toxicity category III with a "Caution" label signal word required, and category II, requiring a "Warning" label signal word. The chart below documents the differences in oral toxicity rating for several topical pesticide active ingredients. The greater the mg/kg value, the less toxic the ingredient. Correspondingly, EPA has designated categories for differences in toxicity. The greater the category number, the less toxic the active ingredient, for example, a category IV designation is the lowest toxicity rating applicable.

The chart below illustrates that the formula for Hartz® UltraGuard Pro® Flea & Tick Drop for Cats is categorized in a lower toxicity category than the competitive commercial formulas listed.

3

Hartz® UltraGuardTM Topical Treatments for Dogs Hartz® flea and tick products for dogs contain highly effective, low toxicity ingredients to provide effective flea and tick control with a low incidence of adverse events. Hartz® UltraGuard Plus® and UltraGuard Pro® Flea & Tick Drops for Dogs have been rated by EPA as having the lowest oral toxicity rating, category IV. The active ingredient in Hartz® UltraGuard treatments for dogs, d-phenothrin, was commercialized over 30 years ago and has a long history of controlling a variety of household pests. The ingredient has been proven to have a very low oral toxicity rating, but is highly effective in killing and repelling fully-grown fleas, ticks and mosquitoes. d-Phenothrin penetrates insects' protective covering, or exoskeleton, and disrupts their nervous system to bring about the death of the pest. Scientific and long-term usage studies have shown that d-phenothrin has a low oral and dermal toxicity rating. d-Phenothrin is one of a class of pyrethroid compounds. Pyrethroids are synthetic compounds based largely on pyrethrins, which are found naturally in chrysanthemum flowers. The chart below documents the differences in oral toxicity rating for several topical pesticide active ingredients. The greater the mg/kg value, the less toxic the ingredient. Correspondingly, EPA has designated categories for differences in toxicity. The greater the category number, the less toxic the active ingredient, for example, a category IV designation is the lowest toxicity rating applicable.

Similar to the Cat Topical Formula Toxicity Chart, the information below illustrates that the formula for Hartz® UltraGuard Pro® Flea & Tick Drop for Dogs and Puppies is categorized as equal to or of a lower toxicity category than competitive commercial formulas.

Information

Microsoft Word - Oral Toxicity Classifications_06.30.09

3 pages

Report File (DMCA)

Our content is added by our users. We aim to remove reported files within 1 working day. Please use this link to notify us:

Report this file as copyright or inappropriate

250880